-
1
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
Wagner EF, Nebreda AR. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 2009; 9: 537-549.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, A.R.2
-
2
-
-
35848938280
-
P38alpha: A suppressor of cell proliferation and tumorigenesis
-
Hui L, Bakiri L, Stepniak E, Wagner EF. P38alpha: A suppressor of cell proliferation and tumorigenesis. Cell Cycle 2007; 6: 2429-2433.
-
(2007)
Cell Cycle
, vol.6
, pp. 2429-2433
-
-
Hui, L.1
Bakiri, L.2
Stepniak, E.3
Wagner, E.F.4
-
3
-
-
34249334506
-
p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-jun pathway
-
Hui L, Bakiri L, Mairhorfer A, Schweifer N, Haslinger C, Kenner L, et al. p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-jun pathway. Nat Genet 2007; 39: 741-749.
-
(2007)
Nat Genet
, vol.39
, pp. 741-749
-
-
Hui, L.1
Bakiri, L.2
Mairhorfer, A.3
Schweifer, N.4
Haslinger, C.5
Kenner, L.6
-
4
-
-
0034624004
-
Growth regulation via p38 mitogen-activated protein kinase in developing liver
-
Awad MM, Enslen H, Boylan JM, Davis RJ, Gruppuso PA. Growth regulation via p38 mitogen-activated protein kinase in developing liver. J Biol Chem 2000; 275: 38716-38721.
-
(2000)
J Biol Chem
, vol.275
, pp. 38716-38721
-
-
Awad, M.M.1
Enslen, H.2
Boylan, J.M.3
Davis, R.J.4
Gruppuso, P.A.5
-
5
-
-
77949808406
-
Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders
-
Goldstein DM, Kuglstatter A, Lou Y, Soth MJ. Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J Med Chem 2010; 53: 2345-2353.
-
(2010)
J Med Chem
, vol.53
, pp. 2345-2353
-
-
Goldstein, D.M.1
Kuglstatter, A.2
Lou, Y.3
Soth, M.J.4
-
6
-
-
0025061488
-
TGF-beta in liver development, regeneration, and carcinogenesis
-
Fausto N, Mead JE, Gruppuso PA, Braun L. TGF-beta in liver development, regeneration, and carcinogenesis. Ann N Y Acad Sci 1990; 593: 231-242.
-
(1990)
Ann N Y Acad Sci
, vol.593
, pp. 231-242
-
-
Fausto, N.1
Mead, J.E.2
Gruppuso, P.A.3
Braun, L.4
-
7
-
-
0029803923
-
Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver
-
Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE. Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. Proc Natl Acad Sci U S A 1996; 93: 12908-12913.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 12908-12913
-
-
Mendelson, K.G.1
Contois, L.R.2
Tevosian, S.G.3
Davis, R.J.4
Paulson, K.E.5
-
8
-
-
0037383455
-
Tumor necrosis factor alpha (TNF-alpha)-induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase: roles of TNF-alpha in alcoholic liver diseases
-
Hirano F, Komura K, Fukawa E, Makino I. Tumor necrosis factor alpha (TNF-alpha)-induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase: roles of TNF-alpha in alcoholic liver diseases. J Hepatol 2003; 38: 483-489.
-
(2003)
J Hepatol
, vol.38
, pp. 483-489
-
-
Hirano, F.1
Komura, K.2
Fukawa, E.3
Makino, I.4
-
9
-
-
0142026209
-
p38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
-
Kumar S, Boehm J, Lee JC. p38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2003; 2: 717-726.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 717-726
-
-
Kumar, S.1
Boehm, J.2
Lee, J.C.3
-
10
-
-
12144286014
-
Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress
-
Serviddio G, Pereda J, Pallardo FV, Carretero J, Borras C, Cutrin J, et al. Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. HEPATOLOGY 2004; 39: 711-720.
-
(2004)
HEPATOLOGY
, vol.39
, pp. 711-720
-
-
Serviddio, G.1
Pereda, J.2
Pallardo, F.V.3
Carretero, J.4
Borras, C.5
Cutrin, J.6
-
11
-
-
43549120265
-
Characterization of time-related changes after experimental bile duct ligation
-
Georgiev P, Jochum W, Heinrich S, Jang JH, Nocito A, Dahm F, et al. Characterization of time-related changes after experimental bile duct ligation. Br J Surg 2008; 95: 646-656.
-
(2008)
Br J Surg
, vol.95
, pp. 646-656
-
-
Georgiev, P.1
Jochum, W.2
Heinrich, S.3
Jang, J.H.4
Nocito, A.5
Dahm, F.6
-
12
-
-
84860863773
-
Mitochondrial dysfunction in cholestatic liver diseases
-
Arduini A, Serviddio G, Tormos AM, Monsalve M, Sastre J. Mitochondrial dysfunction in cholestatic liver diseases. Front Biosci (Elite Ed) 2012; 4: 2233-2252.
