Atrioventricular conduction and arrhythmias at the initiation of beating in embryonic mouse hearts

Developmental Dynamics

Volumn 239, Issue 7, 2010, Pages 1941-1949

  Chen, Fuhua ^a   De Diego, Carlos ^a   Chang, Marvin G ^a   McHarg, Jennifer L ^a   John, Scott ^a   Klitzner, Thomas S ^a   Weiss, James N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Action potential; Arrhythmias; AV conduction; Calcium transient; Cardiac development; Mouse embryo; Optical mapping

Indexed keywords

4 (N ETHYL N PHENYLAMINO) 1,2 DIMETHYL 6 (METHYLAMINO)PYRIMIDINIUM CHLORIDE; ADENOSINE; CALCIUM CHANNEL; NIFEDIPINE; TETRODOTOXIN; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRIOVENTRICULAR CONDUCTION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; EMBRYONAL TISSUE; ENDOPLASMIC RETICULUM; FEMALE; HEART ARRHYTHMIA; HEART BEAT; MEMBRANE POTENTIAL; MOUSE; MOUSE EMBRYO; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; SINUS NODE CONDUCTION VELOCITY; ANIMAL; ATRIOVENTRICULAR BLOCK; CHEMICALLY INDUCED; DRUG EFFECTS; EMBRYOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; HEART; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; ATRIOVENTRICULAR BLOCK; CALCIUM; CALCIUM CHANNEL BLOCKERS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HEART; MALE; MEMBRANE POTENTIALS; MICE; NIFEDIPINE; PREGNANCY;

EID: 77953764758     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22319     Document Type: Article

References (31)

