Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 467, Issue 1, 2000, Pages 11-19

  Piegorsch, Walter W ^a   Simmons, Susan J ^a   Margolin, Barry H ^b   Zeiger, Errol ^c   Gidrol, Xavier M ^d   Gee, Pauline ^d  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b IL   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d Xenometrix Inc USA   (United States)

Author keywords

Ames II strains; Complementary log log link function; Culture by dose interaction; Fluctuation test; Generalized linear model; His mutant tester strains; Many to one testing; Multiple comparisons with a control; Salmonella typhimurium; Statistical methods

Indexed keywords

CUMENE HYDROPEROXIDE; NITROFURANTOIN;

AMES TEST; ARTICLE; GENOTOXICITY; MUTAGEN TESTING; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; STATISTICAL ANALYSIS; STATISTICAL MODEL;

ANALYSIS OF VARIANCE; BENZENE DERIVATIVES; GENOTYPE; MODELS, STATISTICAL; MUTAGENICITY TESTS; MUTAGENS; MUTATION; NITROFURANTOIN; SALMONELLA TYPHIMURIUM; SEROLOGY;

SALMONELLA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0034643459     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(00)00019-X     Document Type: Article

References (18)

1. Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113:1983;173-215.
2. Mortelmans K., Haworth S., Lawlor T., Speck W., Tainer B., Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ. Mutagen. 8(Suppl. 7):1986;1-119.
3. Zeiger E., Anderson B., Haworth S., Lawlor T., Mortelmans K., Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ. Mutagen. 9(Suppl. 9):1987;1-109.
4. Zeiger E., Anderson B., Haworth S., Lawlor T. Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ. Mutagen. 11(Suppl. 12):1988;1-158.
5. Gee P., Sommers C.H., Melick A.S., Gidrol X.M., Todd M.D., Burris R.B., Nelson M.N., Klemm R.C., Zeiger E. Comparison of responses of base-specific Salmonella tester strains with the traditional strains for identifying mutagens: the results of a validation study. Mutat. Res. 412:1998;115-130.
6. Gee P., Maron D.M., Ames B.N. Detection and classification of mutagens: a set of base-specific Salmonella tester strains. Proc. Natl. Acad. Sci. U.S.A. 91:1994;11606-11610.
7. Green M.H.L., Muriel W.J., Bridges B.A. Use of a simplified fluctuation test to detect low levels of mutagens. Mutat. Res. 38:1976;33-42.
8. Gatehouse D.G., Delow G.F. The development of a "microtitre®" fluctuation test for the development of indirect mutagens, and its use in the evaluation of mixed enzyme induction of the liver. Mutat. Res. 60:1979;239-252.
9. Neter J., Kutner M.H., Nachtsheim C.J., Wasserman W. Applied Linear Statistical Models. 4th edn. 1996;R.D. Irwin, Chicago, IL.
10. Piegorsch W.W., Bailer A.J. Statistics for Environmental Biology and Toxicology. 1997;Chapman & Hall/CRC Press, Boca Raton, FL.
11. McCullagh P., Nelder J.A. Generalized Linear Models. 2nd edn. 1989;Chapman & Hall, London.
12. SAS/Stat® Software: Changes and Enhancements through Release 6.12. 1989;SAS Institute, Cary, NC.
13. Piegorsch W.W. One-sided significance tests for generalized linear models under dichotomous response. Biometrics. 46:1990;309-316.
14. Kim B.S., Margolin B.H. Statistical methods for the Ames Salmonella assay: a review. Mutat. Res. 436:1999;113-122.
15. Simpson D.G., Margolin B.H. Recursive nonparametric testing for dose-response relationships subject to downturns at high doses. Biometrika. 73:1986;589-596.
16. Lim D.H., Wolfe D.A. Nonparametric tests for comparing umbrella pattern treatment effects with a control in a randomized block design. Biometrics. 53:1997;410-418.
17. Shi N.-Z. Testing for umbrella order restrictions on multinomial parameters. Sankhya Ser. B. 51:1989;13-23.
18. Cohen A., Sackrowitz H.B. Inadmissibility of some tests for order-restricted alternatives. Stat. Probability Lett. 24:1995;153-156.