Crohn's disease loci are common targets of protozoa-driven selection

Molecular Biology and Evolution

Volumn 30, Issue 5, 2013, Pages 1077-1087

  Cagliani, Rachele ^a   Pozzoli, Uberto ^a   Forni, Diego ^a   Cassinotti, Andrea ^b   Fumagalli, Matteo ^c   Giani, Matteo ^a   Fichera, Maria ^b   Lombardini, Marta ^b   Ardizzone, Sandro ^b   Asselta, Rosanna ^d   De Franchis, Roberto ^b   Riva, Stefania ^a   Biasin, Mara ^d   Comi, Giacomo P ^d   Bresolin, Nereo ^a,d   Clerici, Mario ^d,e   Sironi, Manuela ^a  

^a SCIENTIFIC INSTITUTE   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MILAN   (Italy)

^e IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

Crohn's disease; GWAS; pathogen driven selection; protozoa

Indexed keywords

CELLUBREVIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MICRORNA 31; N ETHYLMALEIMIDE SENSITIVE FACTOR;

ARTICLE; AUTOPHAGY; CROHN DISEASE; DISEASE PREDISPOSITION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; META ANALYSIS; NATURAL SELECTION; NONHUMAN; PROTOZOON; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLELES; CROHN DISEASE; GENES, PROTOZOAN; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; NOD2 SIGNALING ADAPTOR PROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA-BINDING PROTEINS; SELECTION, GENETIC; VESICLE-ASSOCIATED MEMBRANE PROTEIN 3;

PROTOZOA;

EID: 84876547876     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/mst020     Document Type: Article

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