Single and multiple dose pharmacokinetics of maritime pine bark extract (Pycnogenol) after oral administration to healthy volunteers

BMC Clinical Pharmacology

Volumn 6, Issue , 2006, Pages

  Grimm, Tanja ^a   Skrabala, Roswitha ^a   Chovanová, Zuzana ^b   Muchová, Jana ^b   Sumegová, Katarína ^b   Liptákova, Anna ^b   Ďuračková, Zdeňka ^b   Högger, Petra ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Faculty of Medicine of Comenius University and University Hospital Bratislava   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEIC ACID; CATECHIN; DELTA (3 METHOXY 4 HYDROXYPHENYL)GAMMA VALEROLACTONE; DELTA (3,4 DIHYDROXYPHENYL)GAMMA VALEROLACTONE; DRUG METABOLITE; FERULIC ACID; MARITIME PINE BARK EXTRACT; PLANT EXTRACT; PYCNOGENOL; TAXIFOLIN; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG HALF LIFE; DRUG METABOLISM; ELECTROCHEMICAL DETECTION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; ION PAIR CHROMATOGRAPHY; MALE; MULTIPLE DRUG DOSE; NORMAL HUMAN; QUANTITATIVE ANALYSIS; SINGLE DRUG DOSE; STANDARDIZATION; STEADY STATE; ULTRAVIOLET RADIATION;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLAVONOIDS; HUMANS; MALE; PINUS; PLANT BARK; PLANT EXTRACTS;

EID: 33748305800     PISSN: 14726904     EISSN: 14726904     Source Type: Journal    
DOI: 10.1186/1472-6904-6-4     Document Type: Article

References (36)

1. Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Carrier J, Khan IA, Edwards DJ, Shah A: In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin Pharmacol Ther 2004, 76:428-440.
2. Rengelshausen J, Banfield M, Riedel KD, Burhenne J, Weiss J, Thomsen T, Walter-Sack I, Haefeli WE, Mikus G: Opposite effects of short-term and long-term St John's wort intake on voriconazole pharmacokinetics. Clin Pharmacol Ther 2005, 78:25-33.
3. Williamson G, Manach C: Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 2005, 81:243S-255S.
4. Liu JP, Zhang M, Wang WY, Grimsgaard S: Chinese herbal medicines for type 2 diabetes mellitus. Cochrane Database Syst Rev 2004:CD003642.
5. Manach C, Williamson G, Morand C, Scalbert A, Remesy C: Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 2005, 81:230S-242S.
6. Wittemer SM, Ploch M, Windeck T, Muller SC, Drewelow B, Derendorf H, Veit M: Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans. Phytomedicine 2005, 12:28-38.
7. Loew D, Schrodter A, Schwankl W, Marz RW: Measurement of the bioavailability of aescin-containing extracts. Methods Find Exp Clin Pharmacol 2000, 22:537-542.
8. Schulz HU, Schurer M, Bassler D, Weiser D: Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. Arzneimittelforschung 2005, 55:15-22.
9. Vuksan V, Sievenpiper JL: Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Nutr Metab Cardiovasc Dis 2005, 15:149-160.
10. Maritime Pine Extract. In United States Pharmacopeia Volume 28. Rockville, United States Pharmacopeial Convention, Inc.; 2005:2115-2116.
11. Rohdewald P: A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 2002, 40:158-168.
12. Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Rohdewald P, Ippolito E, Ricci A, Cacchio M, Ruffini I, Fano F, Hosoi M: Venous ulcers: microcirculatory improvement and faster healing with local use of pycnogenol((r)). Angiology 2005, 56:699-705.
13. Hosseini S, Pishnamazi S, Sadrzadeh SM, Farid F, Farid R, Watson RR: Pycnogenol((R)) in the Management of Asthma. J Med Food 2001, 4:201-209.
14. Lau BH, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA: Pycnogenol as an adjunct in the management of childhood asthma. J Asthma 2004, 41:825-832.
15. Düweler KG, Rohdewald P: Urinary metabolites of French maritime pine bark extract in humans. Pharmazie 2000, 55:364-368.
16. Virgili F, Pagana G, Bourne L, Rimbach G, Natella F, Rice-Evans C, Packer L: Ferulic acid excretion as a marker of consumption of a French maritime pine (Pinus maritima) bark extract. Free Radic Biol Med 2000, 28:1249-1256.
17. Das NP: Studies on flavonoid metabolism. Absorption and metabolism of (+)-catechin in man. Biochem Pharmacol 1971, 20:3435-3445.
18. Lipinski CA, Lombardo F, Dominy BW, Feeney PJ: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 2001, 46:3-26.
19. Donovan JL, Bell JR, Kasim-Karakas S, German JB, Walzem RL, Hansen RJ, Waterhouse AL: Catechin is present as metabolites in human plasma after consumption of red wine. J Nutr 1999, 129:1662-1668.
20. Bell JR, Donovan JL, Wong R, Waterhouse AL, German JB, Walzem RL, Kasim-Karakas SE: (+)-Catechin in human plasma after ingestion of a single serving of reconstituted red wine. Am J Clin Nutr 2000, 71:103-108.
21. Hackett AM, Griffiths LA, Broillet A, Wermeille M: The metabolism and excretion of (+)-[14C]cyanidanol-3 in man following oral administration. Xenobiotica 1983, 13:279-286.
22. Goldberg DM, Yan J, Soleas GJ: Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 2003, 36:79-87.
23. Caccetta RA, Croft KD, Beilin LJ, Puddey IB: Ingestion of red wine significantly increases plasma phenolic acid concentrations but does not acutely affect ex vivo lipoprotein oxidizability. Am J Clin Nutr 2000, 71:67-74.
24. Simonetti P, Gardana C, Pietta P: Caffeic acid as biomarker of red wine intake. Methods Enzymol 2001, 335:122-130.
25. Nardini M, Cirillo E, Natella F, Scaccini C: Absorption of phenolic acids in humans after coffee consumption. J Agric Food Chem 2002, 50:5735-5741.
26. Nardini M, Natella F, Scaccini C, Ghiselli A: Phenolic acids from beer are absorbed and extensively metabolized in humans. J Nutr Biochem 2006, 17:14-22.
27. Kern SM, Bennett RN, Mellon FA, Kroon PA, Garcia-Conesa MT: Absorption of hydroxycinnamates in humans after high-bran cereal consumption. J Agric Food Chem 2003, 51:6050-6055.
28. Schoefer L, Mohan R, Schwiertz A, Braune A, Blaut M: Anaerobic degradation of flavonoids by Clostridium orbiscindens. Appl Environ Microbiol 2003, 69:5849-5854.
29. Li C, Lee MJ, Sheng S, Meng X, Prabhu S, Winnik B, Huang B, Chung JY, Yan S, Ho CT, Yang CS: Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion. Chem Res Toxicol 2000, 13:177-184.
30. Lee MJ, Maliakal P, Chen L, Meng X, Bondoc FY, Prabhu S, Lambert G, Mohr S, Yang CS: Pharmacokinetics of tea catechins after ingestion of green tea and (-)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol Biomarkers Prev 2002, 11:1025-1032.
31. Sano A, Yamakoshi J, Tokutake S, Tobe K, Kubota Y, Kikuchi M: Procyanidin BI is detected in human serum after intake of proanthocyanidin-rich grape seed extract. Biosci Biotechnol Biochem 2003, 67:1140-1143.
32. Grimm T, Schäfer A, Högger P: Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Free Radic Biol Med 2004, 36:811-822.
33. Koga T, Meydani M: Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells. Am J Clin Nutr 2001, 73:941-948.
34. Moon JH, Tsushida T, Nakahara K, Terao J: Identification of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin. Free Radic Biol Med 2001, 30:1274-1285.
35. Schäfer A, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, Högger P: Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomed Pharmacother 2006, 60:5-9.
36. Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova. A, Durackova Z, Högger P: Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond) 2006, 3:1.