The effect of age, sex, and lifestyle factors on micronucleus frequency in peripheral blood lymphocytes of the Bosnian population

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 753, Issue 1, 2013, Pages 1-11

  Nefic, Hilada ^a   Handzic, Inda ^a  

^a UNIVERSITY OF SARAJEVO   (Bosnia and Herzegovina)

Author keywords

Age; Biomarkers; Human lymphocytes; Lifestyle factors; Sex

Indexed keywords

ADOLESCENT; ADULT; AGED; ALCOHOL CONSUMPTION; APOPTOSIS; ARTICLE; CELL CYCLE CHECKPOINT; CELL DIVISION; CELL VIABILITY; CHROMOSOME ANALYSIS; CHROMOSOME DAMAGE; CYTOTOXICITY; FAMILY HISTORY; FEMALE; HUMAN; HUMAN TISSUE; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MICRONUCLEUS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RADIATION EXPOSURE; SEX; SMOKING;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGING; ALCOHOL DRINKING; APOPTOSIS; BOSNIA-HERZEGOVINA; CELL DIVISION; CELL SURVIVAL; CYTOCHALASIN B; CYTOKINESIS; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; INCIDENCE; LIFE STYLE; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MIDDLE AGED; NEOPLASMS; SEX FACTORS; SMOKING; YOUNG ADULT;

EID: 84876704028     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2013.03.001     Document Type: Article

References (68)

