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Volumn 8, Issue 4, 2013, Pages

The Role of Protein Interactions in Mediating Essentiality and Synthetic Lethality

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONTROLLED STUDY; ESSENTIAL GENE; FUNGAL GENE; GENE CLUSTER; GENE DELETION; GENE DISRUPTION; GENE DUPLICATION; GENETIC IDENTIFICATION; METABOLISM; NONHUMAN; PROTEIN PROTEIN INTERACTION; SYNTHETIC LETHALITY; CELL DEATH; CYTOLOGY; GENETICS; LETHAL GENE; MUTATION; SACCHAROMYCES CEREVISIAE;

EID: 84876925278     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062866     Document Type: Article
Times cited : (8)

References (62)
  • 1
    • 0037173615 scopus 로고    scopus 로고
    • Functional profiling of the Saccharomyces cerevisiae genome
    • Giaever G, Chu AM, Ni L, Connelly C, Riles L, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418: 387-391.
    • (2002) Nature , vol.418 , pp. 387-391
    • Giaever, G.1    Chu, A.M.2    Ni, L.3    Connelly, C.4    Riles, L.5
  • 3
    • 26244440771 scopus 로고    scopus 로고
    • Gene essentiality and the topology of protein interaction networks
    • Coulomb S, Bauer M, Bernard D, Marsolier-Kergoat MC, (2005) Gene essentiality and the topology of protein interaction networks. Proc Biol Sci 272: 1721-1725.
    • (2005) Proc Biol Sci , vol.272 , pp. 1721-1725
    • Coulomb, S.1    Bauer, M.2    Bernard, D.3    Marsolier-Kergoat, M.C.4
  • 4
    • 50949092459 scopus 로고    scopus 로고
    • Why do hubs in the yeast protein interaction network tend to be essential: reexamining the connection between the network topology and essentiality
    • Zotenko E, Mestre J, O'Leary DP, Przytycka TM, (2008) Why do hubs in the yeast protein interaction network tend to be essential: reexamining the connection between the network topology and essentiality. PLoS Comput Biol 4: e1000140.
    • (2008) PLoS Comput Biol , vol.4
    • Zotenko, E.1    Mestre, J.2    O'Leary, D.P.3    Przytycka, T.M.4
  • 5
    • 33745712594 scopus 로고    scopus 로고
    • Why do hubs tend to be essential in protein networks?
    • He X, Zhang J, (2006) Why do hubs tend to be essential in protein networks? PLoS Genet 2: e88.
    • (2006) PLoS Genet , vol.2
    • He, X.1    Zhang, J.2
  • 6
    • 2942624207 scopus 로고    scopus 로고
    • Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast
    • Papp B, Pal C, Hurst LD, (2004) Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature 429: 661-664.
    • (2004) Nature , vol.429 , pp. 661-664
    • Papp, B.1    Pal, C.2    Hurst, L.D.3
  • 10
    • 25444497278 scopus 로고    scopus 로고
    • The concept of synthetic lethality in the context of anticancer therapy
    • Kaelin WG Jr, (2005) The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 5: 689-698.
    • (2005) Nat Rev Cancer , vol.5 , pp. 689-698
    • Kaelin Jr., W.G.1
  • 11
    • 22844450110 scopus 로고    scopus 로고
    • Systematic interpretation of genetic interactions using protein networks
    • Kelley R, Ideker T, (2005) Systematic interpretation of genetic interactions using protein networks. Nat Biotechnol 23: 561-566.
    • (2005) Nat Biotechnol , vol.23 , pp. 561-566
    • Kelley, R.1    Ideker, T.2
  • 13
    • 84862747288 scopus 로고    scopus 로고
    • Neighbor overlap is enriched in the yeast interaction network: analysis and implications
    • Feiglin A, Moult J, Lee B, Ofran Y, Unger R, (2012) Neighbor overlap is enriched in the yeast interaction network: analysis and implications. PLoS One 7: e39662.
