메뉴 건너뛰기




Volumn 28, Issue 2, 2013, Pages 144-152

Analysis of the pharmacokinetic boosting effects of ritonavir on oral bioavailability of drugs in mice

Author keywords

CYP3A; Drug drug interactions; Oral bioavailability; P gp; Ritonavir

Indexed keywords

CYTOCHROME P450 3A; DORMICUM INJECTION; FEXOFENADINE; ISOENZYME; ITRACONAZOLE; MIDAZOLAM; PRAVASTATIN; RITONAVIR; SAQUINAVIR; UNCLASSIFIED DRUG;

EID: 84876762993     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-12-RG-057     Document Type: Article
Times cited : (5)

References (40)
  • 2
    • 0030430035 scopus 로고    scopus 로고
    • Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes
    • Kumar, G. N., Rodrigues, A. D., Buko, A. M. and Denissen, J. F.: Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J. Pharmacol. Exp. Ther., 277: 423-431 (1996).
    • (1996) J. Pharmacol. Exp. Ther , vol.277 , pp. 423-431
    • Kumar, G.N.1    Rodrigues, A.D.2    Buko, A.M.3    Denissen, J.F.4
  • 3
    • 0342940805 scopus 로고    scopus 로고
    • Human immunodeficiency virus protease inhibitors from drug design to clinical studies
    • Lin, J. H.: Human immunodeficiency virus protease inhibitors from drug design to clinical studies. Adv. Drug Deliv. Rev., 27: 215-233 (1997).
    • (1997) Adv. Drug Deliv. Rev , vol.27 , pp. 215-233
    • Lin, J.H.1
  • 4
    • 36549014231 scopus 로고    scopus 로고
    • Overview of boosted protease inhibitors in treatmentexperienced HIV-infected patients
    • Youle, M.: Overview of boosted protease inhibitors in treatmentexperienced HIV-infected patients. J. Antimicrob. Chemother., 60: 1195-1205 (2007).
    • (2007) J. Antimicrob. Chemother , vol.60 , pp. 1195-1205
    • Youle, M.1
  • 5
    • 0034121122 scopus 로고    scopus 로고
    • Pharmacological inhibition of Pglycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes
    • Choo, E. F., Leake, B., Wandel, C., Imamura, H., Wood, A. J. J., Wilkinson, G. R. and Kim, R. B.: Pharmacological inhibition of Pglycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab. Dispos., 28: 655-660 (2000).
    • (2000) Drug Metab. Dispos , vol.28 , pp. 655-660
    • Choo, E.F.1    Leake, B.2    Wandel, C.3    Imamura, H.4    Wood, A.J.J.5    Wilkinson, G.R.6    Kim, R.B.7
  • 7
    • 0036839477 scopus 로고    scopus 로고
    • Fexofenadine transport in Caco-2 cells: Inhibition with verapamil and ritonavir
    • Perloff, M. D., von Moltke, L. L. and Greenblatt, D. J.: Fexofenadine transport in Caco-2 cells: inhibition with verapamil and ritonavir. J. Clin. Pharmacol., 42: 1269-1274 (2002).
    • (2002) J. Clin. Pharmacol , vol.42 , pp. 1269-1274
    • Perloff, M.D.1    von Moltke, L.L.2    Greenblatt, D.J.3
  • 8
    • 2442672102 scopus 로고    scopus 로고
    • HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2)
    • Gupta, A., Zhang, Y., Unadkat, J. D. and Mao, Q.: HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). J. Pharmacol. Exp. Ther., 310: 334-341 (2004).
    • (2004) J. Pharmacol. Exp. Ther , vol.310 , pp. 334-341
    • Gupta, A.1    Zhang, Y.2    Unadkat, J.D.3    Mao, Q.4
  • 9
    • 77951075478 scopus 로고    scopus 로고
    • Interaction of eight HIV protease inhibitors with the canalicular efflux transporter ABCC2 (MRP2) in sandwich-cultured rat and human hepatocytes
