6,7-seco-ent-kaurane diterpenoids from Isodon sculponeatus with cytotoxic activity

Chemistry and Biodiversity

Volumn 7, Issue 12, 2010, Pages 2888-2896

  Li, Xian ^a,b   Pu, Jian Xin ^a   Weng, Zhi Ying ^a,b   Zhao, Yu ^a   Zhao, Yong ^a   Xiao, Wei Lie ^a   Sun, Han Dong ^a  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Cytotoxic activity; Diterpenoids; Isodon sculponeatus; Kaurane diterpenoids; Sculponeatins N S; Structure activity relationship (SAR)

Indexed keywords

DITERPENOID; SCULPONEATIN N; SCULPONEATIN O; SCULPONEATIN P; SCULPONEATIN Q; SCULPONEATIN R; SCULPONEATIN S; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HEPG2; CELL STRAIN K 562; CYTOTOXICITY; DRUG HYDROXYLATION; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; HERB; HUMAN; HUMAN CELL; ISODON SCULPONEATUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OUTCOME ASSESSMENT; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; DITERPENES, KAURANE; HUMANS; ISODON; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; PLANT EXTRACTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

ISODON SCULPONEATUS;

EID: 78650449672     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200900302     Document Type: Article

References (19)

1. E. Fujita, M. Node, in 'Progress in the Chemistry of Organic Natural Products', 1983, Vol. 46, p. 144.
2. H. D. Sun, Y. L. Xu, B. Jiang, 'Diterpenoids from Isodon Species', Science Press, Beijng, 2001, pp. 4-5.
3. H.-D. Sun, Z.-W. Lin, Y.-L. Xu, Y. Minami, T. Marunaka, T. Togo, Y. Takeda, T. Fujita, Heterocycles 1986, 24, 1.
4. R. P. Zhang, H. J. Zhang, Y. L. Zhen, H. D. Sun, Chin. Chem. Lett. 1991, 2, 293.
5. M. H. Yang, B. Jiang, Q. S. Zhao, H. D. Sun, Zhongcaoyao 2001, 32, 397.
6. B. Jiang, S. X. Mei, A. H. Zhao, H. D. Sun, Y. Lu, Q. T. Zheng, Chin. J. Chem. 2002, 20, 887.
7. B. Jiang, Y. Hui, Q. B. Han, Z. Na, H. D. Sun, Chin. Chem. Lett. 2002, 13, 1083.
8. B. Jiang, A.-J. Hou, M.-L. Li, S.-H. Li, Q.-B. Han, S.-J. Wang, Z.-W. Lin, H.-D. Sun, Planta Med. 2002, 68, 921.
9. L.-M. Li, G.-Y. Li, L.-S. Ding, C. Lei, L.-B. Yang, Y. Zhao, Z.-Y. Weng, S.-H. Li, S.-X. Huang, W.-L. Xiao, Q.-B. Han, H.-D. Sun, Tetrahendron Lett. 2007, 48, 9100.
10. C.-H. Leung, S. P. Grill, W. Lam, Q.-B. Han, H.-D. Sun, Y.-C. Cheng, Mol. Pharmacol. 2005, 68, 286.
11. C. A. Elliger, R. Y. Wong, M. Benson, W. Gaffield, A. C. Waiss Jr., J. Nat. Prod. 1992, 55, 1477.
12. Z. Q. Wang, X. R. Wang, J. G. Dong, Z. W. Xue, Acta Bot. Sin. 1986, 28, 79.
13. E. Fujita, T. Fujita, M. Taoka, H. Katayama, M. Shibuya, Chem. Pharm. Bull. 1973, 21, 1357.
14. E. Fujita, T. Fujita, M. Shibuya, Chem. Pharm. Bull. 1968, 16, 1573.
15. E. Fujita, T. Fujita, M. Shibuya, Chem. Pharm. Bull. 1968, 16, 509.
16. Y. Takeda, T. Matsumoto, H. Otsuka, J. Nat. Prod. 1994, 57, 650.
17. Y. Takeda, T. Ichihara, H. Otsuka, J. Nat. Prod. 1990, 53, 138.
18. A. Monks, D. Scudiero, P. Skehan, R. Shoemaker, K. Paull, D. Vistica, C. Hose, P. Langley, P. Cronise, A. Vaigro-Wolff, M. Gray-Goodrich, H. Campbell, J. Mayo, M. Boyd, J. Natl. Cancer Inst. 1991, 83, 757.
19. H.-D. Sun, S.-X. Huang, Q.-B. Han, Nat. Prod. Rep. 2006, 23, 673.