Histone acetyltransferase cofactor Trrap maintains self-renewal and restricts differentiation of embryonic stem cells

Stem Cells

Volumn 31, Issue 5, 2013, Pages 979-991

  Sawan, Carla ^a   Hernandez Vargas, Hector ^a   Murr, Rabih ^a,b   Lopez, Fabrice ^c   Vaissière, Thomas ^a,d   Ghantous, Akram Y ^a   Cuenin, Cyrille ^a   Imbert, Jean ^c   Wang, Zhao Qi ^e   Ren, Bing ^f   Herceg, Zdenko ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^c Aix Marseille university   (France)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e FRITZ LIPMANN INSTITUTE   (Germany)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Embryonic stem cells; Heterochromatization; Histone acetyltransferases; Self renewal; Trrap

Indexed keywords

CELL MARKER; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE COFACTOR TRANSACTIVATION TRANSFORMATION DOMAIN ASSOCIATED PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL RENEWAL; CHROMATIN CONDENSATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; GENE DELETION; GERM LAYER; HISTONE ACETYLATION; HISTONE METHYLATION; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; DOWN-REGULATION; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HISTONE ACETYLTRANSFERASES; HISTONES; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; OCTAMER TRANSCRIPTION FACTOR-3; PROMOTER REGIONS, GENETIC;

EID: 84876544529     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1341     Document Type: Article

References (40)

1. Carrozza MJ, Utley RT, Workman JL et al. The diverse functions of histone acetyltransferase complexes. Trends Genet 2003;19:321-329. (Pubitemid 36694615)
2. Peterson CL, Cote J. Cellular machineries for chromosomal DNA repair. Genes Dev 2004;18:602-616. (Pubitemid 38489929)
3. Loizou JI, Murr R, Finkbeiner MG et al. Epigenetic information in chromatin: The code of entry for DNA repair. Cell Cycle 2006;5:696-701.
4. Murr R, Loizou JI, Yang YG et al. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nat Cell Biol 2006;8:91-99. (Pubitemid 43064802)
5. Cheng AS, Jin VX, Fan M et al. Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters. Mol Cell 2006;21:393-404. (Pubitemid 43163534)
6. Lang SE, Hearing P. The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex. Oncogene 2003;22:2836-2841. (Pubitemid 36609597)
7. McMahon SB, Van Buskirk HA, Dugan KA et al. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 1998;94:363-374. (Pubitemid 28376080)
8. Sierra J, Yoshida T, Joazeiro CA et al. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev 2006;20:586-600. (Pubitemid 43345324)
9. Yanagisawa J, Kitagawa H, Yanagida M et al. Nuclear receptor function requires a TFTC-type histone acetyl transferase complex. Mol Cell 2002;9:553-562. (Pubitemid 34273786)
10. Loizou JI, Oser G, Shukla V et al. Histone acetyltransferase cofactor Trrap is essential for maintaining the hematopoietic stem/progenitor cell pool. J Immunol 2009;183:6422-6431.
11. Fazzio TG, Huff JT, Panning B. An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Cell 2008;134:162-174. (Pubitemid 351905738)
12. Wurdak H, Zhu S, Romero A et al. An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation. Cell Stem Cell 2010;6:37-47.
13. Herceg Z, Hulla W, Gell D et al. Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nat Genet 2001;29:206-211. (Pubitemid 32952660)
14. Mendez J, Stillman B. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis. Mol Cell Biol 2000;20:8602-8612.
15. Xie W, Barr CL, Kim A et al. Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome. Cell 2012;148:816-831.
16. Blankenberg D, Gordon A, Von Kuster G et al. Manipulation of FASTQ data with Galaxy. Bioinformatics 2010;26:1783-1785.
17. Goecks J, Nekrutenko A, Taylor J. Galaxy: A comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences. Genome Biol 2010;11:R86.
18. Langmead B, Trapnell C, Pop M et al. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol 2009;10:R25.
19. Zhang Y, Liu T, Meyer CA et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol 2008;9:R137.
20. Karolchik D, Hinrichs AS, Furey TS et al. The UCSC table browser data retrieval tool. Nucleic Acids Res 2004;32:D493-496. (Pubitemid 38081706)
21. Liang J, Wan M, Zhang Y et al. Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol 2008;10:731-739. (Pubitemid 351772939)
22. Orkin SH, Hochedlinger K. Chromatin connections to pluripotency and cellular reprogramming. Cell 2011;145:835-850.
23. Niwa H. Open conformation chromatin and pluripotency. Genes Dev 2007;21:2671-2676. (Pubitemid 350070715)
24. Ding J, Xu H, Faiola F et al. Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Res 2012;22:155-167.
25. Pereira L, Yi F, Merrill BJ. Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Mol Cell Biol 2006;26:7479-7491. (Pubitemid 44547699)
26. Tam WL, Lim CY, Han J et al. T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells 2008;26:2019-2031.
27. Chew JL, Loh YH, Zhang W et al. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 2005;25:6031-6046. (Pubitemid 40946556)
28. Murr R, Vaissiere T, Sawan C et al. Orchestration of chromatin-based processes: Mind the TRRAP. Oncogene 2007;26:5358-5372. (Pubitemid 47260461)
29. Kaji K, Caballero IM, MacLeod R et al. The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Nat Cell Biol 2006;8:285-292. (Pubitemid 43336071)
30. Shukla V, Vaissiere T, Herceg Z. Histone acetylation and chromatin signature in stem cell identity and cancer. Mutat Res 2008;637:1-15. (Pubitemid 350262807)
31. Burdon T, Smith A, Savatier P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol 2002;12:432-438. (Pubitemid 35239952)
32. Meshorer E, Yellajoshula D, George E et al. Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell 2006;10:105-116. (Pubitemid 43025681)
33. Gaspar-Maia A, Alajem A, Polesso F et al. Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature 2009;460:863-868.
34. Hassan AH, Prochasson P, Neely KE et al. Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes. Cell 2002;111:369-379. (Pubitemid 35345152)
35. Taverna SD, Ueberheide BM, Liu Y et al. Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proc Natl Acad Sci USA 2007;104:2086-2091. (Pubitemid 46391356)
36. Nightingale KP, O'Neill LP, Turner BM. Histone modifications: Signalling receptors and potential elements of a heritable epigenetic code. Curr Opin Genet Dev 2006;16:125-136. (Pubitemid 43376058)
37. Bernstein BE, Mikkelsen TS, Xie X et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006;125:315-326.
38. Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: Impact, heterogeneity, and uncertainty. Cancer Cell 2012;21:283-296.
39. Wei X, Walia V, Lin JC et al. Exome sequencing identifies GRIN2A as frequently mutated in melanoma. Nat Genet 2011;43:442-446.
40. Totoki Y, Tatsuno K, Yamamoto S et al. High-resolution characterization of a hepatocellular carcinoma genome. Nat Genet 2011;43:464-469.