Polychlorinated biphenyls, lead, and mercury are associated with liver disease in american adults: NHANES 2003-2004

Environmental Health Perspectives

Volumn 118, Issue 12, 2010, Pages 1735-1742

  Cave, Matt ^a,b   Appana, Savitri ^b   Patel, Mihir ^a   Falkner, Keith Cameron ^a   McClain, Craig J ^a,b   Brock, Guy ^b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Environmental liver disease; Hepatotoxicity; Lead; Mercury; NAFLD; NASH; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Pcbs; Polychlorinated biphenyls; TASH

Indexed keywords

ALANINE AMINOTRANSFERASE; HEAVY METAL; INSULIN; LEAD; LIPID; MERCURY; POLYCHLORINATED BIPHENYL;

ADULT; AGE; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY MASS; CAUCASIAN; COHORT ANALYSIS; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; HEALTH SURVEY; HUMAN; INCOME; INSULIN RESISTANCE; LEAD BLOOD LEVEL; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OCCUPATIONAL EXPOSURE; POLLUTION; POVERTY; PRIORITY JOURNAL; RACE DIFFERENCE; SOCIAL STATUS; UNITED STATES;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALANINE TRANSAMINASE; CROSS-SECTIONAL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FATTY LIVER; FEMALE; HUMANS; LEAD; MALE; MERCURY; MIDDLE AGED; NUTRITION SURVEYS; POLYCHLORINATED BIPHENYLS; RISK FACTORS; UNITED STATES; YOUNG ADULT;

EID: 78650294829     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1002720     Document Type: Article

References (49)