    • (2012) PLoS One , vol.7
    • Feiglin, A.1    Moult, J.2    Lee, B.3    Ofran, Y.4    Unger, R.5
  • 14
    • 79959687662 scopus 로고    scopus 로고
    • An integrated approach to characterize genetic interaction networks in yeast metabolism
    • Szappanos B, Kovacs K, Szamecz B, Honti F, Costanzo M, et al. (2011) An integrated approach to characterize genetic interaction networks in yeast metabolism. Nat Genet 43: 656-662.
    • (2011) Nat Genet , vol.43 , pp. 656-662
    • Szappanos, B.1    Kovacs, K.2    Szamecz, B.3    Honti, F.4    Costanzo, M.5
  • 15
    • 41349102391 scopus 로고    scopus 로고
    • Evolutionary plasticity of genetic interaction networks
    • Tischler J, Lehner B, Fraser AG, (2008) Evolutionary plasticity of genetic interaction networks. Nat Genet 40: 390-391.
    • (2008) Nat Genet , vol.40 , pp. 390-391
    • Tischler, J.1    Lehner, B.2    Fraser, A.G.3
  • 16
    • 78649688381 scopus 로고    scopus 로고
    • The cellular robustness by genetic redundancy in budding yeast
    • Li J, Yuan Z, Zhang Z, (2010) The cellular robustness by genetic redundancy in budding yeast. PLoS Genet 6: e1001187.
    • (2010) PLoS Genet , vol.6
    • Li, J.1    Yuan, Z.2    Zhang, Z.3
  • 17
    • 14344263352 scopus 로고    scopus 로고
    • Distributed robustness versus redundancy as causes of mutational robustness
    • Wagner A (2005) Distributed robustness versus redundancy as causes of mutational robustness. Bioessays.
    • (2005) Bioessays
    • Wagner, A.1
  • 19
    • 77950585365 scopus 로고    scopus 로고
    • Need-based up-regulation of protein levels in response to deletion of their duplicate genes
    • DeLuna A, Springer M, Kirschner MW, Kishony R, (2010) Need-based up-regulation of protein levels in response to deletion of their duplicate genes. PLoS Biol 8: e1000347.
    • (2010) PLoS Biol , vol.8
    • DeLuna, A.1    Springer, M.2    Kirschner, M.W.3    Kishony, R.4
  • 20
    • 48249132857 scopus 로고    scopus 로고
    • Pervasive and persistent redundancy among duplicated genes in yeast
    • Dean EJ, Davis JC, Davis RW, Petrov DA, (2008) Pervasive and persistent redundancy among duplicated genes in yeast. PLoS Genet 4: e1000113.
    • (2008) PLoS Genet , vol.4
    • Dean, E.J.1    Davis, J.C.2    Davis, R.W.3    Petrov, D.A.4
  • 21
    • 77950533242 scopus 로고    scopus 로고
    • Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes
    • Doyle MA, Gasser RB, Woodcroft BJ, Hall RS, Ralph SA, (2010) Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes. BMC Genomics 11: 222.
    • (2010) BMC Genomics , vol.11 , pp. 222
    • Doyle, M.A.1    Gasser, R.B.2    Woodcroft, B.J.3    Hall, R.S.4    Ralph, S.A.5
  • 22
    • 0347033256 scopus 로고    scopus 로고
    • Role of duplicate genes in genetic robustness against null mutations
    • Gu Z, Steinmetz LM, Gu X, Scharfe C, Davis RW, et al. (2003) Role of duplicate genes in genetic robustness against null mutations. Nature 421: 63-66.
    • (2003) Nature , vol.421 , pp. 63-66
    • Gu, Z.1    Steinmetz, L.M.2    Gu, X.3    Scharfe, C.4    Davis, R.W.5
  • 23
    • 34447637417 scopus 로고    scopus 로고
    • Mouse duplicate genes are as essential as singletons
    • Liao BY, Zhang J, (2007) Mouse duplicate genes are as essential as singletons. Trends Genet 23: 378-381.
