메뉴 건너뛰기




Volumn 89, Issue 9, 2012, Pages 1151-1160

Alterations observed in the endothelial HUVEC cell line exposed to pure Cylindrospermopsin

Author keywords

Cylindrospermopsin; Cytotoxicity; HUVEC; Morphology; Oxidative stress

Indexed keywords

BIOSYNTHESIS; CELL CULTURE; CELL DEATH; ENDOTHELIAL CELLS; MORPHOLOGY; OXIDATIVE STRESS; PEPTIDES; POTABLE WATER;

EID: 84865764327     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2012.06.023     Document Type: Article
Times cited : (36)

References (61)
  • 1
    • 34548363323 scopus 로고    scopus 로고
    • Induction of p53-regulated gene expression in human cell lines exposed to the cyanobacterial toxin cylindrospermopsin
    • Bain P., Shaw G., Patel B. Induction of p53-regulated gene expression in human cell lines exposed to the cyanobacterial toxin cylindrospermopsin. J. Toxicol. Environ. Health A 2007, 70:1687-1693.
    • (2007) J. Toxicol. Environ. Health A , vol.70 , pp. 1687-1693
    • Bain, P.1    Shaw, G.2    Patel, B.3
  • 2
    • 0026066853 scopus 로고
    • 5-((3-Carboxyphenyl)-3-(4,5-dimethylthiazolyl)-3-(4-sulfophenyl)) tetrazolium, inner salt (MTS) and related analogs of 2-(4,5-dimethylthiazolyl)-2,5-diphenylterazolium bromide (MTT) reducing to purple water soluble formazan as cell-viability indicators
    • Baltrop J.A., Owen T.C., Cory A.H., Cory J.G. 5-((3-Carboxyphenyl)-3-(4,5-dimethylthiazolyl)-3-(4-sulfophenyl)) tetrazolium, inner salt (MTS) and related analogs of 2-(4,5-dimethylthiazolyl)-2,5-diphenylterazolium bromide (MTT) reducing to purple water soluble formazan as cell-viability indicators. Bioorg. Med. Chem. Lett. 1991, 1:611.
    • (1991) Bioorg. Med. Chem. Lett. , vol.1 , pp. 611
    • Baltrop, J.A.1    Owen, T.C.2    Cory, A.H.3    Cory, J.G.4
  • 3
    • 0034019763 scopus 로고    scopus 로고
    • 7-Epicylindrospermopsin, a toxic minor metabolite of the cyanobacterium Aphanizomenon ovalisporum from lake Kinneret, Israel
    • Banker R., Teltsch B., Sukenik A., Carmeli S. 7-Epicylindrospermopsin, a toxic minor metabolite of the cyanobacterium Aphanizomenon ovalisporum from lake Kinneret, Israel. J. Nat. Prod. 2000, 63:387-389.
    • (2000) J. Nat. Prod. , vol.63 , pp. 387-389
    • Banker, R.1    Teltsch, B.2    Sukenik, A.3    Carmeli, S.4
  • 4
    • 77950351190 scopus 로고    scopus 로고
    • Genotoxicity of a freshwater cyanotoxin, Cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG
    • Bazin E., Mourot A., Humpage A.R., Fessard V. Genotoxicity of a freshwater cyanotoxin, Cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG. Environ. Mol. Mut. 2010, 51:251-259.
    • (2010) Environ. Mol. Mut. , vol.51 , pp. 251-259
    • Bazin, E.1    Mourot, A.2    Humpage, A.R.3    Fessard, V.4
  • 5
    • 0038498830 scopus 로고    scopus 로고
    • Toxicological comparison of diverse Cylindrospermopsis raciborskii strains: evidence of liver damage caused by a French C. raciborskii strain
    • Bernard C., Harvey M., Biré R., Krys S., Fontaine J.J. Toxicological comparison of diverse Cylindrospermopsis raciborskii strains: evidence of liver damage caused by a French C. raciborskii strain. Environ. Toxicol. 2003, 18:176-186.
    • (2003) Environ. Toxicol. , vol.18 , pp. 176-186
    • Bernard, C.1    Harvey, M.2    Biré, R.3    Krys, S.4    Fontaine, J.J.5
  • 7
    • 0022391554 scopus 로고
    • A simple quantitative procedure using monolayer culture for cytotoxicity assays
    • Borenfreund E., Puerner J.A. A simple quantitative procedure using monolayer culture for cytotoxicity assays. J. Tiss. Cult. Meth. 1984, 9:7-9.
