Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus

Life Sciences

Volumn 77, Issue 19, 2005, Pages 2438-2456

  Kim, Young Ook ^a   Han, Sang Bae ^b   Lee, Hong Woen ^b   Ahnb, Hyo Jung ^b   Yoonb, Yeo Dae ^b   Jungb, Joon Ki ^b   Kimb, Hwan Mook ^b   Shin, Chul Soo ^a  

^a Yonsei University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Immuno stimulating activity; Inonotus obliquus; Mycelial fermentation; Water soluble endo polysaccharide

Indexed keywords

FUNGUS POLYSACCHARIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; INONOTUS OBLIQUUS EXTRACT; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRITE; POLYMYXIN B; POLYSACCHARIDE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; B LYMPHOCYTE ACTIVATION; BATCH FERMENTATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; FEMALE; FUNGAL SCLEROTIUM; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; SPLEEN CELL; SUBMERGED CELL CULTURE; SUBMERGED FERMENTATION; TH2 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; BASIDIOMYCOTA; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CULTURE MEDIA; CYTOKINES; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FERMENTATION; MACROPHAGES; MICE; MICE, INBRED C3H; NITRITES; POLYSACCHARIDES; SOLUBILITY; T-LYMPHOCYTES;

INONOTUS; INONOTUS OBLIQUUS;

EID: 23944472651     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2005.02.023     Document Type: Article

References (35)

1. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Analytical Biochemistry 72 1976 248 254
2. J. Burczyk, A. Gawron, M. Slotwinska, B. Smietana, and K. Terminska Antimitotic activity of aqueous extract of Inonotus obliquus Bollettino Chimico Farmaceutico 135 5 1996 306 309
3. W.A. Campbell, and R.W. Davidson A Poria as the fruiting stage of the fungus causing the sterile conks on birch Mycologia 30 1938 553 560
4. M. Dubois, K. Gilles, J.K. Hamilton, P.A. Robers, and F. Smith Colorimetric method for determination of sugars and related substances Analytical Chemistry 28 1956 350 356
5. W. Galasinski, J. Chlabicz, A. Paszkiewicz-Gadek, C. Marcinkiewicz, and A. Gindzienski The substances of plant origin that inhibit protein biosynthesis Acta Poloniae Pharmaceutica 53 5 1996 311 318
6. S.B. Han, Y.H. Kim, C.W. Lee, S.M. Park, and H.Y. Lee Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai Immunopharmacology 40 1 1998 39 48
7. S.B. Han, S.H. Park, K.H. Lee, H.C. Kim, S.H. Lee, and H.C. Kim Polysaccharide isolated form the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells International Immunopharmacology 1 2001 1969 1978
8. S.B. Han, S.K. Park, H.J. Ahn, Y.D. Yoon, Y.H. Kim, J.J. Lee, K.H. Lee, J.S. Moon, H.C. Kim, and H.M. Kim Characterization of B cell membrane receptors of polysaccharide isolated from the root of Acanthopanax koreanum International Immunopharmacology 3 2003 683 691
9. T. Ichimura, T. Otake, H. Mori, and S. Maruyama HIV-1 protease inhibition and anti-HIV effect of natural and synthetic water-soluble lignin-like substance Bioscience, Biotechnology, and Biochemistry 63 12 1999 2202 2204
10. A. Jarosz, M. Skorska, J. Rzymowska, J. Kochmanska-Rdest, and E. Malarczyk Effect of the extracts from fungus Inonotus obliquus on catalase level on Hela and nocardia cells Acta Biochimica Polonica 37 1 1990 149 151
11. Y.J. Jeon, S.B. Han, K.S. Ahn, and H.M. Kim Activation of NF-κB/Rel in angelan-stimulated macrophages Immunopharmacology 43 1999 1 9
12. K. Kahlos Antifungal activity of cysteine, its effect on C-21 oxygenated lanosterol derivatives and other lipid in Inonotus obliquus, in vitro Applied Microbiology and Biotechnology 3 1994 339 385
13. K. Kahlos Preliminary test of antiviral activity of two Inonotus obliquus strains Fitoterapia LXVII 4 1996 344 347
14. K. Kahlos, L. Kangas, and R. Hiltunen Antitumor activity of some compounds and fractions from an n-hexane extract of Inonotus obliquus Acta Pharmaceutica Fennica 96 1987 33 40
15. P.M. Kidd The use of mushroom glucan and proteoglycans in cancer treatment Alternative Medicine Review 5 1 2000 4 27
16. J.J. Killion, and I.J. Fidler Therapy of cancer metastasis by tumoricidal activation of tissue macrophages using liposome-encapsulaed immunomodulator Pharmacology and Therapeutics 78 1998 141 154
17. G.Y. Kim, H.S. Park, B.H. Nam, S.J. Lee, and J.D. Lee Purification and characterization of acidic proteo-heteroglucan from the fruiting body of Phellinus linteus (Berk. and M.A. Curtis) Teng Bioresource Technology 89 2003 81 87
18. H.M. Kim, S.B. Han, M.S. Kim, J.S. Kang, G.T. Oh, and D.H. Hong Efficient fixation procedure of human leukemia cells in sulforhodamine B cytotoxicity assay Journal of Pharmacological and Toxicological Methods 36 1996 163 169
19. H.M. Kim, S.B. Han, G.T. Oh, Y.H. Kim, D.H. Hong, N.D. Hong, and I.D. Yoo Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus International Journal of Immunopharmacology 18 5 1996 295 303
20. H. Kobayasi, K. Matsunaga, and M. Fujii PSK as a chemopreventive agent Cancer Epidemiology, Biomarkers, and Prevention 2 1993 271 276
21. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
22. J.H. Litchfield Submerged culture of mushroom mycelium H.J. Peppler Microbial Technology 1967 Reinold Publishing Co. New York 107 144
23. F. Liu, V.E.C. Ooi, W.K. Liu, and S.T. Chang Immunomodulation and antitumor activity of polysaccharide-protein complex from the culture filtrates of a local edible mushroom, Tricholoma lobayense General Pharmacology 27 4 1996 621 624
24. T. Mizuno Development of antitumor polysaccharides from mushroom fungi Foods and Food Ingredient Journal of Japan 167 1996 69 85
25. D.C. Morrison, and D.M. Jacobs Inhibition of lipopolysaccharide-initiated activation of serum complement by polymyxin B Infection and Immunology 13 1 1976 298 301
26. T. Ohmori, K. Tamura, N. Ohgani, N. Nakamura, G. Kawanishi, H. Yamada, and K. Nomota The correlation between molecular weight and antitumor activity of galactosaminoglucan (CO-N) from Cordyceps ophioglossoides Chemical and Pharmaceutical Bulletin 37 5 1989 1337 1340
27. D.A. Reid Inonotus obliquus (Pers. Ex Fr.) Pilat in Britain Transactions of the British Mycological Society 67 2 1976 329 332
28. J. Rzymowska The effect of aqueous extracts from lnonotus obliquus on the mitotic index and enzyme activities Bollettino Chimico Farmaceutico 137 1998 13 15
29. M. Saar Fungi in Khanty fork medicine Journal of Ethnopharmacology 31 2 1991 175 179
30. Y.S. Shin, Y. Tamai, and M. Terazawa Chemical constituents of I. obliquus I. A new triterphene; 3β-hydroxy-8,24-dien-lanosta-21,23-lactone from sclerotium Eurasian Journal of Forest Research 1 2000 43 50
31. M. Takashi, Z. Cun, A. Kuniaki, O. Hidehumi, K. Tadash, U. Shigeo, L. Sophie, and M. Laurent Antitumor and hypoglycemic activities of polysaccharides from the sclerotia and mycelia of Inonotus obliquus (Pers.:Fr.) Pil. (Aphyllophoromycetidae) International Journal of Medical Mushroom 1 1999 301 316
32. Y.J. Tang, and J.J. Zhong Fed-batch fermentation of Ganoderma lucidum for hyperproduction of polysaccharide and ganoderic acid Enzyme and Microbial Technology 31 2002 20 28
33. S.P. Wasser Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides Applied Microbiology and Biotechnology 60 2002 258 274
34. J. Zhang, Q. Tang, M. Zimmerman-Kordmanm, W. Reutter, and H. Fan Activation of B lymphocytes by GLIS, a bioactive proteo-glycan from Ganoderma lucidum Life Sciences 71 2002 623 638
35. C. Zhuang, T. Mizuno, A. Shimada, H. Ito, C. Suzuki, Y. Mayuzumi, H. Okamoto, Y. Ma, and J. Li Antitumor protein-containing polysaccharides from a Chinese mushroom Fengweigu or Houbitake, Pleurotus sajor-caju (Fr.) Sing Bioscience, Biotechnology, and Biochemistry 57 1993 901 906