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Volumn 92, Issue 1, 2013, Pages 24-30

The influence of cylindrospermopsin on oxidative DNA damage and apoptosis induction in HepG2 cells

Author keywords

Apoptosis; Cylindrospermopsin; DNA damage; HepG2; Oxidative stress

Indexed keywords

BIOSYNTHESIS; CELL DEATH; MITOCHONDRIA; OXIDATIVE STRESS; PROBES;

EID: 84876964567     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2013.03.023     Document Type: Article
Times cited : (34)

References (45)
  • 1
    • 77950351190 scopus 로고    scopus 로고
    • Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG
    • Bazin E., Mourot A., Humpage A.R., Fessard V. Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG. Environ. Mol. Mutagen. 2010, 51:251-259.
    • (2010) Environ. Mol. Mutagen. , vol.51 , pp. 251-259
    • Bazin, E.1    Mourot, A.2    Humpage, A.R.3    Fessard, V.4
  • 4
    • 0027375157 scopus 로고
    • Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA
    • Collins A.R., Duthie S.J., Dobson V.L. Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 1993, 14:1733-1735.
    • (1993) Carcinogenesis , vol.14 , pp. 1733-1735
    • Collins, A.R.1    Duthie, S.J.2    Dobson, V.L.3
  • 6
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Dröge W. Free radicals in the physiological control of cell function. Physiol. Rev. 2002, 82:47-95.
    • (2002) Physiol. Rev. , vol.82 , pp. 47-95
    • Dröge, W.1
  • 7
    • 84876965895 scopus 로고    scopus 로고
    • EPA, Creating a Cyanotoxin Target List for the Unregulated Contaminant Monitoring Ruley. U.S. Environmental Protection Agenc, Technical Service Center, Cincinnati, OH.
    • EPA, 2010. Creating a Cyanotoxin Target List for the Unregulated Contaminant Monitoring Ruley. U.S. Environmental Protection Agenc, Technical Service Center, Cincinnati, OH.
    • (2010)
  • 8
    • 0035072467 scopus 로고    scopus 로고
    • Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga Cylindrospermopsis raciborskii containing the toxin cylindrospermopsin
    • Falconer I.R., Humpage A.R. Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga Cylindrospermopsis raciborskii containing the toxin cylindrospermopsin. Environ. Toxicol. 2001, 16:192-195.
    • (2001) Environ. Toxicol. , vol.16 , pp. 192-195
    • Falconer, I.R.1    Humpage, A.R.2
  • 9
    • 0033034115 scopus 로고    scopus 로고
    • Hepatic and renal toxicity of the blue-green alga (cyanobacterium) Cylindrospermopsis raciborskii in male Swiss albino mice
    • Falconer I.R., Hardy S.J., Humpage A.R., Froscio S.M., Tozer G.J., Hawkins P.R. Hepatic and renal toxicity of the blue-green alga (cyanobacterium) Cylindrospermopsis raciborskii in male Swiss albino mice. Environ. Toxicol. 1999, 14:143-150.
    • (1999) Environ. Toxicol. , vol.14 , pp. 143-150
    • Falconer, I.R.1    Hardy, S.J.2    Humpage, A.R.3    Froscio, S.M.4    Tozer, G.J.5    Hawkins, P.R.6
  • 10
    • 0141927335 scopus 로고    scopus 로고
    • Cell alterations but no DNA strand breaks induced in vitro by cylindrospermopsin in CHO K1 cells
    • Fessard V., Bernard C. Cell alterations but no DNA strand breaks induced in vitro by cylindrospermopsin in CHO K1 cells. Environ. Toxicol. 2003, 18:353-359.
    • (2003) Environ. Toxicol. , vol.18 , pp. 353-359
    • Fessard, V.1    Bernard, C.2
  • 11
    • 0042978772 scopus 로고    scopus 로고
    • Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes
    • Froscio S.M., Humpage A.R., Burcham P.C., Falconer I.R. Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes. Environ. Toxicol. 2003, 18:243-251.
    • (2003) Environ. Toxicol. , vol.18 , pp. 243-251