1. Chen F, Klitzner TS, Weiss JN. 2006. Autonomic regulation of calcium cycling in developing embryonic mouse hearts. Cell Calcium 39:375-385.
2. Chuck ET, Freeman DM, Watanabe M, Rosenbaum DS. 1997. Changing activation sequence in the embryonic chick heart. Implications for the development of the His-Purkinje system. Circ Res 81:470-476.
3. de Jong F, Opthof T, Wilde AA, Janse MJ, Charles R, Lamers WH, Moorman AF. 1992. Persisting zones of slow impulse conduction in developing chicken hearts. Circ Res 71:240-250.
4. Efimov IR, Nikolski VP, Rothenberg F, Greener ID, Li J, Dobrzynski H, Boyett M. 2004. Structure-function relationship in the AV junction. Anat Rec A Discov Mol Cell Evol Biol 280:952-965.
5. Forouhar AS, Liebling M, Hickerson A, Nasiraei-Moghaddam A, Tsai HJ, Hove JR, Fraser SE, Dickinson ME, Gharib M. 2006. The embryonic vertebrate heart tube is a dynamic suction pump. Science 312:751-753.
6. Herrmann S, Stieber J, Stockl G, Hofmann F, Ludwig A. 2007. HCN4 provides a "depolarization reserve" and is not required for heart rate acceleration in mice. Embo J 26:4423-4432. (Pubitemid 350036626)
7. Husse B, Wussling M. 1996. Developmental changes of calcium transients and contractility during the cultivation of rat neonatal cardiomyocytes. Mol Cell Biochem 163-164:13-21. (Pubitemid 26421481)
8. Klitzner TS, Chen FH, Raven RR, Wetzel GT, Friedman WF. 1991. Calcium current and tension generation in immature mammalian myocardium: effects of diltiazem. J Mol Cell Cardiol 23:807-815.
9. Koushik SV, Wang J, Rogers R, Moskophidis D, Lambert NA, Creazzo TL, Conway SJ. 2001. Targeted inactivation of the sodium-calcium exchanger (Ncx1) results in the lack of a heartbeat and abnormal myofibrillar organization. Faseb J 15:1209-1211.
10. Maltsev VA, Lakatta EG. 2008. Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function. Cardiovasc Res 77:274-284.
11. Mikawa T, Hurtado R. 2007. Development of the cardiac conduction system. Semin Cell Dev Biol 18:90-100.
12. Miura M, Boyden PA, ter Keurs HE. 1998. Ca2+ waves during triggered propagated contractions in intact trabeculae. Am J Physiol 274:H266-276.
13. Moorman AF, Christoffels VM. 2003. Cardiac chamber formation: development, genes, and evolution. Physiol Rev 83:1223-1267. (Pubitemid 37222272)
14. Moorman AF, de Jong F, Denyn MM, Lamers WH. 1998. Development of the cardiac conduction system. Circ Res 82:629-644.
15. Phoon CK. 2001. Circulatory physiology in the developing embryo. Curr Opin Pediatr 13:456-464.
16. Raddatz E, Gardier S, Sarre A. 2006. Physiopathology of the embryonic heart (with special emphasis on hypoxia and reoxygenation). Ann Cardiol Angeiol (Paris) 55:79-89.
17. Reckova M, Rosengarten C, deAlmeida A, Stanley CP, Wessels A, Gourdie RG, Thompson RP, Sedmera D. 2003. Hemodynamics is a key epigenetic factor in development of the cardiac conduction system. Circ Res 93:77-85.
18. Rentschler S, Vaidya DM, Tamaddon H, Degenhardt K, Sassoon D, Morley GE, Jalife J, Fishman GI. 2001. Visualization and functional characterization of the developing murine cardiac conduction system. Development 128:1785-1792. (Pubitemid 32514858)
19. Rentschler S, Zander J, Meyers K, France D, Levine R, Porter G, Rivkees SA, Morley GE, Fishman GI. 2002. Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc Natl Acad Sci USA 99:10464-10469. (Pubitemid 36775531)
20. Reuter H, Henderson SA, Han T, Mottino GA, Frank JS, Ross RS, Goldhaber JI, Philipson KD. 2003. Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange. Cell Calcium 34:19-26. (Pubitemid 36790440)
21. Rothenberg F, Nikolski VP, Watanabe M, Efimov IR. 2005. Electrophysiology and anatomy of embryonic rabbit hearts before and after septation. Am J Physiol Heart Circ Physiol 288:H344-351. (Pubitemid 40023865)
22. Sarre A, Maury P, Kucera P, Kappenberger L, Raddatz E. 2006. Arrhythmogenesis in the developing heart during anoxia-reoxygenation and hypothermia-rewarming: an in vitro model. J Cardiovasc Electrophysiol 17:1350-1359. (Pubitemid 44808558)
23. Sasse P, Zhang J, Cleemann L, Morad M, Hescheler J, Fleischmann BK. 2007. Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells. J Gen Physiol 130:133-144. (Pubitemid 47204905)
24. Sedmera D, Reckova M, DeAlmeida A, Coppen SR, Kubalak SW, Gourdie RG, Thompson RP. 2003. Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system. Anat Rec A DiscovMol Cell Evol Biol 274:773-777.
25. Srinivasan S, Baldwin HS, Aristizabal O, Kwee L, Labow M, Artman M, Turnbull DH. 1998. Noninvasive, in utero imaging of mouse embryonic heart development with 40-MHz echocardiography. Circulation 98:912-918.
26. Stieber J, Herrmann S, Feil S, Loster J, Feil R, Biel M, Hofmann F, Ludwig A. 2003. The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci USA 100:15235-15240.
27. Valderrabano M, Chen F, Dave AS, Lamp ST, Klitzner TS, Weiss JN. 2006. Atrioventricular ring reentry in embryonic mouse hearts. Circulation 114:543-549.
28. Wakimoto K, Kobayashi K, Kuro OM, Yao A, Iwamoto T, Yanaka N, Kita S, Nishida A, Azuma S, Toyoda Y, Omori K, Imahie H, Oka T, Kudoh S, Kohmoto O, Yazaki Y, Shigekawa M, Imai Y, Nabeshima Y, Komuro I. 2000. Targeted disruption of Na+/Ca2+ exchanger gene leads to cardiomyocyte apoptosis and defects in heartbeat. J Biol Chem 275:36991-36998.
29. Wakimoto K, Fujimura H, Iwamoto T, Oka T, Kobayashi K, Kita S, Kudoh S, Kuro-o M, Nabeshima Y, Shigekawa M, Imai Y, Komuro I. 2003. Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes. Comp Biochem Physiol B Biochem Mol Biol 135:9-15.
30. Weiss J, Goldman Y, Morad M. 1976. Electromechanical properties of the single cell-layered heart of tunicate Boltenia ovifera (sea potato). J Gen Physiol 68:503-518.
31. Zimmermann WH, Schneiderbanger K, Schubert P, Didie M, Munzel F, Heubach JF, Kostin S, Neuhuber WL, Eschenhagen T. 2002. Tissue engineering of a differentiated cardiac muscle construct. Circ Res 90:223-230. (Pubitemid 34627092)