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Volumn 97, Issue 7, 2013, Pages 3073-3084

The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum

Author keywords

MFS transporter; Penicillin biosynthetic pathway; Penicillium chrysogenum; Peroxisomal membrane protein; Phenylacetic acid

Indexed keywords

BIOSYNTHETIC PATHWAY; MFS TRANSPORTER; PENICILLIUM CHRYSOGENUM; PEROXISOMAL MEMBRANE PROTEIN; PHENYLACETIC ACID;

EID: 84876679810     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-4425-1     Document Type: Article
Times cited : (26)

References (51)
  • 1
    • 0026800606 scopus 로고
    • Penicillin and cephalosporin biosynthetic genes: Structure, organization, regulation, and evolution
    • 10.1146/annurev.mi.46.100192.002333 10.1146/annurev.mi.46.100192.002333 1:CAS:528:DyaK3sXjtlKisA%3D%3D
    • Aharonowitz Y, Cohen G, Martín JF (1992) Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation, and evolution. Annu Rev Microbiol 46:461-495. doi: 10.1146/annurev.mi.46.100192. 002333
    • (1992) Annu Rev Microbiol , vol.46 , pp. 461-495
    • Aharonowitz, Y.1    Cohen, G.2    Martín, J.F.3
  • 2
    • 0023618509 scopus 로고
    • Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum
    • 10.1128/AAC.31.11.1675 10.1128/AAC.31.11.1675
    • Álvarez E, Cantoral JM, Barredo JL, Díez B, Martín JF (1987) Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum. Antimicrob Agents Chemother 31:1675-1682. doi: 10.1128/AAC.31.11.1675
    • (1987) Antimicrob Agents Chemother , vol.31 , pp. 1675-1682
    • Álvarez, E.1    Cantoral, J.M.2    Barredo, J.L.3    Díez, B.4    Martín, J.F.5
  • 3
    • 0027301365 scopus 로고
    • The isopenicillin-N acyltransferase of Penicillium chrysogenum has isopenicillin-N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities, all of which are encoded by the single penDE gene
    • 10.1111/j.1432-1033.1993.tb18038.x 10.1111/j.1432-1033.1993.tb18038.x
    • Álvarez E, Meesschaert B, Montenegro E, Gutierrez S, Díez B, Barredo JL, Martín JF (1993) The isopenicillin-N acyltransferase of Penicillium chrysogenum has isopenicillin-N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities, all of which are encoded by the single penDE gene. Eur J Biochem 215:323-332. doi: 10.1111/j.1432-1033. 1993.tb18038.x
    • (1993) Eur J Biochem , vol.215 , pp. 323-332
    • Álvarez, E.1    Meesschaert, B.2    Montenegro, E.3    Gutierrez, S.4    Díez, B.5    Barredo, J.L.6    Martín, J.F.7
  • 4
    • 0027717422 scopus 로고
    • Penicillin production by mutants resistant to phenylacetic acid
    • 10.1016/0922-338X(93)90240-9 10.1016/0922-338X(93)90240-9
    • Barrios-González J, Eduardo Montenegro E, Martín JF (1993) Penicillin production by mutants resistant to phenylacetic acid. J Ferment Bioeng 76:455-458. doi: 10.1016/0922-338X(93)90240-9
    • (1993) J Ferment Bioeng , vol.76 , pp. 455-458
    • Barrios-González, J.1    Eduardo Montenegro, E.2    Martín, J.F.3
  • 5
    • 0023187586 scopus 로고
    • High-frequency transformation of Penicillium chrysogenum
    • 10.1038/nbt0587-494 10.1038/nbt0587-494 1:CAS:528:DyaL2sXktVCju78%3D
    • Cantoral JM, Díez B, Barredo JL, Álvarez E, Martín JF (1987) High-frequency transformation of Penicillium chrysogenum. Nat Biotechnol 5:494-497. doi: 10.1038/nbt0587-494
    • (1987) Nat Biotechnol , vol.5 , pp. 494-497
    • Cantoral, J.M.1    Díez, B.2    Barredo, J.L.3    Álvarez, E.4    Martín, J.F.5
  • 6
    • 0031817133 scopus 로고    scopus 로고
