Phloretin differentially inhibits volume-sensitive and cyclic AMP-activated, but not Ca-activated, Cl- channels

British Journal of Pharmacology

Volumn 133, Issue 7, 2001, Pages 1096-1106

  Fan, Hai Tian ^a   Morishima, Shigeru ^a,c   Kida, Hajime ^d   Okada, Yasunobu ^a,b,c  

^a NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d Faculty of Medicine   (Japan)

Author keywords

Cell volume regulation; Cystic fibrosis transmembrane conductance regulator; Phloretin

Indexed keywords

BUCLADESINE; CALCIUM ION; CALPHOSTIN C; CHLORIDE CHANNEL; CYCLIC AMP; FORSKOLIN; IONOMYCIN; ISOBUTYLMETHYLXANTHINE; PHLORETIN; PHLORIZIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; BREAST CELL; CELL VOLUME; CHLORIDE CURRENT; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; INTESTINE CELL; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL;

EID: 0034894091     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704159     Document Type: Article

References (77)

1. - channels from secretory epithelial cells by low internal pH
2. Inhibition of glucose transport into brain by phlorizin, phloretin and glucose analogues
3. + currents by Müller glial cells
4. Antibody against a cystic fibrosis transmembrane conductance regulator-derived synthetic peptide inhibits anion currents in human colonic cell line T84
5. +-dicarboxylate cotransporter
6. - secreting epithelial cells
7. Volume-sensitive chloride conductance in bovine chromaffin cell membrane
8. Molecular identification of a volume-regulated chloride channel
9. Selectivity of the renal collecting duct water channel aquaporin-3
10. Effects of phloretin on chloride channels in epithelial cells
11. Phloretin inhibits a regulatory volume decrease in human epithelial cells
12. Hypotonically activated chloride current in HSG cells
13. Interactions of inhibitors on anion transporter of human erythrocyte
14. Effects of channel modulators on cloned large-conductance calcium-activated potassium channels
15. Calcium and phospholipid-dependent protein kinase activity in mouse epidermis cytosol. Stimulation by complete and incomplete tumor promoters and inhibition by various compounds
16. Blockade of swelling-induced chloride channels by phenol derivatives
17. Volume-sensitive taurine transport in bovine articular chondrocytes
18. - conductances in murine C127 cells
19. ATP release from swollen or CFTR-expressing epithelial cells
20. - channels in cultured human epithelial cells
21. - conductance during the regulatory volume decrease in cultured human epithelial cells
22. Membrane mechanisms in volume and pH regulation in vertebrate cells
23. Molecular cloning and expression of a member of the aqnaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells
24. Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A
25. Expression of the rat GLUT1 glucose transporter in the yeast, Saccharomyces cerevisiae
26. Phloretin affects the fast possium channels in frog nerve fibres
27. The effect of phloretin on single potassium channels in myelinated nerve
28. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
29. + channels in myelinated nerve fibers of Xenopus laevis
30. - channels
31. - channel currents in cultured human epithelial cells
32. CFTR, a regulator of channels
33. Cell swelling activates separate taurine and chloride channels in Ehrilich mouse ascites tumor cells
34. - current in human T84 colonic and B-cell myeloma cell lines
35. Calcium signaling in cell volume regulation
36. Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion
37. 2+- and cAMP-dependent anion conductances in the apical membrane of polarized T84 cells
38. Volume regulation in NIH/3T3 cells not expressing P-glycoprotein. II. Chloride and amino acid fluxes
39. Water movement during cell volume regulation
40. Properties of volume-regulated anion channels in mammalian cells
41. - channel: Fresh start to the molecular identity and volume sensor
42. Volume-regulatory ion channels in human epithelial cells
43. 2+- permeable ion channels is involved in the volume regulation of hypotonically swollen epithelial cells
44. - channels in a human epithelial cell
45. - channel
46. 2+ channels and protein kinase C
47. Osmoregulatory alterations in myo-inositol uptake by bovine lens epithelial cells. Part 5: Mechanism of the myo-inositol efflux pathway
48. Halide and alkyl phenols block volume-sensitive chloride channels in human glial cells (U-138MG)
49. Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor
50. Active glucose uptake by strips of guinea pig intestine; competitive inhibition by phlorhizin and phloretin
51. Cystic fibrosis transmembrane conductance regulator activates water conductance in Xenopus oocytes
52. CFTR is a conductance regulator as well as a chloride channel
53. Biochemistry of natural pigments
54. - channels
55. Ca channels and stretch-activated channels in calcium influx, triggering membrane fusion of chick embryonic myoblasts
56. Progressive effects of phloridzin on melanogenesis in B16 mouse melanoma cells
57. - channel inhibitors
58. Swelling-induced taurine release without chloride channel activity in Xenopus laevis oocytes expressing anion channels and transporters
59. Cellular and molecular physiology of volume-sensitive anion channels
60. Mechanism and regulation of swelling-activated inositol efflux in brain glial cells
61. Effects of the dipolar form of phloretin on potassium conductance in squid giant axons
62. Separate taurine and chloride efflux pathways activated during regulatory volume decrease
63. Characterization of volume-activated chloride currents in endothelial cells from bovine pulmonary artery
64. - channel in CHO cells stably expressing the cystic fibrosis gene
65. 2+ mobilizing hormones potentiate hypotonicity-induced activation of ionic conductances in intestine 407 cells
66. Molecular characterization of a broad selectivity neutral solute channel
67. CIn in Xenopus oocytes differs from the endogenous volume-sensitive chloride current
68. Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase
69. Inactivation of calcium-activated chloride channels in smooth muscle by calcium/calmodulin-dependent protein kinase
70. - channel in guinea pig
71. Protein kinase C regulates the magnitude and stability of CFTR currents in pancreatic duct cells
72. A volume-sensitive chloride conductance in human colonic cell line T84
73. CaMKII mediates stimulation of cholide conductance by calcium in T84 cells
74. 2+-activated anion conductances in C127 epithelial cells expressing WT and ΔF508-CFTR
75. - channel in guinea pig ventricular myocytes and CFTR-transfected mouse fibroblasts