Bi-directional effect of increasing doses of baclofen on reinforcement learning

Frontiers in Behavioral Neuroscience

Volumn , Issue JULY, 2011, Pages

  Terrier, Jean ^a   Ort, Andres ^a   Yvon, Cédric ^a   Saj, Arnaud ^a   Vuilleumier, Patrik ^a   Lüscher, Christian ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Anti craving treatment; Baclofen; Bi directional effect; Instrumental learning; Mesolimbic dopamine system; Reward prediction error; Ventral tegmental area

Indexed keywords

BACLOFEN; DOPAMINE; PLACEBO;

ACCURACY; ADULT; ARTICLE; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINERGIC NERVE CELL; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; HUMAN; HUMAN EXPERIMENT; INSTRUMENTAL CONDITIONING; LEARNING; LEARNING CURVE; LOW DRUG DOSE; MALE; NEUROMODULATION; NORMAL HUMAN; PATHOLOGICAL GAMBLING; PROBABILITY; RANDOMIZED CONTROLLED TRIAL; REINFORCEMENT; REWARD; TASK PERFORMANCE; VOLUNTEER;

EID: 84855251404     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2011.00040     Document Type: Article

References (41)

1. Addolorato, G., Leggio, L., Ferrulli, A., Cardone, S., Vonghia, L., Mirijello, A., Abenavoli, L., D'Angelo, C., Caputo, F., Zambon, A., Haber, P. S., and Gasbarrini, G. (2007). Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol dependent patients with liver cirrhosis: randomized, doubleblind controlled study. Lancet 370, 1915-1922.
2. Agabio, R., Marras, P., Addolorato, G., Carpiniello, B., and Gessa, G. L. (2007). Baclofen suppresses alcohol intake and craving for alcohol in a schizophrenic alcohol dependent patient: a case report. J. Clin. Psychopharmacol. 27, 319-320.
3. Ameisen, O. (2005). Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician. Alcohol Alcohol. 40, 147-150.
4. Balland, B., and Lüscher, C. (2008). Addiction: the dark side of learning. Pediatr. Res. 63, 1.
5. Bechara, A., Nader, K., and van der Kooy, D. (1998). A two-separate-motivational-systems hypothesis of opioid addiction. Pharmacol. Biochem. Behav. 59, 1-17.
6. Borgland, S. L., Malenka, R. C., and Bonci, A. (2004). Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual rats. J. Neurosci. 24, 7482-7490.
7. Brebner, K., Childress, A. R., and Roberts, D. C. (2002). A potential role for GABAB agonists in the treatment of psychostimulant addiction. Alcohol Alcohol. 37, 478-484.
8. Brischoux, F., Chakraborty, S., Brierley, D. I., and Ungless, M. A. (2009). Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli. Proc. Natl. Acad. Sci. U.S.A. 106, 4894-4899.
9. Bucknam, W. (2007). Suppression of symptoms of alcohol dependence and craving using high-dose baclofen. Alcohol Alcohol. 42, 158-160.
10. Compendium Suisse des Medicaments. (2011). Basle: Documed.
11. Cousins, M. S., Roberts, D. C., and de Wit, H. (2002). GABAB receptor agonists for the treatment of drug addiction: a review of recent findings. Drug Alcohol Depend. 65, 209-220.
12. Cruz, H. G., Ivanova, T., Lunn, M. L., Stoffel, M., Slesinger, P. A., and Lüscher, C. (2004). Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system. Nat. Neurosci. 7, 153-159.
13. European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). (2010). Statistical Bulletin. Available at: www.emcdda.europa.eu/stats10
14. Everitt, B. J., and Robbins, T. W. (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 8, 1481-1489.
15. Fiorillo, C. D., Tobler, P. N., and Schultz, W. (2003). Discrete coding of reward probability and uncertainty by dopamine neurons. Science 299, 1898-1902.
16. Franklin, T. R., Harper, D., Kampman, K., Kildea-McCrea, S., Jens, W., Lynch, K. G., O'Brien, C. P., and Childress, A. R. (2009). The GABAB agonist baclofen reduces cigarette consumption in a preliminary double-blind placebocontrolled smoking reduction study. Drug Alcohol Depend. 103, 30-36.
