SCOPUS 정보 검색 플랫폼

Volumn 59, Issue , 2013, Pages 322-328

Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells

(10) Li, Dahong a Cai, Hao a Jiang, Bowen a Liu, Guyue b Wang, Yuetong b Wang, Lei a Yao, Hequan a Wu, Xiaoming a Sun, Yijun c Xu, Jinyi a

a CHINA PHARMACEUTICAL UNIVERSITY (China)

b SHENYANG PHARMACEUTICAL UNIVERSITY (China)

c Drug Screening Center (China)

Author keywords

Anti proliferative activity; Apoptosis; Oridonin; Spirolactone type diterpenoid; Structure activity relationship

Indexed keywords

ANTIMITOTIC AGENT; ENT 1ALPHA O ACETYL 14BETA O BENZOYL 6,7,15 TRIOXO 7,20 EPOXY 6,7 SECO 16 KAURENE; ENT 1ALPHA O ACETYL 14BETA O DIACETYL 6,7,15 TRIOXO 7,20 EPOXY 6,7 SECO 16 KAURENE; ENT 1ALPHA O ACETYL 14BETA O O CHLOROBENZOYL 6,7,15 TRIOXO 7,20 EPOXY 6,7 SECO 16 KAURENE; ENT 1ALPHA O ACETYL 14BETA O PARA CHLOROBENZOYL 6,7,15 TRIOXO 7,20 EPOXY 6,7 SECO 16 KAURENE; ENT 1ALPHA O ACETYL 14BETA O PARA METHOXYBENZOYL 6,7,15 TRIOXO 7,20 EPOXY 6,7 SECO 16 KAURENE; ENT 1ALPHA O ACETYL 14BETA O PARA METHYLBENZOYL 6,7,15 TRIOXO 7,20 EPOXY 6,7 SECO 16 KAURENE; ENT 1ALPHA O ACETYL 14BETA O PARA NITROBENZOYL 6,7,15 TRIOXO 7,20 EPOXY 6,7 SECO 16 KAURENE; ENT 1ALPHA O ACETYL 14BETA O PARA TRIFLUOROMETHYLBENZOYL 6,7,15 TRIOXO 7,20 EPOXY 6,7 SECO 16 KAURENE; ENT 1ALPHA O ACETYL 14BETA O VALERYL 6,7,15 TRIOXO 7,20 EPOXY 6,7 SECO 16 KAURENE; ENT 1ALPHA O, 14BETA O DIACETYL 6,7,15 TRIOXO 7,20 EPOXY 6,7 SECO 16 KAURENE; ORIDONIN; PACLITAXEL; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DITERPENES; DITERPENES, KAURANE; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; MODELS, MOLECULAR; PACLITAXEL; SPIRONOLACTONE;

EID: 84871410742 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2012.11.002 Document Type: Article

Times cited : (34)

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