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Volumn 1, Issue 2, 2002, Pages 175-182

Metabolism of isoflavones in human subjects

Author keywords

Biochanin A; Daidzein; Formononetin; Genistein; Glycitein; Isoflavone; Metabolism; Red clover; Soy

Indexed keywords

BIOCHANIN A; DAIDZEIN; DRUG METABOLITE; EQUOL; FORMONONETIN; GENISTEIN; GLYCITEIN; ISOFLAVONE; O DESMETHYLANGOLENSIN; UNCLASSIFIED DRUG;

EID: 1942459926     PISSN: 15687767     EISSN: 1572980X     Source Type: Journal    
DOI: 10.1023/A:1022555216303     Document Type: Conference Paper
Times cited : (44)

References (39)
  • 1
    • 0025181114 scopus 로고
    • Western diet and Western diseases: Some hormonal and biochemical mechanisms and associations
    • Adlercreutz H (1990) Western diet and Western diseases: some hormonal and biochemical mechanisms and associations. Scand. J. Clin. Lab. Invest. 50, Suppl 201: 3-23.
    • (1990) Scand. J. Clin. Lab. Invest. , vol.50 , Issue.SUPPL. 201 , pp. 3-23
    • Adlercreutz, H.1
  • 2
    • 0020414806 scopus 로고
    • Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian post-menopausal women and in women with breast cancer
    • Adlercreutz H, Fotsis T, Heikkinen R, Dwyer JT, Woods M, Goldin BR & Gorbach SL (1982) Excretion of the lignans enterolactone and enterodiol and of equol in omnivorous and vegetarian post-menopausal women and in women with breast cancer. Lancet 2: 1295-1299.
    • (1982) Lancet , vol.2 , pp. 1295-1299
    • Adlercreutz, H.1    Fotsis, T.2    Heikkinen, R.3    Dwyer, J.T.4    Woods, M.5    Goldin, B.R.6    Gorbach, S.L.7
  • 3
    • 0023612656 scopus 로고
    • Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG)
    • Adlercreutz H, Hockerstedt K, Bannwart C, Bloigu S, Hamalainen E, Fotsis T & Ollus A (1987) Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). J. Steroid Biochem. 27: 1135-1144.
    • (1987) J. Steroid Biochem. , vol.27 , pp. 1135-1144
    • Adlercreutz, H.1    Hockerstedt, K.2    Bannwart, C.3    Bloigu, S.4    Hamalainen, E.5    Fotsis, T.6    Ollus, A.7
  • 6
    • 0034785067 scopus 로고    scopus 로고
    • Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein
    • Allred CD, Ju YH, Allred KF, Chang J & Helferich WG (2001) Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein. Carcinogenesis 22: 1667-1673.
    • (2001) Carcinogenesis , vol.22 , pp. 1667-1673
    • Allred, C.D.1    Ju, Y.H.2    Allred, K.F.3    Chang, J.4    Helferich, W.G.5
  • 7
    • 0020084955 scopus 로고
    • The identification of the weak oestrogen equol [7-hydroxy-3-(4′- hydroxyphenyl)chroman] in human urine
    • Axelson M, Kirk DN, Farrant RD, Cooley G, Lawson AM & Setchell KDR (1982) The identification of the weak oestrogen equol [7-hydroxy-3-(4′- hydroxyphenyl)chroman] in human urine. Biochem. J. 201: 353-357.
    • (1982) Biochem. J. , vol.201 , pp. 353-357
    • Axelson, M.1    Kirk, D.N.2    Farrant, R.D.3    Cooley, G.4    Lawson, A.M.5    Setchell, K.D.R.6
  • 8
    • 0001548239 scopus 로고
    • Identification of O-desmethylangolensin, a metabolite of daidzein, and of matairesinol, one likely plant precurcor of the animal lignan enterolactone, in human urine
    • Bannwart C, Adlercreutz H, Fotsis T, Wähälä K, Hase T & Brunow G (1984) Identification of O-desmethylangolensin, a metabolite of daidzein, and of matairesinol, one likely plant precurcor of the animal lignan enterolactone, in human urine. Finn. Chem. Lett. 4-5: 120-125.
    • (1984) Finn. Chem. Lett. , vol.4-5 , pp. 120-125
    • Bannwart, C.1    Adlercreutz, H.2    Fotsis, T.3    Wähälä, K.4    Hase, T.5    Brunow, G.6
  • 10
    • 0029456024 scopus 로고
    • Rationale for the use of genistein-containing soy matrices in chemoprevention trials for breast and prostate cancer
    • Barnes S, Peterson TG & Coward L (1995) Rationale for the Use of Genistein-containing Soy Matrices in Chemoprevention Trials for Breast and Prostate Cancer. J. Cell. Biochem. Suppl. 22: 181-187.
    • (1995) J. Cell. Biochem. Suppl. , vol.22 , pp. 181-187
    • Barnes, S.1    Peterson, T.G.2    Coward, L.3
  • 11
    • 0002684313 scopus 로고
    • A specific breeding problem of sheep on subterranean clover pastures in Western Australia