-
(2012)
Front Biosci (Elite Ed)
, vol.4
, pp. 2233-2252
-
-
Arduini, A.1
Serviddio, G.2
Tormos, A.M.3
Monsalve, M.4
Sastre, J.5
-
13
-
-
34249807348
-
p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
-
Ventura J, Tenbaum S, Perdiguero E, Huth M, Guerra C, Barbacid M, et al. p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet 2007; 39: 750-758.
-
(2007)
Nat Genet
, vol.39
, pp. 750-758
-
-
Ventura, J.1
Tenbaum, S.2
Perdiguero, E.3
Huth, M.4
Guerra, C.5
Barbacid, M.6
-
14
-
-
34547588567
-
Hsp27 regulates akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to akt signal complex
-
Wu R, Kausar H, Johnson P, Montoya-Durango DE, Merchant M, Rane MJ. Hsp27 regulates akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to akt signal complex. J Biol Chem 2007; 282: 21598-21608.
-
(2007)
J Biol Chem
, vol.282
, pp. 21598-21608
-
-
Wu, R.1
Kausar, H.2
Johnson, P.3
Montoya-Durango, D.E.4
Merchant, M.5
Rane, M.J.6
-
15
-
-
33646821007
-
TEF-1 and C/EBPbeta are major p38alpha MAPK-regulated transcription factors in proliferating cardiomyocytes
-
Ambrosino C, Iwata T, Scafoglio C, Mallardo M, Klein R, Nebreda AR. TEF-1 and C/EBPbeta are major p38alpha MAPK-regulated transcription factors in proliferating cardiomyocytes. Biochem J 2006; 396: 163-172.
-
(2006)
Biochem J
, vol.396
, pp. 163-172
-
-
Ambrosino, C.1
Iwata, T.2
Scafoglio, C.3
Mallardo, M.4
Klein, R.5
Nebreda, A.R.6
-
16
-
-
34547942911
-
A functional role for p38 MAPK in modulating mitotic transit in the absence of stress
-
Cha H, Wang X, Li H, Fornace AJJr. A functional role for p38 MAPK in modulating mitotic transit in the absence of stress. J Biol Chem 2007; 282: 22984-22992.
-
(2007)
J Biol Chem
, vol.282
, pp. 22984-22992
-
-
Cha, H.1
Wang, X.2
Li, H.3
Fornace Jr., A.J.4
-
17
-
-
58949092180
-
The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation
-
Haga S, Ozaki M, Inoue H, Okamoto Y, Ogawa W, Takeda K, et al. The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. HEPATOLOGY 2009; 49: 204-214.
-
(2009)
HEPATOLOGY
, vol.49
, pp. 204-214
-
-
Haga, S.1
Ozaki, M.2
Inoue, H.3
Okamoto, Y.4
Ogawa, W.5
Takeda, K.6
-
18
-
-
0142084679
-
Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation
-
Faridi J, Fawcett J, Wang L, Roth RA. Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation. Am J Physiol Endocrinol Metab 2003; 285: E964-E972.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
-
-
Faridi, J.1
Fawcett, J.2
Wang, L.3
Roth, R.A.4
-
19
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004; 6: 1122-1128.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
-
20
-
-
77955059513
-
Mechanisms and functions of p38 MAPK signalling
-
Cuadrado A, Nebreda AR. Mechanisms and functions of p38 MAPK signalling. Biochem J 2010; 429: 403-417.
-
(2010)
Biochem J
, vol.429
, pp. 403-417
-
-
Cuadrado, A.1
Nebreda, A.R.2
-
21
-
-
59149098536
-
p38 mitogen-activated protein kinase regulates canonical wnt-beta-catenin signaling by inactivation of GSK3beta
-
Bikkavilli RK, Feigin ME, Malbon CC. p38 mitogen-activated protein kinase regulates canonical wnt-beta-catenin signaling by inactivation of GSK3beta. J Cell Sci 2008; 121( Pt 21): 3598-3607.
-
(2008)
J Cell Sci
, vol.121
, Issue.PART 21
, pp. 3598-3607
-
-
Bikkavilli, R.K.1
Feigin, M.E.2
Malbon, C.C.3
-
22
-
-
0034612636
-
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
-
Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 2000; 406: 86-90.
-
(2000)
Nature
, vol.406
, pp. 86-90
-
-
Hoeflich, K.P.1
Luo, J.2
Rubie, E.A.3
Tsao, M.S.4
Jin, O.5
Woodgett, J.R.6
-
23
-
-
0036081578
-
Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes
-
Schwabe RF, Brenner DA. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am J Physiol Gastrointest Liver Physiol 2002; 283: G204-G211.
-
(2002)
Am J Physiol Gastrointest Liver Physiol
, vol.283
-
-
Schwabe, R.F.1
Brenner, D.A.2
-
24
-
-
0036432931
-
Activation of p38 MAPK induces cell cycle arrest via inhibition of Raf/ERK pathway during muscle differentiation
-
Lee J, Hong F, Kwon S, Kim SS, Kim DO, Kang HS, et al. Activation of p38 MAPK induces cell cycle arrest via inhibition of Raf/ERK pathway during muscle differentiation. Biochem Biophys Res Commun 2002; 298: 765-771.