1. Fenech M., Morley A.A. Measurement of micronuclei in lymphocytes. Mutat. Res. 1985, 147:29-36.
2. Fenech M., Morley A.A. Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. Mutat. Res. 1986, 161:193-198.
3. Fenech M. Cytokinesis-block micronucleus cytome assay. Nat. Protoc. 2007, 2:1084-1104.
4. Holland N., Bolognesi C., Kirsch-Volders M., Bonassi S., Zeiger E., Knasmueller S., Fenech M. The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: The HUMN project perspective on current status and knowledge gaps. Mutat. Res. 2008, 659:93-108.
5. Bonassi S., Fenech M., Lando C., Lin Y., Ceppi M., Chang W.P., Holland N., Kirsch-Volders M., Zeiger E., Ban S., Barale R., Bigatti M.P., Bolognesi C., Jia C., Di Giorgio M., Ferguson L.R., Fucic A., Lima O.G., Hrelia P., Krishnaja A.P., Lee T.K., Migliore L., Mikhalevich L., Mirkova E., Mosesso P., Müller W.U., Odagiri Y., Scarfì M.R., Szabova E., Vorobtsova I., Vral A., Zijno A. HUman MicroNucleus Project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei. Environ. Mol. Mutagen. 2001, 37:31-45.
6. Fenech M., Bonassi S., Turner J., Lando C., Ceppi M., Chang W.P., Holland N., Kirsch-Volders M., Zeiger E., Bigatti M.P., Bolognesi C., Jia C., De Luca G., Di Giorgio M., Ferguson L.R., Fucic A., Lima O.G., Hadjidekova V., Hrelia P., Jaworska A., Joksic G., Krishnaja A.P., Lee T.K., Martelli A., McKay M.J., Migliore L., Mirkova E., Müller W.U., Odagiri Y., Orsiere T., Scarfì M.R., Silva M.J., Sofuni T., Suralles J., Trenta G., Vorobtsova I., Vral A., Zijno A. Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project. Mutat. Res. 2003, 534:45-64.
7. Fenech M., Neville S., Rinaldi J. Sex is an important variable affecting spontaneous micronucleus frequency in cytokinesis-blocked lymphocytes. Mutat. Res. 1994, 313:203-207.
8. Ishikawa H., Tian Y., Yamauchit T. Influence of gender, age and lifestyle factors on micronuclei frequency in healthy Japanese populations. J. Occup. Health 2003, 45:179-181.
9. Bonassi S., Abbondandolo A., Camurri L., Dal Pra A., De Ferrari M., Degrassi F., Forni A., Lamberti L., Lando C., Padovani P., Sbrana I., Vecchio D., Puntoni R. Are chromosome aberrations in circulating lymphocytes predictive of a future cancer onset in humans? Preliminary results of an Italian cohort study. Cancer Genet. Cytogenet. 1995, 79:133-135.
10. Hagmar L., Brøgger A., Hansteen I.L., Helm S., Högstedt B., Knudsen L., Lambert B., Linnainmaa K., Mitelman F., Nordenson I., Reuterwall C., Salomaa S., Skerfving S., Sorsa M. Cancer risk in humans predicted by increased levels of chromosomal aberrations in lymphocytes: Nordic Study Group on the Health Effects of Chromosome Damage. Cancer Res. 1994, 54:2919-2922.
11. Bonassi S., El-Zein R., Bolognesi C., Fenech M. Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies. Mutagenesis 2011, 26:93-100.
12. Tucker J.D., Preston R.J. Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment. Mutat. Res. 1996, 365:147-159.
13. Liou S.H., Lung J.C., Chen Y.H., Yang T., Hsieh L.L., Chen C.J., Wu T.N. Increased chromosome-type chromosome aberration frequencies as biomarkers of cancer risk in a blackfoot endemic area. Cancer Res. 1999, 59:1481-1484.
14. Bonassi S., Hagmar L., Strömberg U., Montagud A.H., Tinnerberg H., Forni A., Heikkilä P., Wanders S., Wilhardt P., Hansteen I.L., Knudsen L.E., Norppa H. Chromosomal aberrations in lymphocytes predict human cancer independently of exposure to carcinogens, European Study Group on Cytogenetic Biomarkers and Health. Cancer Res. 2000, 60:1619-1625.
15. Bonassi S., Znaor A., Norppa H., Hagmar L. Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective. Cytogenet. Genome Res. 2004, 104:376-382.
16. Boffetta P., van der Hel O., Norppa H., Fabianova E., Fucic A., Gundy S., Lazutka J., Cebulska-Wasilewska A., Puskailerova D., Znaor A., Kelecsenyi Z., Kurtinaitis J., Rachtan J., Forni A., Vermeulen R., Bonassi S. Chromosomal aberrations and cancer risk: results of a cohort study from Central Europe. Am. J. Epidemiol. 2007, 165:36-43.
17. Bonassi S., Neri M., Lando C., Ceppi M., Lin Y.P., Chang W.P., Holland N., Kirsch-Volders M., Zeiger E., Fenech M., HUMN Collaborative Group Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project. Mutat. Res. 2003, 543:155-166.
18. Soper K.A., Stolley P.D., Galloway S.M., Smith J.G., Nichols W.W., Wolman S.R. Sister-chromatid exchanges (SCEs) report on control subjects in a study of occupationally exposed workers. Mutat. Res. 1984, 129:77-88.
19. Livingston G.K., Fineman R.M. Correlation of human lymphocyte SCE frequency with smoking history. Mutat. Res. 1983, 119:59-64.
20. Norppa H., Luomahaara S., Heikanen H., Roth S., Sorsa M., Renzi L., Lindholm C. Micronucleus assay in lymphocytes as a tool to biomonitor human exposure to aneuploidogens and clastogens. Environ. Health Perspect. 1993, 101:139-143.
