메뉴 건너뛰기




Volumn 97, Issue 2, 2013, Pages 795-808

A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum

Author keywords

MFS transporter; Penicillin biosynthetic pathway; Penicillium chrysogenum; Vacuolar membrane protein

Indexed keywords

ACREMONIUM; BETA-LACTAMS; BIOSYNTHETIC GENE; BIOSYNTHETIC PATHWAY; EXPRESSION LEVELS; FLUORESCENT DYES; FUSION PROTEINS; LASER SCANNING MICROSCOPY; MAJOR FACILITATOR; MEMBRANE PROTEINS; MFS TRANSPORTER; MULTIPLE GENES; NORTHERN BLOT ANALYSIS; PENICILLIUM CHRYSOGENUM; PRODUCTION OF; SYNTHETASES; TRANSMEMBRANES; TRANSPORT PROCESS; TRANSPORTER PROTEINS; TRIPEPTIDE; VACUOLAR MEMBRANES;

EID: 84873990550     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-012-4256-0     Document Type: Article
Times cited : (23)

References (68)
  • 1
    • 0026800606 scopus 로고
    • Penicillin and cephalosporin biosynthetic genes: Structure, organization, regulation, and evolution
    • 10.1146/annurev.mi.46.100192.002333 10.1146/annurev.mi.46.100192.002333 1:CAS:528:DyaK3sXjtlKisA%3D%3D
    • Aharonowitz Y, Cohen G, Martín JF (1992) Penicillin and cephalosporin biosynthetic genes: structure, organization, regulation, and evolution. Annu Rev Microbiol 46:461-495. doi: 10.1146/annurev.mi.46.100192. 002333
    • (1992) Annu Rev Microbiol , vol.46 , pp. 461-495
    • Aharonowitz, Y.1    Cohen, G.2    Martín, J.F.3
  • 2
    • 0023618509 scopus 로고
    • Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum
    • 10.1128/AAC.31.11.1675 10.1128/AAC.31.11.1675
    • Álvarez E, Cantoral JM, Barredo JL, Díez B, Martín JF (1987) Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum. Antimicrob Agents Chemother 31:1675-1682. doi: 10.1128/AAC.31.11.1675
    • (1987) Antimicrob Agents Chemother , vol.31 , pp. 1675-1682
    • Álvarez, E.1    Cantoral, J.M.2    Barredo, J.L.3    Díez, B.4    Martín, J.F.5
  • 3
    • 0033799520 scopus 로고    scopus 로고
    • The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production
    • 10.1007/PL00008697 10.1007/PL00008697 1:CAS:528:DC%2BD3cXmtV2lsbw%3D
    • Andrade AC, Van Nistelrooy JG, Peery RB, Skatrud PL, De Waard MA (2000) The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production. Mol Gen Genet 263:966-977. doi: 10.1007/PL00008697
    • (2000) Mol Gen Genet , vol.263 , pp. 966-977
    • Andrade, A.C.1    Van Nistelrooy, J.G.2    Peery, R.B.3    Skatrud, P.L.4    De Waard, M.A.5
  • 4
    • 0344958846 scopus 로고    scopus 로고
    • Characterization and lysine control of expression of the lys1 gene of Penicillium chrysogenum encoding homocitrate synthase
    • 10.1016/S0378-1119(98)00551-4 10.1016/S0378-1119(98)00551-4
    • Bañuelos O, Casqueiro J, Fierro F, Hijarrubia MJ, Gutierrez S, Martín JF (1999) Characterization and lysine control of expression of the lys1 gene of Penicillium chrysogenum encoding homocitrate synthase. Gene 226:51-59. doi: 10.1016/S0378-1119(98)00551-4
    • (1999) Gene , vol.226 , pp. 51-59
    • Bañuelos, O.1    Casqueiro, J.2    Fierro, F.3    Hijarrubia, M.J.4    Gutierrez, S.5    Martín, J.F.6
  • 5
    • 0024538826 scopus 로고
    • Cloning, sequence analysis and transcriptional study of the isopenicillin N synthase of Penicillium chrysogenum AS-P-78
    • 10.1007/BF00332235 10.1007/BF00332235 1:CAS:528:DyaK3cXjtFaqtQ%3D%3D
    • Barredo JL, Cantoral JM, Álvarez E, Díez B, Martín JF (1989a) Cloning, sequence analysis and transcriptional study of the isopenicillin N synthase of Penicillium chrysogenum AS-P-78. Mol Gen Genet 216:91-98. doi: 10.1007/BF00332235
    • (1989) Mol Gen Genet , vol.216 , pp. 91-98
    • Barredo, J.L.1    Cantoral, J.M.2    Álvarez, E.3    Díez, B.4    Martín, J.F.5
  • 6
    • 0024811804 scopus 로고
    • Large amplification of a 35-kb DNA fragment carrying two penicillin biosynthetic genes in high penicillin producing strains of Penicillium chrysogenum
    • 10.1007/BF00340725 10.1007/BF00340725 1:CAS:528:DyaK3cXhtFGmtLo%3D
    • Barredo JL, Díez B, Álvarez E, Martín JF (1989b) Large amplification of a 35-kb DNA fragment carrying two penicillin biosynthetic genes in high penicillin producing strains of Penicillium chrysogenum. Curr Genet 16:453-459. doi: 10.1007/BF00340725
    • (1989) Curr Genet , vol.16 , pp. 453-459
    • Barredo, J.L.1    Díez, B.2    Álvarez, E.3    Martín, J.F.4
  • 7
    • 0024350391 scopus 로고
    • Cloning and characterization of the acyl-coenzyme A: 6-aminopenicillanic- acid-acyltransferase gene of Penicillium chrysogenum
    • 10.1016/0378-1119(89)90115-7 10.1016/0378-1119(89)90115-7 1:CAS:528:DyaK3cXkslaju78%3D
