Renal epithelial injury and fibrosis

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1832, Issue 7, 2013, Pages 931-939

  Kaissling, Brigitte ^a   LeHir, Michel ^a   Kriz, Wilhelm ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Glomerular injury; Progression to CKD; Tubular injury; Tubulointerstitial fibrosis

Indexed keywords

CISPLATIN; MERCURY CHLORIDE; URANYL ACETATE;

ACUTE KIDNEY FAILURE; BOWMAN CAPSULE; CELL POPULATION; CHRONIC KIDNEY DISEASE; DISEASE COURSE; GLOMERULAR INJURY; GLOMERULOPATHY; HUMAN; KIDNEY FIBROSIS; KIDNEY INJURY; MYOFIBROBLAST; PRIMARY TUBULAR INJURY; PRIORITY JOURNAL; REVIEW; FIBROSIS; GLOMERULUS; KIDNEY; KIDNEY DISEASE; NEPHRON;

FIBROSIS; HUMANS; KIDNEY; KIDNEY DISEASES; KIDNEY GLOMERULUS; NEPHRONS;

EID: 84877018431     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2013.02.010     Document Type: Review

References (71)

1. Kriz W., Le Hir M. Pathways to nephron loss starting from glomerular diseases - insights from animal models. Kidney Int. 2005, 67:404-419.
2. Venkatachalam M., Griffin K., Lan R., Geng H., Saikumar P., Bidani A. Acute kidney injury: a springboard for progression in chronic kidney disease. Am. J. Physiol. Renal Physiol. 2010, 298:F1078-F1094.
3. Nath K. Tubulointerstitial changes as a major determinant in the progression of renal damage. Am. J. Kidney Dis. 1992, 20:1-17.
4. Hill G. Hypertensive nephrosclerosis. Curr. Opin. Nephrol. Hypertens. 2008, 17:266-270.
5. Lan R., Geng H., Polichnowski A., Singha P., Saikumar P., McEwen D., Griffin K., Koesters R., Weinberg J., Bidani A., Kriz W., Venkatachalam K. PTEN loss defines a TGF-ß induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis. Am. J. Physiol. Renal Physiol. 2012, 302:F1210-F1223.
6. Bonventre J., Yang L. Cellular pathophysiology of ischemic acute kidney injury. J. Clin. Invest. 2011, 121:4120-4221.
7. Kretzler M., Koeppen-Hagemann I., Kriz W. Podocyte damage is a critical step in the development of glomerulosclerosis in the uninephrectomized desoxycorticosterone rat. Virchows Arch. A Pathol. Anat. Histopathol. 1994, 425:181-193.
8. Kriz W., Hähnel B., Hosser H., Ostendorf T., Kränzlin B., Gretz N., Shimizu F., Floege J. Pathways to recovery and loss of nephrons in anti-Thy-1 nephritis. J. Am. Soc. Nephrol. 2003, 14:1904-1926.
9. Le Hir M., Keller C., Eschmann V., Hähnel B., Hosser H., Kriz W. Podocyte bridges between the tuft and Bowman's capsule: an early event in experimental crescentic glomerulonephritis. J. Am. Soc. Nephrol. 2001, 12:2060-2071.
10. Remuzzi G. A unifying hypothesis for renal scarring linking protein trafficking to the different mediators of injury. Nephrol. Dial. Transplant. 2000, 15:58-60.
11. Guo J., Marlier A., Shi H., Shan A., Ardito T., Du Z., Kashgarian M., Krause D., Biemesderfer D., Cantley L. Increased tubular proliferation as an adaptive response to glomerular albuminuria. J. Am. Soc. Nephrol. 2012, 23:429-437.
12. Theilig F., Kriz W., Jerichow T., Schrade P., Hähnel B., Willnow T., Le Hir M., Bachmann S. Abrogation of protein uptake through Megalin-deficient proximal tubules does not safeguard against tubulointerstitial injury. J. Am. Soc. Nephrol. 2007, 18:1824-1834.
13. Fine L., Norman J. Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics. Kidney Int. 2008, 74:867-872.
14. Bohle A., Mackensen-Haen S., Wehrmann M. Significance of post-glomerular capillaries in the pathogenesis of chronic renal failure. Kidney Blood Press. Res. 1996, 19:191-195.
15. Rollhäuser H., Kriz W., Heinke W. Das Gefässsystem der Rattenniere. Z. Zellforsch. Mikrosk. Anat. 1964, 64:381-403.
16. Theilig F., Enke A., Scolari B., Polzin D., Bachmann S., Koesters R. Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis. Am. J. Pathol. 2011, 179:2177-2188.
17. Li L., Zepeda-Orozco D., Black R., Lin F. Autophagy is a component of epithelial cell fate in obstructive uropathy. Am. J. Pathol. 2010, 176:1767-1778.
18. Koesters R., Kaissling B., Le Hir M., Picard N., Theilig F., Gebhardt R., Glick A., Hähnel B., Hosser H., Gröne H., Kriz W. Tubular overexpression of transforing growth factor-ß1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells. Am. J. Pathol. 2010, 177:632-643.
19. Grgic I., Campanholle G., Bijol V., Wang C., Sabbisetti V., Ichimura T., Humphreys B., Bonventre J. Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis. Kidney Int. 2012, 82:172-183.