21. Pitarque M., Carbonell E., Lapena N., Marsa M., Torres M., Creus A., Xamena N., Marcos R. No increase in micronuclei frequency in cultured blood lymphocytes from a group of filling station attendants. Mutat. Res. 1996, 367:161-167.
22. da Cruz A.D., McArthur A.G., Silva C.C., Curado M.P., Glickman B.W. Human micronucleus counts are correlated with age, smoking, and cesium-137 dose in the Goiania (Brazil) radiological accident. Mutat. Res. 1994, 313:57-68.
23. Obe G., Natarajan A.T., Meyers M., Den Hertog A. Induction of chromosomal aberrations in peripheral lymphocytes of human blood in vitro and of SCEs in bone-marrow cells of mice in vivo by ethanol and its metabolite acetaldehyde. Mutat. Res. 1979, 68:291-294.
24. Sarto F., Finotto S., Giacomelli L., Mazzotti D., Tomanin R., Levis A.G. The micronucleus assay in exfoliated cells of the human buccal mucosa. Mutagenesis 1987, 2:11-17.
25. Reidy J.A., Chen A.T.L., Welty T.K. Increased sister chromatid exchange associated with smoking and coffee consumption. Environ. Mol. Mutagen. 1988, 12:311-318.
26. Nordic Study Group on Health Risk of Chromosome Damage A Nordic data base on somatic chromosome damage in humans. Mutat. Res. 1990, 214:325-337.
27. Thierens H., Vral A., Barbé M., et al. A cytogenetic study of nuclear power plant workers using the micronucleus-centromere assay. Mutat. Res. 1999, 445:105-111.
28. Eastmond D.A., Thcker J.D. Identification of aneuploidy inducing agents using cytokinesis-blocked human lymphocytes and an anti-kinetochore antibody. Environ. Mol. Mutagen. 1989, 13:34-43.
29. Fenech M. The in vitro micronucleus technique. Mutat. Res. 2000, 455:81-95.
30. Fenech M., Chang W.P., Kirsch-Volders M., Holland N., Bonassi S., Zeiger E. HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat. Res. 2003, 534:65-75.
31. Shimizu N., Itoh N., Utiyama H., Wahl G.M. Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J. Cell Biol. 1998, 140:1307-1320.
32. Shimizu N., Shimuara T., Tanaka T. Selective elimination of acentric double minutes from cancer cells through the extrusion of micronuclei. Mutat. Res. 2000, 448:81-90.
33. Lindberg H.K., Wang X., Järventaus H., Falck G.C., Norppa H., Fenech M. Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes. Mutat. Res. 2007, 617:33-45.
34. Bolognesi C., Abbondandolo A., Barale R., Casalone R., Dalprà L., De Ferrari M., Degrassi F., Forni A., Lamberti L., Lando C., Migliore L., Padovani P., Pasquini R., Puntoni R., Sbrana I., Stella M., Bonassi S. Age-related increase of chromosome aberrations, sister-chromatid exchanges and micronuclei in human lymphocytes. Cancer Epidemiol. Biomarkers Prev. 1997, 6:249-256.
35. Fenech M., Morley A.A. The effect of donor age on spontaneous and induced micronuclei. Mutat. Res. 1985, 148:99-105.
36. Tomanin R., Ballarin C., Nardini B., Mastrangelo G., Saro F. Influence of smoking habit on the frequency of micronuclei in human lymphocytes by the cytokinesis-block method. Mutagenesis 1991, 6:123-126.
37. Au W.W., Walker D.M., Ward J.B., Whorton E., Legator M.S., Singh V. Factors contributing to chromosome damage in lymphocytes of cigarette smokers. Mutat. Res. 1991, 260:137-144.
38. Barale R., Chelotti L., Davini T., Del Ry S., Andreassi M.G., Ballardin M., Bulleri M., He J., Baldacci S., Di Pede F., Gemignani F., Landi S. Sister chromatid exchange and micronucleus frequency in human lymphocytes of 1,650 subjects in an Italian population: II. Contribution of sex, age, and lifestyle. Environ. Mol. Mutagen. 1998, 31:228-242.
39. Yager J.W., Sorsa M., Selvin S. Micronuclei in cytokinesis-blocked lymphocytes as an index of occupational exposure to alkylating cytostatic drugs. IARC Sci. Publ. 1988, 89:213-216.
40. Migliore L., Parrini M., Sbrana I., Biagini C., Battaglia A., Loprieno N. Micronucleated lymphocytes in people occupationally exposed to potential environmental contaminants: the age effect. Mutat. Res. 1991, 256:13-20.
41. Fenech M., Bonassi S. The effect of age, gender, diet and lifestyle on DNA damage measured using micronucleus frequency in human peripheral blood lymphocytes. Mutagenesis 2011, 26:43-49.
42. Jones K.H., York T.P., Jackson-Cook C. Mechanisms leading to the formation of micronuclei containing sex chromosomes differ with age. Mutat. Res. 2012, 747:207-217.
43. Hando J.C., Nath J., Tucker J.D. Sex chromosomes, micronuclei and aging in women. Chromosoma 1994, 103:186-192.
44. Greenrod W., Stockley C.S., Burcham P., Abbey M., Fenech M. Moderate acute intake of de-alcoholized red wine, but not alcohol, is protective against radiation-induced DNA damage ex vivo - results of a comparative in vivo intervention study in younger men. Mutat. Res. 2005, 591:290-301.
45. Thierens H., Vral A., De Ridder L. A cytogenetic study of radiological workers: effect of age, smoking and radiation burden on the micronucleus frequency. Mutat. Res. 1996, 360:75-82.