    • (1984) J. Tiss. Cult. Meth. , vol.9 , pp. 7-9
    • Borenfreund, E.1    Puerner, J.A.2
  • 8
    • 0017184389 scopus 로고
    • A rapid sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. A rapid sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.1
  • 11
    • 0036027412 scopus 로고    scopus 로고
    • Toxicity and uptake mechanism of cylindrospermopsin and lophyrotomin in primary rat hepatocytes
    • Chong M.W.K., Wong B.S.F., Lam P.K.S., Shaw G.R., Seawright A.A. Toxicity and uptake mechanism of cylindrospermopsin and lophyrotomin in primary rat hepatocytes. Toxicon 2002, 40:205-211.
    • (2002) Toxicon , vol.40 , pp. 205-211
    • Chong, M.W.K.1    Wong, B.S.F.2    Lam, P.K.S.3    Shaw, G.R.4    Seawright, A.A.5
  • 12
    • 0028219150 scopus 로고
    • Toxicity of the blue-green alga (cyanobacterium) Microcystis aeruginosa in drinking water to growing pigs, as an animal model for human injury and risk assessment
    • Falconer I.R., Burch M.D., Steffensen A.D., Choice M., Coverdale B.R. Toxicity of the blue-green alga (cyanobacterium) Microcystis aeruginosa in drinking water to growing pigs, as an animal model for human injury and risk assessment. Environ. Toxicol. Water Qual. 1994, 9:131-139.
    • (1994) Environ. Toxicol. Water Qual. , vol.9 , pp. 131-139
    • Falconer, I.R.1    Burch, M.D.2    Steffensen, A.D.3    Choice, M.4    Coverdale, B.R.5
  • 13
    • 0033034115 scopus 로고    scopus 로고
    • Hepatic and renal toxicity of the blue-green alga (cyanobacterium) Cylindrospermopsis raciborskii in male Swiss albino mice
    • Falconer I.R., Hardy S.J., Humpage A.R., Froscio S.M., Tozer G.J., Hawkins P.R. Hepatic and renal toxicity of the blue-green alga (cyanobacterium) Cylindrospermopsis raciborskii in male Swiss albino mice. Environ. Toxicol. 1999, 14:143-150.
    • (1999) Environ. Toxicol. , vol.14 , pp. 143-150
    • Falconer, I.R.1    Hardy, S.J.2    Humpage, A.R.3    Froscio, S.M.4    Tozer, G.J.5    Hawkins, P.R.6
  • 14
    • 0141927335 scopus 로고    scopus 로고
    • Cell alterations but no DNA strand breaks induced in vitro by cylindrospermopsin in CHO K1 cells
    • Fessard V., Bernard C. Cell alterations but no DNA strand breaks induced in vitro by cylindrospermopsin in CHO K1 cells. Environ. Toxicol. 2003, 18:353-359.
    • (2003) Environ. Toxicol. , vol.18 , pp. 353-359
    • Fessard, V.1    Bernard, C.2
  • 15
    • 0042978772 scopus 로고    scopus 로고
    • Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes
    • Froscio S.M., Humpage A.R., Burcham P.C., Falconer I.R. Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes. Environ. Toxicol. 2003, 18:243-251.
    • (2003) Environ. Toxicol. , vol.18 , pp. 243-251
    • Froscio, S.M.1    Humpage, A.R.2    Burcham, P.C.3    Falconer, I.R.4
  • 16
    • 60749114769 scopus 로고    scopus 로고
    • Cytotoxicity screening for the cyanobacterial toxin cylindrospermopsin
    • Froscio S.M., Fanok S., Humpage A.R. Cytotoxicity screening for the cyanobacterial toxin cylindrospermopsin. J. Toxicol. Environ. Health A 2009, 75:345-349.
    • (2009) J. Toxicol. Environ. Health A , vol.75 , pp. 345-349
    • Froscio, S.M.1    Fanok, S.2    Humpage, A.R.3
  • 17
    • 69049109714 scopus 로고    scopus 로고
    • Limited uptake of the cyanobacterial toxin cylindrospermopsin by Vero cells
    • Froscio S.M., Cannon E., Lau H.M., Humpage A.R. Limited uptake of the cyanobacterial toxin cylindrospermopsin by Vero cells. Toxicon 2009, 54:862-868.