    • Ye, Z. W., Camus, S., Augustijns, P. and Annaert, P.: Interaction of eight HIV protease inhibitors with the canalicular efflux transporter ABCC2 (MRP2) in sandwich-cultured rat and human hepatocytes. Biopharm. Drug Dispos., 31: 178-188 (2010).
    • (2010) Biopharm Drug Dispos , vol.31 , pp. 178-188
    • Ye, Z.W.1    Camus, S.2    Augustijns, P.3    Annaert, P.4
  • 10
    • 77149153424 scopus 로고    scopus 로고
    • Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1
    • Annaert, P., Ye, Z. W., Stieger, B. and Augustijns, P.: Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1. Xenobiotica, 40: 163-176 (2010).
    • (2010) Xenobiotica , vol.40 , pp. 163-176
    • Annaert, P.1    Ye, Z.W.2    Stieger, B.3    Augustijns, P.4
  • 11
    • 0346728729 scopus 로고    scopus 로고
    • The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability
    • Chan, L. M. S., Lowes, S. and Hirst, B. H.: The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability. Eur. J. Pharm. Sci., 21: 25-51 (2004).
    • (2004) Eur. J. Pharm. Sci , vol.21 , pp. 25-51
    • Chan, L.M.S.1    Lowes, S.2    Hirst, B.H.3
  • 12
    • 0032159263 scopus 로고    scopus 로고
    • Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein
    • Kim, A. E., Dintaman, J. M., Waddell, D. S. and Silverman, J. A.: Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein. J. Pharmacol. Exp. Ther., 286: 1439-1445 (1998).
    • (1998) J. Pharmacol. Exp. Ther , vol.286 , pp. 1439-1445
    • Kim, A.E.1    Dintaman, J.M.2    Waddell, D.S.3    Silverman, J.A.4
  • 13
    • 56449113167 scopus 로고    scopus 로고
    • Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities
    • Kharasch, E. D., Bedynek, P. S., Walker, A., Whittington, D. and Hoffer, C.: Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. Clin. Pharmacol. Ther., 84: 506-512 (2008).
    • (2008) Clin. Pharmacol. Ther , vol.84 , pp. 506-512
    • Kharasch, E.D.1    Bedynek, P.S.2    Walker, A.3    Whittington, D.4    Hoffer, C.5
  • 14
    • 0035063261 scopus 로고    scopus 로고
    • P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir
    • Huisman, M. T., Smit, J. W., Wiltshire, H. R., Hoetelmans, R. M. W., Beijnen, J. H. and Schinkel, A. H.: P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir. Mol. Pharmacol., 59: 806-813 (2001).
    • (2001) Mol. Pharmacol , vol.59 , pp. 806-813
    • Huisman, M.T.1    Smit, J.W.2    Wiltshire, H.R.3    Hoetelmans, R.M.W.4    Beijnen, J.H.5    Schinkel, A.H.6
  • 16
    • 6344279785 scopus 로고    scopus 로고
    • Comparative effects on intestinal absorption in situ by P-glycoprotein-modifying HIV protease inhibitors
    • Richter, M., Gyémánt, N., Molnár, J. and Hilgeroth, A.: Comparative effects on intestinal absorption in situ by P-glycoprotein-modifying HIV protease inhibitors. Pharm. Res., 21: 1862-1866 (2004).
    • (2004) Pharm. Res , vol.21 , pp. 1862-1866
    • Richter, M.1    Gyémánt, N.2    Molnár, J.3    Hilgeroth, A.4
  • 18
    • 4644301418 scopus 로고    scopus 로고
    • Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/ OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: Analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil
    • Shitara, Y., Hirano, M., Sato, H. and Sugiyama, Y.: Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/ OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J. Pharmacol. Exp. Ther., 311: 228-236 (2004).
    • (2004) J. Pharmacol. Exp. Ther , vol.311 , pp. 228-236
    • Shitara, Y.1    Hirano, M.2    Sato, H.3    Sugiyama, Y.4
