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Volumn 8, Issue 4, 2013, Pages

Facilitated Uptake of a Bioactive Metabolite of Maritime Pine Bark Extract (Pycnogenol) into Human Erythrocytes

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; DELTA (3,4 DIHYDROXYPHENYL) GAMMA VALEROLACTONE; GLUCOSE TRANSPORTER 1; GLUTATHIONE; PYCNOGENOL; UNCLASSIFIED DRUG; FLAVONOID; GLUCOSE; PLANT EXTRACT; PYCNOGENOLS;

EID: 84876953809     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063197     Document Type: Article
Times cited : (28)

References (56)
  • 1
    • 84876959449 scopus 로고    scopus 로고
    • Maritime Pine Extract, ed. Rockville: United States Pharmacopeial Convention, Inc
    • Maritime Pine Extract (2011) In:United States Pharmacopeia. ed. Rockville: United States Pharmacopeial Convention, Inc. 1196-1197.
    • (2011) United States Pharmacopeia , pp. 1196-1197
  • 2
    • 0032839592 scopus 로고    scopus 로고
    • Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol
    • Packer L, Rimbach G, Virgili F, (1999) Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27: 704-724.
    • (1999) Free Radic Biol Med , vol.27 , pp. 704-724
    • Packer, L.1    Rimbach, G.2    Virgili, F.3
  • 3
    • 0036219486 scopus 로고    scopus 로고
    • A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology
    • Rohdewald P, (2002) A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40: 158-168.
    • (2002) Int J Clin Pharmacol Ther , vol.40 , pp. 158-168
    • Rohdewald, P.1
  • 4
    • 78651397865 scopus 로고    scopus 로고
    • A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract
    • Maimoona A, Naeem I, Saddiqe Z, Jameel K, (2011) A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract. J Ethnopharmacol 133: 261-277.
    • (2011) J Ethnopharmacol , vol.133 , pp. 261-277
    • Maimoona, A.1    Naeem, I.2    Saddiqe, Z.3    Jameel, K.4
  • 5
    • 13844281685 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C, Williamson G, Morand C, Scalbert A, Remesy C, (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81: 230S-242S.
    • (2005) Am J Clin Nutr , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 6
    • 33748305800 scopus 로고    scopus 로고
    • Single and multiple dose pharmacokinetics of maritime pine bark extract (Pycnogenol) after oral administration to healthy volunteers
    • Grimm T, Skrabala R, Chovanova Z, Muchova J, Sumegova K, et al. (2006) Single and multiple dose pharmacokinetics of maritime pine bark extract (Pycnogenol) after oral administration to healthy volunteers. BMC Clin Pharmacol 6: 4.
    • (2006) BMC Clin Pharmacol , vol.6 , pp. 4
    • Grimm, T.1    Skrabala, R.2    Chovanova, Z.3    Muchova, J.4    Sumegova, K.5
  • 7
    • 0015185492 scopus 로고
    • Studies on flavonoid metabolism. Absorption and metabolism of (+)-catechin in man
    • Das NP, (1971) Studies on flavonoid metabolism. Absorption and metabolism of (+)-catechin in man. Biochem Pharmacol 20: 3435-3445.
    • (1971) Biochem Pharmacol , vol.20 , pp. 3435-3445
    • Das, N.P.1
  • 8
    • 0342264396 scopus 로고    scopus 로고
    • Urinary metabolites of French maritime pine bark extract in humans
    • Düweler KG, Rohdewald P, (2000) Urinary metabolites of French maritime pine bark extract in humans. Pharmazie 55: 364-368.
    • (2000) Pharmazie , vol.55 , pp. 364-368
    • Düweler, K.G.1    Rohdewald, P.2
  • 9
    • 17144469349 scopus 로고    scopus 로고
    • Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion
    • Li C, Lee MJ, Sheng S, Meng X, Prabhu S, et al. (2000) Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion. Chem Res Toxicol 13: 177-184.
