Ethyl-nitrosourea transformed astrocytes exhibit mitochondrial membrane hyperpolarization and constrained apoptosis

Apoptosis

Volumn 4, Issue 2, 1999, Pages 89-97

  Liang, B C ^a,b,c   Miller, L ^b   Weller, A ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF VERMONT   (United States)

Author keywords

Glioma; Mitochondria; Mitochondrial membrane potential; Transformation

Indexed keywords

CITRIC ACID; ETHYLNITROSOUREA;

APOPTOSIS; ARTICLE; ASTROCYTE; CELL IMMORTALIZATION; CELL TRANSFORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL;

EID: 0032774807     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009610625150     Document Type: Article

References (34)

1. Liang BC, Liang DM. Primary central nervous system neoplasms. In: Biller J, ed. Practical neurology. Philadelphia: Lippencott, 1997.
2. Grant R, Liang BC, Page M, Crane D, Greenberg H, Junck L. Age influences chemotherapy response in glioma, irrespective of tumor grade. Neurology 1995; 45: 929-933.
3. Cavalli LR, Liang BC. Mutagenesis, Tumorigenicity, and Apoptosis: Are the Mitochondria involved? Mutat Res 1998; 398: 19-26.
4. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for bcl-2 regulation of apoptosis. Science 1997; 275: 1132-1136.
5. Yang J, Liu X, Bhalla K, et al. Prevention of apoptosis by bcl-2: release of cytochrome c from mitochondria blocked. Science 1997; 275: 1129-1132.
6. Cavalli LR, Varella-Garcia M, Liang BC. Diminished Tumorigenic Phenotype after Depletion of Mitochondrial DNA. Cell Growth and Diff 1997; 8: 1189-1198.
7. Liang BC, Hays L. Mitochondrial DNA copy number alterations in human gliomas. Cancer Lett 1996; 105: 167-173.
8. Liang BC. Evidence for association of mitochondrial DNA sequence amplification and nuclear localization in human low-grade gliomas. Mutat Res 1996; 354: 27-33.
9. Oudard S, Poirson F, Miccoli L, et al. Mitochondria-bound hexokinase as target for therapy of malignant gliomas. Int J Cancer 1995; 62: 1-7.
10. Liang BC, Ullyatt E. Tryphostin AG17 chemosensitizesglioma cells to BCNU by a mitochondrially mediated mechanism. Clin Cancer Res 1998; 4: 773-782.
11. Lichtor T, Dohrmann GJ. Oxidative metabolism and glycolysis in benign brain tumors. Neurosurgery 1987; 67: 336-340.
12. Gonzalez-Mateos F, Gomez ME, Garcia-Salguero L, Sanchez V, Aragon JJ. Inhibition of glycolysis by amino acids in ascites tumor cells. J Biol Chem 1993; 268: 7809-7817.
13. Li J, Zhu X, Byrnes M, Nelson JW, Chang SH. Site-directed mutagenesis of rabbit muscle phosphofructokinase cDNA. Mutations at glutamine 200 affect the allosteric properties of the enzyme. J Biol Chem 1993; 268: 24599-24606.
14. Hiraga S, Arita N, Takanori O, et al. Transformation of Type 1 Astrocytes with N-Ethyl-N-Nitrosourea: Establishment of an In Vitro System and the Role of the p53 Gene. GLIA 1995; 13: 51-63.
15. Polla BS, Kantengwa S, Francois D, et al. Mitochondria are selective targets for the protective effects of heat shock against oxidativeinjury.Proc Natl Acad Sci USA 1996; 93: 6458-6463.
16. Maftah A, Petit JM, Ratinaud M-H, Julien R. 10-N Nonyl-acridine orange: a fluorescent probe which stains mitochondria independently of their energetic state. Biochem Biophys Res Commun 1989; 164: 185-190.
17. Liang BC. Effects of hypoxia on drug resistance phenotype and genotype in human glioma cell lines. J Neurooncol 1996; 29: 149-155.
18. Newell MK, Vander-Wall J, Beard KS, Freed JH. Ligation of MHC class II molecules mediates apoptotic cell death in resting B lymphocytes. Proc Natl Acad Sci USA 1993; 90: 10459-10463.
19. Sherwood SW, Schimke RT. Cell cycle analysis of apoptosis using flow cytometry. In: Schwartz LM, Osborne BA, eds. Cell death. New York: Academic Press 1995: 77-98.
20. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25: 585-621.
21. Zirvi KA, Masui H, Giuliani FC, Kaplan NO. Correlation of drug sensitivity on human colon adenocarcinoma cells grown in soft agar and in athymic mice. Int J Cancer 1983; 32: 45-51.
22. Andrews PA, Albright KD. Mitochondrial defects in cis-diamminedichloroplatinum (II)-resistant human ovarian carcinoma cells. Cancer Res 1992; 52: 1895-1901.
23. Liang BC, Ullyatt E. Increased sensitivity to cis-diam-minedichloroplatinum-induced apoptosis with mitochondrial depletion. Cell Death and Diff 1998; 5: 694-701.
24. Schipper HM, Cisse S. Mitochondrial constituents of corpora amylacea and autofluorescent astrocytic inclusions in senescent human brain. GLIA 1995; 14: 55-64.
25. Norenberg MD, Mozes LW, Gregorios JB, Norenberg LO. Effects of lactic acid on astrocytes in primary culture. J Neuropathol Exp Neurol 1987; 46: 154-166.
26. Garland JM, A. H. Energy metabolism during apoptosis. J Biol Chem 1997; 272: 4680-4688.
27. Minn AJ, Velez P, Schendel SL, et al. Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature 1997; 385: 353-357.
28. Costello LC, Franklin RB. Bioenergetic theory of prostate malignancy. Prostate 1994; 25: 162-166.
29. Tornheim K, Andres V, Schultz V. Modulation by citrate of glycolytic oscillations in skeletal muscle extracts. J Biol Chem 1991; 266: 15675-15678.
30. Hayashi J, Takemitsu M, Nonaka I. Recovery of the missing tumorigenicity in mitochondrial DNA-less HeLa cells by introduction of mitochondrial DNA from normal human cells. Somatic Cell Mol Genet 1992; 18: 123-129.
31. Richter C, Schweizer M, Cossarizza A, Franceschi C. Control of apoptosis by the cellular ATP level. FEBS lett. 1996; 378: 107-110.
32. Shay JW. Cytoplasmic modification of nuclear gene expression. Mol Cell Biol 1983; 57: 17-26.
33. Israel BA, Schaeffer WI. Cytoplasmic suppression of malignancy. In Vitro Cell Dev Biology 1987; 23: 627-632.
34. Zinkewich-Peotti K, Parent M, Morais R. Mitochondrial DNA modulation of the anchorage-independent phenotype of transformed avian cells. Cancer Res 1990; 50: 6675-6682.