46. Maffei F., Angelini S., Forti G.C., Lodi V., Violante F.S., Mattioli S., Hrelia P. Micronuclei frequencies in hospital workers occupationally exposed to low levels of ionizing radiation: influence of smoking status and other factors. Mutagenesis 2002, 17:405-409.
47. Migliore L., Guidotti P., Favre C., Nardi M., Sessa M.R., Brunori E. Micronuclei in lymphocytes of young patients under antileukemic therapy. Mutat. Res. 1991, 263:243-248.
48. Minicucci E.M., Ribeiro D.A., de Camargo B., Costa M.C., Ribeiro L.R., Favero Salvadori D.M. DNA damage in lymphocytes and buccal mucosa cells of children with malignant tumours undergoing chemotherapy. Clin. Exp. Med. 2008, 8:79-85.
49. Roberts S.A., Spreadborough A.R., Bulman B., Barber J.B., Evans D.G., Scott D. Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer?. Am. J. Hum. Genet. 1999, 65:784-794.
50. Scott D. Chromosomal radiosensitivity and low penetrance predisposition to cancer. Cytogenet. Genome Res. 2004, 104:365-370.
51. Fenech M., Holland N., Chang W.P., Zeiger E., Bonassi S. The HUman MicroNucleus project-an international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans. Mutat. Res. 1999, 428:271-283.
52. Fenech M. Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov. Today 2002, 22:1128-1137.
53. Van Schooten F.J., Besarati Nia A., De Flora S., D'Agostini F., Izzotti A., Camoirano A., Balm A.J.M., Dallinga J.W., Bast A., Haenen G.R.M.M., Van't Veer L., Baas P., Sakai H., Van Zandwijk N. Effects of oral administration of N-acetyl-l-cysteine: a multi-biomarker study in smokers. Cancer Epidemiol. Biomarkers Prev. 2002, 11:167-175.
54. Chang W.P., Hwang B.F., Wang D., Wang J.D. Cytogenetic effect of chronic low-dose, low-dose-rate gamma-radiation in residents of irradiated buildings. Lancet 1997, 350:330-333.
55. Bettega D., Calzolari P., Doneda L., Belloni F., Tallone L., Redpath J.L. Differential effectiveness of solar UVB subcomponents in causing cell death, oncogenic transformation and micronucleus induction in human hybrid cells. Int. J. Radiat. Biol. 2003, 79:211-216.
56. Fenech M., Baghurst P., Luderer W., Turner J., Record S., Ceppi M., Bonassi S. Low intake of calcium, folate, nicotinic acid, vitamin E, retinol, β-carotene and high intake of pantothenic acid, biotin and riboflavin are significantly associated with increased genome instability-results from a dietary intake and micronucleus index survey in South Australia. Carcinogenesis 2005, 26:991-999.
57. El-Zein R., Vral A., Etzel C.J. Cytokinesis-blocked micronucleus assay and cancer risk assessment. Mutagenesis 2011, 26:101-106.
58. Fenech M. Cytokinesis-block micronucleus assay evolves into a "cytome" assay of chromosomal instability, mitotic dysfunction and cell death. Mutat. Res. 2006, 600:58-66.
59. Crott J.W., Mashiyama S.T., Ames B.N., Fenech M. The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiol. Biomarkers Prev. 2001, 10:1089-1096.
60. Hagmar L., Bonassi S., Strömberg U., Brøgger A., Knudsen L., Norppa H., Reuterwall C. Chromosomal aberrations in lymphocytes predict human cancer - a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH). Cancer Res. 1998, 58:4117-4121.
61. Hagmar L., Strömberg U., Bonassi S., Hansteen I.L., Knudsen L.E., Lindholm C., Norppa H. Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian Cohorts. Cancer Res. 2004, 64:2258-2263.
62. Rossner P., Boffetta P., Ceppi M., Bonassi S., Smerhovsky Z., Landa K., Juzova D., Sram R.J. Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer. Environ. Health Perspect. 2005, 113:517-520.
63. Bonassi S., Znaor A., Ceppi M., Lando C., Chang W.P., Holland N., Kirsch-Volders M., Zeiger E., Ban S., Barale R., Bigatti M.P., Bolognesi C., Cebulska-Wasilewska A., Fabianova E., Fucic A., Hagmar L., Joksic G., Martelli A., Migliore L., Mirkova E., Scarfi M.R., Zijno A., Norppa H., Fenech M. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 2007, 28:625-631.
64. El-Zein R.A., Schabath M.B., Etzel C.J., Lopez M.S., Franklin J.D., Spitz M.R. Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk. Cancer Res. 2006, 66:6449-6456.
65. Benner S.E., Lippman S.M., Wargowich M.J., Velasco M., Peters E.J., Morice R.C., Hong W.K. Micronuclei in bronchial biopsy specimens from heavy smokers: characterization of an intermediate marker of lung carcinogenesis. Int. J. Cancer 1992, 52:44-47.
66. Gourabi H., Mozdarani H. A cytokinesis-blocked micronucleus study of the radioadaptive response of lymphocytes of individuals occupationally exposed to chronic doses of radiation. Mutagenesis 1998, 13:475-480.
67. Rothfuss A., Dennog C., Speit G. Adaptive protection against the induction of oxidative DNA damage after hyperbaric oxygen treatment. Carcinogenesis 1998, 19:1913-1917.
68. Kirsch-Volders M., Fenech M. Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes. Mutagenesis 2001, 161:51-58.