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ChemMedChem

Volumn 4, Issue 4, 2009, Pages 649-656

Structure and function of benzoy Iurea-derived A-helix mimetics targeting the Bcl-xL/bak binding interface

(6) Rodriguez, Johanna M a Ross, Nathan T a Katt, William P a Dhar, Deepali a Lee, Gui in b Hamilton, Andrew D a

a YALE UNIVERSITY (United States)

b PENNSYLVANIA STATE UNIVERSITY (United States)

Author keywords

helix mimetics; Bcl xL; Calorimetry; Protiein protiein interactionsn benzoylurea scaffold

Indexed keywords

ANTINEOPLASTIC AGENT; BENZOYLUREA DERIVATIVE; PROTEIN BAK; PROTEIN BCL XL; UNCLASSIFIED DRUG; UREA DERIVATIVE; BENZENE; BIOMIMETIC MATERIAL; PROTEIN BCL X; UREA;

ALPHA HELIX; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG CONFORMATION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TARGETING; FLUORESCENCE POLARIZATION; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; NITROGEN NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; CALORIMETRY; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; TITRIMETRY; X RAY CRYSTALLOGRAPHY;

BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-X PROTEIN; BENZENE; BIOMIMETIC MATERIALS; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TITRIMETRY; UREA;

EID: 65549164451 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.200800387 Document Type: Article

Times cited : (44)

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