  • 19
    • 0032941364 scopus 로고    scopus 로고
    • Quantitative prediction of metabolic inhibition of midazolam by itraconazole and ketoconazole in rats: Implication of concentrative uptake of inhibitors into liver
    • Yamano, K., Yamamoto, K., Kotaki, H., Sawada, Y. and Iga, T.: Quantitative prediction of metabolic inhibition of midazolam by itraconazole and ketoconazole in rats: implication of concentrative uptake of inhibitors into liver. Drug Metab. Dispos., 27: 395-402 (1999).
    • (1999) Drug Metab. Dispos , vol.27 , pp. 395-402
    • Yamano, K.1    Yamamoto, K.2    Kotaki, H.3    Sawada, Y.4    Iga, T.5
  • 20
    • 0033695149 scopus 로고    scopus 로고
    • Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes
    • Emoto, C., Yamazaki, H., Yamasaki, S., Shimada, N., Nakajima, M. and Yokoi, T.: Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes. Xenobiotica, 30: 943-953 (2000).
    • (2000) Xenobiotica , vol.30 , pp. 943-953
    • Emoto, C.1    Yamazaki, H.2    Yamasaki, S.3    Shimada, N.4    Nakajima, M.5    Yokoi, T.6
  • 21
    • 84876771791 scopus 로고    scopus 로고
    • Accessed 22 July
    • Interview form of Saquinavir. http://chugai-pharm.jp/hc/ss/pr/drug/inv_cap0200/if/index.html. Accessed 22 July (2012).
    • (2012) Interview Form of Saquinavir
  • 22
    • 0027275566 scopus 로고
    • Physiological parameters in laboratory animals and humans
    • Davies, B. and Morris, T.: Physiological parameters in laboratory animals and humans. Pharm. Res., 10: 1093-1095 (1993).
    • (1993) Pharm. Res , vol.10 , pp. 1093-1095
    • Davies, B.1    Morris, T.2
  • 23
    • 0031723235 scopus 로고    scopus 로고
    • Prediction of pharmacokinetic alterations caused by drug-drug interactions: Metabolic interaction in the liver
    • Ito, K., Iwatsubo, T., Kanamitsu, S., Ueda, K., Suzuki, H. and Sugiyama, Y.: Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver. Pharmacol. Rev., 50: 387-412 (1998).
    • (1998) Pharmacol. Rev , vol.50 , pp. 387-412
    • Ito, K.1    Iwatsubo, T.2    Kanamitsu, S.3    Ueda, K.4    Suzuki, H.5    Sugiyama, Y.6
  • 24
    • 0033802649 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of oncedaily regimens of soft-gel capsule saquinavir plus minidose ritonavir in human immunodeficiency virus-negative adults
    • Kilby, J. M., Sfakianos, G., Gizzi, N., Siemon-Hryczyk, P., Ehrensing, E., Oo, C., Buss, N. and Saag, M. S.: Safety and pharmacokinetics of oncedaily regimens of soft-gel capsule saquinavir plus minidose ritonavir in human immunodeficiency virus-negative adults. Antimicrob. Agents Chemother., 44: 2672-2678 (2000).
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 2672-2678
    • Kilby, J.M.1    Sfakianos, G.2    Gizzi, N.3    Siemon-Hryczyk, P.4    Ehrensing, E.5    Oo, C.6    Buss, N.7    Saag, M.S.8
  • 25
    • 0038575809 scopus 로고    scopus 로고
    • Saquinavir. A review of its use in boosted regimens for treating HIV infection
    • Plosker, G. L. and Scott, L. J.: Saquinavir. A review of its use in boosted regimens for treating HIV infection. Drugs, 63: 1299-1324 (2003).
    • (2003) Drugs , vol.63 , pp. 1299-1324
    • Plosker, G.L.1    Scott, L.J.2
  • 26
    • 48549096838 scopus 로고    scopus 로고
    • Species differences in in vitro and in vivo small intestinal metabolism of CYP3A substrates