20. Marcussen N. Atubular glomeruli in chronic renal disease. Curr. Top. Pathol. 1995, 88:145-174.
21. Chevalier R., Forbes M. Generation and evaluation of atubular glomeruli in the progression of renal disorders. J. Am. Soc. Nephrol. 2008, 19:197-206.
22. Gröne H., Warnecke E., Olbricht C. Characteristics of renal tubular atrophy in experimental renovascular hypertension: a model of kidney hibernation. Nephron 1996, 72:243-252.
23. Kriz W., Kaissling B., Le Hir M. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?. J. Clin. Invest. 2011, 121:468-474.
24. Picard N., Baum O., Vogetseder A., Kaissling B., Le Hir M. Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat. Histochem. Cell Biol. 2008, 130:141-155.
25. Humphreys B., Lin S.L., Kobayashi A., Hudosn T., Nowlin B., Bonventre J., Valerius M., McMahon A., Duffield J. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am. J. Pathol. 2010, 176:85-97.
26. Duffield J., Park K., Hsiao L., Kelley V., Scadden D., Ichimura T., Bonventre J. Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J. Clin. Invest. 2005, 115:1743-1755.
27. Kaissling B., Le Hir M. The renal cortical interstitium: morphological and functional aspects. Histochem. Cell Biol. 2008, 130:247-262.
28. Tomasek J., Gabbiani G., Hinz B., Chaponnier C., Brown R. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat. Rev. Mol. Cell Biol. 2002, 3:349-363.
29. Chugh K., Sharma B., Singhal P., Das K., Datta B.N. Acute renal failure following copper sulphate intoxication. Postgrad Med. J. 2012, 53:18-23.
30. Loffing J., Loffing-Cueni D., Hegyi I., Kaplan M., Hebert S., Le Hir M., Kaissling B. Thiazide treatment of rats provokes apoptosis in distal tubule cells. Kidney Int. 1996, 50:1180-1190.
31. Le Hir M., Hegyi I., Loffing-Cueni D., Loffing J., Kaissling B. Characterization of renal interstitial fibroblast-specific protein 1/S100A4-positive cells in healthy and inflamed rodent kidneys. Histochem. Cell Biol. 2005, 123:335-346.
32. Fujigaki Y., Muranaka Y., Sun D., Goto T., Zhou H., Sakakima M., Fukasawa H., Yonemura K., Yamamoto T., Hishida A. Transient myofibroblast differentiation of interstitial fibroblastic cells relevant to tubular dilatation in uranyl acetate-induced acute renal failure in rats. Virchows Arch. 2005, 446:164-176.
33. Miller R., Tadagavadi R., Ramesh G., Reeves W. Mechanisms of Cisplatin nephrotoxicity. Toxins 2010, 2:2490-2518.
34. Gröne H., Weber K., Gröne E., Helmchen U., Osborne M. Coexpression of Keratin and Vimentin in damaged and regenerating tubular epithelia of the kidney. Am. J. Pathol. 1987, 129:1-8.
35. Bernascone S., Erriquez J., Ferraro M., Genazzani A., Distasi C. Novel adenosine and cAMP signalling pathways in migrating glial cells. Cell Calcium 2010, 48:83-90.
36. Zhu M., Broe M., Nouwen E. Vimentin expression and distal tubular damage in the rat kidney. Exp. Nephrol. 1996, 4:172-183.
37. Vogetseder A., Palan T., Bacic D., Kaissling B., Le Hir M. Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney. Am. J. Physiol. Cell Physiol. 2007, 292:807-813.
38. Vogetseder A., Picard N., Gaspert A., Walch M., Kaissling B., Le Hir M. Proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells. Am. J. Physiol. Cell Physiol. 2008, 294:22-28.
39. Langworthy M., Zhou B., de Caestecker M., Moeckel G., Baldwin H. NFATc1 identifies a population of proximal tubule cell progenitors. J. Am. Soc. Nephrol. 2009, 20:311-321.
40. B. Smeets, P. Boor, H. Dijkman, S. Sharma, P. Jirak, F.Mooren, K. Berger, J. Bornemann, I. Gelman, J. Floege, J. vanderVlag, J.Wetzels,M.Moeller, Proximal tubular cells contain a phenotypically distinct, scattered cell population involved in tubular regeneration, J. Pathol. in press.
41. Yang L., Besschetnova T., Brooks C., Shah J., Bonventre J. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat. Med. 2010, 16:535-543.
42. Sun D., Fujigaki Y., Fujimoto T., Yonemura K., Hishida A. Possible involvement of myofibroblasts in cellular recovery of uranyl acetate-induced acute renal failure in rats. Am. J. Pathol. 2000, 157:1321-1335.
43. Suzuki T., Kimura M., Asano M., Fujigaki Y., Hishida A. Role of atrophic tubules in development of interstitial fibrosis in microembolism-induced renal failure in rat. Am. J. Pathol. 2001, 158:75-85.
44. Sun D., Fujigaki Y., Fujimoto T., Goto T., Yonemura K., Hishida A. Mycophenolate Mofetil inhibits regenerative repair in uranyl acetate-induced acute renal failure by reduced interstitial cellular response. Am. J. Pathol. 2002, 161:217-227.