    • (2007) Trends Genet , vol.23 , pp. 378-381
    • Liao, B.Y.1    Zhang, J.2
  • 24
    • 34447624151 scopus 로고    scopus 로고
    • Gene essentiality, gene duplicability and protein connectivity in human and mouse
    • Liang H, Li WH, (2007) Gene essentiality, gene duplicability and protein connectivity in human and mouse. Trends Genet 23: 375-378.
    • (2007) Trends Genet , vol.23 , pp. 375-378
    • Liang, H.1    Li, W.H.2
  • 25
    • 65349176464 scopus 로고    scopus 로고
    • Predicting the proportion of essential genes in mouse duplicates based on biased mouse knockout genes
    • Su Z, Gu X, (2008) Predicting the proportion of essential genes in mouse duplicates based on biased mouse knockout genes. J Mol Evol 67: 705-709.
    • (2008) J Mol Evol , vol.67 , pp. 705-709
    • Su, Z.1    Gu, X.2
  • 26
    • 63449086872 scopus 로고    scopus 로고
    • The complex relationship of gene duplication and essentiality
    • Makino T, Hokamp K, McLysaght A, (2009) The complex relationship of gene duplication and essentiality. Trends Genet 25: 152-155.
    • (2009) Trends Genet , vol.25 , pp. 152-155
    • Makino, T.1    Hokamp, K.2    McLysaght, A.3
  • 27
    • 70349969940 scopus 로고    scopus 로고
    • Functional compensation by duplicated genes in mouse
    • Liang H, Li WH, (2009) Functional compensation by duplicated genes in mouse. Trends Genet 25: 441-442.
    • (2009) Trends Genet , vol.25 , pp. 441-442
    • Liang, H.1    Li, W.H.2
  • 28
    • 78449272957 scopus 로고    scopus 로고
    • Genetic interactions reveal the evolutionary trajectories of duplicate genes
    • VanderSluis B, Bellay J, Musso G, Costanzo M, Papp B, et al. (2010) Genetic interactions reveal the evolutionary trajectories of duplicate genes. Mol Syst Biol 6: 429.
    • (2010) Mol Syst Biol , vol.6 , pp. 429
    • VanderSluis, B.1    Bellay, J.2    Musso, G.3    Costanzo, M.4    Papp, B.5
  • 29
    • 0346672411 scopus 로고    scopus 로고
    • Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans
    • Conant GC, Wagner A, (2004) Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans. Proc Biol Sci 271: 89-96.
    • (2004) Proc Biol Sci , vol.271 , pp. 89-96
    • Conant, G.C.1    Wagner, A.2
  • 30
    • 0038157152 scopus 로고    scopus 로고
    • Dosage sensitivity and the evolution of gene families in yeast
    • Papp B, Pal C, Hurst LD, (2003) Dosage sensitivity and the evolution of gene families in yeast. Nature 424: 194-197.
    • (2003) Nature , vol.424 , pp. 194-197
    • Papp, B.1    Pal, C.2    Hurst, L.D.3
  • 31
    • 64549099468 scopus 로고    scopus 로고
    • Construction and application of a protein and genetic interaction network (yeast interactome)
    • Stuart GR, Copeland WC, Strand MK, (2009) Construction and application of a protein and genetic interaction network (yeast interactome). Nucleic Acids Res 37: e54.
    • (2009) Nucleic Acids Res , vol.37
    • Stuart, G.R.1    Copeland, W.C.2    Strand, M.K.3
  • 32
    • 10744230485 scopus 로고    scopus 로고
    • Global mapping of the yeast genetic interaction network
    • Tong AH, Lesage G, Bader GD, Ding H, Xu H, et al. (2004) Global mapping of the yeast genetic interaction network. Science 303: 808-813.
    • (2004) Science , vol.303 , pp. 808-813
    • Tong, A.H.1    Lesage, G.2    Bader, G.D.3    Ding, H.4    Xu, H.5
  • 33
    • 38049133600 scopus 로고    scopus 로고
    • All duplicates are not equal: the difference between small-scale and genome duplication
    • Hakes L, Pinney JW, Lovell SC, Oliver SG, Robertson DL, (2007) All duplicates are not equal: the difference between small-scale and genome duplication. Genome Biol 8: R209.
