Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity

Toxicology and Applied Pharmacology

Volumn 269, Issue 3, 2013, Pages 297-306

  Das, Suvarthi ^a   Kumar, Ashutosh ^b   Seth, Ratanesh Kumar ^a   Tokar, Erik J ^c   Kadiiska, Maria B ^b   Waalkes, Michael P ^c   Mason, Ronald P ^b   Chatterjee, Saurabh ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RTI International   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Adipocytokines; Kupffer cell; Lipid peroxidation; Necrosis; OB OB mice; Oxidative stress; Tumor necrosis factor; Tyrosine nitration

Indexed keywords

3 NITROTYROSINE; BROMODICHLOROMETHANE; CD68 ANTIGEN; FREE RADICAL; ISOCITRATE DEHYDROGENASE; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; ENZYME RELEASE; FATTY LIVER; HISTOPATHOLOGY; KUPFFER CELL; LIPID PEROXIDATION; LIVER LEVEL; LIVER NECROSIS; MALE; MOUSE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PATHOGENESIS;

ADIPOKINES; ANIMALS; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY LIVER; IN SITU NICK-END LABELING; KUPFFER CELLS; LEPTIN; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MICROSCOPY, CONFOCAL; OBESITY; REAL-TIME POLYMERASE CHAIN REACTION; TRIHALOMETHANES;

MUS;

EID: 84876980432     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.02.003     Document Type: Article

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