No induction of structural chromosomal aberrations in cylindrospermopsin-treated CHO-K1 cells without and with metabolic activation

Toxicon

Volumn 50, Issue 8, 2007, Pages 1105-1115

  Lankoff, A ^a   Wojcik, A ^a,b   Lisowska, H ^a   Bialczyk, J ^c   Dziga, D ^c   Carmichael, W W ^d  

^a JAN KOCHANOWSKI UNIVERSITY   (Poland)

^b INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY   (Poland)

^c JAGIELLONIAN UNIVERSITY   (Poland)

^d WRIGHT STATE UNIVERSITY   (United States)

Author keywords

Apoptosis; CHO K1 cells; Chromosomal aberrations; Cylindrospermopsin; Metabolic activation; Mitotic index; Necrosis

Indexed keywords

ALKALOID DERIVATIVE; CLASTOGEN; CYCLOPHOSPHAMIDE; CYLINDROSPERMOPSIN; CYTOCHROME P450; GLUTATHIONE; MITOMYCIN C;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA DAMAGE; DOSE TIME EFFECT RELATION; GLUTATHIONE METABOLISM; METABOLIC ACTIVATION; METABOLITE; MITOSIS; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; APOPTOSIS; BIOTRANSFORMATION; CHO CELLS; CHROMOSOME ABERRATIONS; COMET ASSAY; CRICETINAE; CRICETULUS; MITOTIC INDEX; NECROSIS; URACIL;

ANIMALIA; CYANOBACTERIA;

EID: 36048984373     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2007.07.021     Document Type: Article

References (43)