    • Characterization and nitrogen-source regulation at the transcriptional level of the gdhA gene of Aspergillus awamori encoding an NADP-dependent glutamate dehydrogenase
    • 10.1007/s002940050365 10.1007/s002940050365 1:CAS:528:DyaK1cXks12hsLo%3D
    • Cardoza RE, Moralejo FJ, Gutiérrez S, Casqueiro J, Fierro F, Martín JF (1998) Characterization and nitrogen-source regulation at the transcriptional level of the gdhA gene of Aspergillus awamori encoding an NADP-dependent glutamate dehydrogenase. Curr Genet 34:50-59. doi: 10.1007/s002940050365
    • (1998) Curr Genet , vol.34 , pp. 50-59
    • Cardoza, R.E.1    Moralejo, F.J.2    Gutiérrez, S.3    Casqueiro, J.4    Fierro, F.5    Martín, J.F.6
  • 7
    • 0344958832 scopus 로고    scopus 로고
    • Gene targeting in Penicillium chrysogenum: Disruption of the lys2 gene leads to penicillin overproduction
    • 1:CAS:528:DyaK1MXhsV2qsr0%3D
    • Casqueiro J, Gutierrez S, Bañuelos O, Hijarrubia MJ, Martín JF (1999) Gene targeting in Penicillium chrysogenum: disruption of the lys2 gene leads to penicillin overproduction. J Bacteriol 181:1181-1188
    • (1999) J Bacteriol , vol.181 , pp. 1181-1188
    • Casqueiro, J.1    Gutierrez, S.2    Bañuelos, O.3    Hijarrubia, M.J.4    Martín, J.F.5
  • 8
    • 0025026399 scopus 로고
    • The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl- valine synthetase and linkage to the pcbC and penDE genes
    • Díez B, Gutierrez S, Barredo JL, van Solingen P, van der Voort LH, Martín JF (1990) The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes. J Biol Chem 265:16358-16365
    • (1990) J Biol Chem , vol.265 , pp. 16358-16365
    • Díez, B.1    Gutierrez, S.2    Barredo, J.L.3    Van Solingen, P.4    Van Der Voort, L.H.5    Martín, J.F.6
  • 9
    • 84873990550 scopus 로고    scopus 로고
    • A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum
    • doi: 10.1007/s00253-012-4256-0
    • Fernández-Aguado M, Teijeira F, Martín JF, Ullán RV (2012) A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum. Appl Microbiol Biotechnol. doi: 10.1007/s00253-012-4256-0
    • (2012) Appl Microbiol Biotechnol
    • Fernández-Aguado M, T.1
  • 10
    • 0024730808 scopus 로고
    • Phenylacetic acid transport system in Penicillium chrysogenum Wis 54-1255: Molecular specificity of its induction
    • 10.7164/antibiotics.42.1410 10.7164/antibiotics.42.1410
    • Fernández-Cañón JM, Reglero A, Martínez-Blanco H, Ferrero MA, Luengo JM (1989a) Phenylacetic acid transport system in Penicillium chrysogenum Wis 54-1255: molecular specificity of its induction. J Antibiot (Tokyo) 42:1410-1415. doi: 10.7164/antibiotics.42.1410
    • (1989) J Antibiot (Tokyo) , vol.42 , pp. 1410-1415
    • Fernández-Cañón, J.M.1    Reglero, A.2    Martínez- Blanco, H.3    Ferrero, M.A.4    Luengo, J.M.5
  • 11
    • 0024730758 scopus 로고
    • Uptake of phenylacetic acid by Penicillium chrysogenum Wis 54-1255: A critical regulatory point in benzylpenicillin biosynthesis
    • 10.7164/antibiotics.42.1398 10.7164/antibiotics.42.1398
    • Fernández-Cañón JM, Reglero A, Martínez-Blanco H, Luengo JM (1989b) Uptake of phenylacetic acid by Penicillium chrysogenum Wis 54-1255: a critical regulatory point in benzylpenicillin biosynthesis. J Antibiot (Tokyo) 42:1398-1409. doi: 10.7164/antibiotics.42.1398
    • (1989) J Antibiot (Tokyo) , vol.42 , pp. 1398-1409
    • Fernández-Cañón, J.M.1    Reglero, A.2    Martínez- Blanco, H.3    Luengo, J.M.4
  • 12
    • 0028998750 scopus 로고
