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Volumn 19, Issue 2, 2005, Pages 250-254
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A novel liquid chromatography/tandem mass spectrometry based depletion method for measuring red blood cell partitioning of pharmaceutical compounds in drug discovery
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Author keywords
[No Author keywords available]
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Indexed keywords
ASSAYS;
BLOOD;
CELLS;
DRUG PRODUCTS;
LIQUID CHROMATOGRAPHY;
PRECIPITATION (CHEMICAL);
CELL PARTITIONING;
DRUG CONCENTRATION;
DRUG DISCOVERY;
LC-MS-MS;
LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY;
LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY;
MEASUREMENTS OF;
PLASMA SAMPLES;
RED BLOOD CELL;
WHOLE BLOOD;
MASS SPECTROMETRY;
ACEBUTOLOL;
ACECAINIDE;
ACETAZOLAMIDE;
APOMORPHINE;
ATENOLOL;
CHLOROQUINE;
CHLORTALIDONE;
CYCLOSPORIN;
FLUPHENAZINE;
HEME;
MAPROTILINE;
METHAZOLAMIDE;
METOPROLOL;
PHENPROBAMATE;
PROCAINAMIDE;
PROMAZINE;
PROPRANOLOL;
SULFANILAMIDE;
THIORIDAZINE;
TRIFLUOPERAZINE;
VERAPAMIL;
ACCURACY;
ARTICLE;
BLOOD;
CENTRIFUGATION;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
CORRELATION COEFFICIENT;
DEPLETION;
DRUG BLOOD LEVEL;
DRUG SCREENING;
EQUILIBRIUM CONSTANT;
ERYTHROCYTE;
EXTRACTION;
HUMAN;
INCUBATION TIME;
INTERMETHOD COMPARISON;
LIQUID CHROMATOGRAPHY;
NORMAL HUMAN;
PARTITION COEFFICIENT;
PLASMA;
PRECIPITATION;
REPRODUCIBILITY;
SAMPLING;
TANDEM MASS SPECTROMETRY;
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EID: 12944268377
PISSN: 09514198
EISSN: None
Source Type: Journal
DOI: 10.1002/rcm.1777 Document Type: Article |
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Times cited : (79)
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References (11)
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