    • (2000) Chem Res Toxicol , vol.13 , pp. 177-184
    • Li, C.1    Lee, M.J.2    Sheng, S.3    Meng, X.4    Prabhu, S.5
  • 10
    • 0034967897 scopus 로고    scopus 로고
    • Analysis of urinary metabolites of tea catechins by liquid chromatography/electrospray ionization mass spectrometry
    • Li C, Meng X, Winnik B, Lee MJ, Lu H, et al. (2001) Analysis of urinary metabolites of tea catechins by liquid chromatography/electrospray ionization mass spectrometry. Chem Res Toxicol 14: 702-707.
    • (2001) Chem Res Toxicol , vol.14 , pp. 702-707
    • Li, C.1    Meng, X.2    Winnik, B.3    Lee, M.J.4    Lu, H.5
  • 11
    • 1342328148 scopus 로고    scopus 로고
    • Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol)
    • Grimm T, Schäfer A, Högger P, (2004) Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Free Radic Biol Med 36: 811-822.
    • (2004) Free Radic Biol Med , vol.36 , pp. 811-822
    • Grimm, T.1    Schäfer, A.2    Högger, P.3
  • 12
    • 77957315722 scopus 로고    scopus 로고
    • Determination of quercetin and resveratrol in whole blood - implications for bioavailability studies
    • Biasutto L, Marotta E, Garbisa S, Zoratti M, Paradisi C, (2010) Determination of quercetin and resveratrol in whole blood - implications for bioavailability studies. Molecules 15: 6570-6579.
    • (2010) Molecules , vol.15 , pp. 6570-6579
    • Biasutto, L.1    Marotta, E.2    Garbisa, S.3    Zoratti, M.4    Paradisi, C.5
  • 13
    • 84862287505 scopus 로고    scopus 로고
    • Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol)
    • Uhlenhut K, Högger P, (2012) Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol). Free Radic Biol Med 53: 305-313.
    • (2012) Free Radic Biol Med , vol.53 , pp. 305-313
    • Uhlenhut, K.1    Högger, P.2
  • 14
    • 0029658249 scopus 로고    scopus 로고
    • Erythrocytes and the transport of drugs and endogenous compounds
    • Highley MS, De Bruijn EA, (1996) Erythrocytes and the transport of drugs and endogenous compounds. Pharm Res 13: 186-195.
    • (1996) Pharm Res , vol.13 , pp. 186-195
    • Highley, M.S.1    De Bruijn, E.A.2
  • 15
    • 0030770275 scopus 로고    scopus 로고
    • Red blood cells: a neglected compartment in pharmacokinetics and pharmacodynamics
    • Hinderling PH, (1997) Red blood cells: a neglected compartment in pharmacokinetics and pharmacodynamics. Pharmacol Rev 49: 279-295.
    • (1997) Pharmacol Rev , vol.49 , pp. 279-295
    • Hinderling, P.H.1
  • 16
    • 77957016841 scopus 로고    scopus 로고
    • Plasma protein binding of polyphenols from maritime pine bark extract (USP)
    • Kurlbaum M, Högger P, (2011) Plasma protein binding of polyphenols from maritime pine bark extract (USP). J Pharm Biomed Anal 54: 127-132.
    • (2011) J Pharm Biomed Anal , vol.54 , pp. 127-132
    • Kurlbaum, M.1    Högger, P.2
  • 18
    • 0019156271 scopus 로고
    • Changes in some cytoplasmic enzymes from red cells fractionated into age groups by centrifugation in Ficoll/Triosil gradients. Comparison of normal humans and patients with Duchenne muscular dystrophy
    • Galbraith DA, Watts DC, (1980) Changes in some cytoplasmic enzymes from red cells fractionated into age groups by centrifugation in Ficoll/Triosil gradients. Comparison of normal humans and patients with Duchenne muscular dystrophy. Biochem J 191: 63-70.