    • The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences
    • 10.1016/j.fgb.2006.03.001 10.1073/pnas.92.13.6200 1:CAS:528: DyaK2MXmsFajsL4%3D
    • Fierro F, Barredo JL, Díez B, Gutiérrez S, Fernández FJ, Martín JF (1995) The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences. Proc Natl Acad Sci U S A 92:6200-6204. doi: 10.1016/j.fgb.2006.03.001
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 6200-6204
    • Fierro, F.1    Barredo, J.L.2    Díez, B.3    Gutiérrez, S.4    Fernández, F.J.5    Martín, J.F.6
  • 13
    • 43149089553 scopus 로고    scopus 로고
    • The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing
    • 10.1016/j.fgb.2008.03.005 10.1016/j.fgb.2008.03.005
    • García-Estrada C, Vaca I, Fierro F, Sjollema K, Veenhuis M, Martín JF (2008) The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing. Fungal Genet Biol 45:1043-1052. doi: 10.1016/j.fgb.2008.03. 005
    • (2008) Fungal Genet Biol , vol.45 , pp. 1043-1052
    • García-Estrada, C.1    Vaca, I.2    Fierro, F.3    Sjollema, K.4    Veenhuis, M.5    Martín, J.F.6
  • 14
    • 82255194025 scopus 로고    scopus 로고
    • A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum
    • 10.1016/j.chembiol.2011.08.012 10.1016/j.chembiol.2011.08.012
    • García-Estrada C, Ullán RV, Albillos SM, Fernández-Bodega MA, Durek P, von Dohren H, Martín JF (2011) A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum. Chem Biol 18:1499-1512. doi: 10.1016/j.chembiol.2011.08.012
    • (2011) Chem Biol , vol.18 , pp. 1499-1512
    • García-Estrada, C.1    Ullán, R.V.2    Albillos, S.M.3    Fernández-Bodega, M.A.4    Durek, P.5    Von Dohren, H.6    Martín, J.F.7
  • 16
    • 61349165717 scopus 로고    scopus 로고
    • Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production
    • 10.1186/1471-2164-10-75 10.1186/1471-2164-10-75
    • Harris DM, van der Krogt ZA, Klaassen P, Raamsdonk LM, Hage S, van den Berg MA, Bovenberg RA, Pronk JT, Daran JM (2009) Exploring and dissecting genome-wide gene expression responses of Penicillium chrysogenum to phenylacetic acid consumption and penicillinG production. BMC Genomics 10:75. doi: 10.1186/1471-2164-10-75
    • (2009) BMC Genomics , vol.10 , pp. 75
    • Harris, D.M.1    Van Der Krogt, Z.A.2    Klaassen, P.3    Raamsdonk, L.M.4    Hage, S.5    Van Den Berg, M.A.6    Bovenberg, R.A.7    Pronk, J.T.8    Daran, J.M.9
  • 17
    • 18944372099 scopus 로고    scopus 로고
    • Biogenesis of peroxisomes. Topogenesis of the peroxisomal membrane and matrix proteins
    • 10.1111/j.1742-4658.2005.04690.x 10.1111/j.1742-4658.2005.04690.x 1:CAS:528:DC%2BD2MXksFyrsbo%3D
    • Heiland I, Erdmann R (2005) Biogenesis of peroxisomes. Topogenesis of the peroxisomal membrane and matrix proteins. FEBS J 272:2362-2372. doi: 10.1111/j.1742-4658.2005.04690.x
    • (2005) FEBS J , vol.272 , pp. 2362-2372
    • Heiland, I.1    Erdmann, R.2
  • 18
    • 0032553852 scopus 로고    scopus 로고
    • Modelling of the protonophoric uncoupling by phenoxyacetic acid of the plasma membrane potential of Penicillium chrysogenum
    • 10.1002/(SICI)1097-0290(19981220)60:6 < 761: AID-BIT12 > 3.0.CO;2-N 10.1002/(SICI)1097-0290(19981220)60:6<761: AID-BIT12>3.0.CO;2-N 1:CAS:528:DyaK1cXnsVegurk%3D
    • Henriksen CM, Nielsen J, Villadsen J (1998) Modelling of the protonophoric uncoupling by phenoxyacetic acid of the plasma membrane potential of Penicillium chrysogenum. Biotechnol Bioeng 60:761-767. doi:10.1002/(SICI) 1097-0290(19981220)60:6 < 761::AID-BIT12 > 3.0.CO;2-N
