Expression of the transporter encoded by the cefT gene of Acremonium chrysogenum increases cephalosporin production in Penicillium chrysogenum

Fungal Genetics and Biology

Volumn 45, Issue 10, 2008, Pages 1415-1421

  Nijland, Jeroen G ^a   Kovalchuk, Andriy ^a   van den Berg, Marco A ^b   Bovenberg, Roel A L ^b   Driessen, Arnold J M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b DSM RESOLVE   (Netherlands)

Author keywords

Acremonium; Cephalosporin biosynthesis; Penicillium; Transport

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; CEPHALOSPORIN; CEPHALOSPORIN C; PENICILLIN G;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CEPHALOSPORIUM ACREMONIUM; FUNGAL GENETICS; FUNGAL STRAIN; FUNGUS CULTURE; GENE EXPRESSION; NONHUMAN; PENICILLIUM CHRYSOGENUM; PRIORITY JOURNAL;

ACREMONIUM; ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; FUNGAL PROTEINS; GENE EXPRESSION; GENOME, FUNGAL; MEMBRANE TRANSPORT PROTEINS; PENICILLINS; PENICILLIUM CHRYSOGENUM; PROTEIN TRANSPORT; TRANSCRIPTION, GENETIC;

ACREMONIUM (ASCOMYCOTA); ACREMONIUM CHRYSOGENUM; FUNGI; PENICILLIUM; PENICILLIUM CHRYSOGENUM; STREPTOMYCES CLAVULIGERUS;

EID: 53249134455     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2008.07.008     Document Type: Article

References (19)

1. Alvarez E., Cantoral J.M., Barredo J.L., Diez B., and Martin J.F. Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum. Antimicrob. Agents Chemother. 31 (1987) 1675-1682
2. Andrade A.C., Van Nistelrooy J.G., Peery R.B., Skatrud P.L., and de Waard M.A. The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production. Mol. Gen. Genet. 263 (2000) 966-977
3. Barber M.S., Giesecke U., Reichert A., and Minas W. Industrial enzymatic production of cephalosporin-based beta-lactams. Adv. Biochem. Eng. Biotechnol. 88 (2004) 179-215
4. Coque J.J., Liras P., and Martin J.F. Genes for a beta-lactamase, a penicillin-binding protein and a transmembrane protein are clustered with the cephamycin biosynthetic genes in Nocardia lactamdurans. EMBO J. 12 (1993) 631-639
5. Crawford L., Stepan A.M., McAda P.C., Rambosek J.A., Conder M.J., Vinci V.A., and Reeves C.D. Production of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activity. Biotechnology (NY) 13 (1995) 58-62
6. Elander R.P. Industrial production of beta-lactam antibiotics. Appl. Microbiol. Biotechnol. 61 (2003) 385-392
7. Kolar M., Punt P.J., van den Hondel C.A., and Schwab H. Transformation of Penicillium chrysogenum using dominant selection markers and expression of an Escherichia coli lacZ fusion gene. Gene 62 (1988) 127-134
8. Lichten M., and Goldman A.S. Meiotic recombination hotspots. Annu. Rev. Genet. 29 (1995) 423-444
9. Martin J.F., Casqueiro J., Kosalkova K., Marcos A.T., and Gutierrez S. Penicillin and cephalosporin biosynthesis: mechanism of carbon catabolite regulation of penicillin production. Antonie Van Leeuwenhoek 75 (1999) 21-31
10. Martin J.F., Casqueiro J., and Liras P. Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication. Curr. Opin. Microbiol. 8 (2005) 282-293
11. Monti D., Carrea G., Riva S., Baldaro E., and Frare G. Characterization of an industrial biocatalyst: immobilized glutaryl-7-ACA acylase. Biotechnol. Bioeng. 70 (2000) 239-244
12. Nijland J.G., Evers M.E., and Driessen A.J.M. The isolation and identification of a cephalosporin transporter homologue in Penicillium chrysogenum. XXIII Fungal Genetics Conference, Asilomar, USA. Fungal Genet. Newsl. 52 Suppl. (2005) 50
13. Sambrook J., Fritsch E.F., and Maniatis T. Molecular cloning: a laboratory manual. second ed. (1989), Cold Spring Harbor Laboratory Press
14. Schroen C.G., VandeWiel S., Kroon P.J., DeVroom E., Janssen A.E., and Tramper J. Equilibrium position, kinetics, and reactor concepts for the adipyl-7-ADCA-hydrolysis process. Biotechnol. Bioeng. 70 (2000) 654-661
15. Ullan R.V., Campoy S., Casqueiro J., Fernandez F.J., and Martin J.F. Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes. Chem. Biol. 14 (2007) 329-339
16. Ullan R.V., Liu G., Casqueiro J., Gutierrez S., Banuelos O., and Martin J.F. The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production. Mol. Genet. Genomics 267 (2002) 673-683
17. van den Berg M.A., Westerlaken I., Leeflang C., Kerkman R., and Bovenberg R.A. Functional characterization of the penicillin biosynthetic gene cluster of Penicillium chrysogenum Wisconsin54-1255. Fungal Genet. Biol. 44 (2007) 830-844
18. van den Berg, M.A., Albang, R., Albermann, K., Badger, J.H., Daran, J.-M., Driesswen, A.J.M., Estrada, C.G., Fedorova, N.D., Harris, D., Heijne, W., Joaedar, V., Kiel, J., Kovalchuk, A., Martin, J.F., Nierman, W.C., Nijland, J.G., Pronk, J.T., Roubos, J.A., van der Klei, I., van Peij, N.N.M.E., Veenhuis, M., von Döhren, H., C. Wagner, C., Wortman, J., Bovenberg, R.A.L., Molecular analysis of a microbial strain improvement paradigm: genome sequencing and analysis of Penicillium chrysogenum Wisconsin 54-1255, submitted for publication.
19. Weil J., Miramonti J., and Ladisch M.R. Cephalosporin-C-mode of action and biosynthetic-pathway. Enzyme Microb. Technol. 17 (1995) 85-87