Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation

European Journal of Medicinal Chemistry

Volumn 64, Issue , 2013, Pages 215-221

  Li, Dahong ^a   Xu, Shengtao ^a   Cai, Hao ^a   Pei, Lingling ^a   Zhang, Hengyuan ^a   Wang, Lei ^a   Yao, Hequan ^a   Wu, Xiaoming ^a   Jiang, Jieyun ^b   Sun, Yijun ^c   Xu, Jinyi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF KENTUCKY   (United States)

^c Drug Screening Center   (China)

Author keywords

Anti proliferative activity; Apoptosis; Cell cycle analysis; Enmein type diterpenoid; Oridonin

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; DITERPENOID; ENMEIN TYPE DITERPENOID DERIVATIVE; KAURENE DERIVATIVE; ORIDONIN; PACLITAXEL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HEPATOMA CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; MITOCHONDRION; OXIDATIVE STRESS; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DITERPENES; DITERPENES, KAURANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84877025427     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.04.012     Document Type: Article

References (24)

1. H.-D. Sun, S.-X. Huang, and Q.-B. Han Nat. Prod. Rep. 23 2006 673 698
2. J.N. Harson Nat. Prod. Rep. 28 2011 1755 1772
3. J.Y.W. Mak, and C.M. Williams Nat. Prod. Rep. 29 2012 440 448
4. J.N. Harson Nat. Prod. Rep. 29 2012 890 898
5. D.J. Tantillo Nat. Prod. Rep. 28 2011 1035 1053
6. J.S. Dickschat Nat. Prod. Rep. 28 2011 1917 1936
7. B.D. Schwartz, J.R. Denton, Y. Lian, H.M.L. Davies, and C.M. Williams J. Am. Chem. Soc. 131 2009 8329 8332
8. J.-X. Gong, G.-A. Lin, W.-B. Sun, C.-C. Li, and Z. Yang J. Am. Chem. Soc. 132 2010 16745 16746
9. L. Wang, D.-H. Li, C.-L. Wang, Y.-H. Zhang, and J.-Y. Xu Mini-Rev. Med. Chem. 11 2011 910 919
10. X. Li, J.-X. Pu, Z.-Y. Weng, Y. Zhao, Y. Zhao, W.-L. Xiao, and H.-D. Sun Chem. Biodivers. 7 2010 2888 2896
11. B.-L. Li, and X.-H. Tian Phytochemistry 58 2001 543 546
12. B. Jiang, A.-J. Hou, M.-L. Li, S.-H. Li, Q.-B. Han, S.-J. Wang, Z.-W. Lin, and H.-D. Sun Planta Med. 68 2002 921 925
13. L.-M. Li, G.-Y. Li, J.-X. Pu, W.-L. Xiao, L.-S. Ding, and H.-D. Sun J. Nat. Prod. 72 2009 1851 1856
14. W. Xiang, R.-T. Li, Z.-Y. Wang, S.-H. Li, Q.-S. Zhao, H.-J. Zhang, and H.-D. Sun Phytochemistry 65 2004 1173 1177
15. X.-N. Li, J.-X. Pu, X. Du, L.-G. Lou, L.-M. Li, S.-X. Huang, B. Zhao, M. Zhang, F. He, X. Luo, W.-L. Xiao, and H.-D. Sun J. Nat. Prod. 73 2010 1803 1809
16. B.B. Mishra, and V.K. Tiwari Euro. J. Med. Chem. 46 2011 4769 4807
17. E. Fujita, Y. Nagao, K. Kaneko, S. Nakazawa, and H. Kuroda Chem. Pharm. Bull. 24 1976 2118 2127
18. L. Wang, D.-H. Li, S.-T. Xu, H. Cai, H.-Q. Yao, Y.-H. Zhang, J.-Y. Jiang, and J.-Y. Xu Eur. J. Med. Chem. 52 2012 242 250
19. D.-H. Li, H. Cai, B.-W. Jiang, G.-Y. Liu, Y.-T. Wang, L. Wang, H.-Q. Yao, X.-M. Wu, Y.-J. Sun, and J.-Y. Xu Eur. J. Med. Chem. 59 2013 322 328
20. J.-Y. Xu, J.-Y. Yang, Q. Ran, L. Wang, J. Liu, Z.-X. Wang, X.-M. Wu, W.-Y. Hua, S.-T. Yuan, L.-Y. Zhang, M.-Q. Shen, and Y.-F. Ding Bioorg. Med. Chem. Lett. 18 2008 4741 4744
21. D.-H. Li, L. Wang, H. Cai, Y.-H. Zhang, and J.-Y. Xu Molecules 17 2012 7556 7568
22. L. Wang, Q. Ran, D.-H. Li, H.-Q. Yao, Y.-H. Zhang, S.-T. Yuan, L.-Y. Zhang, M.-Q. Shen, and J.-Y. Xu Chin. J. Nat. Med. 9 2011 161 166
23. M. Shibuya, E. Fujita, H. Katayama, and T. Fujita Chem. Commun. (Lond.) 6 1967 252 254
24. Y. Zhao, X.-M. Niu, L.-P. Qian, Z.-Y. Liu, Q.-S. Zhao, and H.-D. Sun Eur. J. Med. Chem. 42 2007 494 502