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ChemMedChem

Volumn 6, Issue 8, 2011, Pages 1423-1438

Aromatase and Dual Aromatase-Steroid Sulfatase Inhibitors from the Letrozole and Vorozole Templates

(6) Wood, Paul M a Woo, L W Lawrence a Thomas, Mark P a Mahon, Mary F b Purohit, Atul c Potter, Barry V L a

a University of Bath (United Kingdom)

b University of Bath (United Kingdom)

c HAMMERSMITH HOSPITAL (United Kingdom)

Author keywords

Aromatase; Breast cancer; Dual inhibitors; Endocrine therapy; Sulfatase

Indexed keywords

2 BROMO 4 (2 (4 CYANOPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YL)ETHYL)PHENYL; ANTINEOPLASTIC AGENT; LETROZOLE; STERYL SULFATASE; UNCLASSIFIED DRUG; VOROZOLE;

ARTICLE; CHORIOCARCINOMA; CONTROLLED STUDY; DRUG OXIDATION; DRUG POTENCY; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INHIBITION KINETICS; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AROMATASE; AROMATASE INHIBITORS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE, TUMOR; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; NITRILES; STEREOISOMERISM; STERYL-SULFATASE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS; TRIAZOLES;

EID: 79960692837 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201100145 Document Type: Article

Times cited : (61)

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