    • (2007) Genome Biol , vol.8
    • Hakes, L.1    Pinney, J.W.2    Lovell, S.C.3    Oliver, S.G.4    Robertson, D.L.5
  • 34
    • 20044372938 scopus 로고    scopus 로고
    • Identification and characterization of protein subcomplexes in yeast
    • Hollunder J, Beyer A, Wilhelm T, (2005) Identification and characterization of protein subcomplexes in yeast. Proteomics 5: 2082-2089.
    • (2005) Proteomics , vol.5 , pp. 2082-2089
    • Hollunder, J.1    Beyer, A.2    Wilhelm, T.3
  • 35
    • 60849105400 scopus 로고    scopus 로고
    • Functional organization of the yeast proteome by a yeast interactome map
    • Valente AX, Roberts SB, Buck GA, Gao Y, (2009) Functional organization of the yeast proteome by a yeast interactome map. Proc Natl Acad Sci U S A 106: 1490-1495.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1490-1495
    • Valente, A.X.1    Roberts, S.B.2    Buck, G.A.3    Gao, Y.4
  • 37
    • 74249100674 scopus 로고    scopus 로고
    • Genome-wide association data reveal a global map of genetic interactions among protein complexes
    • Hannum G, Srivas R, Guenole A, van Attikum H, Krogan NJ, et al. (2009) Genome-wide association data reveal a global map of genetic interactions among protein complexes. PLoS Genet 5: e1000782.
    • (2009) PLoS Genet , vol.5
    • Hannum, G.1    Srivas, R.2    Guenole, A.3    van Attikum, H.4    Krogan, N.J.5
  • 39
    • 43249117094 scopus 로고    scopus 로고
    • Functional maps of protein complexes from quantitative genetic interaction data
    • Bandyopadhyay S, Kelley R, Krogan NJ, Ideker T, (2008) Functional maps of protein complexes from quantitative genetic interaction data. PLoS Comput Biol 4: e1000065.
    • (2008) PLoS Comput Biol , vol.4
    • Bandyopadhyay, S.1    Kelley, R.2    Krogan, N.J.3    Ideker, T.4
  • 40
    • 78649705725 scopus 로고    scopus 로고
    • Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
    • Baryshnikova A, Costanzo M, Kim Y, Ding H, Koh J, et al. (2010) Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat Methods 7: 1017-1024.
    • (2010) Nat Methods , vol.7 , pp. 1017-1024
    • Baryshnikova, A.1    Costanzo, M.2    Kim, Y.3    Ding, H.4    Koh, J.5
  • 41
    • 34247847827 scopus 로고    scopus 로고
    • Functional analysis of gene duplications in Saccharomyces cerevisiae
    • Guan Y, Dunham MJ, Troyanskaya OG, (2007) Functional analysis of gene duplications in Saccharomyces cerevisiae. Genetics 175: 933-943.
    • (2007) Genetics , vol.175 , pp. 933-943
    • Guan, Y.1    Dunham, M.J.2    Troyanskaya, O.G.3
  • 42
    • 0035861532 scopus 로고    scopus 로고
    • Systematic genetic analysis with ordered arrays of yeast deletion mutants
    • Tong AH, Evangelista M, Parsons AB, Xu H, Bader GD, et al. (2001) Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294: 2364-2368.
    • (2001) Science , vol.294 , pp. 2364-2368
    • Tong, A.H.1    Evangelista, M.2    Parsons, A.B.3    Xu, H.4    Bader, G.D.5
  • 43
    • 26844489762 scopus 로고    scopus 로고
    • Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
    • Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, et al. (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123: 507-519.