    • (1980) Biochem J , vol.191 , pp. 63-70
    • Galbraith, D.A.1    Watts, D.C.2
  • 19
    • 12944268377 scopus 로고    scopus 로고
    • A novel liquid chromatography/tandem mass spectrometry based depletion method for measuring red blood cell partitioning of pharmaceutical compounds in drug discovery
    • Yu S, Li S, Yang H, Lee F, Wu JT, et al. (2005) A novel liquid chromatography/tandem mass spectrometry based depletion method for measuring red blood cell partitioning of pharmaceutical compounds in drug discovery. Rapid Commun Mass Spectrom 19: 250-254.
    • (2005) Rapid Commun Mass Spectrom , vol.19 , pp. 250-254
    • Yu, S.1    Li, S.2    Yang, H.3    Lee, F.4    Wu, J.T.5
  • 20
    • 0028216590 scopus 로고
    • In vitro assessement of the haemolytic potential of candidate drugs
    • Salauze DD, (1994) In vitro assessement of the haemolytic potential of candidate drugs. Comp Haematol Int 4: 34-36.
    • (1994) Comp Haematol Int , vol.4 , pp. 34-36
    • Salauze, D.D.1
  • 21
    • 58349102725 scopus 로고    scopus 로고
    • alpha- and beta-monosaccharide transport in human erythrocytes
    • Leitch JM, Carruthers A, (2009) alpha- and beta-monosaccharide transport in human erythrocytes. Am J Physiol Cell Physiol 296: C151-161.
    • (2009) Am J Physiol Cell Physiol , vol.296
    • Leitch, J.M.1    Carruthers, A.2
  • 22
    • 48749121080 scopus 로고    scopus 로고
    • A sample extraction and chromatographic strategy for increasing LC/MS detection coverage of the erythrocyte metabolome
    • Sana TR, Waddell K, Fischer SM, (2008) A sample extraction and chromatographic strategy for increasing LC/MS detection coverage of the erythrocyte metabolome. J Chromatogr B Analyt Technol Biomed Life Sci 871: 314-321.
    • (2008) J Chromatogr B Analyt Technol Biomed Life Sci , vol.871 , pp. 314-321
    • Sana, T.R.1    Waddell, K.2    Fischer, S.M.3
  • 23
    • 0027205012 scopus 로고
    • Mass spectrometry in the analysis of glutathione conjugates
    • Baillie TA, Davis MR, (1993) Mass spectrometry in the analysis of glutathione conjugates. Biol Mass Spectrom 22: 319-325.
    • (1993) Biol Mass Spectrom , vol.22 , pp. 319-325
    • Baillie, T.A.1    Davis, M.R.2
  • 24
    • 14844316005 scopus 로고    scopus 로고
    • A high-throughput liquid chromatography/tandem mass spectrometry method for screening glutathione conjugates using exact mass neutral loss acquisition
    • Castro-Perez J, Plumb R, Liang L, Yang E, (2005) A high-throughput liquid chromatography/tandem mass spectrometry method for screening glutathione conjugates using exact mass neutral loss acquisition. Rapid Commun Mass Spectrom 19: 798-804.
    • (2005) Rapid Commun Mass Spectrom , vol.19 , pp. 798-804
    • Castro-Perez, J.1    Plumb, R.2    Liang, L.3    Yang, E.4
  • 25
    • 13844271387 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    • Williamson G, Manach C, (2005) Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 81: 243S-255S.
    • (2005) Am J Clin Nutr , vol.81
    • Williamson, G.1    Manach, C.2
  • 26
    • 33646343957 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)
    • Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova A, et al. (2006) Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond) 3: 1.
    • (2006) J Inflamm (Lond) , vol.3 , pp. 1
    • Grimm, T.1    Chovanova, Z.2    Muchova, J.3    Sumegova, K.4    Liptakova, A.5
  • 27
    • 77953193336 scopus 로고    scopus 로고
    • Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells
    • Koren E, Kohen R, Ginsburg I, (2010) Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells. Exp Biol Med (Maywood) 235: 689-699.