    • Barredo JL, van Solingen P, Díez B, Álvarez E, Cantoral JM, Kattevilder A, Smaal EB, Groenen MA, Veenstra AE, Martín JF (1989c) Cloning and characterization of the acyl-coenzyme A: 6-aminopenicillanic-acid- acyltransferase gene of Penicillium chrysogenum. Gene 83:291-300. doi: 10.1016/0378-1119(89)90115-7
    • (1989) Gene , vol.83 , pp. 291-300
    • Barredo, J.L.1    Van Solingen, P.2    Díez, B.3    Álvarez, E.4    Cantoral, J.M.5    Kattevilder, A.6    Smaal, E.B.7    Groenen, M.A.8    Veenstra, A.E.9    Martín, J.F.10
  • 8
    • 0014466324 scopus 로고
    • Multiplicity and regulation of amino acid transport in Penicillium chrysogenum
    • 10.1016/0003-9861(69)90207-0 10.1016/0003-9861(69)90207-0 1:CAS:528:DyaF1MXmsFCgtg%3D%3D
    • Benko PV, Wood TC, Segel IH (1969) Multiplicity and regulation of amino acid transport in Penicillium chrysogenum. Arch Biochem Biophys 129:498-508. doi: 10.1016/0003-9861(69)90207-0
    • (1969) Arch Biochem Biophys , vol.129 , pp. 498-508
    • Benko, P.V.1    Wood, T.C.2    Segel, I.H.3
  • 9
    • 0023187586 scopus 로고
    • High-frequency transformation of Penicillium chrysogenum
    • 10.1038/nbt0587-494 10.1038/nbt0587-494 1:CAS:528:DyaL2sXktVCju78%3D
    • Cantoral JM, Díez B, Barredo JL, Álvarez E, Martín JF (1987) High-frequency transformation of Penicillium chrysogenum. Nat Biotechnol 5:494-497. doi: 10.1038/nbt0587-494
    • (1987) Nat Biotechnol , vol.5 , pp. 494-497
    • Cantoral, J.M.1    Díez, B.2    Barredo, J.L.3    Álvarez, E.4    Martín, J.F.5
  • 10
    • 0031817133 scopus 로고    scopus 로고
    • Characterization and nitrogen-source regulation at the transcriptional level of the gdhA gene of Aspergillus awamori encoding an NADP-dependent glutamate dehydrogenase
    • 10.1007/s002940050365 10.1007/s002940050365 1:CAS:528:DyaK1cXks12hsLo%3D
    • Cardoza RE, Moralejo FJ, Gutiérrez S, Casqueiro J, Fierro F, Martín JF (1998) Characterization and nitrogen-source regulation at the transcriptional level of the gdhA gene of Aspergillus awamori encoding an NADP-dependent glutamate dehydrogenase. Curr Genet 34:50-59. doi: 10.1007/s002940050365
    • (1998) Curr Genet , vol.34 , pp. 50-59
    • Cardoza, R.E.1    Moralejo, F.J.2    Gutiérrez, S.3    Casqueiro, J.4    Fierro, F.5    Martín, J.F.6
  • 11
    • 0022870031 scopus 로고
    • Cloning and expression of the isopenicillin N synthetase gene from Penicillium chrysogenum
    • 10.1016/0378-1119(86)90084-3 10.1016/0378-1119(86)90084-3 1:CAS:528:DyaL2sXitVyktbY%3D
    • Carr LG, Skatrud PL, Scheetz ME, Queener SW 2nd, Ingolia TD (1986) Cloning and expression of the isopenicillin N synthetase gene from Penicillium chrysogenum. Gene 48:257-266. doi: 10.1016/0378-1119(86)90084-3
    • (1986) Gene , vol.48 , pp. 257-266
    • Carr, L.G.1    Skatrud, P.L.2    Scheetz, M.E.3    Queener II, S.W.4    Ingolia, T.D.5
  • 12
    • 0344958832 scopus 로고    scopus 로고
    • Gene targeting in Penicillium chrysogenum: Disruption of the lys2 gene leads to penicillin overproduction
    • 1:CAS:528:DyaK1MXhsV2qsr0%3D
    • Casqueiro J, Gutierrez S, Bañuelos O, Hijarrubia MJ, Martín JF (1999) Gene targeting in Penicillium chrysogenum: disruption of the lys2 gene leads to penicillin overproduction. J Bacteriol 181:1181-1188
    • (1999) J Bacteriol , vol.181 , pp. 1181-1188
    • Casqueiro, J.1    Gutierrez, S.2    Bañuelos, O.3    Hijarrubia, M.J.4    Martín, J.F.5
  • 13
    • 0032096384 scopus 로고    scopus 로고
    • Structure, function, and motility of vacuoles in filamentous fungi
    • 10.1006/fgbi.1998.1051 10.1006/fgbi.1998.1051
    • Cole L, Orlovich DA, Ashford AE (1998) Structure, function, and motility of vacuoles in filamentous fungi. Fungal Genet Biol 24:86-100. doi: 10.1006/fgbi.1998.1051
    • (1998) Fungal Genet Biol , vol.24 , pp. 86-100
    • Cole, L.1    Orlovich, D.A.2    Ashford, A.E.3
  • 14
    • 0033051211 scopus 로고    scopus 로고
    • The beta-lactam antibiotics: Past, present, and future
    • 10.1023/A:1001738823146 10.1023/A:1001738823146 1:CAS:528: DyaK1MXkvFKht74%3D
    • Demain AL, Elander RP (1999) The beta-lactam antibiotics: past, present, and future. Antonie Van Leeuwenhoek 75:5-19. doi: 10.1023/A:1001738823146
    • (1999) Antonie Van Leeuwenhoek , vol.75 , pp. 5-19
    • Demain, A.L.1    Elander, R.P.2
  • 15
    • 0025026399 scopus 로고
    • The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl- valine synthetase and linkage to the pcbC and penDE genes
    • Díez B, Gutierrez S, Barredo JL, van Solingen P, van der Voort LH, Martín JF (1990) The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes. J Biol Chem 265:16358-16365
