Improvement of the circulatory function partially accounts for the neuroprotective action of the phytoestrogen genistein in experimental ischemic stroke

European Journal of Pharmacology

Volumn 708, Issue 1-3, 2013, Pages 88-94

  Cortina, Belén ^a   Torregrosa, Germán ^a,b   Castelló Ruiz, María ^a,b   Burguete, María C ^b   Moscardó, Antonio ^a   Latorre, Ana ^a   Salom, Juan B ^a,b   Vallés, Juana ^a   Santos, María T ^a   Alborch, Enrique ^a,b  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Genistein; Isoflavone; Phytoestrogen; Platelet; Stroke; Thromboxane A 2

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; BETA CYCLODEXTRIN; GENISTEIN; THROMBOXANE A2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN CIRCULATION; BRAIN FUNCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN SLICE; CAROTID ARTERY; CONTROLLED STUDY; LEUKOCYTE AGGREGATION; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN BLOOD LEVEL; RAT; REPERFUSION INJURY; SINGLE DRUG DOSE; THROMBOCYTE AGGREGATION; TREATMENT OUTCOME;

ANIMALS; BRAIN ISCHEMIA; GENISTEIN; MALE; NEUROPROTECTIVE AGENTS; PHYTOESTROGENS; PLATELET AGGREGATION; RATS; RATS, WISTAR; STROKE; THROMBOXANE A2;

EID: 84877053711     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.02.016     Document Type: Article

References (46)

