Antioxidant and immunomodulating activities of exo- and endopolysaccharide fractions from submerged mycelia cultures of culinary-medicinal mushrooms

International Journal of Medicinal Mushrooms

Volumn 15, Issue 3, 2013, Pages 251-266

  Jeong, Sang Chul ^a,b   Koyyalamudi, Sundar Rao ^a   Hughes, J Margaret ^c   Khoo, Cheang ^a   Bailey, Trevor ^a   Marripudi, Karthik ^d   Park, Jong Pil ^b   Kim, Jin Hee ^b   Song, Chi Hyun ^e  

^a UNIVERSITY OF WESTERN SYDNEY   (Australia)

^b Daegu Haany University   (South Korea)

^c UNIVERSITY OF SYDNEY   (Australia)

^d GOSFORD HOSPITAL   (Australia)

^e Daegu University   (South Korea)

Author keywords

Antioxidant activities; Immunomodulating effects; Medicinal mushrooms; Mycelia; Polysaccharides

Indexed keywords

1, 1 DIPHENYL 2 PICRYLHYDRAZYL; ENDOPOLYSACCHARIDE; EXOPOLYSACCHARIDE; FERRIC ION; FERROUS ION; FLAVONOID; FUNGAL POLYSACCHARIDE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; PHENOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BIOASSAY; CHELATION; CHEMICAL ANALYSIS; CONTROLLED STUDY; CORDYCEPS; ENVIRONMENTAL TEMPERATURE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYSOSOME; MACROPHAGE; MEDICINAL MUSHROOM; MOUSE; MYCELIUM; NONHUMAN; NORMAL HUMAN; OPTICAL DENSITY; PERIPHERAL BLOOD MONONUCLEAR CELL; SACCHAROMYCES CEREVISIAE;

AGARICALES; ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; FUNGAL POLYSACCHARIDES; HUMANS; IMMUNOLOGIC FACTORS; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MICE; MYCELIUM; PHENOLS;

BASIDIOMYCOTA; CORDYCEPS MILITARIS; CORDYCEPS SINENSIS; PLEUROTUS CITRINOPILEATUS; SACCHAROMYCES CEREVISIAE; TREMELLA MESENTERICA;

EID: 84876953888     PISSN: 15219437     EISSN: 19404344     Source Type: Journal    
DOI: 10.1615/IntJMedMushr.v15.i3.30     Document Type: Article

References (62)

