In vitro hepatotoxicity of the cyanobacterial alkaloid cyclindrospermopsin and related synthetic analogues

Toxicological Sciences

Volumn 67, Issue 1, 2002, Pages 81-87

  Runnegar, Maria T ^a   Xie, Chaoyu ^b   Snider, Barry B ^b   Wallace, Grier A ^c   Weinreb, Steven M ^c   Kuhlenkamp, John ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Cylindrospermopsin; GSH synthesis inhibition; Hepatocyte toxicity; Protein synthesis inhibition; Toxic cyanobacteria

Indexed keywords

ALKALOID; BACTERIAL TOXIN; CYLINDROSPERMOPSIN; DRINKING WATER; GLUTATHIONE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYANOBACTERIUM; GLUTATHIONE METABOLISM; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; NONHUMAN; PROTEIN SYNTHESIS; RABBIT; RAT; RETICULOCYTE; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANIMALS; CELLS, CULTURED; CYANOBACTERIA; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HEPATOCYTES; L-LACTATE DEHYDROGENASE; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RABBITS; RATS; RETICULOCYTES; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL;

ANIMALIA; BACTERIA (MICROORGANISMS); CYANOBACTERIA; ORYCTOLAGUS CUNICULUS;

EID: 0036094367     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/67.1.81     Document Type: Article

References (27)

1. Uracil moiety is required for toxicity of the cyanobacterial hepatotoxin cylindrospermopsin
2. 7-Epicylindrospermopsin, a toxic minor metabolite of the cyanobacterium Aphanizomenon ovalisporum from lake Kinneret, Israel
3. An outbreak of hepatoenteritis (the Palm Island Mystery Disease) possibly caused by algal intoxication
4. Biosynthesis of cylindrospermopsin
5. Palm Island mystery disease
6. Vinyl and alkynyl pyrimidines as Michael acceptors: An approach to a cylindrospermopsin substructure
7. Hepatic and renal toxicity of the blue-green alga (cyanobacterium) Cylindrospermopsis raciborskii in male Swiss albino mice
8. Studies toward the synthesis of cylindrospermopsin
9. Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya, and Subba Raju isolated from a domestic water supply reservoir
10. Stereoselective total synthesis of the cyanobacterial hepatotoxin 7-epicylindrospermopsin: Revision of the stereochemistry of cylindrospermopsin
11. Studies on total synthesis of cylindrospermopsin: New constructions of uracils from α,β-unsaturated esters
12. Construction of the A-ring of cylindrospermopsin via an intramolecular oxazinone-N-oxide dipolar cycloaddition
13. Stereoselective synthesis of a tricyclic guanidinium model of cylindrospermopsin
14. Isolation and use of liver cells
15. Stability of cylindrospermopsin, the toxin from the cyanobacterium Cylindrospermopsis raciborskii: Effect of pH, temperature, and sunlight on decomposition
16. Cylindrospermopsin: A potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii
17. Cylindrospermopsis raciborskii Seenaya and Subba Raju, an expanding, highly adaptive cyanobacterium: Wordwide distribution and review of its ecology
18. The role of glutathione in the toxicity of a novel cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes
19. Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured hepatocytes
20. The oral toxicity for mice of the tropical cyanobacterium Cylindrospermopsis raciborskii (Woloszynska). (1999)
21. Cylindrospermopsin, a cyanobacterial alkaloid: Evaluation of its toxicologic activity
22. Synthesis of a bicyclic model for the marine hepatotoxin cylindrospermopsin
23. Model studies for the synthesis of the marine hepatotoxin cylindrospermopsin: Preparation of a bicyclic guanidine with the hydroxymethyluracil side chain
24. Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans
25. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
26. Cloning and characterization of SLC26A6, a novel member of the solute carrier 26-gene family
27. Total synthesis of (±) cylindrospermopsin