Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis

American Journal of Pathology

Volumn 180, Issue 1, 2012, Pages 91-103

  Snelgrove, Sarah L ^a   Kausman, Joshua Y ^a   Lo, Cecilia ^a   Lo, Camden ^a   Ooi, Joshua D ^a   Coates, P Toby ^c   Hickey, Michael J ^a   Holdsworth, Stephen R ^a,b   Kurts, Christian ^d   Engel, Daniel R ^d   Kitching, A Richard ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b MONASH MEDICAL CENTRE   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; GLYCOPROTEIN P 15095; T LYMPHOCYTE RECEPTOR; YELLOW FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ACTIVITY; CELL STRUCTURE; CONTROLLED STUDY; DENDRITIC CELL; EX VIVO STUDY; IN VIVO STUDY; KIDNEY; KIDNEY CELL; KIDNEY FIBROSIS; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; OBSTRUCTIVE UROPATHY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD11C; APOPTOSIS; CYTOKINES; DENDRITIC CELLS; FIBROSIS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEPHRITIS; PHENOTYPE; T-LYMPHOCYTES; URETER; URETERAL OBSTRUCTION;

EID: 83455228619     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.09.039     Document Type: Article

References (39)

1. D.N. Hart, J.W. Fabre Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain J Exp Med 154 1981 347 361 (Pubitemid 11044167)
2. J.M. Austyn, D.F. Hankins, C.P. Larsen, P.J. Morris, A.S. Rao, J.A. Roake Isolation and characterization of dendritic cells from mouse heart and kidney J Immunol 152 1994 2401 2410 (Pubitemid 24097932)
3. T. Kruger, D. Benke, F. Eitner, A. Lang, M. Wirtz, E.E. Hamilton-Williams, D. Engel, B. Giese, G. Muller-Newen, J. Floege, C. Kurts Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis J Am Soc Nephrol 15 2004 613 621 (Pubitemid 38294791)
4. T.J. Soos, T.N. Sims, L. Barisoni, K. Lin, D.R. Littman, M.L. Dustin, P.J. Nelson CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney Kidney Int 70 2006 591 596 (Pubitemid 44141588)
5. X. Dong, S. Swaminathan, L.A. Bachman, A.J. Croatt, K.A. Nath, M.D. Griffin Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury Kidney Int 71 2007 619 628 (Pubitemid 46494569)
6. X. Dong, L.A. Bachman, M.N. Miller, K.A. Nath, M.D. Griffin Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction Kidney Int 74 2008 1294 1309
7. J. Scholz, V. Lukacs-Kornek, D.R. Engel, S. Specht, E. Kiss, F. Eitner, J. Floege, H.J. Groene, C. Kurts Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis J Am Soc Nephrol 19 2008 527 537 (Pubitemid 351355396)
8. K. Hochheiser, D.R. Engel, L. Hammerich, F. Heymann, P.A. Knolle, U. Panzer, C. Kurts Kidney dendritic cells become pathogenic during crescentic glomerulonephritis with proteinuria J Am Soc Nephrol 22 2011 306 316
9. R.K. Tadagavadi, W.B. Reeves Renal dendritic cells ameliorate nephrotoxic acute kidney injury J Am Soc Nephrol 21 2010 53 63
10. S. Klahr, J.J. Morrissey The role of growth factors, cytokines, and vasoactive compounds in obstructive nephropathy Semin Nephrol 18 1998 622 632 (Pubitemid 28506734)
11. R. Misseri, R.C. Rink, D.R. Meldrum, K.K. Meldrum Inflammatory mediators and growth factors in obstructive renal injury J Surg Res 119 2004 149 159 (Pubitemid 38625641)
12. Tapmeier TT, Fearn A, Brown K, Chowdhury P, Sacks SH, Sheerin NS, Wong W: Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction. Kidney Int 78:351362
13. S.B. Shappell, T. Gurpinar, J. Lechago, W.N. Suki, L.D. Truong Chronic obstructive uropathy in severe combined immunodeficient (SCID) mice: lymphocyte infiltration is not required for progressive tubulointerstitial injury J Am Soc Nephrol 9 1998 1008 1017 (Pubitemid 28264727)
14. S.R. Clarke, M. Barnden, C. Kurts, F.R. Carbone, J.F. Miller, W.R. Heath Characterization of the ovalbumin-specific TCR transgenic line OT-I: mHC elements for positive and negative selection Immunol Cell Biol 78 2000 110 117 (Pubitemid 30220105)
15. R.L. Lindquist, G. Shakhar, D. Dudziak, H. Wardemann, T. Eisenreich, M.L. Dustin, M.C. Nussenzweig Visualizing dendritic cell networks in vivo Nat Immunol 5 2004 1243 1250 (Pubitemid 41057739)
16. C. Kurts, W.R. Heath, F.R. Carbone, J. Allison, J.F. Miller, H. Kosaka Constitutive class I-restricted exogenous presentation of self antigens in vivo J Exp Med 184 1996 923 930 (Pubitemid 26313550)