    • (1998) Biotechnol Bioeng , vol.60 , pp. 761-767
    • Henriksen, C.M.1    Nielsen, J.2    Villadsen, J.3
  • 19
    • 0029054086 scopus 로고
    • Penicillium chrysogenum takes up the penicillin G precursor phenylacetic acid by passive diffusion
    • 1:CAS:528:DyaK2MXms1Gku78%3D
    • Hillenga DJ, Versantvoort H, van der Molen S, Driessen A, Konings WN (1995) Penicillium chrysogenum takes up the penicillin G precursor phenylacetic acid by passive diffusion. Appl Environ Microbiol 61:2589-2595
    • (1995) Appl Environ Microbiol , vol.61 , pp. 2589-2595
    • Hillenga, D.J.1    Versantvoort, H.2    Van Der Molen, S.3    Driessen, A.4    Konings, W.N.5
  • 20
    • 30544434099 scopus 로고    scopus 로고
    • Fungal secondary metabolism - From biochemistry to genomics
    • 10.1038/nrmicro1286 10.1038/nrmicro1286 1:CAS:528:DC%2BD2MXht1OnsLbF
    • Keller NP, Turner G, Bennett JW (2005) Fungal secondary metabolism - from biochemistry to genomics. Nat Rev Microbiol 3:937-947. doi: 10.1038/nrmicro1286
    • (2005) Nat Rev Microbiol , vol.3 , pp. 937-947
    • Keller, N.P.1    Turner, G.2    Bennett, J.W.3
  • 21
    • 71249102933 scopus 로고    scopus 로고
    • The Penicillium chrysogenum aclA gene encodes a broad-substrate- specificity acyl-coenzyme A ligase involved in activation of adipic acid, a side-chain precursor for cephem antibiotics
    • 10.1016/j.fgb.2009.10.003 10.1016/j.fgb.2009.10.003 1:CAS:528: DC%2BD1MXhsFGrur%2FF
    • Koetsier MJ, Gombert AK, Fekken S, Bovenberg RA, van den Berg MA, Kiel JA, Jekel PA, Janssen DB, Pronk JT, van der Klei IJ, Daran JM (2010) The Penicillium chrysogenum aclA gene encodes a broad-substrate-specificity acyl-coenzyme A ligase involved in activation of adipic acid, a side-chain precursor for cephem antibiotics. Fungal Genet Biol 47:33-42. doi: 10.1016/j.fgb.2009.10.003
    • (2010) Fungal Genet Biol. , vol.47 , pp. 33-42
    • Koetsier, M.J.1    Gombert, A.K.2    Fekken, S.3    Bovenberg, R.A.4    Van Den Berg, M.A.5    Kiel, J.A.6    Jekel, P.A.7    Janssen, D.B.8    Pronk, J.T.9    Van Der Klei, I.J.10    Daran, J.M.11
  • 22
    • 58249093553 scopus 로고    scopus 로고
    • Characterization of a phenylacetate-CoA ligase from Penicillium chrysogenum
    • 10.1042/BJ20081257 10.1042/BJ20081257 1:CAS:528:DC%2BD1cXhsFCisLfE
    • Koetsier MJ, Jekel PA, van den Berg MA, Bovenberg RA, Janssen DB (2009) Characterization of a phenylacetate-CoA ligase from Penicillium chrysogenum. Biochem J 417:467-476. doi: 10.1042/BJ20081257
    • (2009) Biochem J , vol.417 , pp. 467-476
    • Koetsier, M.J.1    Jekel, P.A.2    Van Den Berg, M.A.3    Bovenberg, R.A.4    Janssen, D.B.5
  • 23
    • 58549084975 scopus 로고    scopus 로고
    • The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum
    • 10.1016/j.biochi.2008.09.004 10.1016/j.biochi.2008.09.004 1:CAS:528:DC%2BD1MXhtlGrs78%3D
    • Kosalkova K, García-Estrada C, Ullán RV, Godio RP, Feltrer R, Teijeira F, Mauriz E, Martín JF (2009) The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum. Biochimie 91:214-225. doi: 10.1016/j.biochi.2008.09.004
    • (2009) Biochimie , vol.91 , pp. 214-225
    • Kosalkova, K.1    García-Estrada, C.2    Ullán, R.V.3    Godio, R.P.4    Feltrer, R.5    Teijeira, F.6    Mauriz, E.7    Martín, J.F.8
  • 24
    • 33645581640 scopus 로고    scopus 로고
    • Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase
    • 10.1042/BJ20051599 10.1042/BJ20051599 1:CAS:528:DC%2BD28XitlSnsrk%3D
