Regulation of oxidative stress by Nrf2 in the pathophysiology of infectious diseases

Medecine et Maladies Infectieuses

Volumn 43, Issue 3, 2013, Pages 100-107

  Deramaudt, T B ^a   Dill, C ^a,b   Bonay, M ^a,c  

^a LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^b INSERM   (France)

^c HÔPITAL AMBROISE PARÉ   (France)

Author keywords

Antioxidants; Infection; Nrf2; Oxidative stress; ROS

Indexed keywords

BARDOXOLONE METHYL; EPIGALLOCATECHIN GALLATE; FUMARIC ACID DIMETHYL ESTER; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2;

APOPTOSIS; DEFENSE MECHANISM; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; HERPES SIMPLEX; HUMAN; INFLUENZA A; KIDNEY INJURY; MULTIPLE SCLEROSIS; MYCOBACTERIOSIS; NONHUMAN; OXIDATIVE STRESS; PARASITOSIS; PATHOGENESIS; PATHOPHYSIOLOGY; PHAGOCYTE; PHASE 3 CLINICAL TRIAL (TOPIC); PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PSORIASIS; REVIEW; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; TISSUE INJURY; UNSPECIFIED SIDE EFFECT; VIRUS INFECTION;

ANIMALS; ANTIOXIDANTS; BACTERIAL INFECTIONS; COMMUNICABLE DISEASES; GENE EXPRESSION REGULATION; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR TARGETED THERAPY; MYCOBACTERIUM INFECTIONS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PARASITIC DISEASES; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES; TRANSCRIPTION, GENETIC; VIRUS DISEASES;

EID: 84876788364     PISSN: 0399077X     EISSN: 17696690     Source Type: Journal    
DOI: 10.1016/j.medmal.2013.02.004     Document Type: Review

References (54)