17. S. Jung, D. Unutmaz, P. Wong, G. Sano, K. De los Santos, T. Sparwasser, S. Wu, S. Vuthoori, K. Ko, F. Zavala, E.G. Pamer, D.R. Littman, R.A. Lang In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens Immunity 17 2002 211 220 (Pubitemid 35245963)
18. M.P. Kuligowski, A.R. Kitching, M.J. Hickey Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling J Immunol 176 2006 6991 6999 (Pubitemid 43787879)
19. H. Wadell Volume Shape, and roundness of quartz particles J Geol 43 1935 250 280
20. B. Roediger, L.G. Ng, A.L. Smith, B. Fazekas de St Groth, W. Weninger Visualizing dendritic cell migration within the skin Histochem Cell Biol 130 2008 1131 1146
21. T.K. van den Berg, G. Kraal A function for the macrophage F4/80 molecule in tolerance induction Trends Immunol 26 2005 506 509 (Pubitemid 41297678)
22. G.M. del Hoyo, P. Martin, H.H. Vargas, S. Ruiz, C.F. Arias, C. Ardavin Characterization of a common precursor population for dendritic cells Nature 415 2002 1043 1047 (Pubitemid 34193454)
23. G.J. Randolph, K. Inaba, D.F. Robbiani, R.M. Steinman, W.A. Muller Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo Immunity 11 1999 753 761 (Pubitemid 30030714)
24. C. Varol, L. Landsman, D.K. Fogg, L. Greenshtein, B. Gildor, R. Margalit, V. Kalchenko, F. Geissmann, S. Jung Monocytes give rise to mucosal, but not splenic, conventional dendritic cells J Exp Med 204 2007 171 180 (Pubitemid 46148767)
25. D. Ferenbach, J. Hughes Macrophages and dendritic cells: what is the difference? Kidney Int 74 2008 5 7 (Pubitemid 351841897)
26. M. O'Keeffe, H. Hochrein, D. Vremec, B. Scott, P. Hertzog, L. Tatarczuch, K. Shortman Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors Blood 101 2003 1453 1459 (Pubitemid 36182520)
27. G.J. Randolph, V. Angeli, M.A. Swartz Dendritic-cell trafficking to lymph nodes through lymphatic vessels Nat Rev Immunol 5 2005 617 628 (Pubitemid 41113193)
28. H.H. Lin, D.E. Faunce, M. Stacey, A. Terajewicz, T. Nakamura, J. Zhang-Hoover, M. Kerley, M.L. Mucenski, S. Gordon, J. Stein-Streilein The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance J Exp Med 201 2005 1615 1625 (Pubitemid 40721005)
29. R.L. Chevalier, M.S. Forbes, B.A. Thornhill Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy Kidney Int 75 2009 1145 1152
30. J.L. Bascands, J.P. Schanstra Obstructive nephropathy: insights from genetically engineered animals Kidney Int 68 2005 925 937 (Pubitemid 43246409)
31. Y. Liu Renal fibrosis: new insights into the pathogenesis and therapeutics Kidney Int 69 2006 213 217 (Pubitemid 43323069)
32. P.M. Dominguez, C. Ardavin Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation Immunol Rev 234 2010 90 104
33. K.K. Meldrum, P. Metcalfe, J.A. Leslie, R. Misseri, K.L. Hile, D.R. Meldrum TNF-alpha neutralization decreases nuclear factor-kappaB activation and apoptosis during renal obstruction J Surg Res 131 2006 182 188
34. K.K. Meldrum, R. Misseri, P. Metcalfe, C.A. Dinarello, K.L. Hile, D.R. Meldrum TNF-alpha neutralization ameliorates obstruction-induced renal fibrosis and dysfunction Am J Physiol Regul Integr Comp Physiol 292 2007 R1456 R1464
35. S.H. Kassim, N.K. Rajasagi, X. Zhao, R. Chervenak, S.R. Jennings In vivo ablation of CD11c-positive dendritic cells increases susceptibility to herpes simplex virus type 1 infection and diminishes NK and T-cell responses J Virol 80 2006 3985 3993
36. A. Sapoznikov, J.A. Fischer, T. Zaft, R. Krauthgamer, A. Dzionek, S. Jung Organ-dependent in vivo priming of naive CD4+, but not CD8+ T cells by plasmacytoid dendritic cells J Exp Med 204 2007 1923 1933 (Pubitemid 47236327)
37. K. Kitamoto, Y. Machida, J. Uchida, Y. Izumi, M. Shiota, T. Nakao, H. Iwao, T. Yukimura, T. Nakatani, K. Miura Effects of liposome clodronate on renal leukocyte populations and renal fibrosis in murine obstructive nephropathy J Pharmacol Sci 111 2009 285 292
38. S.L. Lin, A.P. Castano, B.T. Nowlin, M.L. Lupher Jr., J.S. Duffield Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations J Immunol 183 2009 6733 6743
39. Y. Machida, K. Kitamoto, Y. Izumi, M. Shiota, J. Uchida, Y. Kira, T. Nakatani, K. Miura Renal fibrosis in murine obstructive nephropathy is attenuated by depletion of monocyte lineage, not dendritic cells J Pharmacol Sci 114 2010 464 473