45. Lin H. Transforming growth factor-ß and the kidney revisited: introduction. Semin. Nephrol. 2012, 32:225-227.
46. Geng H., Lan R., Singha P., Gilchrist A., Weinreb P., Violette S., Weinberg J., Saikumar P., Venkatachalam K. Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvß6 integrin-dependent activation of TGF-ß. Am. J. Pathol. 2012, 181:1236-1249.
47. Spurgeon K., Donohoe D., Basile D. Transforming growth factor-beta in acute renal failure: receptor expression, effects on proliferation, cellularity, and vascularization after recovery from injury. Am. J. Physiol. Renal Physiol. 2005, 288:F568-F577.
48. Bielesz B., Sirin Y., Si H., Niranjan T., Gruenwald A., Ahn S., Kato H., Pullman J., Gessler M., Haase V., Susztak K. Epithelial notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J. Clin. Invest. 2010, 120:4040-4054.
49. Yang L., Humphreys B.D., Bonventre J.V. Pathophysiology of acute kidney injury to chronic kidney disease: maladaptive repair. Contrib. Nephrol. 2011, 174:149-155.
50. Okada H., Kikuta T., Kobayashi T., Inoue T., Kanno Y., Takigawa M., Sugaya T., Kopp J., Suzuki H. Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrosis. J. Am. Soc. Nephrol. 2005, 16:133-143.
51. Mazzali M., Kipari T., Ophascharoensuk V., Wesson J., Johnson R., Hughes J. Osteopontin - a molecule for all seasons. QJM 2002, 95:3-13.
52. Kinsey G., Li L., Okusa M. Inflammation in acute kidney injury. Nephron Exp. Nephrol. 2008, 109:102-107.
53. Chung A., Lan H. Chemokines in renal injury. J. Am. Soc. Nephrol. 2011, 22:802-809.
54. Rock K., Latz E., Ontiveros F., Kono H. The sterile inflammatory response. Annu. Rev. Immunol. 2010, 28:321-342.
55. Snelgrove S., Kausman J., Lo C., Lo C., Coates P., Hickey M., Holdsworth S., Kurts C., Engel D., Kitching A. Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis. Am. J. Pathol. 2012, 180:91-103.
56. Desmouliere A., Chaponnier C., Gabbiani G. Tissue repair, contraction, and the myofibroblast. Wound Repair Regen. 2005, 13:7-12.
57. Bechtel W., McGoohan S., Zeisberg E., Müller G., Kalbacher H., Salant D., Müller C., Kalluri R., Zeisberg M. Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat. Med. 2010, 16:544-551.
58. Liu Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int. 2012, 69:213-217.
59. Ridson R., Sloper J., de Wardener H. Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis. Lancet 1968, 2:363-366.
60. Bohle A., Glomb D., Grund K., Mackensen S. Correlations between relative interstitial volume of the renal cortex and serum creatinine concentration in minimal changes with nephrotic syndrome and in focal sclerosing glomerulonephritis. Virchows Arch. A Pathol. Anat. Histopathol. 1977, 376:221-232.
61. d'Amico G., Ferrario F., Rastaldi M. Tubulointerstitial damage in glomerular diseases: its role in the progression of renal damage. Am. J. Kidney Dis. 1995, 26:124-132.
62. Cameron J. Tubular and interstitial factors in the progression of glomerulonephritis. Pediatr. Nephrol. 1992, 6:292-303.
63. Kanwar Y. Biology of disease. Biophysiology of glomerular filtration and proteinuria. Lab. Invest. 1984, 51:7-21.
64. Yang G., Morrison A. Three large dissectable rat glomerular models reconstructed from wide-field electron micrographs. Anat. Rec. 1980, 196:431-440.
65. Bajema I., Hagen E., Hermans J., Noel L., Waldherr R., Ferrario F., van der Woude F., Bruijn J. Kidney biopsy as a predictor for renal outcome in ANCA-associated necrotizing glomerulonephritis. Kidney Int. 1999, 56:1751-1758.
66. Lubran M. Renal function in the elderly. Ann. Clin. Lab. Sci. 1995, 25:122-133.
67. Bendtsen T., Nyengaard J. The number of glomeruli in type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1992, 35:844-850.
68. Hostetter T., Olson J., Rennke H., Venkatachalam M., Brenner B. Hyperfiltration in remnant nephrons:a potentially adverse response to renal ablation. Am. J. Physiol. 1981, 241:F85-F93.
69. Brenner B., Lawler E., Mackenzie H. The hyperfiltration theory: a paradigma shift in nephrology. Kidney Int. 1996, 49:1774-1777.
70. Leung K., Tonelli M., James M. Chronic kidney disease following acute kidney injury - risk and outcomes. Nat. Rev. Nephrol. 2013, 9:77-85.
71. Takahashi-Iwanaga H. The three-dimensional spaces of the kidney. Cell Tissue Res. 1991, 264:269-281.