1. Carmichael W.W., Azevedo S.M.F.O., An J.S., Molica R.J.R., Jochimsen E.M., Lau S., Rinehart K.L., Shaw G.R., and Eaglesham G.K. Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins. Environ. Health Perspect. 109 (2001) 663-668
2. Chong M.W.K., Wong B.S.F., Lam P.K.S., Shaw G.R., and Seawright A.A. Toxicity and uptake mechanism of cylindrospermopsin and lophyrotomin in primary rat hepatocytes. Toxicon 40 (2002) 205-211
3. Dean R.G., Bynum G., Jacobson-Kram D., and Hadley E. Activation of polycyclic hydrocarbons in Reuber H4-II-E hepatoma cells. An in vitro system for the induction of SCEs. Mutat. Res. 111 (1983) 419-427
4. Eaglesham G.K., Norris R.L., Shaw G.R., Smith M.J., Chiswell R.K., Davis B.C., Neville G.R., Seawright A.A., and Moore M.R. Use of HPLC-MS/MS to monitor cylindrospermopsin, a blue-green algal toxin, for public health purposes. Environ. Toxicol. 14 (1999) 151-154
5. Engeland M., Nieland L.J.W., Ramaekers F.C.S., Schutte B., and Reutelingsperger C.P.M. Annexin V-affinity assay. A review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 31 (1998) 1-9
6. Evans H.J. Cytological methods for detecting chemical mutagens. In: Hollander A. (Ed). Chemical Mutagens, Principles and Methods for Their Detection vol. 4 (1976), Plenym Press, New York, London 1-29
7. Falconer I.R., and Humpage A.R. Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga Cylindrospermopsis raciborskii containing the toxin cylindrospermopsin. Environ. Toxicol. 16 (2001) 192-195
8. Falconer I.R., Hardy S.J., Humpage A.R., Froscio S.M., Tozer G.J., and Hawkins P.R. Hepatic and renal toxicity of the blue-green alga (cyanobacterium) Cylindrospermopsis raciborskii in male Swiss albino mice. Environ. Toxicol. 14 (1999) 143-150
9. Fessard V., and Bernard C. Cell alterations but no DNA strand breaks induced in vitro by cylindrospermopsin in CHO K1 cells. Environ. Toxicol. 18 (2003) 353-359
10. Friday, C., Carmichael, W.W., Rinehart, K.L., 2002. Analyses of cyanotoxins in the filamentous waterbloom forming cyanobacterium Cylindrospermopsis raciborskii. In: Proceedings of the Xth International Conference on Harmful Algae Blooms, St. Petersburg, Florida, October 21-25.
11. Froscio S.M., Humpage A.R., Burcham P.C., and Falconer I.R. Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes. Environ. Toxicol. 18 (2003) 43-251
12. Griffiths D.J., and Saker M.L. The palm island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin. Environ. Toxicol. 18 (2003) 78-93
13. Harada K.-I., Ohtani I., Iwamoto K., Suzuki M., Watanabe M.F., Watanabe M., and Terao K. Isolation of cylindrospermopsin from a cyanobacterium Umezakia natans and its screening method. Toxicon 32 (1994) 73-84
14. Hawkins P.R., Runnegar M.T.C., Jackson A.R.B., and Falconer I.R. Severe hepatotoxicity caused by the tropical cyanobacterium (blue green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir. Appl. Environ. Microbiol. 50 (1985) 1292-1295
15. Humpage A.R., Fenech M., Thomas P., and Falconer I.R. Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin. Mutat. Res. 472 (2000) 155-161
16. Humpage A.R., Fontaine F., Froscio S., Burcham P., and Falcone I.R. Cylindrospermopsin genotoxicity and cytotoxicity: role of cytochrome P-450 and oxidative stress. J. Toxicol. Environ. Health A. 68 (2005) 739-753
17. Kizaki H., Ohnishi Y., Azuma Y., Mizuno Y., and Ohsaka F. 1-beta-d-arabinosylcytosine and 5-azacytidine induce internucleosomal DNA fragmentation and cell death in thymocytes. Immunopharmacology 25 (1993) 19-27
18. Ku W.W., Bigger A., Brambilla G., Glatt H., Gocke E., Guzzie P.J., Hakura A., Honma M., Martus H.-J., Obach R.S., and Roberts S. Strategy for genotoxicity testing-metabolic considerations. Mutat. Res. 627 (2007) 59-77
19. Lankoff A., Banasik A., Obe G., Deperas M., Kuźmiński K., Tarczyńska M., Jurczak T., and Wójcik A. Effect of microcystin-LR and cyanobacterial extract from Polish reservoir of drinking water on cell cycle progression, mitotic spindle and apoptosis in CHO-K1 cells. Toxicol. Appl. Pharmacol. 189 (2003) 204-213
20. Li R., Carmichael W.W., Brittain S., Eaglesham G.K., Shaw G.R., Mahakhant A., Noparatnaraporn N., Yongmanitchai W., Kaya K., and Watanabe M.M. Isolation and identification of the cyanotoxin cylindrospermopsin and deoxycylindrospermopsin from a Thailand strain of Cylindrospermopsis raciborskii (Cyanobacteria). Toxicon 39 (2001) 973-980
