Phosphorylation of Plk1 at Ser326 regulates its functions during mitotic progression

Oncogene

Volumn 27, Issue 52, 2008, Pages 6635-6645

  Tang, J ^a   Yang, X ^a,b   Liu, X ^a  

^a PURDUE UNIVERSITY   (United States)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Mitosis; MK2; Phosphorylation; Plk1

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; POLO LIKE KINASE 1; SERINE; CELL CYCLE PROTEIN; MAP KINASE ACTIVATED KINASE 2; MAP-KINASE-ACTIVATED KINASE 2; ONCOPROTEIN; PHOSPHOSERINE; POLO-LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; METAPHASE; MITOSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROPHASE; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SPINDLE POLE BODY; GENETICS; HELA CELL; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING; SIGNAL TRANSDUCTION;

MAMMALIA;

CELL CYCLE PROTEINS; ENZYME ACTIVATION; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MITOSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS;

EID: 56149111920     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.262     Document Type: Article

References (24)

1. Barr FA, Sillje HH, Nigg EA. (2004). Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol 5: 429-440.
2. Campos CB, Bedard PA, Linden R. (2002). Activation of p38 mitogen-activated protein kinase during normalmitosis in the developing retina. Neuroscience 112: 583-591.
3. Cha H, Wang X, Li H, Fornace AJ. (2007). A functional role for p38 MAPK in modulating mitotic transit in the absence of stress. J Biol Chem 282: 22984-22992.
4. Eckerdt F, Yuan J, Strebhardt K. (2005). Polo-like kinases and oncogenesis. Oncogene 24: 267-276.
5. Fan L, Yang X, Du J, Marshall M, Blanchard K, Ye X. (2005). A novel role of p38 alpha MAPK in mitotic progression independent of its kinase activity. Cell Cycle 4: 1616-1624.
6. Golsteyn RM, Schultz SJ, Bartek J, Ziemiecki A, Ried T, Nigg EA. (1994). Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. J Cell Sci 107(Part 6): 1509-1517.
7. Knecht R, Elez R, Oechler M, Solbach C, von Ilberg C, Strebhardt K. (1999). Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck. Cancer Res 59: 2794-2797.
8. Knecht R, Oberhauser C, Strebhardt K. (2000). PLK (polo-like kinase), a new prognostic marker for oropharyngeal carcinomas. Int J Cancer 89: 535-536.
9. Li H, Wang Y, Liu X. (2008). Plk1-dependent phosphorylation regulates functions of DNA topoisomerase IIalpha in cell cycle progression. J Biol Chem 283: 6209-6221.
10. Lindon C, Pines J. (2004). Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells. J Cell Biol 164: 233-241.
11. Liu X, Erikson RL. (2002). Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA. Proc Natl Acad Sci USA 99: 8672-8676.
12. Liu X, Erikson RL. (2003). Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells. Proc Natl Acad Sci USA 100: 5789-5794.
13. Lowery DM, Lim D, Yaffe MB. (2005). Structure and function of Polo-like kinases. Oncogene 24: 248-259.
14. Manke IA, Nguyen A, Lim D, Stewart MQ, Elia AE, Yaffe MB. (2005). MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol Cell 17: 37-48.
15. Mikhailov A, Shinohara M, Rieder CL. (2004). Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway. J Cell Biol 166: 517-526.
16. Mulvihill DP, Petersen J, Ohkura H, Glover DM, Hagan IM. (1999). Plo1 kinase recruitment to the spindle pole body and its role in cell division in Schizosaccharomyces pombe. Mol Biol Cell 10: 2771-2785.
17. Olson JM, Hallahan AR. (2004). p38 MAP kinase: a convergence point in cancer therapy. Trends Mol Med 10: 125-129.
18. Petersen J, Hagan IM. (2005). Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast. Nature 435: 507-512.
19. Shirayama M, Zachariae W, Ciosk R, Nasmyth K. (1998). The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae. EMBO J 17: 1336-1349.
20. Sui G, Soohoo C, Affar EB, Gay F, Shi Y, Forrester WC et al. (2002). A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci USA 99: 5515-5520.
21. Takai N, Hamanaka R, Yoshimatsu J, Miyakawa I. (2005). Polo-like kinases (Plks) and cancer. Oncogene 24: 287-291.
22. Tang J, Erikson RL, Liu X. (2006a). Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1). Proc Natl Acad Sci USA 103: 11964-11969.
23. Tang J, Erikson RL, Liu X. (2006b). Ectopic expression of Plk1 leads to activation of the spindle checkpoint. Cell Cycle 5: 2484-2488.
24. Zarubin T, Han J. (2005). Activation and signaling of the p38 MAP kinase pathway. Cell Res 15: 11-18.