1. Silva M.T. When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system. J Leukoc Biol 2010, 87(1):93-106.
2. Calkins M.J., Johnson D.A., Townsend J.A., Vargas M.R., Dowell J.A., Williamson T.P., et al. The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease. Antioxid Redox Signal 2009, 11(3):497-508.
3. Touyz R.M. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance?. Hypertension 2004, 44(3):248-252.
4. Van Eeden S., Leipsic J., Paul Man S.F., Sin D.D. The relationship between lung inflammation and cardiovascular disease. Am J Respir Crit Care Med 2012, 186(1):11-16.
5. Kregel K.C., Zhang H.J. An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. Am J Physiol Regul Integr Comp Physiol 2007, 292(1):R18-R36.
6. Kundu J.K., Surh Y.J. Emerging avenues linking inflammation and cancer. Free Radic Biol Med 2012, 52(9):2013-2037.
7. Moi P., Chan K., Asunis I., Cao A., Kan Y.W. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci U S A 1994, 91(21):9926-9930.
8. Cullinan S.B., Gordan J.D., Jin J., Harper J.W., Diehl J.A. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol 2004, 24(19):8477-8486.
9. Jin Y., Kim H.P., Chi M., Ifedigbo E., Ryter S.W., Choi A.M. Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1. Am J Respir Cell Mol Biol 2008, 39(2):171-179.
10. Volonte D., Galbiati F. Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence. EMBO Rep 2009, 10(12):1334-1340.
11. Li W., Liu H., Zhou J.S., Cao J.F., Zhou X.B., Choi A.M., et al. Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2). J Biol Chem 2012, 287(25):20922-20930.
12. Kang K.W., Lee S.J., Park J.W., Kim S.G. Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress. Mol Pharmacol 2002, 62(5):1001-1010.
13. Kimura M., Yamamoto T., Zhang J., Itoh K., Kyo M., Kamiya T., et al. Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer. J Biol Chem 2007, 282(46):33681-33690.
14. Alam J., Stewart D., Touchard C., Boinapally S., Choi A.M., Cook J.L. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 1999, 274(37):26071-26078.
15. Jain A.K., Jaiswal A.K. GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2. J Biol Chem 2007, 282(22):16502-16510.
16. Rada P., Rojo A.I., Chowdhry S., McMahon M., Hayes J.D., Cuadrado A. SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol 2011, 31(6):1121-1133.
17. Yu S., Khor T.O., Cheung K.L., Li W., Wu T.Y., Huang Y., et al. Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice. PLoS One 2010, 5(1):e8579.
18. Arisawa T., Tahara T., Shibata T., Nagasaka M., Nakamura M., Kamiya Y., et al. The relationship between Helicobacter pylori infection and promoter polymorphism of the Nrf2 gene in chronic gastritis. Int J Mol Med 2007, 19(1):143-148.
19. Thimmulappa R.K., Scollick C., Traore K., Yates M., Trush M.A., Liby K.T., et al. Nrf2-dependent protection from LPS-induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun 2006, 351(4):883-889.
20. MacGarvey N.C., Suliman H.B., Bartz R.R., Fu P., Withers C.M., Welty-Wolf K.E., et al. Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis. Am J Respir Crit Care Med 2012, 185(8):851-861.
21. Athale J., Ulrich A., Chou Macgarvey N., Bartz R.R., Welty-Wolf K.E., Suliman H.B., et al. Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice. Free Radic Biol Med 2012, 53(8):1584-1594.
22. Hoetzenecker W., Echtenacher B., Guenova E., Hoetzenecker K., Woelbing F., Bruck J., et al. ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nat Med 2011, 18(1):128-134.
23. Seto S., Tsujimura K., Koide Y. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Traffic 2011, 12(4):407-420.
24. Vijayamalini M., Manoharan S. Lipid peroxidation, vitamins C, E and reduced glutathione levels in patients with pulmonary tuberculosis. Cell Biochem Funct 2004, 22(1):19-22.
25. Palanisamy G.S., Kirk N.M., Ackart D.F., Shanley C.A., Orme I.M., Basaraba R.J. Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis. PLoS One 2011, 6(10):e26254.
26. Roux A.L., Ray A., Pawlik A., Medjahed H., Etienne G., Rottman M., et al. Overexpression of pro-inflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants. Cell Microbiol 2011, 13(5):692-704.
27. Oberley-Deegan R.E., Rebits B.W., Weaver M.R., Tollefson A.K., Bai X., McGibney M., et al. An oxidative environment promotes growth of Mycobacterium abscessus. Free Radic Biol Med 2010, 49(11):1666-1673.
28. Oberley-Deegan R.E., Lee Y.M., Morey G.E., Cook D.M., Chan E.D., Crapo J.D. The antioxidant mimetic MnTE-2-PyP, reduces intracellular growth of Mycobacterium abscessus. Am J Respir Cell Mol Biol 2009, 41(2):170-178.