1. Aykin-Burns N, Laegeler A, Kellogg G, Ercal N. 2003. Oxidative effects of lead in young and adult Fisher 344 rats. Arch Environ Contam Toxicol 44(3):417-420.
2. Benjamini Y, Hochberg Y. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 57(1):289-300.
3. Brautbar N, Williams J 2nd. 2002. Industrial solvents and liver toxicity: risk assessment, risk factors, and mechanisms. Int J Hyg Environ Health 205(6):479-491.
4. Breivik K, Sweetman A, Pacyna JM, Jones KC. 2002. Towards a global historical emission inventory for selected PCB congeners-a mass balance approach. 1. Global production and consumption. Sci Total Environ 290(1-3):181-198.
5. Cave M, Deaciuc I, Mendez C, Song Z, Joshi-Barve S, Barve S, et al. 2007. Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition. J Nutr Biochem 18(3):184-195.
6. Cave M, Falkner KC, Ray M, Joshi-Barve S, Brock G, Khan R, et al. 2010. Toxicant-associated steatohepatitis in vinyl chloride workers. Hepatology 51(2):474-481.
7. Chang LW, Yamaguchi S. 1974. Ultrastructural changes of the liver after long-term diet of mercury-contaminated tuna. Environ Res 7(2):133-148.
8. Charnley G. 2006. Assessing and managing methylmercury risks associated with power plant mercury emissions in the United States. MedGenMed 8(1):64. Available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681952/?tool=pubmed [accessed 2 November 2010].
9. Clark JM. 2006. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol 40(suppl 1):S5-S10.
10. Clark JM, Brancati FL, Diehl AM. 2003. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 98(5):960-967.
11. Cotrim HP, Andrade ZA, Parana R, Portugal M, Lyra LG, Freitas LA. 1999. Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. Liver 19(4):299-304.
12. Cotrim HP, De Freitas LA, Freitas C, Braga L, Sousa R, Carvalho F, et al. 2004. Clinical and histopathological features of NASH in workers exposed to chemicals with or without associated metabolic conditions. Liver Int 24(2):131-135.
13. Dean CE Jr, Benjamin SA, Chubb LS, Tessari JD, Keefe TJ. 2002. Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphe-nyls in female rat livers. Toxicol Sci 66(1):54-61.
14. Desnoyers PA, Chang LW. 1975a. Ultrastructural changes in rat hepatocytes following acute methyl mercury intoxication. Environ Res 9(3):224-239.
15. Desnoyers PA, Chang LW. 1975b. Ultrastructural changes in the liver after chronic exposure to methylmercury. Environ Res 10(1):59-75.
16. Dunn W, Xu R, Wingard DL, Rogers C, Angulo P, Younossi ZM, et al. 2008. Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study. Am J Gastroenterol 103(9):2263-2271.
17. Fisher CD, Lickteig AJ, Augustine LM, Oude Elferink RP, Besselsen DG, Erickson RP, et al. 2009a. Experimental nonalcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats. Eur J Pharmacol 613(1-3):119-127.
18. Fisher CD, Lickteig AJ, Augustine LM, Ranger-Moore J, Jackson JP, Ferguson SS, et al. 2009b. Hepatic cyto-chrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab Dispos 37(10):2087-2094.
19. Futatsuka M, Kitano T, Nagano M, Inaoka T, Arimatsu Y, Ueno T, et al. 1992. An epidemiological study with risk analysis of liver diseases in the general population living in a methyl mercury polluted area. J Epidemiol Community Health 46(3):237-240.
20. Futatsuka M, Kitano T, Shono M, Nagano M, Wakamiya J, Miyamoto K, et al. 2005. Long-term follow-up study of health status in population living in methylmercury-polluted area. Environ Sci 12(5):239-282.
21. Futatsuka M, Shibata Y, Kinjo Y. 1987. Cause specifc standard mortality ratio for Minamata disease patients. Kumanoto Med J 40:119-128.
22. Graubard BI, Korn EL. 1999. Analyzing health surveys for cancer-related objectives. J Natl Cancer Inst 91(12):1005-1016.
23. Green RM, Flamm S. 2002. AGA technical review on the evaluation of liver chemistry tests. Gastroenterology 123(4):1367-1384.
24. Hennig B, Reiterer G, Toborek M, Matveev SV, Daugherty A, Smart E, et al. 2005. Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density lipoprotein receptor. Environ Health Perspect 113:83-87.
25. Honchel R, Marsano L, Cohen D, Shedlofsky S, McClain CJ. 1991. Lead enhances lipopolysaccharide and tumor necrosis factor liver injury. J Lab Clin Med 117(3):202-208.
26. Kirpich I, Gobejishvili L, Bon Homme M, Waigel S, Cave M, Arteel G, et al. In press. Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease. J Nutr Biochem.
27. Klein R, Herman SP, Brubaker P, Lucier GW. 1972. A model of acute methyl mercury intoxication in rats. Arch Path 93(5):408-418.
28. Kojima M, Masui T, Nemoto K, Degawa M. 2004. Lead nitrate-induced development of hypercholesterolemia in rats: sterol-independent gene regulation of hepatic enzymes responsible for cholesterol homeostasis. Toxicol Lett 154(1-2):35-44.
29. Korn EL, Graubard BI. 1991. Epidemiologic studies utilizing surveys: accounting for the sampling design. Am J Public Health 81(9):1166-1173.
30. Lee DH, Lee IK, Jin SH, Steffes M, Jacobs DR Jr. 2007a. Association between serum concentrations of persistent organic pollutants and insulin resistance among nondiabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002. Diabetes Care 30(3):622-628.
31. Lee DH, Lee IK, Porta M, Steffes M, Jacobs DR Jr. 2007b. Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among nondiabetic adults: results from the National Health and Nutrition Examination Survey 1999- 2002. Diabetologia 50(9):1841-1851.
32. Liangpunsakul S, Chalasani N. 2004. Relationship between unexplained elevations in alanine aminotransferase and serum leptin in U.S. adults: results from the Third National Health and Nutrition Examination Survey (NHANES III). J Clin Gastroenterol 38(10):891-897.
33. Liangpunsakul S, Chalasani N. 2005. Unexplained elevations in alanine aminotransferase in individuals with the metabolic syndrome: results from the third National Health and Nutrition Survey (NHANES III). Am J Med Sci 329(3):111-116.
34. Lin TH, Huang YL, Huang SF. 1996. Lipid peroxidation in liver of rats administrated with methyl mercuric chloride. Biol Trace Elem Res 54(1):33-41.
35. Milosevic N, Maier P. 2000. Lead stimulates intercellular signalling between hepatocytes and Kupffer cells. Eur J Pharmacol 401(3):317-328.
36. Mudipalli A. 2007. Lead hepatotoxicity and potential health effects. Indian J Med Res 126(6):518-527.
37. National Institutes of Health. 1998. Clinical guidelines on the identifcation, evaluation, and treatment of overweight and obesity in adults-the evidence report. Obes Res 6(suppl 2):51S-209S.
38. NCHS (National Center for Health Statistics). 2005. NHANES 2003-2004 Public General Release File Documentation. Available: http://www.cdc.gov/nchs/data/nhanes/nhanes_03_04/general_data_release_doc_03-04.pdf [accessed 2 November 2010].
39. NCHS (National Center for Health Statistics). 2003-2004. NHANES 2003-2004 Laboratory Procedure Manual: Alanine Amino Transferase (ALT) in Refrigerated Serum. Available: http://origin.cdc.gov/nchs/data/nhanes/nhanes_03_04/l40_c_met_alanine_amino_transferase.pdf [accessed 17 February 2010].
40. NTP (National Toxicology Program). 2006a. NTP technical report on the toxicology and carcinogenesis studies of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS no. 35065-27-1) in female Harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser (529):4-168.
41. NTP (National Toxicology Program). 2006b. NTP toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (CAS no. 57465-28-8) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS no. 35065-27-1) in female Harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser (530):1-258.
42. NTP (National Toxicology Program). 2006c. NTP toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (CAS no. 57465-28-8) and 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (CAS no. 31508-00-6) in female Harlan Sprague-Dawley rats (gavage studies). Natl Toxicol Program Tech Rep Ser (531):1-218.
43. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, et al. 2002. Updated defnitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 137(1):1-10.
44. Reed AH, Henry RJ, Mason WB. 1971. Infuence of statistical method used on the resulting estimate of normal range. Clin Chem 17:275-284.
45. Ruhl CE, Everhart JE. 2009. Elevated serum alanine aminotrans-ferase and gamma-glutamyltransferase and mortality in the United States population. Gastroenterology 136(2):477-485.
46. Safe SH. 1993. Toxicology, structure-function relationship, and human and environmental health impacts of polychlori-nated biphenyls: progress and problems. Environ Health Perspect 100:259-268.
47. Sandhir R, Gill KD. 1995. Effect of lead on lipid peroxidation in liver of rats. Biol Trace Elem Res 48(1):91-97.
48. Schwartz GG, Il'yasova D, Ivanova A. 2003. Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III. Diabetes Care 26(2):468-470.
49. Yu ML, Guo YL, Hsu CC, Rogan WJ. 1997. Increased mortality from chronic liver disease and cirrhosis 13 years after the Taiwan "yucheng" ("oil disease") incident. Am J Ind Med 31(2):172-175.