메뉴 건너뛰기




Volumn 267, Issue 5, 2002, Pages 673-683

The cefT gene of Acremonium chrysogenum C10 encodes a putative multidrug efflux pump protein that significantly increases cephalosporin C production

Author keywords

Acremonium chrysogenum; Antibiotic secretion; Cephalosporin; MFS; Multidrug efflux pumps

Indexed keywords

ALPHA AMINOADIPYLCYSTEINYLVALINE SYNTHETASE; CARBOXYLIC ACID DERIVATIVE; CEPHALOSPORIN C; DEXTRO HYDROXYACID DEHYDROGENASE; ISOVALERIC ACID; MEMBRANE PROTEIN; OXIDOREDUCTASE; PHENYLACETIC ACID; PROTEIN CEFT; SYNTHETASE; TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

EID: 0036323756     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-002-0702-5     Document Type: Article
Times cited : (71)

References (48)
  • 5
    • 0027525974 scopus 로고
    • Gene for a β-lactamase, a penicillin-binding protein and a transmembrane protein are clustered with the cephamycin biosynthetic genes in Nocardia lactamdurans
    • (1993) EMBO J , vol.12 , pp. 631-639
    • Coque, J.J.R.1    Liras, P.2    Martín, J.F.3
  • 8
    • 0023219813 scopus 로고
    • Copurification and characterization of deacetoxycephalosporin C synthetase/hydroxylase from Cephalosporium acremonium
    • (1987) J Bacteriol , vol.169 , pp. 1611-1618
    • Dotzlaf, J.E.1    Yeh, W.K.2
  • 13
    • 0025904272 scopus 로고
    • Characterization of the Cephalosporium acremonium pcbAB gene encoding β-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: Linkage to the pcbC gene as a cluster of early cephalsoporin biosynthetic genes and evidence of multiple functional domains
    • (1991) J Bacteriol , vol.173 , pp. 2354-2365
    • Gutiérrez, S.1    Díez, B.2    Montenegro, E.3    Martín, J.F.4
  • 17
    • 0021253525 scopus 로고
    • Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing
    • (1984) Gene , vol.28 , pp. 351-359
    • Henikoff, S.1
  • 25
    • 0024296027 scopus 로고
    • Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
    • (1988) Nature , vol.336 , pp. 348-352
    • Mansour, S.L.1    Thomas, K.R.2    Capecchi, M.R.3
  • 26
    • 0026816531 scopus 로고
    • Clusters of genes for the biosynthesis of antibiotics: Regulatory genes and overproduction of pharmaceuticals
    • (1992) J Ind Microbiol , vol.9 , pp. 73-90
    • Martín, J.F.1
  • 27
    • 0033762376 scopus 로고    scopus 로고
    • α-Aminoadipyl-cysteinyl-valine synthetases in β-lactam producing organisms. From Abraham's discoveries to novel concepts of non-ribosomal peptide synthesis
    • (2000) J Antibiot , vol.53 , pp. 1008-1021
    • Martín, J.F.1
  • 33
    • 0027408932 scopus 로고
    • Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes-an analysis
    • (1993) Gene , vol.124 , pp. 1-11
    • Paulsen, I.T.1    Skurray, R.A.2
  • 37
    • 0022445075 scopus 로고
    • Coordinate increase of isopenicillin N synthetase, isopenicillin N epimerase and deacetoxycephalosporin C synthetase in a high cephalosporin-producing mutant of A. chrysogenum and simultaneous loss of the three enzymes in a non-producing mutant
    • (1986) FEMS Microbiol Lett , vol.35 , pp. 123-127
    • Ramos, F.R.1    López-Nieto, J.M.2    Martín, J.F.3
  • 45
    • 0023037417 scopus 로고
    • Levels of isopenicillin N synthetase and deacetoxycephalosporin C synthetase in Cephalosporium acremonium producing high and low levels of cephalosporin C
    • (1986) Biotechnology , vol.4 , pp. 61-64
    • Shen, Y.Q.1    Wolfe, S.2    Demain, A.L.3
  • 48
    • 0027373644 scopus 로고
    • Targeted integration into the Acremonium chrysogenum genome: Disruption of the pcbC gene
    • (1993) Curr Genet , vol.24 , pp. 421-427
    • Waltz, M.1    Kück, U.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.