29. Itzhaki R.F., Lin W.R., Shang D., Wilcock G.K., Faragher B., Jamieson G.A. Herpes simplex virus type 1 in brain and risk of Alzheimer's disease. Lancet 1997, 349(9047):241-244.
30. Schachtele S.J., Hu S., Lokensgard J.R. Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment. PLoS One 2012, 7(4):e36216.
31. Sacktor N., Haughey N., Cutler R., Tamara A., Turchan J., Pardo C., et al. Novel markers of oxidative stress in actively progressive HIV dementia. J Neuroimmunol 2004, 157(1-2):176-184.
32. Price T.O., Uras F., Banks W.A., Ercal N. A novel antioxidant N-acetylcysteine amide prevents gp120- and Tat-induced oxidative stress in brain endothelial cells. Exp Neurol 2006, 201(1):193-202.
33. Fan X., Joshi P.C., Koval M., Guidot D.M. Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats. Alcohol Clin Exp Res 2011, 35(10):1866-1875.
34. Lupberger J., Hildt E. Hepatitis B virus-induced oncogenesis. World J Gastroenterol 2007, 13(1):74-81.
35. Schaedler S., Krause J., Himmelsbach K., Carvajal-Yepes M., Lieder F., Klingel K., et al. Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2. J Biol Chem 2010, 285(52):41074-41086.
36. Ivanov A.V., Smirnova O.A., Ivanova O.N., Masalova O.V., Kochetkov S.N., Isaguliants M.G. Hepatitis C virus proteins activate NRF2/ARE pathway by distinct ROS-dependent and independent mechanisms in HUH7 cells. PLoS One 2011, 6(9):e24957.
37. Kosmider B., Messier E.M., Janssen W.J., Nahreini P., Wang J., Hartshorn K.L., et al. Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus. Respir Res 2012, 13(1):43.
38. Kesic M.J., Simmons S.O., Bauer R., Jaspers I. Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells. Free Radic Biol Med 2011, 51(2):444-453.
39. Boutten A., Goven D., Artaud-Macari E., Boczkowski J., Bonay M. NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease. Trends Mol Med 2011, 17(7):363-371.
40. Goven D., Boutten A., Lecon-Malas V., Marchal-Somme J., Amara N., Crestani B., et al. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Thorax 2008, 63(10):916-924.
41. Yageta Y., Ishii Y., Morishima Y., Masuko H., Ano S., Yamadori T., et al. Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice. J Virol 2011, 85(10):4679-4690.
42. Paiva C.N., Feijo D.F., Dutra F.F., Carneiro V.C., Freitas G.B., Alves L.S., et al. Oxidative stress fuels Trypanosoma cruzi infection in mice. J Clin Invest 2012, 122(7):2531-2542.
43. Olagnier D., Lavergne R.A., Meunier E., Lefevre L., Dardenne C., Aubouy A., et al. Nrf2, a PPARgamma alternative pathway to promote CD36 expression on inflammatory macrophages: implication for malaria. PLoS Pathog 2011, 7(9):e1002254.
44. Harvey C.J., Thimmulappa R.K., Sethi S., Kong X., Yarmus L., Brown R.H., et al. Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model. Sci Transl Med 2011, 3(78):78ra32.
45. Ling J.X., Wei F., Li N., Li J.L., Chen L.J., Liu Y.Y., et al. Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea. Acta Pharmacol Sin 2012, 33(12):1533-1541.
46. Steinmann J., Buer J., Pietschmann T., Steinmann E. Anti-infective properties of Epigallocatechin-3-gallate (EGCG), a component of Green Tea. Br J Pharmacol 2013, 168(5):1059-1073.
47. Kappos L., Gold R., Miller D.H., Macmanus D.G., Havrdova E., Limmroth V., et al. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet 2008, 372(9648):1463-1472.
48. Seidel P., Merfort I., Hughes J.M., Oliver B.G., Tamm M., Roth M. Dimethylfumarate inhibits NF-{kappa}B function at multiple levels to limit airway smooth muscle cell cytokine secretion. Am J Physiol Lung Cell Mol Physiol 2009, 297(2):L326-L339.
49. Linker R.A., Lee D.H., Ryan S., van Dam A.M., Conrad R., Bista P., et al. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 2011, 134(Pt 3):678-692.
50. Albrecht P., Bouchachia I., Goebels N., Henke N., Hofstetter H.H., Issberner A., et al. Effects of dimethyl fumarate on neuroprotection and immunomodulation. J Neuroinflammation 2012, 9:163.
51. Wu Q.Q., Wang Y., Senitko M., Meyer C., Wigley W.C., Ferguson D.A., et al. Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2 PPARgamma, and HO-1. Am J Physiol Renal Physiol 2011, 300(5):F1180-F1192.
52. Kim S.B., Pandita R.K., Eskiocak U., Ly P., Kaisani A., Kumar R., et al. Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation. Proc Natl Acad Sci USA 2012, 109(43):E2949-E2955.
53. Zhang D.D. Bardoxolone brings Nrf2-based therapies to light. Antioxid Redox Signal 2012, 10.1089/ars.2012.5118.
54. Kanno T., Tanaka K., Yanagisawa Y., Yasutake K., Hadano S., Yoshii F., et al. A novel small molecule N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell-death by activating the Nrf2-ARE pathway: Therapeutic implications for ALS. Free Radic Biol Med 2012, 53(11):2028-2042.