메뉴 건너뛰기




Volumn 110, Issue 17, 2013, Pages 6991-6996

Paracrine Wnt signaling both promotes and inhibits human breast tumor growth

Author keywords

Luciferase; Tumor stroma; Wnt responsive reporter

Indexed keywords

CLAUDIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; LENTIVIRUS VECTOR; WNT PROTEIN; WNT3A PROTEIN;

EID: 84876861153     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303671110     Document Type: Article
Times cited : (69)

References (38)
  • 1
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • Clevers H, Nusse R (2012) Wnt/β-catenin signaling and disease. Cell 149(6):1192-1205.
    • (2012) Cell , vol.149 , Issue.6 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 2
    • 0020216124 scopus 로고
    • Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
    • Nusse R, Varmus HE (1982) Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31(1): 99-109.
    • (1982) Cell , vol.31 , Issue.1 , pp. 99-109
    • Nusse, R.1    Varmus, H.E.2
  • 3
    • 33644857012 scopus 로고    scopus 로고
    • Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism
    • Ayyanan A, et al. (2006) Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci USA 103(10):3799-3804.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.10 , pp. 3799-3804
    • Ayyanan, A.1
  • 4
    • 79960857043 scopus 로고    scopus 로고
    • Key signaling nodes in mammary gland development and cancer: β-catenin
    • Incassati A, Chandramouli A, Eelkema R, Cowin P (2010) Key signaling nodes in mammary gland development and cancer: β-catenin. Breast Cancer Res 12(6):213.
    • (2010) Breast Cancer Res , vol.12 , Issue.6 , pp. 213
    • Incassati, A.1    Chandramouli, A.2    Eelkema, R.3    Cowin, P.4
  • 5
    • 0033976526 scopus 로고    scopus 로고
    • Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer
    • Jönsson M, Borg A, Nilbert M, Andersson T (2000) Involvement of adenomatous polyposis coli (APC)/beta-catenin signalling in human breast cancer. Eur J Cancer 36(2):242-248.
    • (2000) Eur J Cancer , vol.36 , Issue.2 , pp. 242-248
    • Jönsson, M.1    Borg, A.2    Nilbert, M.3    Andersson, T.4
  • 6
    • 0034636153 scopus 로고    scopus 로고
    • Beta-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression
    • Lin SY, et al. (2000) Beta-catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci USA 97(8): 4262-4266.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.8 , pp. 4262-4266
    • Lin, S.Y.1
  • 7
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487(7407):330-337.
    • (2012) Nature , vol.487 , Issue.7407 , pp. 330-337
  • 8
    • 3142590865 scopus 로고    scopus 로고
    • Wnt signaling and breast cancer
    • Howe LR, Brown AM (2004) Wnt signaling and breast cancer. Cancer Biol Ther 3(1): 36-41.
    • (2004) Cancer Biol Ther , vol.3 , Issue.1 , pp. 36-41
    • Howe, L.R.1    Brown, A.M.2
  • 9
    • 47149097853 scopus 로고    scopus 로고
    • Epigenetic gene silencing in the Wnt pathway in breast cancer
    • Klarmann GJ, Decker A, Farrar WL (2008) Epigenetic gene silencing in the Wnt pathway in breast cancer. Epigenetics 3(2):59-63.
    • (2008) Epigenetics , vol.3 , Issue.2 , pp. 59-63
    • Klarmann, G.J.1    Decker, A.2    Farrar, W.L.3
  • 10
    • 0035138178 scopus 로고    scopus 로고
    • Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling
    • van de Wetering M, et al. (2001) Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling. Cancer Res 61(1):278-284.
    • (2001) Cancer Res , vol.61 , Issue.1 , pp. 278-284
    • Van De Wetering, M.1
  • 11
    • 7944230668 scopus 로고    scopus 로고
    • An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells
    • Bafico A, Liu G, Goldin L, Harris V, Aaronson SA (2004) An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell 6(5):497-506.
    • (2004) Cancer Cell , vol.6 , Issue.5 , pp. 497-506
    • Bafico, A.1    Liu, G.2    Goldin, L.3    Harris, V.4    Aaronson, S.A.5
  • 12
    • 74049105681 scopus 로고    scopus 로고
    • WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth
    • Matsuda Y, Schlange T, Oakeley EJ, Boulay A, Hynes NE (2009) WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth. Breast Cancer Res 11(3):R32.
    • (2009) Breast Cancer Res , vol.11 , Issue.3