    • (1990) J Biol Chem , vol.265 , pp. 16358-16365
    • Díez, B.1    Gutierrez, S.2    Barredo, J.L.3    Van Solingen, P.4    Van Der Voort, L.H.5    Martín, J.F.6
  • 16
    • 14744279916 scopus 로고    scopus 로고
    • Compartmentalization and transport in beta-lactam antibiotics biosynthesis
    • 10.1007/b99259 1:CAS:528:DC%2BD2MXis1Gltrc%3D
    • Evers ME, Trip H, van den Berg MA, Bovenberg RA, Driessen AJ (2004) Compartmentalization and transport in beta-lactam antibiotics biosynthesis. Adv Biochem Eng Biotechnol 88:111-135. doi: 10.1007/b99259
    • (2004) Adv Biochem Eng Biotechnol , vol.88 , pp. 111-135
    • Evers, M.E.1    Trip, H.2    Van Den Berg, M.A.3    Bovenberg, R.A.4    Driessen, A.J.5
  • 17
    • 0028998750 scopus 로고
    • The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences
    • 10.1016/j.fgb.2006.03.001 10.1073/pnas.92.13.6200 1:CAS:528: DyaK2MXmsFajsL4%3D
    • Fierro F, Barredo JL, Díez B, Gutiérrez S, Fernández FJ, Martín JF (1995) The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences. Proc Natl Acad Sci USA 92:6200-6204. doi: 10.1016/j.fgb.2006.03.001
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6200-6204
    • Fierro, F.1    Barredo, J.L.2    Díez, B.3    Gutiérrez, S.4    Fernández, F.J.5    Martín, J.F.6
  • 18
    • 33746806667 scopus 로고    scopus 로고
    • Transcriptional and bioinformatic analysis of the 56.8 kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum
    • 10.1016/j.fgb.2006.03.001 10.1016/j.fgb.2006.03.001 1:CAS:528: DC%2BD28XotV2lsbo%3D
    • Fierro F, García-Estrada C, Castillo NI, Rodriguez R, Velasco-Conde T, Martín JF (2006) Transcriptional and bioinformatic analysis of the 56.8 kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum. Fungal Genet Biol 43:618-629. doi: 10.1016/j.fgb.2006.03.001
    • (2006) Fungal Genet Biol , vol.43 , pp. 618-629
    • Fierro, F.1    García-Estrada, C.2    Castillo, N.I.3    Rodriguez, R.4    Velasco-Conde, T.5    Martín, J.F.6
  • 19
    • 0034095749 scopus 로고    scopus 로고
    • Confocal microscopy of FM4-64 as a tool for analysing endocytosis and vesicle trafficking in living fungal hyphae
    • 10.1046/j.1365-2818.2000.00708 10.1046/j.1365-2818.2000.00708.x 1:CAS:528:DC%2BD3cXkslygtrs%3D
    • Fischer-Parton S, Parton RM, Hickey PC, Dijksterhuis J, Atkinson HA, Read ND (2000) Confocal microscopy of FM4-64 as a tool for analysing endocytosis and vesicle trafficking in living fungal hyphae. J Microsc 198:246-259. doi: 10.1046/j.1365-2818.2000.00708
    • (2000) J Microsc , vol.198 , pp. 246-259
    • Fischer-Parton, S.1    Parton, R.M.2    Hickey, P.C.3    Dijksterhuis, J.4    Atkinson, H.A.5    Read, N.D.6
  • 20
    • 82255194025 scopus 로고    scopus 로고
    • A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum
    • 10.1016/j.chembiol.2011.08.012 10.1016/j.chembiol.2011.08.012
    • García-Estrada C, Ullán RV, Albillos SM, Fernández-Bodega MA, Durek P, von Dohren H, Martín JF (2011) A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum. Chem Biol 18:1499-1512. doi: 10.1016/j.chembiol.2011.08.012
    • (2011) Chem Biol , vol.18 , pp. 1499-1512
    • García-Estrada, C.1    Ullán, R.V.2    Albillos, S.M.3    Fernández-Bodega, M.A.4    Durek, P.5    Von Dohren, H.6    Martín, J.F.7
  • 22
    • 0024844772 scopus 로고
    • Regulation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine and isopenicillin N biosynthesis in Penicillium chrysogenum by the alpha-aminoadipate pool size
    • 10.1016/0378-1097(89)90368-6 1:STN:280:DyaK3c7ivVWqug%3D%3D
    • Honlinger C, Kubicek CP (1989) Regulation of delta-(L-alpha-aminoadipyl)- L-cysteinyl-D-valine and isopenicillin N biosynthesis in Penicillium chrysogenum by the alpha-aminoadipate pool size. FEMS Microbiol Lett 53:71-75
    • (1989) FEMS Microbiol Lett , vol.53 , pp. 71-75
    • Honlinger, C.1    Kubicek, C.P.2
  • 23
    • 0035732760 scopus 로고    scopus 로고
    • Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladium inflatum
    • 10.1007/s002030100324 10.1007/s002030100324 1:CAS:528: DC%2BD3MXotVShsro%3D
    • Hoppert M, Gentzsch C, Schorgendorfer K (2001) Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladium inflatum. Arch Microbiol 176:285-293. doi: 10.1007/s002030100324
    • (2001) Arch Microbiol , vol.176 , pp. 285-293
    • Hoppert, M.1    Gentzsch, C.2    Schorgendorfer, K.3
  • 24
    • 0015054297 scopus 로고
    • Acidic and basic amino acid transport systems of Penicillium chrysogenum
    • 10.1016/0003-9861(71)90466-8 10.1016/0003-9861(71)90466-8 1:CAS:528:DyaE3MXktlWlsLo%3D