1. Mau JL, Chao GR, Wu KT. Antioxidant properties of methanolic extracts from several ear mushrooms. J Agric Food Chem. 2001;49:5461-5467.
2. Li SP, Zhang GH, Zeng Q, Huang ZG, Wang YT, Dong TT, Tsim KWKX. Hypoglycemic activity of polysaccha ride, with antioxidation, isolated from cultured Cordyceps mycelia. Phytomedicine. 2006;13:428-483.
3. Li H, Xu J, Liu Y, Ali S, Qin F, Li Z, Zhang H, Huang Z. Antioxidant and moisture-retention activities of the polysaccharide from Nostoc commune. Carbohydr Polym. 2011;83:1821-1827.
4. Kino K, Yamashita A,Yamaoka K, Watanabe J, Tanaka S, Ko K, Shimizu K, Tsunoo H. Isolation and characterization of a new immunomodulatory protein, ling zhi-8 (LZ-8), from Ganoderma lucidium. J Biol Chem. 1989;264:472-478.
5. Wang G, Zhang J, Mizuno T, Zhuang C, Ito H, Mayu-zumi H, Okamoto H, Li J. Antitumor active polysaccharides from the Chinese mushroom Songshan lingzhi, the fruiting body of Ganoderma tsugae. Biosci Biotech Biochem. 1993;57:894-900.
6. Mizuno T. The extraction and development of antitumor-active polysaccharides from medicinal mushrooms in Japan (review). Int J Med Mushrooms. 1999;1:9-29.
7. Chang ST, Wasser SP. The role of culinary-medicinal mushrooms on human welfare with a pyramid model for human health. Int J Med Mushrooms. 2012;14:95-134.
8. Ooi VEC, Liu F. Immunomodulation and anticancer activity of polysaccharide-protein complexes. Curr Med Chem. 2000;7:715-728.
9. Shamtsyan M, Konusova V, Maksimova Y, Goloshchev A, Panchenko A, Simbirtsev A, Petrishchev N, Denisova N. Immunomodulating and anti-tumor action of extracts of several mushrooms. J Biotechnol. 2004;113:77-83.
10. Wasser SP. Medicinal mushroom science: history, current status, future trends, and unsolved problems. Int J Med Mushrooms. 2010;13:1-16.
11. Kozarski M, Klaus A, Niksic M, Jakovljevic D, Helsper JPFG, Van Griensven LJLD. Antioxidative and immu nomodulating activities of polysaccharides extracts of the medicinal mushrooms Agaricus bisporus, Agaricus brasiliensis, Ganoderma lucidum and Phellinus linteus. Food Chem. 2011;129:1667-1675.
12. Carvajal AESS, Koehnlein EA, Soares AA, Eler GJ, Nakashima ATA, Bracht A, Rosane M, Peralta RM. Bioactives of fruiting bodies and submerged culture mycelia of Agaricus brasiliensis (A. blazei) and their antioxidant properties. Food Sci Technol. 2012;46:493-499.
13. Tsai SY, Tsai HL, Mau JL. Antioxidant properties of Agaricus blazei, Agrocybe cylindracea and Boletus edulis. Food Sci Technol. 2007;40:1392-1402.
14. Tang SY, Whiteman M, Peng ZF, Jenner A, Yong EL, Halliwell B. Characterization of antioxidant and antigly cation properties and isolation of active ingredients from traditional Chinese medicines. Free Radical Bio Med. 2004;36:1575-1587.
15. Cai Y, Sun M, Xing J, Corke H. Antioxidant phenolic constituents in roots of Rheum officinale and Rubia cordifolia: structure-radical scavenging activity relationships. J Agric Food Chem. 2004;52:7884-7890.
16. Kang H, Ahn KS, Cho C, Bae HS. Immunomodulatory effect of Astragali radix extract on murine Th1/Th2 cell lineage development. Biol Pharm Bull. 2004;27:1946-1950.
17. Arthur RP, Mason D. T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation. J Exp Med. 1986;163:774-786.
18. Tepper R, Levinson DA, Stanger BZ, Campos-Tovinson J, Abbas AK, Leder P. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell. 1990;62:457-467.
19. Ricci M, Matucci A, Rossi O. IL-4 as a key factor in fluencing the development of allergen-specific Th2-like cells in atopic individuals. J Invest Allerg Clin. 1997;7:144-150.
20. Sandeson CJ. Interleukin-5, eosinophils and disease. Blood. 1992;79:3101-3109.
