SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities

DNA Repair

Volumn 12, Issue 5, 2013, Pages 356-366

  Ju, Limei ^a   Wing, Jonathan ^a   Taylor, Elaine ^a,k   Brandt, Renata ^b   Slijepcevic, Predrag ^c   Horsch, Marion ^d   Rathkolb, Birgit ^d,e   Rácz, Ildikó ^d,f   Becker, Lore ^d,g   Hans, Wolfgang ^d   Adler, Thure ^d,h   Beckers, Johannes ^d,i,j   Rozman, Jan ^d,i   Klingenspor, Martin ⁱ   Wolf, Eckhard ^e   Zimmer, Andreas ^f   Klopstock, Thomas ^g   Busch, Dirk H ^h   Gailus Durner, Valérie ^d,j   Fuchs, Helmut ^d,j   Angelis, Martin Hrabě de ^d,g,i,j   van der Horst, Gilbertus ^b   Lehmann, Alan R ^a   more..

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c BRUNEL UNIVERSITY   (United Kingdom)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f UNIVERSITY OF BONN   (Germany)

^g LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^h TECHNICAL UNIVERSITY OF MUNICH   (Germany)

ⁱ TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^j GERMAN CENTER FOR DIABETES RESEARCH DZD   (Germany)

^k LANCASTER UNIVERSITY   (United Kingdom)

more..

Author keywords

DNA repair; Mouse model; Sister chromatid exchange; SMC Protein

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CARRIER PROTEINS AND BINDING PROTEINS; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3 ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; MITOMYCIN; PROTEIN SMC5; PROTEIN SMC6; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; ESSENTIAL GENE; FEMALE; FIBROBLAST; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; GLUCOSE TOLERANCE; HEMATOPOIESIS; HYDROLYSIS; LOXP SITE; MALE; MEGALOCYTOSIS; MOUSE; NOCICEPTION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; SISTER CHROMATID EXCHANGE; ULTRAVIOLET RADIATION;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; ANIMALS; CATALYTIC DOMAIN; CELL CYCLE PROTEINS; CELLS, CULTURED; FERTILITY; FIBROBLASTS; GENES, ESSENTIAL; GLUCOSE INTOLERANCE; HEMATOPOIESIS; HYDROLYSIS; INTRONS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOMYCIN; MUTATION, MISSENSE; NOCICEPTION; PHENOTYPE; SISTER CHROMATID EXCHANGE; ULTRAVIOLET RAYS;

MAMMALIA; MUS;

EID: 84876699668     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2013.02.006     Document Type: Article

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