    • (2009) Toxicon , vol.54 , pp. 862-868
    • Froscio, S.M.1    Cannon, E.2    Lau, H.M.3    Humpage, A.R.4
  • 18
    • 38949178055 scopus 로고    scopus 로고
    • Human health risk assessment related to cyanotoxins exposure
    • Funari E., Testai E. Human health risk assessment related to cyanotoxins exposure. Crit. Rev. Toxicol. 2008, 38:97-125.
    • (2008) Crit. Rev. Toxicol. , vol.38 , pp. 97-125
    • Funari, E.1    Testai, E.2
  • 20
    • 79961128284 scopus 로고    scopus 로고
    • Toxicity and glutathione implication in the effects observed by exposure of the liver fish cell line PLHC-1 to pure Cylindrospermopsin
    • Gutierrez-Praena D., Pichardo S., Jos A., Camean A.M. Toxicity and glutathione implication in the effects observed by exposure of the liver fish cell line PLHC-1 to pure Cylindrospermopsin. Ecotoxicol. Environ. Saf. 2011, 74:1567-1572.
    • (2011) Ecotoxicol. Environ. Saf. , vol.74 , pp. 1567-1572
    • Gutierrez-Praena, D.1    Pichardo, S.2    Jos, A.3    Camean, A.M.4
  • 21
    • 79959398476 scopus 로고    scopus 로고
    • Oxidative stress responses in tilapia (Oreochromis niloticus) exposed to a single dose of pure cylindrospermopsin under laboratory conditions: influence of the exposure way and the time of sacrifice
    • Gutierrez-Praena D., Jos A., Pichardo S., Camean A.M. Oxidative stress responses in tilapia (Oreochromis niloticus) exposed to a single dose of pure cylindrospermopsin under laboratory conditions: influence of the exposure way and the time of sacrifice. Aquat. Toxicol. 2011, 105:100-106.
    • (2011) Aquat. Toxicol. , vol.105 , pp. 100-106
    • Gutierrez-Praena, D.1    Jos, A.2    Pichardo, S.3    Camean, A.M.4
  • 22
    • 84856658679 scopus 로고    scopus 로고
    • Biochemical and pathological toxic effects induced by the cyanotoxin Cylindrospermopsin on the human cell line Caco-2
    • Gutierrez-Praena D., Pichardo S., Jos A., Moreno F.J., Cameán A.M. Biochemical and pathological toxic effects induced by the cyanotoxin Cylindrospermopsin on the human cell line Caco-2. Wat. Res. 2012, 46:1566-1575.
    • (2012) Wat. Res. , vol.46 , pp. 1566-1575
    • Gutierrez-Praena, D.1    Pichardo, S.2    Jos, A.3    Moreno, F.J.4    Cameán, A.M.5
  • 23
    • 0028158344 scopus 로고
    • Isolation of cylindrospermopsin from a cyanobacterium Umezakia natans and its screening method
    • Harada K.I., Othani I., Iwamoto K., Suzuki M., Watanabe M.F., Watanabe M., Terao K. Isolation of cylindrospermopsin from a cyanobacterium Umezakia natans and its screening method. Toxicon 1994, 32:73-84.
    • (1994) Toxicon , vol.32 , pp. 73-84
    • Harada, K.I.1    Othani, I.2    Iwamoto, K.3    Suzuki, M.4    Watanabe, M.F.5    Watanabe, M.6    Terao, K.7
  • 24
    • 0022402504 scopus 로고
    • Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir
    • Hawkins P.R., Runnegar M.T., Jackson A., Falconer I.R. Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir. Appl. Environ. Microbiol. 1985, 50:1292-1295.
    • (1985) Appl. Environ. Microbiol. , vol.50 , pp. 1292-1295
    • Hawkins, P.R.1    Runnegar, M.T.2    Jackson, A.3    Falconer, I.R.4
  • 25
    • 0026129184 scopus 로고
    • Endothelium in control
    • Henderson A.H. Endothelium in control. Br. Heart. J. 1991, 65:116-125.