1. Antithrombotic Trialists' Collaboration Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients Br. Med. J. 324 2002 71 86
2. C. Arce, J.L. Arteaga, E. Sánchez-Mendoza, M.J. Oset-Gasque, S. Cañadas, and M.P. González Added after anoxia-reoxigenation stress, genistein rescues from death the rat embryo cortical neurons Neurosci. Med. 1 2010 50 59
3. I. Azcoitia, A. Moreno, P. Carrero, S. Palacios, and L.M. García-Segura Neuroprotective effects of soy phytoestrogens in the rat brain Gynecol. Endocrinol. 22 2006 63 69
4. T. Baluchnejadmojarad, and M. Roghani Chronic administration of genistein improves aortic reactivity of streptozotocin-diabetic rats: mode of action Vascul. Pharmacol. 9 2008 1 5
5. J.B. Bederson, L.H. Pitts, S.M. Germano, M.C. Nishimura, R.L. Davis, and H.M. Bartkowski Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats Stroke 17 1986 1304 1308
6. L.T. Bloedon, R. Jeffcoat, W. Lopaczynski, M.J. Schell, T.M. Black, K.J. Dix, B.F. Thomas, C. Albright, M.G. Busby, J.A. Crowell, and S.H. Zeisel Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women Am. J. Clin. Nutr. 76 2002 1126 1137
7. M.C. Burguete, G. Torregrosa, F.J. Pérez-Asensio, M. Castelló-Ruiz, J.B. Salom, J.V. Gil, and E. Alborch Dietary phytoestrogens improve stroke outcome after transient focal cerebral ischemia in rats Eur. J. Neurosci. 23 2006 703 710
8. M. Castelló-Ruiz, G. Torregrosa, M.C. Burguete, J.B. Salom, J.V. Gil, F.J. Miranda, T. Jover-Mengual, V.G. Marrachelli, and E. Alborch Soy-derived phytoestrogens as preventive and acute neuroprotectors in experimental ischemic stroke: influence of rat strain Phytomedicine 18 2011 513 515
9. M.J. Cipolla, and L.V. Bullinger Reactivity of brain parenchymal arterioles after ischemia and reperfusion Microcirculation 15 2008 495 501
10. W. Durante, V.B. Schini, M.H. Kroll, S. Catovsky, T. Scott-Burden, J.G. White, P.M. Vanhoutte, and A.I. Schafer Platelets inhibit the induction of nitric oxide synthesis by interleukin-1 beta in vascular smooth muscle cells Blood 83 1994 1831 1838
11. Z.G. Franks, R.A. Campbell, A.S. Weyrich, and M.T. Rondina Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke Ann. N. Y. Acad. Sci. 1207 2010 11 17
12. 2 receptor J. Thromb. Haemost. 3 2005 369 376
13. S.-M. Heinonen, K. Wähälä, and H. Adlercreutz Metabolism of isoflavones in human subjects Phytochem. Rev. 1 2002 175 182
14. K.W. Hong, H.K. Shin, C.D. Kim, W.S. Lee, and B.Y. Rhim Restoration of vasodilation and CBF autoregulation by genistein in rat pial artery after brain injury Am. J. Physiol. Heart Circ. Physiol. 281 2001 H308 H315
15. P. Janning, U.S. Schuhmacher, A. Upmeier, P. Diel, H. Michna, G.H. Degen, and H.M. Bolt Toxicokinetics of the phytoestrogen daidzein in female DA/Han rats Arch. Toxicol. 74 2000 421 430
16. M.R. Karamsetty, J.R. Klinger, and N.S. Hill Phytoestrogens restore nitric oxide-mediated relaxation in isolated pulmonary arteries from chronically hypoxic rats J. Pharmacol. Exp. Ther. 297 2001 968 974
17. Y. Kokubo, H. Iso, J. Ishihara, K. Okada, M. Inoue, S. Tsugane, and Group JPHC Study Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations. The Japan Public Health Center-based (JPHC) study cohort I Circulation 116 2007 2553 2562
18. K. Kondo, Y. Suzuki, Y. Ikeda, and K. Umemura Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation Eur. J. Pharmacol. 455 2002 53 57
19. 2-induced contraction of rat small mesenteric arteries PLoS one 5 2010 e11098
20. H.-W. Liang, S.-F. Qiu, J. Shen, L.-N. Sun, J.-Y. Wang, I.C. Bruce, and Q. Xia Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus Neurosci. Lett. 438 2008 116 120
21. E.Z. Longa, P.R. Weinstein, S. Carlson, and R. Cummins Reversible middle cerebral artery occlusion without craniectomy in rats Stroke 20 1989 84 91
22. L expression in experimental stroke Neuroscience 148 2007 644 652
23. L.M. Mallis, A.B. Sarkahian, H.A. Harris, M.-Y. Zhang, and O.J. McConnell Determination of rat oral bioavailability of soy-derived phytoestrogens using an automated on-column extraction procedure and electrospray tandem mass spectrometry J. Chromatogr. B 796 2003 71 86
24. S. Martinez-Revelles, F. Jiménez-Altayó, L. Caracuel, F.J. Pérez-Asensio, A.M. Planas, and E. Vila Endothelial dysfunction in rat mesenteric resistance artery after transient middle cerebral artery occlusion J. Pharmacol. Exp. Ther. 325 2008 363 369