    • Hunter DR, Segel IH (1971) Acidic and basic amino acid transport systems of Penicillium chrysogenum. Arch Biochem Biophys 144:168-183. doi: 10.1016/0003-9861(71)90466-8
    • (1971) Arch Biochem Biophys , vol.144 , pp. 168-183
    • Hunter, D.R.1    Segel, I.H.2
  • 25
    • 0033886562 scopus 로고    scopus 로고
    • The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations
    • 1:CAS:528:DC%2BD3cXmtVemsLw%3D
    • Jack DL, Paulsen IT, Saier MH (2000) The amino acid/polyamine/ organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations. Microbiology 146(Pt 8):1797-1814
    • (2000) Microbiology , vol.146 , Issue.PART 8 , pp. 1797-1814
    • Jack, D.L.1    Paulsen, I.T.2    Saier, M.H.3
  • 26
    • 77953172467 scopus 로고    scopus 로고
    • Proteome analysis of the penicillin producer Penicillium chrysogenum: Characterization of protein changes during the industrial strain improvement
    • 10.1074/mcp.M900327-MCP200 10.1074/mcp.M900327-MCP200 1:CAS:528:DC%2BC3cXpsFCrtL0%3D
    • Jami MS, Barreiro C, García-Estrada C, Martín JF (2010a) Proteome analysis of the penicillin producer Penicillium chrysogenum: characterization of protein changes during the industrial strain improvement. Mol Cell Proteomics 9:1182-1198. doi: 10.1074/mcp.M900327-MCP200
    • (2010) Mol Cell Proteomics , vol.9 , pp. 1182-1198
    • Jami, M.S.1    Barreiro, C.2    García-Estrada, C.3    Martín, J.F.4
  • 27
    • 78650081816 scopus 로고    scopus 로고
    • The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology
    • 10.1074/mcp.M110.001412 10.1074/mcp.M110.001412 1:CAS:528: DC%2BC3MXhs12qsw%3D%3D
    • Jami MS, García-Estrada C, Barreiro C, Cuadrado AA, Salehi-Najafabadi Z, Martín JF (2010b) The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology. Mol Cell Proteomics 9:2729-2744. doi: 10.1074/mcp.M110.001412
    • (2010) Mol Cell Proteomics , vol.9 , pp. 2729-2744
    • Jami, M.S.1    García-Estrada, C.2    Barreiro, C.3    Cuadrado, A.A.4    Salehi-Najafabadi, Z.5    Martín, J.F.6
  • 28
    • 0025170681 scopus 로고
    • The fungal vacuole: Composition, function, and biogenesis
    • 1:CAS:528:DyaK3cXmt1Omu70%3D
    • Klionsky DJ, Herman PK, Emr SD (1990) The fungal vacuole: composition, function, and biogenesis. Microbiol Rev 54:266-292
    • (1990) Microbiol Rev , vol.54 , pp. 266-292
    • Klionsky, D.J.1    Herman, P.K.2    Emr, S.D.3
  • 29
    • 58249093553 scopus 로고    scopus 로고
    • Characterization of a phenylacetate-CoA ligase from Penicillium chrysogenum
    • 10.1042/BJ20081257 10.1042/BJ20081257 1:CAS:528:DC%2BD1cXhsFCisLfE
    • Koetsier MJ, Jekel PA, van den Berg MA, Bovenberg RA, Janssen DB (2009) Characterization of a phenylacetate-CoA ligase from Penicillium chrysogenum. Biochem J 417:467-476. doi: 10.1042/BJ20081257
    • (2009) Biochem J , vol.417 , pp. 467-476
    • Koetsier, M.J.1    Jekel, P.A.2    Van Den Berg, M.A.3    Bovenberg, R.A.4    Janssen, D.B.5
  • 30
    • 58549084975 scopus 로고    scopus 로고
    • The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum
    • 10.1016/j.biochi.2008.09.004 10.1016/j.biochi.2008.09.004 1:CAS:528:DC%2BD1MXhtlGrs78%3D
    • Kosalkova K, García-Estrada C, Ullán RV, Godio RP, Feltrer R, Teijeira F, Mauriz E, Martín JF (2009) The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum. Biochimie 91:214-225. doi: 10.1016/j.biochi.2008.09.004
    • (2009) Biochimie , vol.91 , pp. 214-225
    • Kosalkova, K.1    García-Estrada, C.2    Ullán, R.V.3    Godio, R.P.4    Feltrer, R.5    Teijeira, F.6    Mauriz, E.7    Martín, J.F.8
  • 31
    • 0023501173 scopus 로고
    • Biosynthesis of benzylpenicillin by Penicillium chrysogenum and its Golgi apparatus
    • Kurylowicz W, Kurzatkowski W, Kurzatkowski J (1987) Biosynthesis of benzylpenicillin by Penicillium chrysogenum and its Golgi apparatus. Arch Immunol Ther Exp (Warsz) 35:699-724
    • (1987) Arch Immunol Ther Exp (Warsz) , vol.35 , pp. 699-724
    • Kurylowicz, W.1    Kurzatkowski, W.2    Kurzatkowski, J.3
  • 32
    • 0033059655 scopus 로고    scopus 로고
    • Organization of the gene cluster for biosynthesis of penicillin in Penicillium nalgiovense and antibiotic production in cured dry sausages
    • 1:CAS:528:DyaK1MXhslWku78%3D
    • Laich F, Fierro F, Cardoza RE, Martín JF (1999) Organization of the gene cluster for biosynthesis of penicillin in Penicillium nalgiovense and antibiotic production in cured dry sausages. Appl Environ Microbiol 65:1236-1240
    • (1999) Appl Environ Microbiol , vol.65 , pp. 1236-1240
    • Laich, F.1    Fierro, F.2    Cardoza, R.E.3    Martín, J.F.4
  • 33
