Phytoestrogens restore nitric oxide-mediated relaxation in isolated pulmonary arteries from chronically hypoxic rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 3, 2001, Pages 968-974

  Karamsetty, M R ^a,b   Klinger, J R ^a   Hill, N S ^a  

^a BROWN UNIVERSITY   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CARBACHOL; DAIDZEIN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; FULVESTRANT; GENISTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLEPHRINE; PHYTOESTROGEN; PROTEIN TYROSINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; HYPOXIA; ISOLATED ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SOYBEAN; VASCULAR DISEASE;

ANIMALS; ANOXIA; CARBACHOL; CHOLINERGIC AGONISTS; CHRONIC DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGENS, NON-STEROIDAL; GENISTEIN; HYPERTENSION, PULMONARY; ISOFLAVONES; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHYTOESTROGENS; PLANT PREPARATIONS; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 0034998916     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Adnot S, Raffestin B, Eddahibi S, Braquet P and Chabrier PE (1991) Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J Clin Invest 87:155-162.
2. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M and Fukami Y (1987) Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262:5592-5595.
3. Akiyama T and Ogawara H (1991) Use and specificity of genistein as inhibitor of protein-tyrosine kinases. Methods Enzymol 201:362-370.
4. Berkenbosch JW, Baribeau J and Perreault T (2000) Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 278:L276-L283.
5. Brett SJ, Simon J, Gibbs R, Pepper JR and Evans TW (1996) Impairment of endothelium-dependent pulmonary vasodilation in patients with primary pulmonary hypertension. Thorax 51:89-91.
6. Cai Q and Wei H (1996) Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice. Nutr Cancer 25:1-7.
7. Channick RN, Hoch RC, Newhart JW, Johnson FW and Smith CM (1994) Improvement in pulmonary hypertension and hypoxemia during nitric oxide inhalation in a patient with end-stage pulmonary fibrosis. Am J Respir Crit Care Med 149:811-814.
8. Channick RN, Newhart JW, Johnson FW, Williams PJ, Auger WR, Fedullo PF and Moser KM (1996) Pulsed delivery of inhaled nitric oxide to patients with primary pulmonary hypertension: an ambulatory delivery system and initial clinical tests. Chest 109:1545-1549.
9. Dinh-Xuan AT, Pepke-Zaba J, Butt AY, Cremona G and Higenbottam TW (1993) Impairment of pulmonary-artery endothelium-dependent relaxation in chronic obstructive lung disease is not due to dysfunction of endothelial cell membrane receptors nor to L-arginine deficiency. Br J Pharmacol 109:587-591
10. Durmowicz AG, Orton EC and Stenmark KR (1993) Progressive loss of vasodilator responsive component of pulmonary hypertension in neonatal calves exposed to 4,570 m. Am J Physiol 265:H2175-H2183.
11. Eddahibi S, Raffestin B, Braquet P, Chabrier PE and Adnot S (1991) Pulmonary vascular reactivity to endothelin-1 in normal and chronically pulmonary hypertensive rats. J Cardiovasc Pharmacol 17:8358-3361.
12. Farhat MY, Chen MF, Bhatti T, Iqbal A, Cathapermal S and Ramwell PW (1993) Protection by oestradiol against the development of cardiovascular changes associated with monocrotaline pulmonary hypertension in rats. Br J Pharmacol 110: 719-723.
13. Higenbottam TW and Laude EA (1998) Endothelial dysfunction providing the basis for the treatment of pulmonary hypertension: Giles P. Filley lecture. Chest 114: S72-S79.
14. Honore EK, Williams JK, Anthony MS and Clarkson TB (1997) Soy isoflavones enhance coronary vascular reactivity in atherosclerotic female macaques. Fertil Steril 67:148-154.
15. Karamsetty VS, MacLean MR, McCulloch KM, Kane KA and Wadsworth RM (1996) Hypoxic constrictor response in the isolated pulmonary artery from chronically hypoxic rats. Respir Physiol 105:85-93.
16. Kerry N and Abbey M (1998) The isoflavone genistein inhibits copper and peroxyl radical mediated low density lipoprotein oxidation in vitro. Atherosclerosis 140: 341-347.
17. Kitazono T, Ibayashi S, Nagao T, Fujii K, Kagiyama T and Fujisaima M (1998) Role of tyrosine kinase in dilator responses of rat basilar artery in vivo. Hypertension 31:861-865.
18. Klinger JR, Wrenn DS, Warburton RR, Pietras L, Ou LC and Hill NS (1997) Atrial natriuretic peptide expression in rats with different pulmonary hypertensive responses to hypoxia. Am J Physiol 273:H411-H417.
19. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B and Gustafsson JA (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139:4252-4263.
20. Maruyama K, Maruyama J, Yokochi A, Muneyuki M and Miyasaka K (1995) Vasodilatory effects of ketamine on pulmonary arteries in rats with chronic hypoxic pulmonary hypertension. Anesth Analg 80:786-792.
21. Miksicek RJ (1994) Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor. J Steroid Biochem Mol Biol 49:153-160.
22. Mitchell JH, Gardner PT, McPhail DB, Morrice PC, Collins AR and Duthie GG (1998) Antioxidant efficacy of phytoestrogens in chemical and biological model systems. Arch Biochem Biophys 360:142-148.
23. Parker TA, Dunbar Ivy D, Galan HL, Grover TR, Kinsella JP and Abman SH (2000) Estradiol improves pulmonary hemodynamics and vascular remodeling in perinatal pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 278:L374-L381.
24. Ruiz-Larrea MB, Mohan AR, Paganga G, Miller NJ, Bolwell GP and Rice-Evans CA (1997) Antioxidant activity of phytoestrogenic isoflavones. Free Radical Res 26: 63-70.
25. Sargeant P, Farndale RW and Sage SO (1993) ADP-and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets. J Biol Chem 268:18151-18156.
26. Satake N, Imanishi M and Shibata S (1999) Increased nitroglycerin-induced relaxation by genistein in rat aortic rings. Eur J Pharmacol 377:193-197.
27. Squadrito F, Altavilla D, Squadrito G, Saitta A, Cucinotta D, Minutoli L, Deodato B, Ferlito M, Campo GM, Bova A, et al. (2000) Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats. Cardiovasc Res 45:454-462.
28. Trieu VN, Dong Y, Zheng Y and Uckun FM (1999) In vivo antioxidant activity of genistein in a murine model of singlet oxygen-induced cerebral stroke. Radiat Res 152:508-516.
29. Uzun O, Demiryurek AT and Kanzik I (1998) The role of tyrosine kinase in hypoxic constriction of sheep pulmonary artery rings. Eur J Pharmacol 358:41-47.
30. Wakeling AE and Bowler J (1992) ICI 182,780, a new antioestrogen with clinical potential. J Steroid Biochem Mol Biol 43:173-177.
31. Wanstall JC, Kaye JA and Gambino A (1997) The in vitro pulmonary vascular effects of FK409 (nitric oxide donor): a study in normotensive and pulmonary hypertensive rats. Br J Pharmacol 121:280-286.
32. Wei H, Bowen R, Cai Q, Barnes S and Wang Y (1995) Antioxidant and antipromotional effects of the soybean isoflavone genistein. Proc Soc Exp Biol Med 208:124-130.