    • Komura, H. and Iwaki, M.: Species differences in in vitro and in vivo small intestinal metabolism of CYP3A substrates. J. Pharm. Sci., 97: 1775-1800 (2008).
    • (2008) J. Pharm. Sci , vol.97 , pp. 1775-1800
    • Komura, H.1    Iwaki, M.2
  • 27
    • 0033979574 scopus 로고    scopus 로고
    • Midazolam and triazolam biotransformation in mouse and human liver microsomes: Relative contribution of CYP3A and CYP2C isoforms
    • Perloff, M. D., von Moltke, L. L., Court, M. H., Kotegawa, T., Shader, R. I. and Greenblatt, D. J.: Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms. J. Pharmacol. Exp. Ther., 292: 618-628 (2000).
    • (2000) J. Pharmacol. Exp. Ther , vol.292 , pp. 618-628
    • Perloff, M.D.1    von Moltke, L.L.2    Court, M.H.3    Kotegawa, T.4    Shader, R.I.5    Greenblatt, D.J.6
  • 29
    • 69249202502 scopus 로고    scopus 로고
    • Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein
    • Tachibana, T., Kato, M., Watanabe, T., Mitsui, T. and Sugiyama, Y.: Method for predicting the risk of drug-drug interactions involving inhibition of intestinal CYP3A4 and P-glycoprotein. Xenobiotica, 39: 430-443 (2009).
    • (2009) Xenobiotica , vol.39 , pp. 430-443
    • Tachibana, T.1    Kato, M.2    Watanabe, T.3    Mitsui, T.4    Sugiyama, Y.5
  • 30
    • 24144448562 scopus 로고    scopus 로고
    • The advantages of the using chamber in drug absorption studies
    • Gotoh, Y., Kamada, N. and Momose, D.: The advantages of the using chamber in drug absorption studies. J. Biomol. Screen., 10: 517-523 (2005).
    • (2005) J. Biomol. Screen , vol.10 , pp. 517-523
    • Gotoh, Y.1    Kamada, N.2    Momose, D.3
  • 31
    • 22344436690 scopus 로고    scopus 로고
    • P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion
    • Tahara, H., Kusuhara, H., Fuse, E. and Sugiyama, Y.: P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion. Drug Metab. Dispos., 33: 963-968 (2005).
    • (2005) Drug Metab. Dispos , vol.33 , pp. 963-968
    • Tahara, H.1    Kusuhara, H.2    Fuse, E.3    Sugiyama, Y.4
  • 34
    • 80053530180 scopus 로고    scopus 로고
    • Vectorial transport of fexofenadine across Caco-2 cells: Involvement of apical uptake and basolateral efflux transporters
    • Ming, X., Knight, B. M. and Thakker, D. R.: Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters. Mol. Pharm., 8: 1677-1686 (2011).
    • (2011) Mol. Pharm , vol.8 , pp. 1677-1686
    • Ming, X.1    Knight, B.M.2    Thakker, D.R.3
  • 35
    • 77957956134 scopus 로고    scopus 로고
    • Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers
    • Akamine, Y., Miura, M., Sunagawa, S., Kagaya, H., Yasui-Furukori, N. and Uno, T.: Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers. Xenobiotica, 40: 782-789 (2010).
    • (2010) Xenobiotica , vol.40 , pp. 782-789
    • Akamine, Y.1    Miura, M.2    Sunagawa, S.3    Kagaya, H.4    Yasui-Furukori, N.5    Uno, T.6
  • 37
    • 0036596181 scopus 로고    scopus 로고
    • Interspecies comparison of the oral absorption of itraconazole in laboratory animals
    • Yoo, S. D., Kang, E., Shin, B. S., Jun, H., Lee, S., Lee, K. C. and Lee, K.: Interspecies comparison of the oral absorption of itraconazole in laboratory animals. Arch. Pharm. Res., 25: 387-391 (2002).
    • (2002) Arch. Pharm. Res , vol.25 , pp. 387-391
    • Yoo, S.D.1    Kang, E.2    Shin, B.S.3    Jun, H.4    Lee, S.5    Lee, K.C.6    Lee, K.7
  • 38


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.