    • Lamas-Maceiras M, Vaca I, Rodríguez E, Casqueiro J, Martín JF (2006) Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase. Biochem J 395:147-155. doi: 10.1042/BJ20051599
    • (2006) Biochem J , vol.395 , pp. 147-155
    • Lamas-Maceiras, M.1    Vaca, I.2    Rodríguez, E.3    Casqueiro, J.4    Martín, J.F.5
  • 25
    • 84856643514 scopus 로고    scopus 로고
    • Proteomic and biochemical evidence support a role for transport vesicles and endosomes in stress response and secondary metabolism in Aspergillus parasiticus
    • 10.1021/pr2006389 10.1021/pr2006389 1:CAS:528:DC%2BC3MXhsV2nu73P
    • Linz JE, Chanda A, Hong SY, Whitten DA, Wilkerson C, Roze LV (2012) Proteomic and biochemical evidence support a role for transport vesicles and endosomes in stress response and secondary metabolism in Aspergillus parasiticus. J Proteome Res 11:767-775. doi: 10.1021/pr2006389
    • (2012) J Proteome Res , vol.11 , pp. 767-775
    • Linz, J.E.1    Chanda, A.2    Hong, S.Y.3    Whitten, D.A.4    Wilkerson, C.5    Roze, L.V.6
  • 26
    • 0033762376 scopus 로고    scopus 로고
    • Alpha-aminoadipyl-cysteinyl-valine synthetases in beta-lactam producing organisms. from Abraham's discoveries to novel concepts of non-ribosomal peptide synthesis
    • 10.7164/antibiotics.53.100 10.7164/antibiotics.53.1008
    • Martín JF (2000) Alpha-aminoadipyl-cysteinyl-valine synthetases in beta-lactam producing organisms. From Abraham's discoveries to novel concepts of non-ribosomal peptide synthesis. J Antibiot (Tokyo) 53:1008-1021. doi: 10.7164/antibiotics.53.100
    • (2000) J Antibiot (Tokyo) , vol.53 , pp. 1008-1021
    • Martín, J.F.1
  • 27
    • 77953172576 scopus 로고    scopus 로고
    • Regulation and compartmentalization of beta-lactam biosynthesis
    • 10.1111/j.1751-7915.2009.00123.x 10.1111/j.1751-7915.2009.00123.x
    • Martín JF, Ullán RV, García-Estrada C (2010) Regulation and compartmentalization of beta-lactam biosynthesis. Microb Biotechnol 3:285-299. doi: 10.1111/j.1751-7915.2009.00123.x
    • (2010) Microb Biotechnol , vol.3 , pp. 285-299
    • Martín, J.F.1    Ullán, R.V.2    García-Estrada, C.3
  • 28
    • 84873987111 scopus 로고    scopus 로고
    • Genes encoding penicillin and cephalosporin biosynthesis in Acremonium chrysogenum: Two separate clusters are required
    • Gupta VK and Ayyachamy M (eds)
    • Martín JF, García-Estrada C, Ullán RV (2012) Genes encoding penicillin and cephalosporin biosynthesis in Acremonium chrysogenum: two separate clusters are required. In: Gupta VK and Ayyachamy M (eds) Biotechnology of fungal genes. Science, pp 113-138
    • (2012) Biotechnology of Fungal Genes. Science , pp. 113-138
    • Martín, J.F.1    García-Estrada, C.2    Ullán, R.V.3
  • 29
    • 0343244936 scopus 로고
    • Extrachromosomal genetics of Cephalosporium acremonium
    • 10.1007/BF00391811 10.1007/BF00391811 1:CAS:528:DyaL3sXht1agtg%3D%3D
    • Minuth W, Tudzynski P, Esser K (1982) Extrachromosomal genetics of Cephalosporium acremonium. Curr Genet 5:227-231. doi: 10.1007/BF00391811
    • (1982) Curr Genet , vol.5 , pp. 227-231
    • Minuth, W.1    Tudzynski, P.2    Esser, K.3
  • 32
    • 53249134455 scopus 로고    scopus 로고
    • Expression of the transporter encoded by the cefT gene of Acremonium chrysogenum increases cephalosporin production in Penicillium chrysogenum
    • 10.1016/j.fgb.2008.07.008 10.1016/j.fgb.2008.07.008 1:CAS:528: DC%2BD1cXht1ejtbbJ
