Medicinal mushroom science: History, current status, future trends and unsolved problems

International Journal of Medicinal Mushrooms

Volumn 12, Issue 1, 2010, Pages 1-16

  Wasser, Solomon P ^a,b  

^a UNIVERSITY OF HAIFA   (Israel)

^b M G KHOLODNY INSTITUTE OF BOTANY   (Ukraine)

Author keywords

Agaricus brasiliensis; Antitumor; Beta glucans; Ehrlich carcinoma; Ganoderma lucidum; Immunoceuticals; Immunomodulator activity; Lentinus edodes; Macrophages; Medicinal mushrooms; Polysaccharide protein complexes; Polysaccharides; Sarcoma 180; Trametes versicolor

Indexed keywords

AMYLOBAN; BEFUNGIN; BETA GLUCAN; CAFFEIC ACID PHENETHYL ESTER; FOMES FOMENTARIUS EXTRACT; HERICENONE; KRESTIN; LENTINAN; NUTRACEUTICAL; PANEPOXYDONE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; POLYSACCHARIDE; SCHIZOPYLLAN; SCLEROGLUCAN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; BIOMASS PRODUCTION; DIET SUPPLEMENTATION; DRUG DETOXIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; FUNGUS CULTURE; HUMAN; IMMUNOMODULATION; IMMUNOSTIMULATION; LIVER PROTECTION; MEDICINAL PLANT; MUSHROOM; NONHUMAN; REVIEW; TRADITIONAL MEDICINE;

AGARICUS BRASILIENSIS; BASIDIOMYCOTA; FUNGI; GANODERMA LUCIDUM; HOMOBASIDIOMYCETES; LENTINULA EDODES; TRAMETES VERSICOLOR;

EID: 77950807429     PISSN: 15219437     EISSN: None     Source Type: Journal    
DOI: 10.1615/IntJMedMushr.v12.i1.10     Document Type: Review

References (52)

