Increased tubular proliferation as an adaptive response to glomerular albuminuria

Journal of the American Society of Nephrology

Volumn 23, Issue 3, 2012, Pages 429-437

  Guo, Jian Kan ^a   Marlier, Arnaud ^a   Shi, Hongmei ^a   Shan, Alan ^a   Ardito, Thomas A ^a   Du, Zhao Peng ^a   Kashgarian, Michael ^a   Krause, Diane S ^a   Biemesderfer, Daniel ^a   Cantley, Lloyd G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN; GROWTH ARREST SPECIFIC PROTEIN 6; PROTEIN AXL; RECEPTOR; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APICAL MEMBRANE; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; GLOMERULOSCLEROSIS; HISTOPATHOLOGY; KIDNEY FAILURE; KIDNEY FUNCTION; KIDNEY TUBULE CELL; KIDNEY TUBULE DAMAGE; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; URINE;

EID: 84857966377     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2011040396     Document Type: Article

References (35)

1. Tryggvason K, Wartiovaara J: How does the kidney filter plasma? Physiology (Bethesda) 20: 96-101, 2005 (Pubitemid 40627550)
2. Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P: Actin up: Regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 17: 428-437, 2007 (Pubitemid 47499042)
3. Wiggins RC: The spectrum of podocytopathies: A unifying view of glomerular diseases. Kidney Int 71: 1205-1214, 2007
4. Gubler MC: Podocyte differentiation and hereditary proteinuria/nephrotic syndromes. J Am Soc Nephrol 14[Suppl 1]: S22-S26, 2003
5. Johnstone DB, Holzman LB: Clinical impact of research on the podocyte slit diaphragm. Nat Clin Pract Nephrol 2: 271-282, 2006 (Pubitemid 43787260)
6. LeHir M, Kriz W: New insights into structural patterns encountered in glomerulosclerosis. Curr Opin Nephrol Hypertens 16: 184-191, 2007
7. Nosadini R: Hypertension and renal complications in type 2 diabetes. Semin Vasc Med 2: 109-119, 2002
8. Shah SN, He CJ, Klotman P: Update on HIV-associated nephropathy. Curr Opin Nephrol Hypertens 15: 450-455, 2006 (Pubitemid 44297989)
9. Fogo AB: Animal models of FSGS: lessons for pathogenesis and treatment. Semin Nephrol 23: 161-171, 2003
10. Lu TC, He JC, Klotman P: Animal models of HIV-associated nephropathy. Curr Opin Nephrol Hypertens 15: 233-237, 2006
11. Erkan E, Devarajan P, Schwartz GJ: Apoptotic response to albumin overload: Proximal vs. distal/collecting tubule cells. Am J Nephrol 25:121-131, 2005 (Pubitemid 40864181)
12. Donadelli R, Zanchi C, Morigi M, Buelli S, Batani C, Tomasoni S, Corna D, Rottoli D, Benigni A, Abbate M, Remuzzi G, Zoja C: Protein overload induces fractalkine upregulation in proximal tubular cells through nuclear factor kappaB- and p38 mitogen-activated protein kinase-dependent pathways. J Am Soc Nephrol 14: 2436-2446, 2003 (Pubitemid 37169329)
13. Shalamanova L, McArdle F, Amara AB, Jackson MJ, Rustom R: Albumin overload induces adaptive responses in human proximal tubular cells through oxidative stress but not via angiotensin II type 1 receptor. Am J Physiol Renal Physiol 292: F1846-F1857, 2007 (Pubitemid 47105374)
14. Ohse T, Inagi R, Tanaka T, Ota T, Miyata T, Kojima I, Ingelfinger JR, Ogawa S, Fujita T, Nangaku M: Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells. Kidney Int 70: 1447-1455, 2006 (Pubitemid 44527314)
15. Caruso-Neves C, Pinheiro AA, Cai H, Souza-Menezes J, Guggino WB: PKB and megalin determine the survival or death of renal proximal tubule cells. Proc Natl Acad Sci USA 103: 18810-18815, 2006 (Pubitemid 44913492)
16. Iglesias J, Abernethy VE, Wang Z, Lieberthal W, Koh JS, Levine JS: Albumin is a major serum survival factor for renal tubular cells and macrophages through scavenging of ROS. Am J Physiol 277: F711-F722, 1999