    • (2010) Exp Biol Med (Maywood) , vol.235 , pp. 689-699
    • Koren, E.1    Kohen, R.2    Ginsburg, I.3
  • 29
    • 0028152377 scopus 로고
    • Facilitative glucose transporters
    • Mueckler M, (1994) Facilitative glucose transporters. Eur J Biochem 219: 713-725.
    • (1994) Eur J Biochem , vol.219 , pp. 713-725
    • Mueckler, M.1
  • 30
    • 80054717982 scopus 로고    scopus 로고
    • Hexose transporter GLUT1 harbors several distinct regulatory binding sites for flavones and tyrphostins
    • Perez A, Ojeda P, Ojeda L, Salas M, Rivas CI, et al. (2011) Hexose transporter GLUT1 harbors several distinct regulatory binding sites for flavones and tyrphostins. Biochemistry 50: 8834-8845.
    • (2011) Biochemistry , vol.50 , pp. 8834-8845
    • Perez, A.1    Ojeda, P.2    Ojeda, L.3    Salas, M.4    Rivas, C.I.5
  • 31
    • 0028909335 scopus 로고
    • cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1
    • Garcia CK, Brown MS, Pathak RK, Goldstein JL, (1995) cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. J Biol Chem 270: 1843-1849.
    • (1995) J Biol Chem , vol.270 , pp. 1843-1849
    • Garcia, C.K.1    Brown, M.S.2    Pathak, R.K.3    Goldstein, J.L.4
  • 32
    • 1542782592 scopus 로고    scopus 로고
    • Phlorizin recognition in a C-terminal fragment of SGLT1 studied by tryptophan scanning and affinity labeling
    • Raja MM, Tyagi NK, Kinne RK, (2003) Phlorizin recognition in a C-terminal fragment of SGLT1 studied by tryptophan scanning and affinity labeling. J Biol Chem 278: 49154-49163.
    • (2003) J Biol Chem , vol.278 , pp. 49154-49163
    • Raja, M.M.1    Tyagi, N.K.2    Kinne, R.K.3
  • 33
    • 0034894091 scopus 로고    scopus 로고
    • Phloretin differentially inhibits volume-sensitive and cyclic AMP-activated, but not Ca-activated, Cl(-) channels
    • Fan HT, Morishima S, Kida H, Okada Y, (2001) Phloretin differentially inhibits volume-sensitive and cyclic AMP-activated, but not Ca-activated, Cl(-) channels. Br J Pharmacol 133: 1096-1106.
    • (2001) Br J Pharmacol , vol.133 , pp. 1096-1106
    • Fan, H.T.1    Morishima, S.2    Kida, H.3    Okada, Y.4
  • 34
    • 0035808368 scopus 로고    scopus 로고
    • Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3
    • Yang B, Ma T, Verkman AS, (2001) Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J Biol Chem 276: 624-628.
    • (2001) J Biol Chem , vol.276 , pp. 624-628
    • Yang, B.1    Ma, T.2    Verkman, A.S.3
  • 35
    • 0030480168 scopus 로고    scopus 로고
    • Functional differentiation of the human red blood cell and kidney urea transporters
    • Martial S, Olives B, Abrami L, Couriaud C, Bailly P, et al. (1996) Functional differentiation of the human red blood cell and kidney urea transporters. Am J Physiol 271: F1264-1268.
    • (1996) Am J Physiol , vol.271
    • Martial, S.1    Olives, B.2    Abrami, L.3    Couriaud, C.4    Bailly, P.5
  • 36
    • 45649084417 scopus 로고    scopus 로고
    • Apical and basolateral localisation of GLUT2 transporters in human lung epithelial cells
    • Kalsi KK, Baker EH, Medina RA, Rice S, Wood DM, et al. (2008) Apical and basolateral localisation of GLUT2 transporters in human lung epithelial cells. Pflugers Arch 456: 991-1003.
    • (2008) Pflugers Arch , vol.456 , pp. 991-1003
    • Kalsi, K.K.1    Baker, E.H.2    Medina, R.A.3    Rice, S.4    Wood, D.M.5
  • 37
    • 0345724769 scopus 로고    scopus 로고
    • The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes
    • Martin HJ, Kornmann F, Fuhrmann GF, (2003) The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes. Chem Biol Interact 146: 225-235.
