A Genetic Screen Using the PiggyBac Transposon in Haploid Cells Identifies Parp1 as a Mediator of Olaparib Toxicity

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Pettitt, Stephen J ^a   Rehman, Farah L ^a   Bajrami, Ilirjana ^a   Brough, Rachel ^a   Wallberg, Fredrik ^a   Kozarewa, Iwanka ^a   Fenwick, Kerry ^a   Assiotis, Ioannis ^a   Chen, Lina ^a   Campbell, James ^a   Lord, Christopher J ^a   Ashworth, Alan ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; OLAPARIB; TIOGUANINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARP1 PROTEIN, HUMAN; PHTHALAZINE DERIVATIVE; PIPERAZINE DERIVATIVE; TRANSPOSON;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG SCREENING; GENE; GENE MUTATION; GENETIC SCREENING; HAPLOIDY; HUMAN; HUMAN CELL; MAMMAL CELL; MISMATCH REPAIR; PIGGYBAC TRANSPOSON; POLY(ADP RIBOSE)POLYMERASE 1 GENE; RNA INTERFERENCE; TRANSPOSON; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; EMBRYONIC STEM CELL; GENETICS; METABOLISM; MOUSE; MUTATION;

MAMMALIA;

ANIMALS; DNA TRANSPOSABLE ELEMENTS; EMBRYONIC STEM CELLS; GENETIC TESTING; HAPLOIDY; HUMANS; MICE; MUTATION; PHTHALAZINES; PIPERAZINES; POLY(ADP-RIBOSE) POLYMERASES;

EID: 84876715061     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061520     Document Type: Article

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