    • Froscio, S.M.1    Humpage, A.R.2    Burcham, P.C.3    Falconer, I.R.4
  • 14
    • 0038508656 scopus 로고    scopus 로고
    • The Palm Island mystery disease 20years on: a review of research on the cyanotoxin cylindrospermopsin
    • Griffiths D.J., Saker M.L. The Palm Island mystery disease 20years on: a review of research on the cyanotoxin cylindrospermopsin. Environ. Toxicol. 2003, 18:78-93.
    • (2003) Environ. Toxicol. , vol.18 , pp. 78-93
    • Griffiths, D.J.1    Saker, M.L.2
  • 15
    • 84865764327 scopus 로고    scopus 로고
    • Alterations observed in the endothelial HUVEC cell line exposed to pure Cylindrospermopsin
    • Gutiérrez-Praena D., Pichardo S., Jos Á., Moreno F.J., Cameán A.M. Alterations observed in the endothelial HUVEC cell line exposed to pure Cylindrospermopsin. Chemosphere 2012, 89:1151-1160.
    • (2012) Chemosphere , vol.89 , pp. 1151-1160
    • Gutiérrez-Praena, D.1    Pichardo, S.2    Jos, Á.3    Moreno, F.J.4    Cameán, A.M.5
  • 16
    • 84856658679 scopus 로고    scopus 로고
    • Biochemical and pathological toxic effects induced by the cyanotoxin Cylindrospermopsin on the human cell line Caco-2
    • Gutiérrez-Praena D., Pichardo S., Jos Á., Moreno F.J., Cameán A.M. Biochemical and pathological toxic effects induced by the cyanotoxin Cylindrospermopsin on the human cell line Caco-2. Water Res. 2012, 46:1566-1575.
    • (2012) Water Res. , vol.46 , pp. 1566-1575
    • Gutiérrez-Praena, D.1    Pichardo, S.2    Jos, Á.3    Moreno, F.J.4    Cameán, A.M.5
  • 17
    • 0022402504 scopus 로고
    • Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir
    • Hawkins P.R., Runnegar M.T., Jackson A.R., Falconer I.R. Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir. Appl. Environ. Microbiol. 1985, 50:1292-1295.
    • (1985) Appl. Environ. Microbiol. , vol.50 , pp. 1292-1295
    • Hawkins, P.R.1    Runnegar, M.T.2    Jackson, A.R.3    Falconer, I.R.4
  • 18
    • 0034695122 scopus 로고    scopus 로고
    • Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin
    • Humpage A.R., Fenech M., Thomas P., Falconer I.R. Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin. Mutat. Res./Genet. Toxicol. Environ. Mutagen. 2000, 472:155-161.
    • (2000) Mutat. Res./Genet. Toxicol. Environ. Mutagen. , vol.472 , pp. 155-161
    • Humpage, A.R.1    Fenech, M.2    Thomas, P.3    Falconer, I.R.4
  • 20
    • 33646811861 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and ischemic neuronal death
    • Iijima T. Mitochondrial membrane potential and ischemic neuronal death. Neurosci. Res. 2006, 55:234-243.
    • (2006) Neurosci. Res. , vol.55 , pp. 234-243
    • Iijima, T.1
  • 22
    • 0033198273 scopus 로고    scopus 로고
    • Mitochondrial depolarization is not required for neuronal apoptosis
    • Krohn A.J., Wahlbrink T., Prehn J.H.M. Mitochondrial depolarization is not required for neuronal apoptosis. J. Neurosci. 1999, 19:7394-7404.
    • (1999) J. Neurosci. , vol.19 , pp. 7394-7404
    • Krohn, A.J.1    Wahlbrink, T.2    Prehn, J.H.M.3
  • 23
    • 36048984373 scopus 로고    scopus 로고
    • No induction of structural chromosomal aberrations in cylindrospermopsin-treated CHO-K1 cells without and with metabolic activation
    • Lankoff A., Wojcik A., Lisowska H., Bialczyk J., Dziga D., Carmichael W.W. No induction of structural chromosomal aberrations in cylindrospermopsin-treated CHO-K1 cells without and with metabolic activation. Toxicon: Official J. Int. Soc. Toxinol. 2007, 50:1105-1115.
    • (2007) Toxicon: Official J. Int. Soc. Toxinol. , vol.50 , pp. 1105-1115