1. Mizuno T. The extraction and development of antitumoractive polysaccharides from medicinal mushrooms in Japan (review). Int J Med Mushr. 1999;1:9-29.
2. Chang ST. Global impact of edible and medicinal mushrooms on human welfare in the 21st century: nongreen revolution. Int J Med Mushr. 1999;1:1-8.
3. Wasser SP, Weis AL. Medicinal properties of substances occurring in higher Basidiomycetes mushrooms: current perspectives (review). Int J Med Mushr. 1999;1:31-62.
4. Reshetnikov SV, Wasser SP, Tan KK. Higher Basidiomycota as source of antitumor and immunostimulating polysaccharides. Int J Med Mushr. 2001;3:361-94.
5. Wasser SP. Medicinal mushrooms: ancient traditions, contemporary knowledge, and scientifi c enquiries. Int J Med Mushr. 2007;9:187-9.
6. Van Griensven LJLD. Culinary-medicinal mushrooms: Must action be taken- Int J Med Mushr. 2009;11:281-6.
7. Pöder R. The Ice man-s fungi: facts and mysteries. Int J Med Mushr. 2005;7:357-9.
8. Wasson RG. Soma. Divine mushroom of immortality. New York: Harcourt Brace Jovanovich; 1968
9. Hawksworth DL. Mushrooms: the extent of the unexplored potential. Int J Med Mushr. 2001;3:333-40.
10. Kirk PM, Cannon PF, David JC, Stalpers JA. Ainsworth & Brisby-s dictionary of the fungi. 10th ed. Wallingford: CAB International; 2008. 771
11. Mueller GM, Schmit JP. Fungal biodiversity: what do we know- What can we predict- Biodivers Conserv.2007;16:1-5.
12. Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol. 2002;60:258-74.
13. Smith JE, Sullivan R, Rowan NJ. The role of polysaccharides derived from medicinal mushrooms in cancer treatment programs: current perspectives (review). Int J Med Mushr. 2003;5:217-34.
14. Dai Y-Ch, Yang Z-L, Ui B-K, Yu Ch-J, Zhou L-W. Species diversity and utilization of medicinal mushrooms and fungi in China (review). Int J Med Mushr. 2009;11:287-302.
15. Gao Y, Zhou S, Chen G, Dai X, Ye J. A phase I/II study of a Ganoderma lucidum extract (Ganopoly) in patients with advanced cancer. Int J Med Mushr. 2002;4:207-14.
16. Gao Y, Zhou S, Huang M, Xu A. Antibacterial and antiviral value of the genus Ganoderma P. Karst. species (Aphyllophoromycetideae): a review. Int J Med Mushr. 2003;5:235-46.
17. Gao Y, Lan J, Dai X, Ye J, Zhou S. A phase I/II study of Ling Zhi mushroom Ganoderma lucidum (W. Curt.: Fr.) Lloyd (Aphyllophoromycetideae) extract in patients with type II diabetes mellitus. Int J Med Mushr. 2004;6:96-107.
18. Didukh MYa, Wasser SP, Nevo E. Medicinal value of species of the family Agaricaceae Cohn (higher Basidiomycetes): current stage of knowledge and future perspectives. Int J Med Mushr. 2003;5:133-52.
19. Rowan NJ, Smith JE, Sullivan R. Immunomodulatory activities of mushroom glucans and polysaccharideprotein complexes in animals and humans (a review). Int J Med Mushr. 2003;5:95-110.
20. Zhang M, Cui SW, Cheung PCK, Wang Q. Antitumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and antitumor activity. Trends Food Sci Technol. 2007;18:4-19. (Pubitemid 44827599)
21. Chihara G, Maeda Y, Hamuro J, Sasaki T, Fukuoka F. Inhibition of mouse Sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) Sing. Nature. 1969;222:687-8.
22. Chihara G, Hamuro J, Maeda YY, Arai Y, Fukuoka F. Fractionation and purifi cation of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom). Cancer Res. 1970;30:2776-81.
23. Hobbs Ch. Medicinal value of Lentinus edodes (Berk.) Sing. (Agaricomycetideae). A literature review. Int J Med Mushr. 2000;2:287-302.
24. Wasser SP. Shiitake (Lentinus edodes). In: Encyclopedia of dietary supplements. In: Coates PM, Blackman MR, Cragg G, Levine M, Moss J, White J, editors. Encyclopedia of dietary supplements. New York: Marcel Dekker; 2005. p. 653-64.
25. Boh B, Berovic M. Grifola frondosa (Dicks.: Fr.) S.F. Gray (Maitake mushroom): medicinal properties, active compounds, and biotechnological cultivation. Int J Med Mushr. 2007;9:89-108. (Pubitemid 47013337)
26. Zhuang C, Wasser SP. Medicinal value of culinarymedicinal Maitake mushroom Grifola frondosa (Dicks.: Fr.) S.F. Gray (Aphyllophoromycetideae). Review. Int J Med Mushr. 2004;6:287-313.
27. Hobbs Ch. The chemistry, nutritional value, immunopharmacology, and safety of the traditional food of medicinal split-gill fungus Schizophyllum commune Fr.: Fr. (Aphyllophoromycetideae). A literature review. Int J Med Mushr. 2005;7:127-40.