21. Leckie MJ, Ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, Mathur AK, Cowley HC, Chung KF, Djukanovic R, Hansel TT, Holgate ST, Sterk PJ, Barnes PJ. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyperresponsiveness, and the late asthmatic response. Lancet. 2000;356:2144-21448.
22. Keller R, Keist R, Wechsler A, Leist TP, Van der Meide PH. Mechanisms of macrophage-mediated tumor cell killing: a comparative analysis of the roles of reactive nitrogen intermediates and tumor necrosis factor. Int J Cancer. 1990;46:682-86.
23. Jeong SC, Cho SP, Yang BK, Jeong YT, Ra KS, Song CH. Immunomodulating activity of the exopolymer from submerged mycelial culture of Phellinus pini. J Micro biol Biotechnol. 2004;14:15-21.
24. Yang BK, Jeong SC, Song CH. Hypolipidemic effect ofexo and endo-biopolymers produced from submerged mycelial culture of Ganoderma lucidum in rats. J Micro biol Biotechnol. 2002;12:872-877.
25. Cicco N, Lanorte MT, Paraggio M, Viggiano M, Lattan zio V. A reproducible, rapid and inexpensive Folin-Cio-calteu micro-method in determining phenolics of plant methanol extracts. Microchem J. 2009;91:107-110.
26. Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci. 2004;74:2157-2184.
27. Zhishen J, Mengcheng T, Jianming W. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 1999;64:555-559.
28. Brand-Williams W, Cuveleir ME, Berset C. Use of a free radical method to evaluate antioxidant activity. Food Sci Technol. 1995;28:25-30.
29. Wu MJ, O'Doherty PJ, Fernandez HR, Lyons V, Rogers PJ, Dawes IW, Higgins VJ. An antioxidant screening assay based on oxidant induced growth arrest in Saccha romyces cerevisiae. FEMS Yeast Res. 2011;11:379-387.
30. Chua MT, Tung YT, Chang ST. Antioxidant activities of ethanolic extracts from twigs of Cinnamomum osmophleum. Bioresource Technol. 2008;99:1918-1925.
31. Oyaizu M. Studies on product of browning reaction pre pared from glucosamine. Jpn J Nutr. 1986;44:307-315.
32. Jeong SC, Yang BK, Ra KS, Wilson MA, Cho Y, Gu YA, Song CH. Characteristics of anti-complementary biopolymer extracted from Coriolus versicolor. Carbohydr Polym. 2004;55:255-263.
33. Suzuki I, Tanaka H, Kinoshita A, Oikawa S, Sato K, Osa wa M, Yadomae T. Effect of orally administered β-glucan on macrophage function in mice. Int J Immunopharma col. 1990;12:675-684.
34. Lowry OH, Rosebriugh NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
35. Dubois M, Gilles K, Hamilton JK, Rebers PA, Smith F. A colorimetric method for determination of sugar. Nature. 1951;168:67.
36. Adesegun SA, Fajana A, Orabueze CI, Coker HAB. Evaluation of antioxidant properties of Phaulopis fascisepala C.B.CI (Acanthaceae). Evid Based Complement Alternat Med. 2009;6:227-31.
37. Barrett JT. Textbook of Immunology. 5th ed. St. Louis: CV Mosby; 1988.
38. Li SP, Zhao KJ, Ji ZN, Song ZH, Dong TTX, Lo CK, Cheung JKH, Zhu SQ, Tsim KWK. A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury. Life Sci. 2003;73:2503-2513.
39. Bors W, Heller W, Michel C, Saran M. Radical chemistry of flavonoid antioxidants. Adv Exp Med Biol. 1990;264:165-170.
40. Yuan YV, Bone DE, Carrington MF. Antioxidant activity of dulse (Palmaria palmata) extract evaluated in vitro. Food Chem. 2005;91:485-494.
41. Prior RL, Wu X, Karen S.K. Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. J Agric Food Chem. 2005;53:4290-4302.
42. Zheng RL, Liu GS, Xing GX, Jia ZJ, Du M, Tan LQ. Free radical scavenging and antifatigue activities of Saussurea involucrate polysaccharides. Zhongguo Yao Li Xue Bao. 1993;14:47-49.
43. Kozarski M, Klaus A, Niksic M, Vrvic MM, Todorovic N, Jakovljevic D, Van Griensven LJLD. Antioxid ative activities and chemical characterization of polysaccharide extracts from the widely used mushrooms Ganoderma applanatum, Ganoderma lucidum, Lentinus edodes and Trametes versicolour. J Food Compos Anal. 2012;26:144-53.