    • Lankoff, A.1    Wojcik, A.2    Lisowska, H.3    Bialczyk, J.4    Dziga, D.5    Carmichael, W.W.6
  • 24
    • 0026554428 scopus 로고
    • Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
    • LeBel C.P., Ischiropoulos H., Bondy S.C. Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 1992, 5:227-231.
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 227-231
    • LeBel, C.P.1    Ischiropoulos, H.2    Bondy, S.C.3
  • 25
    • 0032774807 scopus 로고    scopus 로고
    • Ethyl-nitrosourea transformed astrocytes exhibit mitochondrial membrane hyperpolarization and constrained apoptosis
    • Liang B.C., Miller L., Weller A. Ethyl-nitrosourea transformed astrocytes exhibit mitochondrial membrane hyperpolarization and constrained apoptosis. Apoptosis 1999, 4:89-97.
    • (1999) Apoptosis , vol.4 , pp. 89-97
    • Liang, B.C.1    Miller, L.2    Weller, A.3
  • 26
    • 0037879052 scopus 로고    scopus 로고
    • The mitochondrial membrane potential (δψm) in apoptosis; an update
    • Ly J.D., Grubb D.R., Lawen A. The mitochondrial membrane potential (δψm) in apoptosis; an update. Apoptosis 2003, 8:115-128.
    • (2003) Apoptosis , vol.8 , pp. 115-128
    • Ly, J.D.1    Grubb, D.R.2    Lawen, A.3
  • 27
    • 34247360451 scopus 로고    scopus 로고
    • Nitric oxide, mitochondrial hyperpolarization, and T cell activation
    • Nagy G., Koncz A., Fernandez D., Perl A. Nitric oxide, mitochondrial hyperpolarization, and T cell activation. Free Radical Biol. Med. 2007, 42:1625-1631.
    • (2007) Free Radical Biol. Med. , vol.42 , pp. 1625-1631
    • Nagy, G.1    Koncz, A.2    Fernandez, D.3    Perl, A.4
  • 28
    • 0037098869 scopus 로고    scopus 로고
    • Oxidative DNA damage: assessment of the role in carcinogenesis, atherosclerosis, and acquired immunodeficiency syndrome
    • Olinski R., Gackowski D., Foksinski M., Rozalski R., Roszkowski K., Jaruga P. Oxidative DNA damage: assessment of the role in carcinogenesis, atherosclerosis, and acquired immunodeficiency syndrome. Free Radical Biol. Med. 2002, 33:192-200.
    • (2002) Free Radical Biol. Med. , vol.33 , pp. 192-200
    • Olinski, R.1    Gackowski, D.2    Foksinski, M.3    Rozalski, R.4    Roszkowski, K.5    Jaruga, P.6
  • 29
    • 0032839105 scopus 로고    scopus 로고
    • Tacrine-induced reactive oxygen species in a human liver cell line: the role of anethole dithiolethione as a scavenger
    • Osseni R.A., Debbasch C., Christen M.O., Rat P., Warnet J.M. Tacrine-induced reactive oxygen species in a human liver cell line: the role of anethole dithiolethione as a scavenger. Toxicol. In Vitro 1999, 13:683-688.
    • (1999) Toxicol. In Vitro , vol.13 , pp. 683-688
    • Osseni, R.A.1    Debbasch, C.2    Christen, M.O.3    Rat, P.4    Warnet, J.M.5
  • 30
    • 0028042389 scopus 로고
    • The cytochromes P450 and mechanisms of chemical carcinogenesis
    • Parke D.V. The cytochromes P450 and mechanisms of chemical carcinogenesis. Environ. Health Perspect. 1994, 102:852-853.
    • (1994) Environ. Health Perspect. , vol.102 , pp. 852-853
    • Parke, D.V.1
  • 31
    • 2942635457 scopus 로고    scopus 로고
    • Mitochondrial hyperpolarization: a checkpoint of T-cell life, death and autoimmunity
    • Perl A., Gergely P., Nagy G., Koncz A., Banki K. Mitochondrial hyperpolarization: a checkpoint of T-cell life, death and autoimmunity. Trends Immunol. 2004, 25:360-367.
    • (2004) Trends Immunol. , vol.25 , pp. 360-367
    • Perl, A.1    Gergely, P.2    Nagy, G.3    Koncz, A.4    Banki, K.5
  • 33
    • 33747884339 scopus 로고    scopus 로고
    • DNA damage-induced cell death by apoptosis