    • (1991) Br. Heart. J. , vol.65 , pp. 116-125
    • Henderson, A.H.1
  • 26
    • 0034695122 scopus 로고    scopus 로고
    • Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin
    • Humpage A.R., Fenech M., Thomas P., Falconer I.R. Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin. Mutat. Res./Genetic Toxicol. Environ. Mut. 2000, 472:155-161.
    • (2000) Mutat. Res./Genetic Toxicol. Environ. Mut. , vol.472 , pp. 155-161
    • Humpage, A.R.1    Fenech, M.2    Thomas, P.3    Falconer, I.R.4
  • 28
    • 0032583203 scopus 로고    scopus 로고
    • SAPK2/p38-dependent F-Actin Reorganization Regulates Early Membrane Blebbing during Stress-induced Apoptosis
    • Huot J., Houle F., Rousseau S., Deschesnes R.G., Shah G.M., Landry J. SAPK2/p38-dependent F-Actin Reorganization Regulates Early Membrane Blebbing during Stress-induced Apoptosis. J. Cell Biol. 1998, 143(5):1361-1373.
    • (1998) J. Cell Biol. , vol.143 , Issue.5 , pp. 1361-1373
    • Huot, J.1    Houle, F.2    Rousseau, S.3    Deschesnes, R.G.4    Shah, G.M.5    Landry, J.6
  • 29
    • 60849118364 scopus 로고    scopus 로고
    • The antioxidant glutathione in the fish cell lines EPC and BCF-2: response to model pro-oxidants as measured by three different fluorescent dyes
    • Jos A., Camean A.M., Pflugmacher S., Segner H. The antioxidant glutathione in the fish cell lines EPC and BCF-2: response to model pro-oxidants as measured by three different fluorescent dyes. Toxicol. In Vitro 2009, 23:546-553.
    • (2009) Toxicol. In Vitro , vol.23 , pp. 546-553
    • Jos, A.1    Camean, A.M.2    Pflugmacher, S.3    Segner, H.4
  • 30
    • 64749101189 scopus 로고    scopus 로고
    • Discovery of a new RNA-containing nuclear structure in UVC-induced apoptotic cells by integrated laser electron microscopy
    • Karreman M.A., Agronskaia A.V., Verkleij A.J., Cremers F.F.M., Gerritsen H.C., Humbel B.M. Discovery of a new RNA-containing nuclear structure in UVC-induced apoptotic cells by integrated laser electron microscopy. Biol. Cell 2009, 101:287-299.
    • (2009) Biol. Cell , vol.101 , pp. 287-299
    • Karreman, M.A.1    Agronskaia, A.V.2    Verkleij, A.J.3    Cremers, F.F.M.4    Gerritsen, H.C.5    Humbel, B.M.6
  • 31
    • 77952515545 scopus 로고    scopus 로고
    • Cylindrospermopsin: a decade of progress on bioaccumulation research
    • Kinnear S. Cylindrospermopsin: a decade of progress on bioaccumulation research. Mar. Drugs. 2010, 8:542-564.
    • (2010) Mar. Drugs. , vol.8 , pp. 542-564
    • Kinnear, S.1
  • 33
    • 0035686147 scopus 로고    scopus 로고
    • First report of the cyanotoxins Cylindrospermopsin and Deoxycylindrospermopsin from Raphidiopsis curvata (Cyanobacteria)
    • Li R., Carmichael W.W., Brittain S., Eaglesham G.K., Shaw G.R., Watanabe M.M. First report of the cyanotoxins Cylindrospermopsin and Deoxycylindrospermopsin from Raphidiopsis curvata (Cyanobacteria). J. Phycol. 2001, 37:1121-1126.
    • (2001) J. Phycol. , vol.37 , pp. 1121-1126
    • Li, R.1    Carmichael, W.W.2    Brittain, S.3    Eaglesham, G.K.4    Shaw, G.R.5    Watanabe, M.M.6
  • 34
    • 0028962030 scopus 로고
    • The improved Allium/Vicia root tip micronucleus assay for clastogenicity of environmental pollutants
    • Ma T.H., Xu Z., Xu C., McConnell H., Rabago E.V., Arreola G.A., Zhang H. The improved Allium/Vicia root tip micronucleus assay for clastogenicity of environmental pollutants. Mutat. Res. 1995, 334:185-195.