-
(2002)
Biochem Biophys Res Commun
, vol.298
, pp. 765-771
-
-
Lee, J.1
Hong, F.2
Kwon, S.3
Kim, S.S.4
Kim, D.O.5
Kang, H.S.6
-
25
-
-
18844383961
-
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
-
Engel FB, Schebesta M, Duong MT, Lu G, Ren S, Madwed JB, et al. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev 2005; 19: 1175-1187.
-
(2005)
Genes Dev
, vol.19
, pp. 1175-1187
-
-
Engel, F.B.1
Schebesta, M.2
Duong, M.T.3
Lu, G.4
Ren, S.5
Madwed, J.B.6
-
26
-
-
33947100032
-
Genetic analysis of p38 MAP kinases in myogenesis: Fundamental role of p38alpha in abrogating myoblast proliferation
-
Perdiguero E, Ruiz-Bonilla V, Gresh L, Hui L, Ballestar E, Sousa-Victor P, et al. Genetic analysis of p38 MAP kinases in myogenesis: Fundamental role of p38alpha in abrogating myoblast proliferation. EMBO J 2007; 26: 1245-1256.
-
(2007)
EMBO J
, vol.26
, pp. 1245-1256
-
-
Perdiguero, E.1
Ruiz-Bonilla, V.2
Gresh, L.3
Hui, L.4
Ballestar, E.5
Sousa-Victor, P.6
-
27
-
-
36248956543
-
Liver tetraploidization is controlled by a new process of incomplete cytokinesis
-
Margall-Ducos G, Celton-Morizur S, Couton D, Bregerie O, Desdouets C. Liver tetraploidization is controlled by a new process of incomplete cytokinesis. J Cell Sci 2007; 120( Pt 20): 3633-3639.
-
(2007)
J Cell Sci
, vol.120
, Issue.PART 20
, pp. 3633-3639
-
-
Margall-Ducos, G.1
Celton-Morizur, S.2
Couton, D.3
Bregerie, O.4
Desdouets, C.5
-
29
-
-
68449096617
-
The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents
-
Celton-Morizur S, Merlen G, Couton D, Margall-Ducos G, Desdouets C. The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents. J Clin Invest 2009; 119: 1880-1887.
-
(2009)
J Clin Invest
, vol.119
, pp. 1880-1887
-
-
Celton-Morizur, S.1
Merlen, G.2
Couton, D.3
Margall-Ducos, G.4
Desdouets, C.5
-
30
-
-
33749257848
-
CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway
-
Rousseau S, Dolado I, Beardmore V, Shpiro N, Marquez R, Nebreda AR, et al. CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway. Cell Signal 2006; 18: 1897-1905.
-
(2006)
Cell Signal
, vol.18
, pp. 1897-1905
-
-
Rousseau, S.1
Dolado, I.2
Beardmore, V.3
Shpiro, N.4
Marquez, R.5
Nebreda, A.R.6
-
31
-
-
0036143720
-
Hsp27 as a negative regulator of cytochrome C release
-
Paul C, Manero F, Gonin S, Kretz-Remy C, Virot S, Arrigo AP. Hsp27 as a negative regulator of cytochrome C release. Mol Cell Biol 2002; 22: 816-834.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 816-834
-
-
Paul, C.1
Manero, F.2
Gonin, S.3
Kretz-Remy, C.4
Virot, S.5
Arrigo, A.P.6
-
32
-
-
84869130983
-
Mnk1 kinase activity is required for abscission
-
Rannou Y, Salaun P, Benaud C, Khan J, Dutertre S, Giet R, et al. Mnk1 kinase activity is required for abscission. J Cell Sci 2012; 125( Pt 12): 2844-2852.
-
(2012)
J Cell Sci
, vol.125
, Issue.PART 12
, pp. 2844-2852
-
-
Rannou, Y.1
Salaun, P.2
Benaud, C.3
Khan, J.4
Dutertre, S.5
Giet, R.6
-
33
-
-
56149111920
-
Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression
-
Tang J, Yang X, Liu X. Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression. Oncogene 2008; 27: 6635-4665.
-
(2008)
Oncogene
, vol.27
, pp. 6635-4665
-
-
Tang, J.1
Yang, X.2
Liu, X.3
-
34
-
-
77649171804
-
Nuclear size measurement is a simple method for the assessment of hepatocellular aging in non-alcoholic fatty liver disease: comparison with telomere-specific quantitative FISH and p21 immunohistochemistry
-
Nakajima T, Nakashima T, Okada Y, Jo M, Nishikawa T, Mitsumoto Y, et al. Nuclear size measurement is a simple method for the assessment of hepatocellular aging in non-alcoholic fatty liver disease: comparison with telomere-specific quantitative FISH and p21 immunohistochemistry. Pathol Int 2010; 60: 175-183.
-
(2010)
Pathol Int
, vol.60
, pp. 175-183
-
-
Nakajima, T.1
Nakashima, T.2
Okada, Y.3
Jo, M.4
Nishikawa, T.5
Mitsumoto, Y.6
|