25. S. Meairs, N. Wahlgren, U. Dirnagl, O. Lindvall, P. Rothwell, J.-C. Baron, K. Hossmann, B. Engelhardt, J. Ferro, J. McCulloch, M. Kaste, M. Endres, J. Koistinaho, A. Planas, D. Vivien, R. Dijkuizen, A. Czlonkowska, A. Hagen, A. Evans, De G. Libero, Z. Nagy, D. Rastenyte, J. Reess, A. Davalos, G.L. Lenzi, P. Amarenco, and M. Hennerici Stroke research in the European Union Edition 2007 Office for Official Publications of the European Communities Luxembourg
26. L. Monge, N. Fernández, A. Salcedo, A.L. García- Villalón, and G. Diéguez Role of α-adrenoceptors and prostacyclin in the enhanced adrenergic reactivity of goat cerebral arteries after ischemia-reperfusion Brain Res. 1346 2010 121 131
27. 2 receptor in human platelets Thromb. Res. 123 2009 740 744
28. 4 in platelets Br. J. Pharmacol. 158 2009 1548 1556
29. R. O'Connor, L.M. Cryan, K. Wynne, A. de Stefani, D. Fitzgerald, C. O'Brien, and G. Cagney Proteomics strategy for identifying candidate bioactive proteins in complex mixtures: application to platelet releasate J. Biomed. Biotechnol. Article ID 107859. 2010 10.1155/2010/107859
30. J.W. Phillis, L.A. Horrocks, and A.A. Farooqui Cyclooxygenases, lipoxigenases, and epoxygenases in CNS: their role and involvement in neurological disorders Brain Res. Rev. 52 2006 201 243
31. X. Qin, P.D. Hurn, and M.T. Littleton-Kearney Estrogen restores postischemic sensitivity to the thromboxane mimetic U46619 in rat pial artery J. Cereb. Blood Flow Metab. 25 2005 1041 1046
32. C.E. Rüfer, A. Bub, J. Möseneder, P. Winterhalter, M. Stürtz, and S.E. Kulling Pharmacokinetics of the soybean isoflavone daidzein in its aglycone and glucoside form: a randomized, double-blind, crossover study J. Clin. Nutr. 87 2008 1314 1323
33. 2 and prothrombotic effects of erythrocytes are important determinants of aspirin resistance in patients with vascular disease J. Thromb. Haemost. 6 2008 615 621
34. D.A. Schreihofer, K.D. Do, and A.M. Schreihofer High-soy diet decreases infarct size after permanent middle cerebral artery occlusion in female rats Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 2005 R103 R108
35. D.A. Schreihofer, and L. Redmond Soy phytoestrogens are neuroprotective against stroke-like injury in vitro Neuroscience 158 2009 602 609
36. K.D.R. Setchell, N.M. Brown, P. Desai, L. Zimmer-Nechemias, B.E. Wolfe, W.T. Brashear, A.S. Kirschner, A. Cassidy, and J.E. Heubi Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements J. Nutr. 131 2001 1362S 1375S
37. M. Sonee, T. Sum, C. Wang, and S.K. Mukherjee The soy isoflavone, genistein, protects human cortical neuronal cells from oxidative stress NeuroToxicology 25 2004 885 891
38. J.N. Stankowski, and R. Gupta Therapeutic targets for neuroprotection in acute ischemic stroke: lost in translation? Antioxid Redox Signal. 14 2011 1841 1851
39. 1 receptor-mediated contraction in rats Stroke 35 2004 970 974
40. M. Tamura Effects of intestinal flora on the metabolism and absorption of isoflavones Jpn. Agric. Res. Q. 40 2006 45 50
41. G. Torregrosa, M.C. Burguete, F.J. Pérez-Asensio, J.B. Salom, J.V. Gil, and E. Alborch Pharmacological profile of phytoestrogens in cerebral vessels: in vitro study with rabbit basilar artery Eur. J. Pharmacol. 482 2003 227 234
42. V.N. Trieu, and F.M. Uckun Genistein is neuroprotective in murine models of familial amyotrophic lateral sclerosis and stroke Biochem. Biophys. Res. Commun. 258 1999 685 688
43. B. Turgut, N. Turgut, Y. Çelik, E. Tekgündüz, G.E. PamuK, and M. Demir Differences in platelet-leukocyte aggregates among subtypes of acute cerebral ischemia J. Neurol. Sci. 305 2011 126 130
44. J. Valles, M.T. Santos, J. Aznar, A.J. Marcus, V. Martinez-Sales, M. Portoles, M.J. Broekman, and L.B. Safier Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment Blood 78 1991 154 162
45. S. Vergne, K. Titier, V. Bernard, J. Asselineau, M. Durand, V. Lamothe, M. Potier, P. Perez, J. Demotes-Mainard, P. Chantre, N. Moore, C. Bennetau-Pelissero, and P. Sauvant Bioavailability and urinary excretion of isoflavones in humans: effects of soy-based supplements formulation and equol production J. Pharm. Biomed. Anal. 43 2007 1488 1494
46. 2 receptor uncouples endothelial nitric oxide synthase Arterioscler. Thromb. Vasc. Biol. 31 2011 125 132