    • (1995) Mutat. Res. , vol.334 , pp. 185-195
    • Ma, T.H.1    Xu, Z.2    Xu, C.3    McConnell, H.4    Rabago, E.V.5    Arreola, G.A.6    Zhang, H.7
  • 35
    • 77951653083 scopus 로고    scopus 로고
    • Morphological cell transformation of Syrian hamster embryo (SHE) cells by the cyanotoxin, cylindrospermopsin
    • Maire M.A., Bazin E., Fessard V., Rast C., Humpage A.R., Vasseur P. Morphological cell transformation of Syrian hamster embryo (SHE) cells by the cyanotoxin, cylindrospermopsin. Toxicon 2010, 55:1317-1322.
    • (2010) Toxicon , vol.55 , pp. 1317-1322
    • Maire, M.A.1    Bazin, E.2    Fessard, V.3    Rast, C.4    Humpage, A.R.5    Vasseur, P.6
  • 36
    • 34548311604 scopus 로고    scopus 로고
    • Studies of the comparative in vitro toxicology of the cyanobacterial metabolite deoxycylindrospermopsin
    • Neumann C., Bain P., Shaw G. Studies of the comparative in vitro toxicology of the cyanobacterial metabolite deoxycylindrospermopsin. J. Toxicol. Environ. Health A 2007, 70:1679-1686.
    • (2007) J. Toxicol. Environ. Health A , vol.70 , pp. 1679-1686
    • Neumann, C.1    Bain, P.2    Shaw, G.3
  • 39
    • 80052850108 scopus 로고
    • Cylindrospermopsin: A Potent Hepatotoxin from the Blue-Green Alga Cylindrospermopsis raciborskii
    • Ohtani I., Moore R.E., Runnegar M.T. Cylindrospermopsin: A Potent Hepatotoxin from the Blue-Green Alga Cylindrospermopsis raciborskii. J. Am. Chem. Soc. 1992, 114:7941-7942.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 7941-7942
    • Ohtani, I.1    Moore, R.E.2    Runnegar, M.T.3
  • 40
    • 27644577702 scopus 로고    scopus 로고
    • The use of the fish cell lines RTG-2 and PLHC-1 to compare the toxic effects produced by Microcystins LR and RR
    • Pichardo S., Jos A., Zurita J.L., Salguero M., Camean A.M., Repetto G. The use of the fish cell lines RTG-2 and PLHC-1 to compare the toxic effects produced by Microcystins LR and RR. Toxicol. In Vitro. 2005, 19:865-873.
    • (2005) Toxicol. In Vitro. , vol.19 , pp. 865-873
    • Pichardo, S.1    Jos, A.2    Zurita, J.L.3    Salguero, M.4    Camean, A.M.5    Repetto, G.6
  • 41
    • 36048967265 scopus 로고    scopus 로고
    • Acute and subacute toxic effects produced by microcystin-YR on the fish cell lines RTG-2 and PLHC-1
    • Pichardo S., Jos A., Zurita J.L., Salguero M., Cameán A.M., Repetto G. Acute and subacute toxic effects produced by microcystin-YR on the fish cell lines RTG-2 and PLHC-1. Toxicol. In Vitro 2007, 21:1460-1467.
    • (2007) Toxicol. In Vitro , vol.21 , pp. 1460-1467
    • Pichardo, S.1    Jos, A.2    Zurita, J.L.3    Salguero, M.4    Cameán, A.M.5    Repetto, G.6
  • 42
    • 0031788805 scopus 로고    scopus 로고
    • Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication
    • Pflugmacher S., Wiegand C., Oberemm A., Beattie K.A., Krause E., Codd G.A., Steinberg C.E.W. Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication. Biochim. Biophys. Acta. 1998, 1425:527-533.
    • (1998) Biochim. Biophys. Acta. , vol.1425 , pp. 527-533
    • Pflugmacher, S.1    Wiegand, C.2    Oberemm, A.3    Beattie, K.A.4    Krause, E.5    Codd, G.A.6    Steinberg, C.E.W.7
  • 43
    • 31344460347 scopus 로고    scopus 로고
    • First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes
    • Preussel K., Stüken A., Wiedner C., Chorus I., Fastner J. First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes. Toxicon 2006, 47:156-162.