    • 0036193358 scopus 로고    scopus 로고
    • Production of penicillin by fungi growing on food products: Identification of a complete penicillin gene cluster in Penicillium griseofulvum and a truncated cluster in Penicillium verrucosum
    • 10.1128/AEM.68.3.1211-1219.2002 10.1128/AEM.68.3.1211-1219.2002 1:CAS:528:DC%2BD38XitFSjsro%3D
    • Laich F, Fierro F, Martín JF (2002) Production of penicillin by fungi growing on food products: identification of a complete penicillin gene cluster in Penicillium griseofulvum and a truncated cluster in Penicillium verrucosum. Appl Environ Microbiol 68:1211-1219. doi: 10.1128/AEM.68.3.1211- 1219.2002
    • (2002) Appl Environ Microbiol , vol.68 , pp. 1211-1219
    • Laich, F.1    Fierro, F.2    Martín, J.F.3
  • 34
    • 33645581640 scopus 로고    scopus 로고
    • Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase
    • 10.1042/BJ20051599 10.1042/BJ20051599 1:CAS:528:DC%2BD28XitlSnsrk%3D
    • Lamas-Maceiras M, Vaca I, Rodríguez E, Casqueiro J, Martín JF (2006) Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase. Biochem J 395:147-155. doi: 10.1042/BJ20051599
    • (2006) Biochem J , vol.395 , pp. 147-155
    • Lamas-Maceiras, M.1    Vaca, I.2    Rodríguez, E.3    Casqueiro, J.4    Martín, J.F.5
  • 35
    • 0027518445 scopus 로고
    • Subcellular compartmentation of penicillin biosynthesis in Penicillium chrysogenum. The amino acid precursors are derived from the vacuole
    • 1:CAS:528:DyaK3sXjsFGmuw%3D%3D
    • Lendenfeld T, Ghali D, Wolschek M, Kubicek-Pranz EM, Kubicek CP (1993) Subcellular compartmentation of penicillin biosynthesis in Penicillium chrysogenum. The amino acid precursors are derived from the vacuole. J Biol Chem 268:665-671
    • (1993) J Biol Chem , vol.268 , pp. 665-671
    • Lendenfeld, T.1    Ghali, D.2    Wolschek, M.3    Kubicek-Pranz, E.M.4    Kubicek, C.P.5
  • 36
    • 0033762376 scopus 로고    scopus 로고
    • Alpha-aminoadipyl-cysteinyl-valine synthetases in beta-lactam producing organisms. from Abraham's discoveries to novel concepts of non-ribosomal peptide synthesis
    • 10.7164/antibiotics.53.100 10.7164/antibiotics.53.1008
    • Martín JF (2000) Alpha-aminoadipyl-cysteinyl-valine synthetases in beta-lactam producing organisms. From Abraham's discoveries to novel concepts of non-ribosomal peptide synthesis. J Antibiot (Tokyo) 53:1008-1021. doi: 10.7164/antibiotics.53.100
    • (2000) J Antibiot (Tokyo) , vol.53 , pp. 1008-1021
    • Martín, J.F.1
  • 37
    • 20444502568 scopus 로고    scopus 로고
    • Secretion systems for secondary metabolites: How producer cells send out messages of intercellular communication
    • 10.1016/j.mib.2005.04.009 10.1016/j.mib.2005.04.009
    • Martín JF, Casqueiro J, Liras P (2005) Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication. Curr Opin Microbiol 8:282-293. doi: 10.1016/j.mib.2005.04.009
    • (2005) Curr Opin Microbiol , vol.8 , pp. 282-293
    • Martín, J.F.1    Casqueiro, J.2    Liras, P.3
  • 38
    • 77953172576 scopus 로고    scopus 로고
    • Regulation and compartmentalization of beta-lactam biosynthesis
    • 10.1111/j.1751-7915.2009.00123.x 10.1111/j.1751-7915.2009.00123.x
    • Martín JF, Ullán RV, García-Estrada C (2010) Regulation and compartmentalization of beta-lactam biosynthesis. Microb Biotechnol 3:285-299. doi: 10.1111/j.1751-7915.2009.00123.x
    • (2010) Microb Biotechnol , vol.3 , pp. 285-299
    • Martín, J.F.1    Ullán, R.V.2    García-Estrada, C.3
  • 39
    • 84873987111 scopus 로고    scopus 로고
    • Genes encoding penicillin and cephalosporin biosynthesis in Acremonium chrysogenum: Two separate clusters are required
    • V.K. Gupta M. Ayyachamy (eds) Science Enfield 10.1201/b11777-7
    • Martín JF, García-Estrada C, Ullán RV (2012) Genes encoding penicillin and cephalosporin biosynthesis in Acremonium chrysogenum: two separate clusters are required. In: Gupta VK, Ayyachamy M (eds) Biotechnology of fungal genes. Science, Enfield, pp 113-138
    • (2012) Biotechnology of Fungal Genes , pp. 113-138
    • Martín, J.F.1    García-Estrada, C.2    Ullán, R.V.3
  • 41
    • 0343244936 scopus 로고
    • Extrachromosomal genetics of Cephalosporium acremonium
    • 10.1007/BF00391811 10.1007/BF00391811 1:CAS:528:DyaL3sXht1agtg%3D%3D
    • Minuth W, Tudzynski P, Esser K (1982) Extrachromosomal genetics of Cephalosporium acremonium. Curr Genet 5:227-231. doi: 10.1007/BF00391811
    • (1982) Curr Genet , vol.5 , pp. 227-231
    • Minuth, W.1    Tudzynski, P.2    Esser, K.3
  • 44
    • 53249134455 scopus 로고    scopus 로고
