Nimodipine nanocrystals for oral bioavailability improvement: Role of mesenteric lymph transport in the oral absorption

International Journal of Pharmaceutics

Volumn 448, Issue 1, 2013, Pages 290-297

  Fu, Qiang ^a   Sun, Jin ^a   Ai, Xiaoyu ^a   Zhang, Peng ^a   Li, Mo ^b   Wang, Yongjun ^a   Liu, Xiaohong ^a   Sun, Yinghua ^a   Sui, Xiaofan ^b   Sun, Le ^a   Han, Xiaopeng ^a   Zhu, Meng ^a   Zhang, Yuyang ^a   Wang, Siling ^a   He, Zhonggui ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Liaoning Institute for Food and Drug Control   (China)

Author keywords

Endocytosis; Mesenteric lymph transport; Nanocrystals; Nimodipine; Solid dispersions; Unfavoured in vitro in vivo correlation

Indexed keywords

NANOCRYSTAL; NIMODIPINE;

ANIMAL CELL; ARTICLE; COLON; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DUODENUM; EXUDATE; ILEUM; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CELL; MALE; MESENTERY LYMPH NODE; NONHUMAN; PERMEABILITY; PINOCYTOSIS; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CALCIUM CHANNEL BLOCKERS; ENDOCYTOSIS; HUMANS; INTESTINAL ABSORPTION; LYMPH; MALE; MESENTERY; NANOPARTICLES; NIMODIPINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84876687471     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.01.065     Document Type: Article

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