Bacterial mutagenicity screening in the pharmaceutical industry

Mutation Research - Reviews in Mutation Research

Volumn 752, Issue 2, 2013, Pages 99-118

  Escobar, P A ^a   Kemper, R A ^a,m   Tarca, J ^a   Nicolette, J ^c   Kenyon, M ^d   Glowienke, S ^e   Sawant, S G ^f   Christensen, J ^b   Johnson, T E ^b   McKnight, C ^b   Ward, G ^b   Galloway, S M ^b   Custer, L ^g   Gocke, E ^h   O'Donovan, M R ⁱ   Braun, K ^j   Snyder, R D ^b,k   Mahadevan, B ^b,l  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c ABBVIE INC   (United States)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^e NOVARTIS PHARMA AG   (Switzerland)

^f AMGEN INC   (United States)

^g BRISTOL MYERS SQUIBB   (United States)

^h F HOFFMANN LA ROCHE LTD   (Switzerland)

ⁱ ASTRAZENECA   (United Kingdom)

^j SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^k RDS Consulting Services   (United States)

^l ABBOTT LABORATORIES   (United States)

^m HOFFMANN LA ROCHE INC   (United States)

more..

Author keywords

Ames assay; Genotoxicity; High throughput; Miniaturized Ames test; Mutagenicity; Screening; Screening Ames

Indexed keywords

DNA; FLUOROURACIL; ANTIINFECTIVE AGENT; MUTAGENIC AGENT;

AMES MICROPLATE FORMAT ASSAY; AMES TEST; ASSAY; BACTERIAL STRAIN; DNA REPAIR; DRUG INDUSTRY; ESCHERICHIA COLI; GENOTOXICITY; MODIFIED FLUCTUATION TEST; MODIFIED VITOTOX ASSAY; MUTAGEN TESTING; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; REVIEW; SALMONELLA; SCREENING TEST; SENSITIVITY AND SPECIFICITY; SOS CHROMOTEST; BACTERIA; DRUG EFFECTS; DRUG SCREENING; GENETICS; HUMAN; MUTATION; PROCEDURES;

BACTERIA (MICROORGANISMS);

ANTI-BACTERIAL AGENTS; BACTERIA; DRUG EVALUATION, PRECLINICAL; DRUG INDUSTRY; HUMANS; MUTAGENICITY TESTS; MUTAGENS; MUTATION;

EID: 84876815371     PISSN: 13835742     EISSN: 13882139     Source Type: Journal    
DOI: 10.1016/j.mrrev.2012.12.002     Document Type: Review

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