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Volumn 8, Issue 5, 2013, Pages 726-732

Design of Libraries Targeting Protein-Protein Interfaces

(10) Fry, David a Huang, Kuo Sen a DiLello, Paola a Mohr, Peter b Müller, Klaus b So, Sung Sau a Harada, Takeo c Stahl, Martin b Vu, Binh a Mauser, Harald b

a HOFFMANN LA ROCHE INC (United States)

b F HOFFMANN LA ROCHE LTD (Switzerland)

c CHUGAI PHARMACEUTICAL CO LTD (Japan)

Author keywords

Library design; Pharmacophore searching; Protein protein inhibition; Structure based design

Indexed keywords

NUCLEAR RECEPTOR NUR77; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN INHIBITOR; PROTEIN MCL 1; PROTEIN MDM2; PROTEIN MDMX; RO 5508946; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG DETERMINATION; DRUG POTENCY; DRUG SYNTHESIS; DRUG TARGETING; HIGH THROUGHPUT SCREENING; IC 50; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MDM2; RATS; REFERENCE STANDARDS; SMALL MOLECULE LIBRARIES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84877059094 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201200540 Document Type: Article

Times cited : (30)

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