    • (2003) Chem Biol Interact , vol.146 , pp. 225-235
    • Martin, H.J.1    Kornmann, F.2    Fuhrmann, G.F.3
  • 38
    • 0029938022 scopus 로고    scopus 로고
    • Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes
    • Thorens B, (1996) Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes. Am J Physiol 270: G541-553.
    • (1996) Am J Physiol , vol.270
    • Thorens, B.1
  • 40
    • 0037469538 scopus 로고    scopus 로고
    • Centrifugal and chromatographic analyses of tryptophan and tyrosine uptake by red blood cells and GLUT1 proteoliposomes with permeability estimates and observations on dihydrocytochalasin B
    • Lagerquist Hagglund C, Lundahl P, (2003) Centrifugal and chromatographic analyses of tryptophan and tyrosine uptake by red blood cells and GLUT1 proteoliposomes with permeability estimates and observations on dihydrocytochalasin B. J Biochem Biophys Methods. 55: 127-140.
    • (2003) J Biochem Biophys Methods , vol.55 , pp. 127-140
    • Lagerquist Hagglund, C.1    Lundahl, P.2
  • 43
    • 40849102818 scopus 로고    scopus 로고
    • Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin C
    • Montel-Hagen A, Kinet S, Manel N, Mongellaz C, Prohaska R, et al. (2008) Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin C. Cell. 132: 1039-1048.
    • (2008) Cell , vol.132 , pp. 1039-1048
    • Montel-Hagen, A.1    Kinet, S.2    Manel, N.3    Mongellaz, C.4    Prohaska, R.5
  • 44
    • 33646836322 scopus 로고    scopus 로고
    • Docking studies show that D-glucose and quercetin slide through the transporter GLUT1
    • Cunningham P, Afzal-Ahmed I, Naftalin RJ, (2006) Docking studies show that D-glucose and quercetin slide through the transporter GLUT1. J Biol Chem 281: 5797-5803.
    • (2006) J Biol Chem , vol.281 , pp. 5797-5803
    • Cunningham, P.1    Afzal-Ahmed, I.2    Naftalin, R.J.3
  • 45
    • 0042664107 scopus 로고    scopus 로고
    • Role of red blood cells in pharmacokinetics of chemotherapeutic agents
    • Schrijvers D, (2003) Role of red blood cells in pharmacokinetics of chemotherapeutic agents. Clin Pharmacokinet 42: 779-791.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 779-791
    • Schrijvers, D.1
  • 46
    • 0025123704 scopus 로고
    • Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization
    • Pardridge WM, Boado RJ, Farrell CR, (1990) Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization. J Biol Chem 265: 18035-18040.
    • (1990) J Biol Chem , vol.265 , pp. 18035-18040
    • Pardridge, W.M.1    Boado, R.J.2    Farrell, C.R.3
  • 47
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues
    • Tietze F, (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27: 502-522.
    • (1969) Anal Biochem , vol.27 , pp. 502-522
    • Tietze, F.1
  • 48
    • 0018195093 scopus 로고
    • Glutathione transferase from human erythrocytes. Nonidentity with the enzymes from liver
    • Marcus CJ, Habig WH, Jakoby WB, (1978) Glutathione transferase from human erythrocytes. Nonidentity with the enzymes from liver. Arch Biochem Biophys 188: 287-293.
    • (1978) Arch Biochem Biophys , vol.188 , pp. 287-293
    • Marcus, C.J.1    Habig, W.H.2    Jakoby, W.B.3
  • 49
    • 0021061108 scopus 로고
    • Detoxification of xenobiotics by glutathione S-transferases in erythrocytes: the transport of the conjugate of glutathione and 1-chloro-2,4-dinitrobenzene
    • Awasthi YC, Misra G, Rassin DK, Srivastava SK, (1983) Detoxification of xenobiotics by glutathione S-transferases in erythrocytes: the transport of the conjugate of glutathione and 1-chloro-2,4-dinitrobenzene. Br J Haematol 55: 419-425.