    • Nijland JG, Kovalchuk A, van den Berg MA, Bovenberg RA, Driessen AJ (2008) Expression of the transporter encoded by the cefT gene of Acremonium chrysogenum increases cephalosporin production in Penicillium chrysogenum. Fungal Genet Biol 45:1415-1421. doi: 10.1016/j.fgb.2008.07.008
    • (2008) Fungal Genet Biol , vol.45 , pp. 1415-1421
    • Nijland, J.G.1    Kovalchuk, A.2    Van Den Berg, M.A.3    Bovenberg, R.A.4    Driessen, A.J.5
  • 33
    • 0021918078 scopus 로고
    • Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts delta-(l-alpha-aminoadipyl)-l-cysteinyl-d-valine to isopenicillin N
    • 10.1128/AAC.27.3.380 10.1128/AAC.27.3.380 1:CAS:528:DyaL2MXhs1alu7o%3D
    • Ramos FR, López-Nieto MJ, Martín JF (1985) Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts delta-(l-alpha-aminoadipyl)-l-cysteinyl-d-valine to isopenicillin N. Antimicrob Agents Chemother 27:380-387. doi: 10.1128/AAC.27.3.380
    • (1985) Antimicrob Agents Chemother , vol.27 , pp. 380-387
    • Ramos, F.R.1    López-Nieto, M.J.2    Martín, J.F.3
  • 34
    • 0034836582 scopus 로고    scopus 로고
    • Reduced function of a phenylacetate-oxidizing cytochrome p450 caused strong genetic improvement in early phylogeny of penicillin-producing strains
    • 10.1128/JB.183.19.5465-5471.2001 10.1128/JB.183.19.5465-5471.2001
    • Rodríguez-Saiz M, Barredo JL, Moreno MA, Fernández- Cañon JM, Peñalva MA, Díez B (2001) Reduced function of a phenylacetate-oxidizing cytochrome p450 caused strong genetic improvement in early phylogeny of penicillin-producing strains. J Bacteriol 183:5465-5471. doi: 10.1128/JB.183.19.5465-5471.2001
    • (2001) J Bacteriol , vol.183 , pp. 5465-5471
    • Rodríguez-Saiz, M.1    Barredo, J.L.2    Moreno, M.A.3    Fernández- Cañon, J.M.4    Peñalva, M.A.5    Díez, B.6
  • 35
    • 16244402009 scopus 로고    scopus 로고
    • Why did the Fleming strain fail in penicillin industry?
    • 10.1016/j.fgb.2005.01.014 10.1016/j.fgb.2005.01.014
    • Rodríguez-Saiz M, Díez B, Barredo JL (2005) Why did the Fleming strain fail in penicillin industry? Fungal Genet Biol 42:464-470. doi: 10.1016/j.fgb.2005.01.014
    • (2005) Fungal Genet Biol , vol.42 , pp. 464-470
    • Rodríguez-Saiz, M.1    Díez, B.2    Barredo, J.L.3
  • 36
    • 3042724871 scopus 로고    scopus 로고
    • Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signals
    • 10.1091/mbc.E04-03-0188 10.1091/mbc.E04-03-0188 1:CAS:528: DC%2BD2cXlslWnsbY%3D
    • Rottensteiner H, Kramer A, Lorenzen S, Stein K, Landgraf C, Volkmer-Engert R, Erdmann R (2004) Peroxisomal membrane proteins contain common Pex19p-binding sites that are an integral part of their targeting signals. Mol Biol Cell 15:3406-3417. doi: 10.1091/mbc.E04-03-0188
    • (2004) Mol Biol Cell , vol.15 , pp. 3406-3417
    • Rottensteiner, H.1    Kramer, A.2    Lorenzen, S.3    Stein, K.4    Landgraf, C.5    Volkmer-Engert, R.6    Erdmann, R.7
  • 37
    • 78650208991 scopus 로고    scopus 로고
    • Compartmentalization and molecular traffic in secondary metabolism: A new understanding of established cellular processes
    • 10.1016/j.fgb.2010.05.006 10.1016/j.fgb.2010.05.006 1:CAS:528: DC%2BC3cXhsVGnur7F
    • Roze LV, Chanda A, Linz JE (2011) Compartmentalization and molecular traffic in secondary metabolism: a new understanding of established cellular processes. Fungal Genet Biol 48:35-48. doi: 10.1016/j.fgb.2010.05.006
    • (2011) Fungal Genet Biol , vol.48 , pp. 35-48
    • Roze, L.V.1    Chanda, A.2    Linz, J.E.3
  • 38