44. Liu F, Ooi VEC, Chang ST. Free radical scavenging activities of mushroom polysaccharide extracts. Life Sci. 1997;60:763-771.
45. Kim YO, Han SB, Lee HW, Ahn HJ, Yoon YD, Jung JK,Kim HM, Shin CS. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci. 2005;77:2438-2456.
46. Page RC, Davies P, Allison AC. The macrophage as a secretory cell. Int Rev Cytol. 1978;52:119-123.
47. Kim BH, Kweon MH, Lim WJ, Song HC, Yang HC. Structural characterization of the anti-complementary and macrophage activating polysaccharides isolated from Agaricus bisporus. Korean J Food Sci Technol. 1998;30:709-716.
48. Tsukagoshi S, Ohashi F. Protein-bound polysaccharide preparation, PSK, effective against mouse Sarcoma 180 and rat ascites hepatoma AH-13 by oral use. Gann. 1974;65:557-558.
49. Bernadete PS, Joao BFT, Jose PP. Immunologically active polysaccharides from Centrosema pubescens. Fitote rapia. 2000;71:513-518.
50. Shin KH, Lim SS, Lee S, Lee YS, Jung SH, Cho SY. Anti-tumor and immuno-stimulating activities of the fruiting bodies of Paecilomyces japonica, a new type of Cordyceps sp. Phytother Res. 2003;17:830-833.
51. Romagnami S, Maggi E, Del Prete GF, Parronchi P, Tiri A, Ricci M. Role of interleukin 4 and gamma interferon in the regulation of human IgE systhesis: possible alterations in atopic patients. Int Arch Allergy Appl Immunol. 1989;88:111-113.
52. Maggi E, Parronchi P, Manetti R, Simonelli C, Piccinni MP, Rugin FS, De Carli M, Ricci M, Romagnani S. Reciprocal regulatory effect of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol. 1992;148:2142-2147.
53. Finkelman FD, Katona IM, Mosmann TR, Coffman RL. IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune response. J Immunol. 1988;140:1022-1027.
54. Nakajima H, Iwamoto I, Yoshida S. Aerosolized recom-binatant interferon-gamma prevents antigen-induced eo sinophil recruitment in mouse trachea. Am Rev Respir Dis. 1993;148:1102-1104.
55. Liu M, Li J, Kong F, Lin J, Gao Y. Induction of immuno-modulating cytokines by a new polysaccharide-peptide complex from culture mycelia of Lentinus edodes. Immunopharmacology. 1998;40:187-198.
56. She QB, Ng TB, Liu WK. A novel lectin with potentimmunomodulatory activity isolated from both fruiting bodies and cultured mycelia of the edible mushroom Volvariella volvacea. Biochem Biophys Res Commun. 1998;247:106-111.
57. Ko JL, Hsu CI, Lin RH, Kao CL, Lin JY. A new fungalimmunomodulatory protein FIP-fve isolated from the edible fungus Flammulina velutipes and its complete amino acid sequence. Eur J Biochem. 1995;228:244-249.
58. Mizuno M, Kawakami S, Sakamoto Y, Fujitake N. Macrophages stimulated by polysaccharide purified from Agaricus brasiliensis S. Wasser et al. (Agarico mycetideae) enhances mRNA expression of Th1 cytokine including IL-12 and 18. Int J Med Mushrooms. 2003;5:383-389.
59. Liu WK, Ng TB, Sze SF, Tsui KW. Activation of peri-toneal macrophages by polysaccharopeptide from the mushroom, Coriolus versicolor. Immunopharmacology. 1993;26:139-146.
60. Ooi LSM, Ooi VEC, Fung MC. Induction of gene ex-pression of immunomodulatory cytokines in the mouse by a polysaccharide from Ganoderma lucidum (Curt.:Fr.) P. Karst. (Aphyllophoromycetideae). Int J Med Mushrooms. 2002;4:27-35.
61. Kim GY, Oh YH, Park YM. Acidic polysaccharide iso-lated from Phellinus linteus Induces nitric oxide-mediated tumoricidal activity of macrophages through protein tyrosine kinase and protein kinase C. Biochem Biophys Res Commun. 2003;309:399-407.
62. Wang HX, Liu WK, Ng TB, Ooi VEC, Chang ST. Theimmunomodulatory and antitumor activities of lectins from the mushroom Tricholoma mongolicum. Immuno pharmacology. 1996;31:205-211.