    • Matsuda, Y.1    Schlange, T.2    Oakeley, E.J.3    Boulay, A.4    Hynes, N.E.5
  • 13
    • 67650496215 scopus 로고    scopus 로고
    • A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer
    • DiMeo TA, et al. (2009) A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res 69(13):5364-5373.
    • (2009) Cancer Res , vol.69 , Issue.13 , pp. 5364-5373
    • Dimeo, T.A.1
  • 14
    • 68049137311 scopus 로고    scopus 로고
    • A novel far-red bimolecular fluorescence complementation system that allows for efficient visualization of protein interactions under physiological conditions
    • Chu J, et al. (2009) A novel far-red bimolecular fluorescence complementation system that allows for efficient visualization of protein interactions under physiological conditions. Biosens Bioelectron 25(1):234-239.
    • (2009) Biosens Bioelectron , vol.25 , Issue.1 , pp. 234-239
    • Chu, J.1
  • 15
    • 58749086442 scopus 로고    scopus 로고
    • Assaying beta-catenin/TCF transcription with beta-cat-enin/TCF transcription-based reporter constructs
    • Biechele TL, Moon RT (2008) Assaying beta-catenin/TCF transcription with beta-cat-enin/TCF transcription-based reporter constructs. Methods Mol Biol 468:99-110.
    • (2008) Methods Mol Biol , vol.468 , pp. 99-110
    • Biechele, T.L.1    Moon, R.T.2
  • 16
    • 36148965120 scopus 로고    scopus 로고
    • Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID beta2mnull mice
    • Nervi B, et al. (2007) Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID beta2mnull mice. Exp Hematol 35(12):1823-1838.
    • (2007) Exp Hematol , vol.35 , Issue.12 , pp. 1823-1838
    • Nervi, B.1
  • 17
    • 84874848068 scopus 로고    scopus 로고
    • Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities
    • Green JL, et al. (2013) Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities. PLoS ONE 8(3): e58395.
    • (2013) PLoS ONE , vol.8 , Issue.3
    • Green, J.L.1
  • 18
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, et al. (2000) Molecular portraits of human breast tumours. Nature 406(6797):747-752.
    • (2000) Nature , vol.406 , Issue.6797 , pp. 747-752
    • Perou, C.M.1
  • 19
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sørlie T, et al. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98(19):10869-10874.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.19 , pp. 10869-10874
    • Sørlie, T.1
  • 20
    • 34548863946 scopus 로고    scopus 로고
    • Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    • Herschkowitz JI, et al. (2007) Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 8(5):R76.
    • (2007) Genome Biol , vol.8 , Issue.5
    • Herschkowitz, J.I.1
  • 21
    • 67650252530 scopus 로고    scopus 로고
    • Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery
    • Kao J, et al. (2009) Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. PLoS ONE 4(7): e6146.
    • (2009) PLoS ONE , vol.4 , Issue.7
    • Kao, J.1
  • 22
    • 33845209913 scopus 로고    scopus 로고
    • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    • Neve RM, et al. (2006) A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 10(6):515-527.
    • (2006) Cancer Cell , vol.10 , Issue.6 , pp. 515-527
    • Neve, R.M.1
  • 23
    • 78049308800 scopus 로고    scopus 로고
    • Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
    • Prat A, et al. (2010) Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res 12(5):R68.
    • (2010) Breast Cancer Res , vol.12 , Issue.5
    • Prat, A.1
  • 24
    • 1842687362 scopus 로고    scopus 로고
    • Reconstruction of functionally normal and malignant human breast tissues in mice
    • Kuperwasser C, et al. (2004) Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci USA 101(14):4966-4971.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.14 , pp. 4966-4971
    • Kuperwasser, C.1
  • 25
    • 81255135837 scopus 로고    scopus 로고
    • Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes
    • DeRose YS, et al. (2011) Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes. Nat Med 17(11):1514-1520.
    • (2011) Nat Med , vol.17 , Issue.11 , pp. 1514-1520
    • Derose, Y.S.1
  • 26
    • 0027509891 scopus 로고
    • Keratin immunohistochemistry: Update of applications and pitfalls