17. Garbutt, J. C., Kampov-Polevoy, A. B., Gallop, R., Kalka-Juhl, L., and Flannery, B. A. (2010). Efficacy and safety of baclofen for alcohol dependence: a randomized, double-blind, placebo-controlled trial. Alcohol. Clin. Exp. Res. 11, 1849-1857.
18. Hoddes, E., Zarcone, V., Smythe, H., Phillips, R., and Dement, W. C. (1973). Quantification of sleepiness: a new approach. Psychophysiology 14, 431-436.
19. Katzung, B. (2009). Basic and Clinical Pharmacology, 11th Edn. New York, NY: McGraw Hill Companies.
20. Kauer, J. A., and Malenka, R. C. (2007). Synaptic plasticity and addiction. Nat. Rev. Neurosci. 8, 844-858.
21. Koob, G. F., and Volkow, N. D. (2010). Neurocircuitry of addiction. Neuropsychopharmacology 35, 217-238.
22. Kourrich, S., Rothwell, P. E., Klug, J. R., and Thomas, M. J. (2007). Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens. J. Neurosci. 27, 7921-7928.
23. Labouèbe, G., Lomazzi, M., Cruz, H. G., Creton, C., Luján, R., Li, M., Yanagawa, Y., Obata, K., Watanabe, M., Wickman, K., Boyer, S. B., Slesinger, P. A, and Lüscher, C. (2007). RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area. Nat. Neurosci. 10, 1559-1568.
24. Li, X., Lu, Z. L., D'Argembeau, A., Ng, M., and Bechara, A. (2010). The Iowa gambling task in fMRI images. Hum. Brain Mapp. 31, 410-423.
25. Lomazzi, M., Slesinger, P. A., and Lüscher, C. (2008). Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins. Trends Pharmacol. Sci. 29, 544-549.
26. Lüscher, C., and Bellone, C. (2008). Cocaine-evoked synaptic plasticity: a key to addiction? Nat. Neurosci. 11, 737-738.
27. Lüscher, C., and Ungless, M. A. (2006). The mechanistic classification of addictive drugs. PLoS Med. 3, e437. doi: 10.1371/journal.pmed.0030437
28. Matsumoto, M., and Hikosaka, O. (2008). Representation of negative motivational value in the primate lateral habenula. Nat. Neurosci. 12, 77-84.
29. Matsumoto, M., and Hikosaka, O. (2009). Two types of dopamine neuron distinctly convey positive and negative motivational signals. Nature 459, 837-841.
30. Paton, J. J., Belova, M. A., Morrison, S. E., and Salzman, C. D. (2006). The primate amygdala represents the positive and negative value of visual stimuli during learning. Nature 439, 865-870.
31. Pessiglione, M., Seymour, B., Flandin, G., Dolan, R. J., and Frith, C. D. (2006), Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans. Nature 442, 1042-1045.
32. Redish, A. D., Jensen, S., and Johnson, A. (2008). A unified framework for addiction: vulnerabilities in the decision process. Behav. Brain Sci. 31, 415-437.
33. Saal, D., Dong, Y., Bonci, A., and Malenka, R. C. (2003). Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron 37, 577-582.
34. Schultz, W. (2007). Behavioral dopamine signals. Trends Neurosci. 30, 203-210.
35. Schultz, W. (2010). Dopamine signals for reward value and risk: basic and recent data. Behav. Brain Funct. 6, 24.
36. Schultz, W., Dayan, P., and Montague, P. R. (1997). A neural substrate of prediction and reward. Science 275, 1593-1599.
37. Sun, X., Zhao, Y., and Wolf, M. E. (2005). Dopamine receptor stimulation modulates AMPA receptor synaptic insertion in prefrontal cortex neurons. J. Neurosci. 25, 7342-7351.
38. Thorndike, E. (1898). Some experiments on animal intelligence. Science 7, 818-824.
39. Ungless, M. A., Magill, P. J., and Bolam, J. P. (2004). Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. Science 303, 2040-2042.
40. Ungless, M. A., Whistler, J. L., Malenka, R. C., and Bonci, A. (2001). Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411, 583-587.
41. Voon, V., Pessiglione, M., Brezing, C., Gallea, C., Fernandez, H. H., Dolan, R. J., and Hallett, M. (2010). Mechanisms underlying dopamine mediated reward bias in compulsive behaviors. Neuron 65, 135-142.