    • Roos W.P., Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol. Med. 2006, 12:440-450.
    • (2006) Trends Mol. Med. , vol.12 , pp. 440-450
    • Roos, W.P.1    Kaina, B.2
  • 34
    • 0028853288 scopus 로고
    • Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes
    • Runnegar M.T., Kong S.-M., Zhong Y.-Z., Lu S.C. Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biochem. Pharmacol. 1995, 49:219-225.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 219-225
    • Runnegar, M.T.1    Kong, S.-M.2    Zhong, Y.-Z.3    Lu, S.C.4
  • 35
    • 0036094367 scopus 로고    scopus 로고
    • In Vitro hepatotoxicity of the cyanobacterial alkaloid cylindrospermopsin and related synthetic analogues
    • Runnegar M.T., Xie C., Snider B.B., Wallace G.A., Weinreb S.M., Kuhlenkamp J. In Vitro hepatotoxicity of the cyanobacterial alkaloid cylindrospermopsin and related synthetic analogues. Toxicol. Sci. 2002, 67:81-87.
    • (2002) Toxicol. Sci. , vol.67 , pp. 81-87
    • Runnegar, M.T.1    Xie, C.2    Snider, B.B.3    Wallace, G.A.4    Weinreb, S.M.5    Kuhlenkamp, J.6
  • 36
    • 0033980562 scopus 로고    scopus 로고
    • Cylindrospermopsin, A cyanobacterial alkaloid: evaluation of its toxicologic activity
    • Shaw G.R., Seawright A.A., Moore M.R., Lam P.K.S. Cylindrospermopsin, A cyanobacterial alkaloid: evaluation of its toxicologic activity. Ther. Drug Monit. 2000, 22:89-92.
    • (2000) Ther. Drug Monit. , vol.22 , pp. 89-92
    • Shaw, G.R.1    Seawright, A.A.2    Moore, M.R.3    Lam, P.K.S.4
  • 39
    • 82355182748 scopus 로고    scopus 로고
    • Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line
    • Štraser A., Filipič M., Žegura B. Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line. Arch. Toxicol. 2011, 85:1617-1626.
    • (2011) Arch. Toxicol. , vol.85 , pp. 1617-1626
    • Štraser, A.1    Filipič, M.2    Žegura, B.3
  • 40
    • 84876980857 scopus 로고    scopus 로고
    • Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells.
    • Submitted for publication.
    • Štraser, A., Filipič, M., Žegura, B., submitted for publication. Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells.
    • Štraser, A..1    Filipič, M..2    Žegura, B.3
  • 42
  • 43
    • 2542434173 scopus 로고    scopus 로고
    • The role of reactive oxygen species in microcystin-LR-induced DNA damage
    • Žegura B., Lah T.T., Filipič M. The role of reactive oxygen species in microcystin-LR-induced DNA damage. Toxicology 2004, 200:59-68.
    • (2004) Toxicology , vol.200 , pp. 59-68
    • Žegura, B.1    Lah, T.T.2    Filipič, M.3
  • 44
    • 82555179238 scopus 로고    scopus 로고
    • Cylindrospermopsin induced DNA damage and alteration in the expression of genes involved in the response to DNA damage, apoptosis and oxidative stress
    • Žegura B., Gajski G., Štraser A., Garaj-Vrhovac V. Cylindrospermopsin induced DNA damage and alteration in the expression of genes involved in the response to DNA damage, apoptosis and oxidative stress. Toxicon: Official J. Int. Soc. Toxinol. 2011, 58:471-479.
    • (2011) Toxicon: Official J. Int. Soc. Toxinol. , vol.58 , pp. 471-479
    • Žegura, B.1    Gajski, G.2    Štraser, A.3    Garaj-Vrhovac, V.4
  • 45
    • 79955104001 scopus 로고    scopus 로고
    • Genotoxicity and potential carcinogenicity of cyanobacterial toxins - a review
    • Žegura B., Štraser A., Filipič M. Genotoxicity and potential carcinogenicity of cyanobacterial toxins - a review. Mutat. Res./Rev. Mutat. Res. 2011, 727:16-41.
    • (2011) Mutat. Res./Rev. Mutat. Res. , vol.727 , pp. 16-41
    • Žegura, B.1    Štraser, A.2    Filipič, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.