    • (2006) Toxicon , vol.47 , pp. 156-162
    • Preussel, K.1    Stüken, A.2    Wiedner, C.3    Chorus, I.4    Fastner, J.5
  • 44
    • 77952096858 scopus 로고    scopus 로고
    • Microcystin-LR induces toxic effects in differentiated and undifferentiated Caco-2 cells
    • Puerto M., Pichardo S., Jos A., Camean A.M. Microcystin-LR induces toxic effects in differentiated and undifferentiated Caco-2 cells. Arch. Toxicol. 2010, 84:405-410.
    • (2010) Arch. Toxicol. , vol.84 , pp. 405-410
    • Puerto, M.1    Pichardo, S.2    Jos, A.3    Camean, A.M.4
  • 45
    • 84874189792 scopus 로고    scopus 로고
    • Estrés oxidativo y alteraciones histopatológicas en hígado tras la exposición oral de tilapias (Oreochromis niloticus) a Cilindrospermopsina
    • Puerto M., Jos A., Pichardo S., Moyano R., Blanco A., Cameán A.M. Estrés oxidativo y alteraciones histopatológicas en hígado tras la exposición oral de tilapias (Oreochromis niloticus) a Cilindrospermopsina. Rev. Toxicol. 2011, 28:83.
    • (2011) Rev. Toxicol. , vol.28 , pp. 83
    • Puerto, M.1    Jos, A.2    Pichardo, S.3    Moyano, R.4    Blanco, A.5    Cameán, A.M.6
  • 46
    • 0028352665 scopus 로고
    • The role of glutathione in the toxicity of a novel cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes
    • Runnegar M.T., Kong S.M., Zhong Y.Z., Ge J.L., Lu S.C. The role of glutathione in the toxicity of a novel cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biomed. Biophys. Res. Commun. 1994, 201:235-241.
    • (1994) Biomed. Biophys. Res. Commun. , vol.201 , pp. 235-241
    • Runnegar, M.T.1    Kong, S.M.2    Zhong, Y.Z.3    Ge, J.L.4    Lu, S.C.5
  • 47
    • 0028853288 scopus 로고
    • Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes
    • Runnegar M.T., Kong S.M., Zhong Y.Z., Lu S.C. Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biochem. Pharmacol. 1995, 49:219-225.
    • (1995) Biochem. Pharmacol. , vol.49 , pp. 219-225
    • Runnegar, M.T.1    Kong, S.M.2    Zhong, Y.Z.3    Lu, S.C.4
  • 48
    • 0036094367 scopus 로고    scopus 로고
    • In vitro hepatotoxicity of the cyanobacterial alkaloid cylindrospermopsin and related synthetic analogues
    • Runnegar M.T., Xie C., Snider B.B., Wallace G.A., Weinreb S.M., Kuhlenkamp J. In vitro hepatotoxicity of the cyanobacterial alkaloid cylindrospermopsin and related synthetic analogues. Toxicol. Sci. 2002, 67:81-87.
    • (2002) Toxicol. Sci. , vol.67 , pp. 81-87
    • Runnegar, M.T.1    Xie, C.2    Snider, B.B.3    Wallace, G.A.4    Weinreb, S.M.5    Kuhlenkamp, J.6
  • 49
    • 0038706470 scopus 로고    scopus 로고
    • First report and toxicological assessment of the cyanobacterium Cylindrospermopsis raciborskii from Portuguese freshwaters
    • Saker M., Nogueira I.C.G., Vasconcelos V.M., Neilan B.A., Eaglesham G.K., Pereira P. First report and toxicological assessment of the cyanobacterium Cylindrospermopsis raciborskii from Portuguese freshwaters. Ecotoxicol. Environ. Saf. 2003, 55:243-250.
    • (2003) Ecotoxicol. Environ. Saf. , vol.55 , pp. 243-250
    • Saker, M.1    Nogueira, I.C.G.2    Vasconcelos, V.M.3    Neilan, B.A.4    Eaglesham, G.K.5    Pereira, P.6
  • 51
    • 0022300420 scopus 로고
    • γ-Glutamylcystein synthetase from rat kidney
    • Seelig G.F., Meister A. γ-Glutamylcystein synthetase from rat kidney. Methods Enzymol. 1985, 113:379-390.
    • (1985) Methods Enzymol. , vol.113 , pp. 379-390
    • Seelig, G.F.1    Meister, A.2
  • 52
    • 39749200115 scopus 로고    scopus 로고
    • Apoptosis is involved in the senescence of endothelial cells induced by angiotensin II
    • Shan H.Y., Bai X.J., Chen X.M. Apoptosis is involved in the senescence of endothelial cells induced by angiotensin II. Cell Biol. Int. 2008, 32:264-270.