21. Natarajan A.T., Tates A.D., Van Buul P.P., Meijers M., and De Vogel N. Cytogenetic effects of mutagens/carcinogens after activation in a microsomal system in vitro I. Induction of chromosome aberrations and sister chromatid exchanges by diethylnitrosamine (DEN) and dimethylnitrosamine (DMN) in CHO cells in the presence of rat-liver microsomes. Mutat. Res. 37 (1976) 83-90
22. Norris R.L., Seawright A.A., Shaw G.R., Senogles P., Eaglesham G.K., Smith M.J., Chiswell R.K., and Moore M.R. Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse. Toxicon 40 (2002) 471-476
23. Nowak C., and Obe G. On the origin of chromosomal aberrations in human peripheral lymphocytes in vitro. I. Experiments with Neurospora endonuclease and polyethylene glycol. Hum. Genet. 66 (1984) 335-343
24. O'Farrell P.H. Triggering the all-or-nothing switch into mitosis. Trends Cell Biol. 11 (2001) 512-519
25. Ohtani I., Moore R.E., and Runnegar M.T.C. Cylindrospermopsin, a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii. J. Am. Chem. Soc. 114 (1992) 7941-7942
26. Perry P., and Wolff S. New Giemsa method for the differential staining of sister chromatids. Nature 251 (1974) 156-158
27. Plaat B., Kole A., Mastik M., Hoekstra H., Molenaar W., and Vaalburg W. Protein synthesis rate measured with L-[1-11C]tyrosine positron emission tomography correlates with mitotic activity and MIB-1 antibody-detected proliferation in human soft tissue sarcomas. Eur. J. Nucl. Med. 26 (1999) 328-332
28. Preußel K., Stüken A., Wiedner C., Chorus I., and Fastner J. First report on cylindrospermopsin producing Aphanizomenon flos-aquae (Cyanobacteria) isolated from two German lakes. Toxicon 47 (2006) 156-162
29. 2 and 60Co gamma-radiation. Mutat. Res. 289 (1993) 197-204
30. Runnegar M.T., Kong S.-M., Zhong Y.-Z., Ge J.-L., and Lu S.C. The role of glutathione in the toxicity of a novel cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biochem. Biophys. Res. Commun. 201 (1994) 235-241
31. Runnegar M.T., Kong S.-M., Zhong Y.-Z., and Lu S.C. Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biochem. Pharmacol. 49 (1995) 219-225
32. Saker M.L., and Eaglesham G.K. The accumulation of cylindrospermopsin from the cyanobacterium Cylindrospermopsis racibroskii in tissues of redclaw crayfish Cherax quadricarinatus. Toxicon 37 (1999) 1065-1077
33. Salaun P., Le Breton M., Morales J., Belle R., Boulben S., Mulner-Lorillon O., and Cormier P. Signal transduction pathways that contribute to CDK1/cyclin B activation during the first mitotic division in sea urchin embryos. Exp. Cell Res. 296 (2004) 347-357
34. Savage J.R.K. Classification and relationships of induced chromosomal structural changes. J. Med. Genet. 12 (1975) 103-122
35. Schembri M.A., Neilan B.A., and Saint C.P. Identification of genes implicated in toxin production in the cyanobacterium Cylindrospermopsis raciborskii. Environ. Toxicol. 16 (2001) 413-421
36. Scott D., and Roberts S.A. Extrapolation from in vitro tests to human risk: experience with sodium fluoride clastogenicity. Mutat. Res. 189 (1987) 47-58
37. Seifert M., McGregor G., Eaglesham G., Wickramasinghe W., and Shaw G. First evidence for the production of cylindrospermopsin and deoxy-cylindrospermopsin by the freshwater benthic cyanobacterium, Lyngbya wollei (Farlow ex Gomont) Speziale and Dyck. Harmful Algae 6 (2007) 73-80
38. Shaw G.R., Sukenik A., Livne A., Chiswell R.K., Smith M.J., Seawright A.A., Norris R.L., Eaglesham G.K., and Moore M.R. Blooms of the hepatotoxic cyanobacterium, Aphanizomenon ovalisporum (Forti) in newly constructed lakes, Queensland, Australia. Environ. Toxicol. 14 (1999) 167-177
39. Shaw G.R., Seawright A.A., Moore M.R., and Lam P.K.S. Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity. Ther. Drug Monit. 22 (2000) 89-92
40. Shen X., Lam P.K., Shaw G.R., and Wickramasinghe W. Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin. Toxicon 40 (2002) 1499-1501
41. Singh N.P., McCoy M.T., Tice R.R., and Schneider E.L. A simple technique for quantification of low levels of DNA damage in individual cells. Exp. Cell Res. 175 (1988) 184-191
42. Terao K., Ohmori S., Igarashi K., Ohtani I., Watanabe M.F., Harada K.I., Ito E., and Watanabe M. Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from the blue-green alga Umezakia natans. Toxicon 32 (1994) 833-844
43. White S.H., Duivenvoorden L.J., Fabbro L.D., and Eaglesham G.K. Mortality and toxin bioaccumulation in Bufo marinus following exposure to Cylindrospermopsis raciborskii cell extracts and live cultures. Environ. Pollut. 147 (2007) 158-167