    • 0026102071 scopus 로고
    • Distinct cis-acting signals enhance 3′ endpoint formation of cyc1 mRNA in the yeast Saccharomyces cerevisiae
    • 1:CAS:528:DyaK3MXisVWkt78%3D
    • Russo P, Li WZ, Hampsey DM, Zaret KS, Sherman F (1991) Distinct cis-acting signals enhance 3′ endpoint formation of cyc1 mRNA in the yeast Saccharomyces cerevisiae. EMBO J 10:563-571
    • (1991) EMBO J , vol.10 , pp. 563-571
    • Russo, P.1    Li, W.Z.2    Hampsey, D.M.3    Zaret, K.S.4    Sherman, F.5
  • 39
    • 61949235019 scopus 로고    scopus 로고
    • Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans
    • 10.1128/EC.00374-08 10.1128/EC.00374-08
    • Spröte P, Brakhage AA, Hynes MJ (2009) Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans. Eukaryot Cell 8:421-423. doi: 10.1128/EC.00374-08
    • (2009) Eukaryot Cell , vol.8 , pp. 421-423
    • Spröte, P.1    Brakhage, A.A.2    Hynes, M.J.3
  • 40
    • 59849116926 scopus 로고    scopus 로고
    • The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production
    • 10.1042/BJ20081180 10.1042/BJ20081180 1:CAS:528:DC%2BD1MXhtFSht7Y%3D
    • Teijeira F, Ullán RV, Guerra SM, García-Estrada C, Vaca I, Martín JF (2009) The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production. Biochem J 418:113-124. doi: 10.1042/BJ20081180
    • (2009) Biochem J , vol.418 , pp. 113-124
    • Teijeira, F.1    Ullán, R.V.2    Guerra, S.M.3    García-Estrada, C.4    Vaca, I.5    Martín, J.F.6
  • 41
    • 0030721441 scopus 로고    scopus 로고
    • Purification and characterization of delta-(l-alpha-aminoadipyl)-l- cysteinyl-d-valine synthetase from Penicillium chrysogenum
    • 1:CAS:528:DyaK2sXmvVGqsb0%3D
    • Theilgaard HB, Kristiansen KN, Henriksen CM, Nielsen J (1997) Purification and characterization of delta-(l-alpha-aminoadipyl)-l-cysteinyl-d- valine synthetase from Penicillium chrysogenum. Biochem J 327:185-191
    • (1997) Biochem J , vol.327 , pp. 185-191
    • Theilgaard, H.B.1    Kristiansen, K.N.2    Henriksen, C.M.3    Nielsen, J.4
  • 42
    • 0033019615 scopus 로고    scopus 로고
    • Metabolic control analysis of the penicillin biosynthetic pathway: The influence of the LLD-ACV:bisACV ratio on the flux control
    • 10.1023/A:1001781808150 10.1023/A:1001781808150 1:CAS:528: DyaK1MXkvFKht7c%3D
    • Theilgaard HA, Nielsen J (1999) Metabolic control analysis of the penicillin biosynthetic pathway: the influence of the LLD-ACV:bisACV ratio on the flux control. Antonie Van Leeuwenhoek 75:145-154. doi: 10.1023/A: 1001781808150
    • (1999) Antonie Van Leeuwenhoek , vol.75 , pp. 145-154
    • Theilgaard, H.A.1    Nielsen, J.2
  • 43
    • 0036323756 scopus 로고    scopus 로고
    • The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production
    • 10.1007/s00438-002-0702-5 10.1007/s00438-002-0702-5
    • Ullán RV, Liu G, Casqueiro J, Gutierrez S, Bañuelos O, Martín JF (2002) The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production. Mol Genet Genomics 267:673-683. doi: 10.1007/s00438-002-0702-5
    • (2002) Mol Genet Genomics , vol.267 , pp. 673-683
    • Ullán, R.V.1    Liu, G.2    Casqueiro, J.3    Gutierrez, S.4    Bañuelos, O.5    Martín, J.F.6
  • 44
    • 33947267597 scopus 로고    scopus 로고
    • Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes
    • 10.1016/j.chembiol.2007.01.012 10.1016/j.chembiol.2007.01.012
    • Ullán RV, Campoy S, Casqueiro J, Fernández FJ, Martín JF (2007) Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes. Chem Biol 14:329-339. doi: 10.1016/j.chembiol.2007.01.012