28. Wasser SP. Reishi or Ling Zhi (Ganoderma lucidum). In: Encyclopedia of dietary supplements. In: Coates PM, Blackman MR, Cragg G, Levine M, Moss J, White J, editors. Encyclopedia of dietary supplements. New York: Marcel Dekker; 2005. p. 603-22.
29. Lin Z-B. Lingzhi. From mystery to science. China: Peking University Press; 2009. 162 p.
30. Yuen JWM, Gohel MDI. Anticancer effects of Ganoderma lucidum: a review of scientifi c evidence. Nutr Cancer. 2005;53:11-7.
31. Zhou X, Lin J, Yin Y, Zhao J, Sun X, Tang K. Gano dermataceae: natural products and their related pharmacological functions. Am J Chin Med. 2005; 35:559-74. (Pubitemid 47307695)
32. Mahajna J, Dotan N, Zaidman B-Z, Petrova RD, Wasser SP. Pharmacological values of medicinal mushrooms for prostate cancer therapy: the case of Ganoderma lucidum. Nutr Cancer. 2009;61:16-26.
33. Hobbs Ch. Medicinal value of Turkey Tail fungus Trametes versicolor (L.: Fr.) Pil-t (Aphyllophoromycetideae). Int J Med Mushr. 2004;6:195-218.
34. Yang Q-Y. Advanced research in PSP. Tsim Sha Tsu, Kowloon: The Hong Kong Association for Health Care Ltd; 1999. 350
35. Mizuno T, Zhuang C, Abe K, Okamoto H, Kiho T, Ukai S, Leclerc S, Meijer L. Antitumor and hypoglycemic activities of polysaccharides from the sclerotia and mycelia of Inonotus obliquus (Pers.: Fr.) Pil.(Aphyllophoromycetideae). Int J Med Mushr. 1999; 1:301-16.
36. Park YM, Won JH, Kim YH, Choi JW, Park HJ, Lee KT. In vivo and in vitro anti-infl ammatory and antinociceptive effects of the methanol extract of Inonotus obliquus. J Ethnopharmacol. 2005;101:120-8.
37. Yoon DH, Lee WH, Han SK, Shrestha B, Kim CH, Lim MH, Chang W, Lim S, Choi S, Song WO, Sung JM, Hwang KC, Kim TW. Phellinus linteus inhibits infl ammatory mediators by suppressing redox-based NF--B and MAPKs activation in lipopolysaccharide induced RAW 264.7 macrophage. J Ethnopharmacol.2007;114:307- 15. (Pubitemid 350026213)
38. Maruyama H, Ikekawa T. Immunomodulation and antitumor activity of a mushroom product, profl amin, isolated from Flammulina velutipes (W. Curt.: Fr.) Singer (Agaricomycetideae). Int J Med Mushr. 2007;9: 109-22. (Pubitemid 47013338)
39. Holliday H, Cleaver M. Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) Link (Ascomycetes). A review. Int J Med Mushr. 2008;10: 209-18. (Pubitemid 352031881)
40. Zaidman B-Z, Yassin M, Mahajna J, Wasser SP. Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol. 2005;67:453-68. (Pubitemid 40909591)
41. Petrova RD, Reznick AZ, Wasser SP, Denchev CM, Nevo E, Mahajna J. Fungal metabolites modulating NF-kappaB activity: an approach to cancer therapy and chemoprevention (review). Oncol Reports. 2008;19:299-308. (Pubitemid 351176088)
42. Yassin M, Wasser SP, Mahajna J. Substances from the medicinal mushroom Daedalea gibbosa inhibit kinase activity of native and T315I mutated Bcr-Abl. Int J Oncol. 2008;32:1197-204.
43. Zaidman B-Z, Wasser SP, Nevo E, Mahajna J. Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells. Mol Biol Rep. 2008;35:107-17. (Pubitemid 351713238)
44. Petrova RD, Mahajna J, Wasser SP, Ruimi N, Denchev CM, Sussan S, Nevo E, Reznick AZ. Marasmius oreades substances block NF-kappaB activity through interference with IKK activation pathway. Mol Biol Rep. 2009;36:737 44.
45. Rouhana-Toubi A, Wasser SP, Fares F. Ethyl acetate extracts of submerged cultured mycelium of higher Basidiomycetes mushrooms inhibit human ovarian cancer cell growth. Int J Med Mushr. 2009;11:29-37.
46. Chang ST, Buswell JA. Medicinal mushrooms-a prominent source of nutriceuticals for the 21st century. Curr Topics Nutraceutical Res. 2003;1:257-80.
47. Chang ST. The need for scientifi c validation of culinarymedicinal mushroom products. Int J Med Mushr. 2006;8: 187-95.
48. Wasser SP, Akavia E. Regulatory issues of mushrooms as functional foods and dietary supplements: safety and effi cacy. Cheung PRC, editor. In: Mushrooms as functional foods. Chapter 6. New York: Wiley & Sons; 2008. p. 199-221.
49. Wasser SP, Zmitrovich IV, Didukh MYa, Spirin WA, Malysheva VF. Morphological traits of Ganoderma lucidum complex highlighting G. tsugae var. jannieae: the current generalization. Nevo E, Wasser SP, editors. Ruggell, Liechtenstein: A.R.A. Gantner Verlag K.-G.; 2006. 187
50. Moncalvo J-M, Rivarden L. A nomenclatural study of the Ganodermataceae. Oslo: Fungifl ora; 1997. 114 p.
51. Zhao J-D. The Ganodermataceae of China. Bibliotheca Mycologica 132. Berlin, Stuttgart: J. Cramer; 1989. 176 p.
52. Moncalvo J-M. Molecular systematic of Ganoderma: What is Reishi- Int J Med Mushr. 2005;7:353-4.