17. Iglesias J, Levine JS: Albuminuria and renal injury-Beware of proteins bearing gifts. Nephrol Dial Transplant 16: 215-218, 2001 (Pubitemid 32123903)
18. Buch T, Heppner FL, Tertilt C, Heinen TJ, Kremer M, Wunderlich FT, Jung S, Waisman A: A Cre-inducible diphtheria toxin receptor-mediates cell lineage ablation after toxin administration. Nat Methods 2: 419-426, 2005 (Pubitemid 40916560)
19. Moeller MJ, Sanden SK, Soofi A, Wiggins RC, Holzman LB: Podocyte-specific expression of cre recombinase in transgenic mice. Genesis 35:39-42, 2003 (Pubitemid 36150980)
20. Wharram BL, Goyal M, Wiggins JE, Sanden SK, Hussain S, Filipiak WE, Saunders TL, Dysko RC, Kohno K, Holzman LB, Wiggins RC: Podocyte depletion causes glomerulosclerosis: Diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 16: 2941-2952, 2005 (Pubitemid 44743492)
21. Yamaizumi M, Mekada E, Uchida T, Okada Y: One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell. Cell 15: 245-250, 1978 (Pubitemid 9027527)
22. Yamaizumi M, Uchida T, Takamatsu K, Okada Y: Intracellular stability of diphtheria toxin fragment A in the presence and absence of anti-fragment A antibody. Proc Natl Acad Sci USA 79: 461-465, 1982 (Pubitemid 12137731)
23. Erkan E, Devarajan P, Schwartz GJ: Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cells. J Am Soc Nephrol 18: 1199-1208, 2007 (Pubitemid 46536906)
24. Duffield JS, Park KM, Hsiao LL, Kelley VR, Scadden DT, Ichimura T, Bonventre JV: Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest 115: 1743-1755, 2005 (Pubitemid 40979713)
25. Lin F, Moran A, Igarashi P: Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney, J Clin Invest 115: 1756-1764, 2005 (Pubitemid 40979714)
26. Kriz W, LeHir M: Pathways to nephron loss starting from glomerular diseases-insights from animal models. Kidney Int 67: 404-419, 2005 (Pubitemid 40139832)
27. Goruppi S, Ruaro E, Varnum B, Schneider C: Requirement of phosphatidylinositol 3-kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH3T3 fibroblasts. Mol Cell Biol 17: 4442-4453, 1997 (Pubitemid 27318121)
28. Goruppi S, Ruaro E, Varnum B, Schneider C: Gas6-mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of Ras. Oncogene 18: 4224-4236, 1999 (Pubitemid 29377853)
29. Pohl M, Kaminski H, Castrop H, Bader M, Himmerkus N, Bleich M, Bachmann S, Theilig F: Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron. J Biol Chem 285: 41935-41946, 2010
30. Marinó M, Andrews D, Brown D, McCluskey RT: Transcytosis of retinol-binding protein across renal proximal tubule cells after megalin (gp 330)-mediated endocytosis. J Am Soc Nephrol 12: 637-648, 2001 (Pubitemid 32246691)
31. Theilig F, Kriz W, Jerichow T, Schrade P, Hähnel B, Willnow T, Le Hir M, Bachmann S: Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulointerstitial injury. J Am Soc Nephrol 18: 1824-1834, 2007 (Pubitemid 46870319)
32. Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y, Fujita T: Modification of mineralocorticoid receptor function by Rac1GTPase: implication in proteinuric kidney disease. Nat Med 14: 1370-1376, 2008
33. Charles AK, Mall S, Watson J, Berry PJ: Expression of the Wilms' tumour gene WT1 in the developing human and in paediatric renal tumours: an immunohistochemical study. Mol Pathol 50: 138-144, 1997 (Pubitemid 27454998)
34. Biemesderfer D, DeGray B, Aronson PS: Active (9.6 s) and inactive (21 s) oligomers of NHE3 in microdomains of the renal brush border. J Biol Chem 276: 10161-10167, 2001
35. Provost J, Wallert M: MTT Proliferation Protocol, Moorehead, MN, Minnesota State University, 2007