    • (2007) Chem Biol , vol.14 , pp. 329-339
    • Ullán, R.V.1    Campoy, S.2    Casqueiro, J.3    Fernández, F.J.4    Martín, J.F.5
  • 45
    • 50549086676 scopus 로고    scopus 로고
    • RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: Validation studies using beta-lactam genes expression
    • 10.1016/j.mimet.2008.06.001 10.1016/j.mimet.2008.06.001
    • Ullán RV, Godio RP, Teijeira F, Vaca I, García-Estrada C, Feltrer R, Kosalkova K, Martín JF (2008a) RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: validation studies using beta-lactam genes expression. J Microbiol Methods 75:209-218. doi: 10.1016/j.mimet.2008.06. 001
    • (2008) J Microbiol Methods , vol.75 , pp. 209-218
    • Ullán, R.V.1    Godio, R.P.2    Teijeira, F.3    Vaca, I.4    García-Estrada, C.5    Feltrer, R.6    Kosalkova, K.7    Martín, J.F.8
  • 46
    • 50849126781 scopus 로고    scopus 로고
    • Expression of the Acremonium chrysogenum cefT gene in Penicillum chrysogenum indicates that it encodes an hydrophilic beta-lactam transporter
    • 10.1007/s00294-008-0207-9 10.1007/s00294-008-0207-9
    • Ullán RV, Teijeira F, Martin JF (2008b) Expression of the Acremonium chrysogenum cefT gene in Penicillum chrysogenum indicates that it encodes an hydrophilic beta-lactam transporter. Curr Genet 54:153-161. doi: 10.1007/s00294-008-0207-9
    • (2008) Curr Genet , vol.54 , pp. 153-161
    • Ullán, R.V.1    Teijeira, F.2    Martin, J.F.3
  • 47
    • 78649608529 scopus 로고    scopus 로고
    • Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C
    • 10.1042/BJ20100827 10.1042/BJ20100827
    • Ullán RV, Teijeira F, Guerra SM, Vaca I, Martín JF (2010) Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C. Biochem J 432:227-236. doi: 10.1042/BJ20100827
    • (2010) Biochem J , vol.432 , pp. 227-236
    • Ullán, R.V.1    Teijeira, F.2    Guerra, S.M.3    Vaca, I.4    Martín, J.F.5
  • 48
    • 0033020288 scopus 로고    scopus 로고
    • Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi
    • 10.1023/A:1001775932202 10.1023/A:1001775932202
    • van de Kamp M, Driessen AJ, Konings WN (1999) Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi. Antonie Van Leeuwenhoek 75:41-78. doi: 10.1023/A:1001775932202
    • (1999) Antonie Van Leeuwenhoek , vol.75 , pp. 41-78
    • Van De Kamp, M.1    Driessen, A.J.2    Konings, W.N.3
  • 50
    • 79959769183 scopus 로고    scopus 로고
    • Transcriptional regulatory elements in fungal secondary metabolism
    • 10.1007/s12275-011-1009-1 10.1007/s12275-011-1009-1 1:CAS:528: DC%2BC3MXotlyhu78%3D
    • Yin W, Keller NP (2011) Transcriptional regulatory elements in fungal secondary metabolism. J Microbiol 49:329-339. doi: 10.1007/s12275-011-1009-1
    • (2011) J Microbiol , vol.49 , pp. 329-339
    • Yin, W.1    Keller, N.P.2
  • 51
    • 79960058417 scopus 로고    scopus 로고
    • Cloning and characterization of a novel CoA-ligase gene from Penicillium chrysogenum
    • 10.1007/s12223-011-0044-y 10.1007/s12223-011-0044-y 1:CAS:528: DC%2BC3MXosFCgt74%3D
    • Yu ZL, Liu J, Wang FQ, Dai M, Zhao BH, He JG, Zhang H (2011) Cloning and characterization of a novel CoA-ligase gene from Penicillium chrysogenum. Folia Microbiol (Praha) 56:246-252. doi: 10.1007/s12223-011-0044-y
    • (2011) Folia Microbiol (Praha) , vol.56 , pp. 246-252
    • Yu, Z.L.1    Liu, J.2    Wang, F.Q.3    Dai, M.4    Zhao, B.H.5    He, J.G.6    Zhang, H.7


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