    • Expression of the transporter encoded by the cefT gene of Acremonium chrysogenum increases cephalosporin production in Penicillium chrysogenum
    • 10.1016/j.fgb.2008.07.008 10.1016/j.fgb.2008.07.008 1:CAS:528: DC%2BD1cXht1ejtbbJ
    • Nijland JG, Kovalchuk A, van den Berg MA, Bovenberg RA, Driessen AJ (2008) Expression of the transporter encoded by the cefT gene of Acremonium chrysogenum increases cephalosporin production in Penicillium chrysogenum. Fungal Genet Biol 45:1415-1421. doi: 10.1016/j.fgb.2008.07.008
    • (2008) Fungal Genet Biol , vol.45 , pp. 1415-1421
    • Nijland, J.G.1    Kovalchuk, A.2    Van Den Berg, M.A.3    Bovenberg, R.A.4    Driessen, A.J.5
  • 45
    • 0030570932 scopus 로고    scopus 로고
    • A structured model for hyphal differentiation and penicillin production using Penicillium chrysogenum
    • 10.1002/(SICI)1097-0290(19960905)51:5<558: AID-BIT8>3.0.CO;2-B 10.1002/(SICI)1097-0290(19960905)51:5<558: AID-BIT8>3.3.CO;2-G 1:CAS:528:DyaK28Xks1Oru74%3D
    • Paul GC, Thomas CR (1996) A structured model for hyphal differentiation and penicillin production using Penicillium chrysogenum. Biotechnol Bioeng 51:558-572. doi:10.1002/(SICI)1097-0290(19960905)51:5<558::AID-BIT8>3.0. CO;2-B
    • (1996) Biotechnol Bioeng , vol.51 , pp. 558-572
    • Paul, G.C.1    Thomas, C.R.2
  • 46
    • 0021918078 scopus 로고
    • Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N
    • 10.1128/AAC.27.3.380 10.1128/AAC.27.3.380 1:CAS:528:DyaL2MXhs1alu7o%3D
    • Ramos FR, López-Nieto MJ, Martín JF (1985) Isopenicillin N synthetase of Penicillium chrysogenum, an enzyme that converts delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N. Antimicrob Agents Chemother 27:380-387. doi: 10.1128/AAC.27.3.380
    • (1985) Antimicrob Agents Chemother , vol.27 , pp. 380-387
    • Ramos, F.R.1    López-Nieto, M.J.2    Martín, J.F.3
  • 47
    • 0029038392 scopus 로고
    • Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes
    • 10.1038/375700a0 10.1038/375700a0 1:CAS:528:DyaK2MXmsFKrt7c%3D
    • Roach PL, Clifton IJ, Fulop V, Harlos K, Barton GJ, Hajdu J, Andersson I, Schofield CJ, Baldwin JE (1995) Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. Nature 375:700-704. doi: 10.1038/375700a0
    • (1995) Nature , vol.375 , pp. 700-704
    • Roach, P.L.1    Clifton, I.J.2    Fulop, V.3    Harlos, K.4    Barton, G.J.5    Hajdu, J.6    Andersson, I.7    Schofield, C.J.8    Baldwin, J.E.9
  • 48
    • 0030947388 scopus 로고    scopus 로고
    • Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation
    • 10.1038/42990 10.1038/42990 1:CAS:528:DyaK2sXktVyjtL0%3D
    • Roach PL, Clifton IJ, Hensgens CM, Shibata N, Schofield CJ, Hajdu J, Baldwin JE (1997) Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. Nature 387:827-830. doi: 10.1038/42990
    • (1997) Nature , vol.387 , pp. 827-830
    • Roach, P.L.1    Clifton, I.J.2    Hensgens, C.M.3    Shibata, N.4    Schofield, C.J.5    Hajdu, J.6    Baldwin, J.E.7
  • 49
    • 0026441194 scopus 로고
    • Quelling: Transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences
    • 10.1111/j.1365-2958.1992.tb02202.x 10.1111/j.1365-2958.1992.tb02202.x 1:CAS:528:DyaK3sXlsF2hsw%3D%3D
    • Romano N, Macino G (1992) Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences. Mol Microbiol 6:3343-3353. doi: 10.1111/j.1365-2958.1992.tb02202.x
    • (1992) Mol Microbiol , vol.6 , pp. 3343-3353
    • Romano, N.1    MacIno, G.2
  • 50
    • 0035968245 scopus 로고    scopus 로고
    • A family of yeast proteins mediating bidirectional vacuolar amino acid transport
    • 10.1074/jbc.M008028200 10.1074/jbc.M008028200 1:CAS:528: DC%2BD3MXltVWjurY%3D
    • Russnak R, Konczal D, McIntire SL (2001) A family of yeast proteins mediating bidirectional vacuolar amino acid transport. J Biol Chem 276:23849-23857. doi: 10.1074/jbc.M008028200
    • (2001) J Biol Chem , vol.276 , pp. 23849-23857
    • Russnak, R.1    Konczal, D.2    McIntire, S.L.3
  • 51
    • 0026102071 scopus 로고
    • Distinct cis-acting signals enhance 3′ endpoint formation of cyc1 mRNA in the yeast Saccharomyces cerevisiae
    • 1:CAS:528:DyaK3MXisVWkt78%3D
    • Russo P, Li WZ, Hampsey DM, Zaret KS, Sherman F (1991) Distinct cis-acting signals enhance 3′ endpoint formation of cyc1 mRNA in the yeast Saccharomyces cerevisiae. EMBO J 10:563-571
    • (1991) EMBO J , vol.10 , pp. 563-571
    • Russo, P.1    Li, W.Z.2    Hampsey, D.M.3    Zaret, K.S.4    Sherman, F.5
  • 52
    • 11944275233 scopus 로고
    • Cloning and heterologous expression of the penicillin biosynthetic gene cluster from Penicillum chrysogenum
    • 10.1038/nbt0190-39 10.1038/nbt0190-39 1:CAS:528:DyaK3cXhtlektLo%3D