    • Bennetts HW, Underwood EJ & Shier FL (1946) A specific breeding problem of sheep on subterranean clover pastures in Western Australia. Aust. J. Agric. Res. 22: 131-138.
    • (1946) Aust. J. Agric. Res. , vol.22 , pp. 131-138
    • Bennetts, H.W.1    Underwood, E.J.2    Shier, F.L.3
  • 13
    • 0036195172 scopus 로고    scopus 로고
    • Soy, soy phytoestrogens and cardiovascular disease
    • Clarkson TB (2002) Soy, soy phytoestrogens and cardiovascular disease. J. Nutr. 132: 566S-569S.
    • (2002) J. Nutr. , vol.132
    • Clarkson, T.B.1
  • 14
    • 0036148571 scopus 로고    scopus 로고
    • Comparative metabolism of genistin by human and rat gut microflora: Detection and identification of the end-products of metabolism
    • Coldham NG, Darby C, Hows M, King LJ, Zhang AQ & Sauer MJ (2002) Comparative metabolism of genistin by human and rat gut microflora: detection and identification of the end-products of metabolism. Xenobiotica 32: 45-62.
    • (2002) Xenobiotica , vol.32 , pp. 45-62
    • Coldham, N.G.1    Darby, C.2    Hows, M.3    King, L.J.4    Zhang, A.Q.5    Sauer, M.J.6
  • 16
    • 0016030980 scopus 로고
    • A new phyto-oesteogen metabolite in sheep
    • Cox R & Braden A (1974) A new phyto-oesteogen metabolite in sheep. J. Reprod. Fertil. 36: 492.
    • (1974) J. Reprod. Fertil. , vol.36 , pp. 492
    • Cox, R.1    Braden, A.2
  • 17
    • 0032566518 scopus 로고    scopus 로고
    • Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity
    • Day AJ, DuPont MS, Ridley S, Rhodes M, Rhodes MJ, Morgan MR & Williamson G (1998) Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity. FEBS Lett. 436: 71-75.
    • (1998) FEBS Lett. , vol.436 , pp. 71-75
    • Day, A.J.1    Dupont, M.S.2    Ridley, S.3    Rhodes, M.4    Rhodes, M.J.5    Morgan, M.R.6    Williamson, G.7
  • 18
    • 0034062036 scopus 로고    scopus 로고
    • Analysis of soy isoflavone conjugation in vitro and in human blood using liquid chromatography-mass spectrometry
    • Doerge DR, Chang HC, Churchwell MI & Holder CL (2000) Analysis of soy isoflavone conjugation in vitro and in human blood using liquid chromatography-mass spectrometry. Drug Metab. Dispos. 28: 298-307.
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 298-307
    • Doerge, D.R.1    Chang, H.C.2    Churchwell, M.I.3    Holder, C.L.4
  • 19
    • 0037165568 scopus 로고    scopus 로고
    • Characterization of isoflavones and their conjugates in female rat urine using LC/MS/MS
    • Fang N, Yu S & Badger TM (2002) Characterization of Isoflavones and Their Conjugates in Female Rat Urine Using LC/MS/MS. J. Agric. Food Chem. 50: 2700-2707.
    • (2002) J. Agric. Food Chem. , vol.50 , pp. 2700-2707
    • Fang, N.1    Yu, S.2    Badger, T.M.3
  • 20
    • 0345425673 scopus 로고    scopus 로고
    • Identification of isoflavone metabolites dihydrodaidzein, dihydrogenistein, 6′-OH-O-dma, and cis-4-OH-equol in human urine by gas chromatography - Mass spectroscopy using authentic reference compounds
    • Heinonen S, Wähälä K & Adlercreutz H (1999) Identification of isoflavone metabolites dihydrodaidzein, dihydrogenistein, 6′-OH-O-dma, and cis-4-OH-equol in human urine by gas chromatography - mass spectroscopy using authentic reference compounds. Anal. Biochem. 274: 211-219.
    • (1999) Anal. Biochem. , vol.274 , pp. 211-219
    • Heinonen, S.1    Wähälä, K.2    Adlercreutz, H.3
  • 22
    • 0034333424 scopus 로고    scopus 로고
    • Biotransformation of the isoflavonoids biochanin A, formononetin, and glycitein by Eubacterium limosum
    • Hur H & Rafii F (2000) Biotransformation of the isoflavonoids biochanin A, formononetin, and glycitein by Eubacterium limosum. FEMS Microbiol. Lett. 192: 21-25.
    • (2000) FEMS Microbiol. Lett. , vol.192 , pp. 21-25
    • Hur, H.1    Rafii, F.2
  • 24
    • 0029099538 scopus 로고
    • A urinary profile study of dietary phytoesteogens. The identification and mode of metabolism of new isoflavonoids
    • Joannou GE, Kelly GE, Reeder AY, Waring M & Nelson C (1995) A urinary profile study of dietary phytoesteogens. The identification and mode of metabolism of new isoflavonoids. J. Steroid Biochem. Mol. Biol. 54: 167-184.