    • (2005) Cell , vol.123 , pp. 507-519
    • Schuldiner, M.1    Collins, S.R.2    Thompson, N.J.3    Denic, V.4    Bhamidipati, A.5
  • 44
    • 77956046092 scopus 로고    scopus 로고
    • Quantitative genetic interaction mapping using the E-MAP approach
    • Collins SR, Roguev A, Krogan NJ, (2010) Quantitative genetic interaction mapping using the E-MAP approach. Methods Enzymol 470: 205-231.
    • (2010) Methods Enzymol , vol.470 , pp. 205-231
    • Collins, S.R.1    Roguev, A.2    Krogan, N.J.3
  • 45
    • 79960642108 scopus 로고    scopus 로고
    • Molecular mechanisms of epistasis within and between genes
    • Lehner B, (2011) Molecular mechanisms of epistasis within and between genes. Trends Genet 27: 323-331.
    • (2011) Trends Genet , vol.27 , pp. 323-331
    • Lehner, B.1
  • 46
    • 53349117774 scopus 로고    scopus 로고
    • High-quality binary protein interaction map of the yeast interactome network
    • Yu H, Braun P, Yildirim MA, Lemmens I, Venkatesan K, et al. (2008) High-quality binary protein interaction map of the yeast interactome network. Science 322: 104-110.
    • (2008) Science , vol.322 , pp. 104-110
    • Yu, H.1    Braun, P.2    Yildirim, M.A.3    Lemmens, I.4    Venkatesan, K.5
  • 47
    • 34547787599 scopus 로고    scopus 로고
    • A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality
    • Hart GT, Lee I, Marcotte ER, (2007) A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality. BMC Bioinformatics 8: 236.
    • (2007) BMC Bioinformatics , vol.8 , pp. 236
    • Hart, G.T.1    Lee, I.2    Marcotte, E.R.3
  • 51
    • 55949124306 scopus 로고    scopus 로고
    • Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes
    • Dixon SJ, Fedyshyn Y, Koh JL, Prasad TS, Chahwan C, et al. (2008) Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci U S A 105: 16653-16658.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16653-16658
    • Dixon, S.J.1    Fedyshyn, Y.2    Koh, J.L.3    Prasad, T.S.4    Chahwan, C.5
  • 54
    • 0033529707 scopus 로고    scopus 로고
    • Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis
    • Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, et al. (1999) Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285: 901-906.
    • (1999) Science , vol.285 , pp. 901-906
    • Winzeler, E.A.1    Shoemaker, D.D.2    Astromoff, A.3    Liang, H.4    Anderson, K.5
  • 56
    • 0030831182 scopus 로고    scopus 로고
    • Genetic and physical maps of Saccharomyces cerevisiae
    • Cherry JM, Ball C, Weng S, Juvik G, Schmidt R, et al. (1997) Genetic and physical maps of Saccharomyces cerevisiae. Nature 387: 67-73.
    • (1997) Nature , vol.387 , pp. 67-73
    • Cherry, J.M.1    Ball, C.2    Weng, S.3    Juvik, G.4    Schmidt, R.5
  • 59
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W, Sherman BT, Lempicki RA, (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • da Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 61
    • 38949195338 scopus 로고    scopus 로고
    • Molecular and cellular approaches for the detection of protein-protein interactions: latest techniques and current limitations
    • Lalonde S, Ehrhardt DW, Loque D, Chen J, Rhee SY, et al. (2008) Molecular and cellular approaches for the detection of protein-protein interactions: latest techniques and current limitations. Plant J 53: 610-635.
    • (2008) Plant J , vol.53 , pp. 610-635
    • Lalonde, S.1    Ehrhardt, D.W.2    Loque, D.3    Chen, J.4    Rhee, S.Y.5
  • 62
    • 51049106560 scopus 로고    scopus 로고
    • Advanced technologies for studies on protein interactomes
    • Guan H, Kiss-Toth E, (2008) Advanced technologies for studies on protein interactomes. Adv Biochem Eng Biotechnol 110: 1-24.
    • (2008) Adv Biochem Eng Biotechnol , vol.110 , pp. 1-24
    • Guan, H.1    Kiss-Toth, E.2


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