    • (1983) Br J Haematol , vol.55 , pp. 419-425
    • Awasthi, Y.C.1    Misra, G.2    Rassin, D.K.3    Srivastava, S.K.4
  • 50
    • 0041307025 scopus 로고    scopus 로고
    • Quenching of quercetin quinone/quinone methides by different thiolate scavengers: stability and reversibility of conjugate formation
    • Awad HM, Boersma MG, Boeren S, Van Bladeren PJ, Vervoort J, et al. (2003) Quenching of quercetin quinone/quinone methides by different thiolate scavengers: stability and reversibility of conjugate formation. Chem Res Toxicol 16: 822-831.
    • (2003) Chem Res Toxicol , vol.16 , pp. 822-831
    • Awad, H.M.1    Boersma, M.G.2    Boeren, S.3    Van Bladeren, P.J.4    Vervoort, J.5
  • 51
    • 80255136353 scopus 로고    scopus 로고
    • An essential difference in the reactivity of the glutathione adducts of the structurally closely related flavonoids monoHER and quercetin
    • doi:10.1016/j.freeradbiomed.2011.09.013
    • Jacobs H, Moalin M, van Gisbergen MW, Bast A, van der Vijgh WJ, et al. (2011) An essential difference in the reactivity of the glutathione adducts of the structurally closely related flavonoids monoHER and quercetin. Free Radic Biol Med doi:10.1016/j.freeradbiomed.2011.09.013.
    • (2011) Free Radic Biol Med
    • Jacobs, H.1    Moalin, M.2    van Gisbergen, M.W.3    Bast, A.4    van der Vijgh, W.J.5
  • 52
    • 0034534421 scopus 로고    scopus 로고
    • Glutathione conjugation as a bioactivation reaction
    • van Bladeren PJ, (2000) Glutathione conjugation as a bioactivation reaction. Chem Biol Interact 129: 61-76.
    • (2000) Chem Biol Interact , vol.129 , pp. 61-76
    • van Bladeren, P.J.1
  • 53
    • 27744529413 scopus 로고    scopus 로고
    • The reversibility of the glutathionyl-quercetin adduct spreads oxidized quercetin-induced toxicity
    • Boots AW, Balk JM, Bast A, Haenen GR, (2005) The reversibility of the glutathionyl-quercetin adduct spreads oxidized quercetin-induced toxicity. Biochem Biophys Res Commun 338: 923-929.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 923-929
    • Boots, A.W.1    Balk, J.M.2    Bast, A.3    Haenen, G.R.4
  • 54
    • 77954385964 scopus 로고    scopus 로고
    • Inhibition of oxidative hemolysis by quercetin, but not other antioxidants
    • Hapner CD, Deuster P, Chen Y, (2010) Inhibition of oxidative hemolysis by quercetin, but not other antioxidants. Chem Biol Interact 186: 275-279.
    • (2010) Chem Biol Interact , vol.186 , pp. 275-279
    • Hapner, C.D.1    Deuster, P.2    Chen, Y.3
  • 55
    • 77955159974 scopus 로고    scopus 로고
    • Coexistence of passive and carrier-mediated processes in drug transport
    • Sugano K, Kansy M, Artursson P, Avdeef A, Bendels S, et al. (2010) Coexistence of passive and carrier-mediated processes in drug transport. Nat Rev Drug Discov 9: 597-614.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 597-614
    • Sugano, K.1    Kansy, M.2    Artursson, P.3    Avdeef, A.4    Bendels, S.5
  • 56
    • 84863814630 scopus 로고    scopus 로고
    • In silico kinetic study of the glucose transporter
    • Alonso GL, Gonzalez DA, (2007) In silico kinetic study of the glucose transporter. J Biol Phys 33: 485-498.
    • (2007) J Biol Phys , vol.33 , pp. 485-498
    • Alonso, G.L.1    Gonzalez, D.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.