    • Miettinen M (1993) Keratin immunohistochemistry: Update of applications and pitfalls. Pathol Annu 28(Pt 2):113-143.
    • (1993) Pathol Annu , vol.28 , Issue.PART 2 , pp. 113-143
    • Miettinen, M.1
  • 27
    • 77957262381 scopus 로고    scopus 로고
    • Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    • Taube JH, et al. (2010) Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci USA 107(35):15449-15454.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.35 , pp. 15449-15454
    • Taube, J.H.1
  • 28
    • 84867371728 scopus 로고    scopus 로고
    • Canonical Wnt signaling regulates Slug activity and links epi-thelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression
    • Wu ZQ, et al. (2012) Canonical Wnt signaling regulates Slug activity and links epi-thelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression. Proc Natl Acad Sci USA 109(41):16654-16659.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.41 , pp. 16654-16659
    • Wu, Z.Q.1
  • 29
    • 33751514601 scopus 로고    scopus 로고
    • A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells
    • Yook JI, et al. (2006) A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 8(12):1398-1406.
    • (2006) Nat Cell Biol , vol.8 , Issue.12 , pp. 1398-1406
    • Yook, J.I.1
  • 30
    • 40449138006 scopus 로고    scopus 로고
    • Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation
    • Schlange T, Matsuda Y, Lienhard S, Huber A, Hynes NE (2007) Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res 9(5):R63.
    • (2007) Breast Cancer Res , vol.9 , Issue.5
    • Schlange, T.1    Matsuda, Y.2    Lienhard, S.3    Huber, A.4    Hynes, N.E.5
  • 31
    • 84863352083 scopus 로고    scopus 로고
    • Activation status of Wnt/ß-catenin signaling in normal and neoplastic breast tissues: Relationship to HER2/neu expression in human and mouse
    • Khalil S, Tan GA, Giri DD, Zhou XK, Howe LR (2012) Activation status of Wnt/ß-catenin signaling in normal and neoplastic breast tissues: Relationship to HER2/neu expression in human and mouse. PLoS ONE 7(3):e33421.
    • (2012) PLoS ONE , vol.7 , Issue.3
    • Khalil, S.1    Tan, G.A.2    Giri, D.D.3    Zhou, X.K.4    Howe, L.R.5
  • 32
    • 79551624262 scopus 로고    scopus 로고
    • Beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation
    • Geyer FC, et al. (2011) beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation. Mod Pathol 24(2): 209-231.
    • (2011) Mod Pathol , vol.24 , Issue.2 , pp. 209-231
    • Geyer, F.C.1
  • 33
    • 77953183234 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    • Khramtsov AI, et al. (2010) Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am J Pathol 176(6):2911-2920.
    • (2010) Am J Pathol , vol.176 , Issue.6 , pp. 2911-2920
    • Khramtsov, A.I.1
  • 34
    • 84871392766 scopus 로고    scopus 로고
    • Expression of Wnt3 activates Wnt/beta-catenin pathway and promotes EMT-like phenotype in trastuzumab resistant HER2-overexpressing breast cancer cells
    • Wu Y, et al. (2012) Expression of Wnt3 activates Wnt/beta-catenin pathway and promotes EMT-like phenotype in trastuzumab resistant HER2-overexpressing breast cancer cells. Mol Cancer Res 10(12):1597-1606.
    • (2012) Mol Cancer Res , vol.10 , Issue.12 , pp. 1597-1606
    • Wu, Y.1
  • 35
    • 13944259795 scopus 로고    scopus 로고
    • Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia
    • Teulière J, et al. (2005) Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia. Development 132(2):267-277.
    • (2005) Development , vol.132 , Issue.2 , pp. 267-277
    • Teulière, J.1
  • 36
    • 0037039355 scopus 로고    scopus 로고
    • Activation of beta-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias
    • Miyoshi K, et al. (2002) Activation of beta-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias. Proc Natl Acad Sci USA 99(1):219-224.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.1 , pp. 219-224
    • Miyoshi, K.1
  • 38
    • 48149107133 scopus 로고    scopus 로고
    • Wnt signaling promotes reprogramming of somatic cells to pluripotency
    • Marson A, et al. (2008) Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell 3(2):132-135.
    • (2008) Cell Stem Cell , vol.3 , Issue.2 , pp. 132-135
    • Marson, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.