    • Smith DJ, Burnham MK, Edwards J, Earl AJ, Turner G (1990) Cloning and heterologous expression of the penicillin biosynthetic gene cluster from Penicillum chrysogenum. Biotechnology (N Y) 8:39-41. doi: 10.1038/nbt0190-39
    • (1990) Biotechnology (N Y) , vol.8 , pp. 39-41
    • Smith, D.J.1    Burnham, M.K.2    Edwards, J.3    Earl, A.J.4    Turner, G.5
  • 53
    • 59849116926 scopus 로고    scopus 로고
    • The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production
    • 10.1042/BJ20081180 10.1042/BJ20081180 1:CAS:528:DC%2BD1MXhtFSht7Y%3D
    • Teijeira F, Ullán RV, Guerra SM, García-Estrada C, Vaca I, Martín JF (2009) The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production. Biochem J 418:113-124. doi: 10.1042/BJ20081180
    • (2009) Biochem J , vol.418 , pp. 113-124
    • Teijeira, F.1    Ullán, R.V.2    Guerra, S.M.3    García-Estrada, C.4    Vaca, I.5    Martín, J.F.6
  • 54
    • 0037144132 scopus 로고    scopus 로고
    • Cloning and characterization of an aromatic amino acid and leucine permease of Penicillium chrysogenum
    • 10.1016/S0005-2736(02)00510-2 10.1016/S0005-2736(02)00510-2 1:CAS:528:DC%2BD38XmvVahur4%3D
    • Trip H, Evers ME, Konings WN, Driessen AJ (2002) Cloning and characterization of an aromatic amino acid and leucine permease of Penicillium chrysogenum. Biochim Biophys Acta 1565:73-80. doi: 10.1016/S0005-2736(02)00510-2
    • (2002) Biochim Biophys Acta , vol.1565 , pp. 73-80
    • Trip, H.1    Evers, M.E.2    Konings, W.N.3    Driessen, A.J.4
  • 55
    • 4143080613 scopus 로고    scopus 로고
    • Uptake of the beta-lactam precursor alpha-aminoadipic acid in Penicillium chrysogenum is mediated by the acidic and the general amino acid permease
    • 10.1128/AEM.70.8.4775-4783.2004 10.1128/AEM.70.8.4775-4783.2004 1:CAS:528:DC%2BD2cXms1elu70%3D
    • Trip H, Evers ME, Kiel JA, Driessen AJ (2004) Uptake of the beta-lactam precursor alpha-aminoadipic acid in Penicillium chrysogenum is mediated by the acidic and the general amino acid permease. Appl Environ Microbiol 70:4775-4783. doi: 10.1128/AEM.70.8.4775-4783.2004
    • (2004) Appl Environ Microbiol , vol.70 , pp. 4775-4783
    • Trip, H.1    Evers, M.E.2    Kiel, J.A.3    Driessen, A.J.4
  • 56
    • 0037195848 scopus 로고    scopus 로고
    • A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum
    • 10.1074/jbc.M207482200 10.1074/jbc.M207482200
    • Ullán RV, Casqueiro J, Bañuelos O, Fernández FJ, Gutierrez S, Martín JF (2002) A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum. J Biol Chem 277:46216-46225. doi: 10.1074/jbc.M207482200
    • (2002) J Biol Chem , vol.277 , pp. 46216-46225
    • Ullán, R.V.1    Casqueiro, J.2    Bañuelos, O.3    Fernández, F.J.4    Gutierrez, S.5    Martín, J.F.6
  • 57
    • 13244249752 scopus 로고    scopus 로고
    • Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis
    • 10.1007/s00438-004-1087-4 10.1007/s00438-004-1087-4
    • Ullán RV, Casqueiro J, Naranjo L, Vaca I, Martín JF (2004) Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis. Mol Genet Genomics 272:562-570. doi: 10.1007/s00438-004-1087-4
    • (2004) Mol Genet Genomics , vol.272 , pp. 562-570
    • Ullán, R.V.1    Casqueiro, J.2    Naranjo, L.3    Vaca, I.4    Martín, J.F.5
  • 58
    • 33947267597 scopus 로고    scopus 로고
    • Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes
    • 10.1016/j.chembiol.2007.01.012 10.1016/j.chembiol.2007.01.012
    • Ullán RV, Campoy S, Casqueiro J, Fernández FJ, Martín JF (2007) Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes. Chem Biol 14:329-339. doi: 10.1016/j.chembiol.2007.01.012
    • (2007) Chem Biol , vol.14 , pp. 329-339
    • Ullán, R.V.1    Campoy, S.2    Casqueiro, J.3    Fernández, F.J.4    Martín, J.F.5
  • 59
    • 50549086676 scopus 로고    scopus 로고
    • RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: Validation studies using beta-lactam genes expression
    • 10.1016/j.mimet.2008.06.001 10.1016/j.mimet.2008.06.001
    • Ullán RV, Godio RP, Teijeira F, Vaca I, García-Estrada C, Feltrer R, Kosalkova K, Martín JF (2008a) RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: validation studies using beta-lactam genes expression. J Microbiol Methods 75:209-218. doi: 10.1016/j.mimet.2008.06. 001
    • (2008) J Microbiol Methods , vol.75 , pp. 209-218
    • Ullán, R.V.1    Godio, R.P.2    Teijeira, F.3    Vaca, I.4    García-Estrada, C.5    Feltrer, R.6    Kosalkova, K.7    Martín, J.F.8
  • 60
    • 50849126781 scopus 로고    scopus 로고