    • (2008) Cell Biol. Int. , vol.32 , pp. 264-270
    • Shan, H.Y.1    Bai, X.J.2    Chen, X.M.3
  • 53
    • 0033980562 scopus 로고    scopus 로고
    • Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity
    • Shaw G.R., Seawright A.A., Moore M.R., Lam P.K.S. Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity. Therap. Drug Monitor. 2000, 22:89-92.
    • (2000) Therap. Drug Monitor. , vol.22 , pp. 89-92
    • Shaw, G.R.1    Seawright, A.A.2    Moore, M.R.3    Lam, P.K.S.4
  • 56
    • 82355182748 scopus 로고    scopus 로고
    • Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line
    • Straser A., Filipic M., Zegura B. Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line. Arch. Toxicol. 2011, 85:1617-1626.
    • (2011) Arch. Toxicol. , vol.85 , pp. 1617-1626
    • Straser, A.1    Filipic, M.2    Zegura, B.3
  • 57
    • 33751559918 scopus 로고    scopus 로고
    • Distribution of three alien cyanobacterial species (Nostocales) in northeast Germany: Cylindrospermopsis raciborskii, Anabaena bergii and Aphanizomenon aphanizomenoides
    • Stüken A., Rücker J., Endrulat T., Preussel K., Hemm M., Nixdorf B., Karsten U., Wiedner C. Distribution of three alien cyanobacterial species (Nostocales) in northeast Germany: Cylindrospermopsis raciborskii, Anabaena bergii and Aphanizomenon aphanizomenoides. Phycologia 2006, 45:696-703.
    • (2006) Phycologia , vol.45 , pp. 696-703
    • Stüken, A.1    Rücker, J.2    Endrulat, T.3    Preussel, K.4    Hemm, M.5    Nixdorf, B.6    Karsten, U.7    Wiedner, C.8
  • 58
    • 0028200062 scopus 로고
    • Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans
    • Terao K., Ohmori S., Igarashi K., Ohtani I., Watanabe M.F., Harada K.I., Ito E., Watanabe M. Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans. Toxicon 1994, 32:833-843.
    • (1994) Toxicon , vol.32 , pp. 833-843
    • Terao, K.1    Ohmori, S.2    Igarashi, K.3    Ohtani, I.4    Watanabe, M.F.5    Harada, K.I.6    Ito, E.7    Watanabe, M.8
  • 59
    • 43849110966 scopus 로고    scopus 로고
    • Effects of blue-green algal toxin cylindrospermopsin (CYN) on human granulosa cells in vitro
    • Young F.M., Micklem J., Humpage A.R. Effects of blue-green algal toxin cylindrospermopsin (CYN) on human granulosa cells in vitro. Reprod. Toxicol. 2008, 25:374-380.
    • (2008) Reprod. Toxicol. , vol.25 , pp. 374-380
    • Young, F.M.1    Micklem, J.2    Humpage, A.R.3
  • 60
    • 82555179238 scopus 로고    scopus 로고
    • Cylindrospermopsin induced DNA damage and alteration in the expression of genes involved in the response to DNA damage, apoptosis and oxidative stress
    • Zegura B., Gajski G., Straser A., Garaj-Vrhovac V. Cylindrospermopsin induced DNA damage and alteration in the expression of genes involved in the response to DNA damage, apoptosis and oxidative stress. Toxicon 2011, 58:471-479.
    • (2011) Toxicon , vol.58 , pp. 471-479
    • Zegura, B.1    Gajski, G.2    Straser, A.3    Garaj-Vrhovac, V.4
  • 61
    • 0025119450 scopus 로고
    • Neutral red (NR) assay for cell viability and xenobiotic-induced cytotoxicity in primary cultures of human and rat hepatocytes
    • Zhang S.Z., Lipsky M.M., Trump B.F., Hsu I.C. Neutral red (NR) assay for cell viability and xenobiotic-induced cytotoxicity in primary cultures of human and rat hepatocytes. Cell Biol. Toxicol. 1990, 6:219-234.
    • (1990) Cell Biol. Toxicol. , vol.6 , pp. 219-234
    • Zhang, S.Z.1    Lipsky, M.M.2    Trump, B.F.3    Hsu, I.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.