    • (1995) J. Steroid Biochem. Mol. Biol. , vol.54 , pp. 167-184
    • Joannou, G.E.1    Kelly, G.E.2    Reeder, A.Y.3    Waring, M.4    Nelson, C.5
  • 26
    • 0034841150 scopus 로고    scopus 로고
    • Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo
    • Kulling SE, Honig DM & Metzler M (2001) Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo. J. Agric. Food Chem. 49: 3024-3033.
    • (2001) J. Agric. Food Chem. , vol.49 , pp. 3024-3033
    • Kulling, S.E.1    Honig, D.M.2    Metzler, M.3
  • 27
    • 0033789387 scopus 로고    scopus 로고
    • Oxidative in vitro metabolism of the soy phytoestrogens daidzein and genistein
    • Kulling SE, Honig DM, Simat TJ & Metzler M (2000) Oxidative in vitro metabolism of the soy phytoestrogens daidzein and genistein. J. Agric. Food Chem. 48: 4963-4972.
    • (2000) J. Agric. Food Chem. , vol.48 , pp. 4963-4972
    • Kulling, S.E.1    Honig, D.M.2    Simat, T.J.3    Metzler, M.4
  • 28
    • 0028216956 scopus 로고
    • Soy intake and cancer risk: A rewiew of the in vitro and in vivo data
    • Messina MJ, Persky V, Setchell KDR & Barnes S (1994) Soy intake and cancer risk: a rewiew of the in vitro and in vivo data. Nutr. Cancer 21: 113-131.
    • (1994) Nutr. Cancer , vol.21 , pp. 113-131
    • Messina, M.J.1    Persky, V.2    Setchell, K.D.R.3    Barnes, S.4
  • 29
    • 0034184193 scopus 로고    scopus 로고
    • Determination of the levels of isoflavonoids in soybeans and soy-derived foods and estimation of isoflavonoids in the Japanese daily intake
    • Nakamura Y, Tsuji S & Tonogai Y (2000) Determination of the levels of isoflavonoids in soybeans and soy-derived foods and estimation of isoflavonoids in the Japanese daily intake. J. AOAC Int. 83(3): 635-650.
    • (2000) J. AOAC Int. , vol.83 , Issue.3 , pp. 635-650
    • Nakamura, Y.1    Tsuji, S.2    Tonogai, Y.3
  • 31
    • 0033048388 scopus 로고    scopus 로고
    • Daidzein and genistein but not their glucosides are absorbed from the rat stomach
    • Piskula MK, Yamakoshi J & Iwai Y (1999) Daidzein and genistein but not their glucosides are absorbed from the rat stomach. FEBS Lett. 447:287-291.
    • (1999) FEBS Lett. , vol.447 , pp. 287-291
    • Piskula, M.K.1    Yamakoshi, J.2    Iwai, Y.3
  • 32
    • 0021908716 scopus 로고
    • Naturally occuring oestrogens in foods - A review
    • Rice KR & Fenwick GR (1985) Naturally occuring oestrogens in foods - A review. Food Add. Contam. 2: 73.
    • (1985) Food Add. Contam. , vol.2 , pp. 73
    • Rice, K.R.1    Fenwick, G.R.2
  • 36
    • 0036073599 scopus 로고    scopus 로고
    • Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability
    • Setchell KD, Brown NM, Zimmer-Nechemias L, Brashear WT, Wolfe BE, Kirschner AS & Heubi JE (2002) Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. Am. J. Clin. Nutr. 76: 447-453.
    • (2002) Am. J. Clin. Nutr. , vol.76 , pp. 447-453
    • Setchell, K.D.1    Brown, N.M.2    Zimmer-Nechemias, L.3    Brashear, W.T.4    Wolfe, B.E.5    Kirschner, A.S.6    Heubi, J.E.7
  • 37
    • 84971064915 scopus 로고
    • Quantitative aspects of phyto-oestrogen metabolism in sheep fed on subterranean clover (trifolium subterraneum cultivar clare) or red clover (trifolium pratense)
    • Shutt DA, Weston RH & Hogan JP (1970) Quantitative aspects of phyto-oestrogen metabolism in sheep fed on subterranean clover (trifolium subterraneum cultivar clare) or red clover (trifolium pratense). Austr. J. Agric. Res. 21: 713-722.
    • (1970) Austr. J. Agric. Res. , vol.21 , pp. 713-722
    • Shutt, D.A.1    Weston, R.H.2    Hogan, J.P.3
  • 38
    • 0031886016 scopus 로고    scopus 로고
    • Synthesis of novel mammalian metabolites of the isoflavonoid phytoestrogens daidzein and genistein
    • Wähälä K, Salakka A & Adlercreutz H (1998) Synthesis of novel mammalian metabolites of the isoflavonoid phytoestrogens daidzein and genistein. Proc. Soc. Exp. Biol. Med. 217: 293-299.
    • (1998) Proc. Soc. Exp. Biol. Med. , vol.217 , pp. 293-299
    • Wähälä, K.1    Salakka, A.2    Adlercreutz, H.3


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