    • Expression of the Acremonium chrysogenum cefT gene in Penicillum chrysogenum indicates that it encodes an hydrophilic beta-lactam transporter
    • 10.1007/s00294-008-0207-9 10.1007/s00294-008-0207-9
    • Ullán RV, Teijeira F, Martin JF (2008b) Expression of the Acremonium chrysogenum cefT gene in Penicillum chrysogenum indicates that it encodes an hydrophilic beta-lactam transporter. Curr Genet 54:153-161. doi: 10.1007/s00294-008-0207-9
    • (2008) Curr Genet , vol.54 , pp. 153-161
    • Ullán, R.V.1    Teijeira, F.2    Martin, J.F.3
  • 61
    • 78649608529 scopus 로고    scopus 로고
    • Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C
    • 10.1042/BJ20100827 10.1042/BJ20100827
    • Ullán RV, Teijeira F, Guerra SM, Vaca I, Martín JF (2010) Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C. Biochem J 432:227-236. doi: 10.1042/BJ20100827
    • (2010) Biochem J , vol.432 , pp. 227-236
    • Ullán, R.V.1    Teijeira, F.2    Guerra, S.M.3    Vaca, I.4    Martín, J.F.5
  • 62
    • 0033020288 scopus 로고    scopus 로고
    • Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi
    • 10.1023/A:1001775932202 10.1023/A:1001775932202
    • van de Kamp M, Driessen AJ, Konings WN (1999) Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi. Antonie Van Leeuwenhoek 75:41-78. doi: 10.1023/A:1001775932202
    • (1999) Antonie Van Leeuwenhoek , vol.75 , pp. 41-78
    • Van De Kamp, M.1    Driessen, A.J.2    Konings, W.N.3
  • 63
    • 34547417000 scopus 로고    scopus 로고
    • Functional characterization of the penicillin biosynthetic gene cluster of Penicillium chrysogenum Wisconsin54-1255
    • 10.1016/j.fgb.2007.03.008 10.1016/j.fgb.2007.03.008
    • van den Berg MA, Westerlaken I, Leeflang C, Kerkman R, Bovenberg RA (2007) Functional characterization of the penicillin biosynthetic gene cluster of Penicillium chrysogenum Wisconsin54-1255. Fungal Genet Biol 44:830-844. doi: 10.1016/j.fgb.2007.03.008
    • (2007) Fungal Genet Biol , vol.44 , pp. 830-844
    • Van Den Berg, M.A.1    Westerlaken, I.2    Leeflang, C.3    Kerkman, R.4    Bovenberg, R.A.5
  • 65
    • 0036392191 scopus 로고    scopus 로고
    • Delta-(L-alpha-Aminoadipyl)-L-cysteinyl-D-valine synthetase, that mediates the first committed step in penicillin biosynthesis, is a cytosolic enzyme
    • 10.1016/S1087-1845(02)00036-1 10.1016/S1087-1845(02)00036-1
    • van der Lende TR, van de Kamp M, Berg M, Sjollema K, Bovenberg RA, Veenhuis M, Konings WN, Driessen AJ (2002) Delta-(L-alpha-Aminoadipyl)-L- cysteinyl-D-valine synthetase, that mediates the first committed step in penicillin biosynthesis, is a cytosolic enzyme. Fungal Genet Biol 37:49-55. doi: 10.1016/S1087-1845(02)00036-1
    • (2002) Fungal Genet Biol , vol.37 , pp. 49-55
    • Van Der Lende, T.R.1    Van De Kamp, M.2    Berg, M.3    Sjollema, K.4    Bovenberg, R.A.5    Veenhuis, M.6    Konings, W.N.7    Driessen, A.J.8
  • 66
    • 34447095636 scopus 로고    scopus 로고
    • Molecular cloning and functional identification of a novel phenylacetyl-CoA ligase gene from Penicillium chrysogenum
    • 10.1016/j.bbrc.2007.06.074 10.1016/j.bbrc.2007.06.074 1:CAS:528:DC%2BD2sXnslSquro%3D
    • Wang FQ, Liu J, Dai M, Ren ZH, Su CY, He JG (2007) Molecular cloning and functional identification of a novel phenylacetyl-CoA ligase gene from Penicillium chrysogenum. Biochem Biophys Res Commun 360:453-458. doi: 10.1016/j.bbrc.2007.06.074
    • (2007) Biochem Biophys Res Commun , vol.360 , pp. 453-458
    • Wang, F.Q.1    Liu, J.2    Dai, M.3    Ren, Z.H.4    Su, C.Y.5    He, J.G.6
  • 67
    • 0032926335 scopus 로고    scopus 로고
    • The amino acid/auxin:proton symport permease family
    • 10.1016/S0005-2736(98)00196-5 1:CAS:528:DyaK1MXivVWgsA%3D%3D
    • Young GB, Jack DL, Smith DW, Saier MH Jr (1999) The amino acid/auxin:proton symport permease family. Biochim Biophys Acta 1415:306-322
    • (1999) Biochim Biophys Acta , vol.1415 , pp. 306-322
    • Young, G.B.1    Jack, D.L.2    Smith, D.W.3    Saier, Jr.M.H.4
  • 68
    • 79960058417 scopus 로고    scopus 로고
    • Cloning and characterization of a novel CoA-ligase gene from Penicillium chrysogenum
    • 10.1007/s12223-011-0044-y 10.1007/s12223-011-0044-y 1:CAS:528: DC%2BC3MXosFCgt74%3D
    • Yu ZL, Liu J, Wang FQ, Dai M, Zhao BH, He JG, Zhang H (2011) Cloning and characterization of a novel CoA-ligase gene from Penicillium chrysogenum. Folia Microbiol (Praha) 56:246-252. doi: 10.1007/s12223-011-0044-y
    • (2011) Folia Microbiol (Praha) , vol.56 , pp. 246-252
    • Yu, Z.L.1    Liu, J.2    Wang, F.Q.3    Dai, M.4    Zhao, B.H.5    He, J.G.6    Zhang, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.