Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Schachtele, Scott J ^a   Hu, Shuxian ^a   Lokensgard, James R ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE PEROXIDASE 1; HEME OXYGENASE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; REACTIVE OXYGEN METABOLITE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; MESSENGER RNA; SULFORAFAN; THIOCYANIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASTROCYTE; BRAIN DAMAGE; CELL ACTIVATION; CELL INFILTRATION; CELL STIMULATION; CONTROLLED STUDY; ENZYME REGULATION; FEMALE; HERPES SIMPLEX ENCEPHALITIS; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; MACROPHAGE; MICROGLIA; MORTALITY; MOUSE; NERVE INJURY; NERVOUS SYSTEM INFLAMMATION; NEUROMODULATION; NEUROPROTECTION; NEUROTOXICITY; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN INDUCTION; UPREGULATION; ANIMAL; BRAIN; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HERPES SIMPLEX VIRUS 1; IMMUNOLOGY; METABOLISM; NERVE CELL; NEUTROPHIL CHEMOTAXIS; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; TRANSCRIPTION INITIATION; VIROLOGY;

HERPES; HUMAN HERPESVIRUS 1; MURINAE; MUS; SIMPLEXVIRUS;

ANIMALS; ANTIOXIDANTS; ASTROCYTES; BRAIN; ENCEPHALITIS, HERPES SIMPLEX; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HERPESVIRUS 1, HUMAN; MACROPHAGES; MICE; MICROGLIA; NEURONS; NEUTROPHIL INFILTRATION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; THIOCYANATES; TRANSCRIPTIONAL ACTIVATION;

EID: 84860469478     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036216     Document Type: Article

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