Exome sequencing identifies GRIN2A as frequently mutated in melanoma

Nature Genetics

Volumn 43, Issue 5, 2011, Pages 442-448

  Wei, Xiaomu ^a   Walia, Vijay ^a   Lin, Jimmy C ^b   Teer, Jamie K ^a   Prickett, Todd D ^a   Gartner, Jared ^a   Davis, Sean ^c   Stemke Hale, Katherine ^d   Davies, Michael A ^d   Gershenwald, Jeffrey E ^d   Robinson, William ^e   Robinson, Steven ^e   Rosenberg, Steven A ^c   Samuels, Yardena ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CARNITINE PALMITOYLTRANSFERASE I; DNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A;

ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EXOME; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; HUMAN; MELANOMA; MUTATION; NONHUMAN; PRIORITY JOURNAL;

EID: 85027946522     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.810     Document Type: Article

References (30)

1. Jemal, A., Siegel, R., Xu, J. & Ward, E. Cancer statistics, 2010. CA Cancer J. Clin. 60, 277-300 (2010).
2. Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002). (Pubitemid 34716871)
3. Curtin, J.A., Busam, K., Pinkel, D. & Bastian, B.C. Somatic activation of KIT in distinct subtypes of melanoma. J. Clin. Oncol. 24, 4340-4346 (2006). (Pubitemid 46630793)
4. Prickett, T.D. et al. Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. Nat Genet. 41, 1127-1132 (2009).
5. Pleasance, E.D. et al. A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 463, 191-196 (2010).
6. Gnirke, A. et al. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Nat. Biotechnol. 27, 182-189 (2009).
7. Sjöblom, T. et al. The consensus coding sequences of human breast and colorectal cancers. Science 314, 268-274 (2006). (Pubitemid 44571966)
8. Greenman, C et al. Patterns of somatic mutation in human cancer genomes. Nature 446, 153-158 (2007). (Pubitemid 46398669)
9. Bos, J.L. et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 327, 293-297 (1987). (Pubitemid 17075079)
10. Samuels, Y. et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554 (2004). (Pubitemid 38541907)
11. McMahon, S.B., Van Buskirk, H.A., Dugan, K.A., Copeland, T.D. & Cole, M.D. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94, 363-374 (1998). (Pubitemid 28376080)
12. Barlev, N.A. et al. Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol. Cell 8, 1243-1254 (2001). (Pubitemid 34084996)
13. Herceg, Z. et al. Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nat Genet. 29, 206-211 (2001). (Pubitemid 32952660)
14. Johnson, J.W. & Ascher, P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325, 529-531 (1987). (Pubitemid 17056733)
15. Vogelstein, B. & Kinzler, K.W. Cancer genes and the pathways they control. Nat Med. 10, 789-799 (2004). (Pubitemid 39070849)
16. Hollmann, M. & Heinemann, S. Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31-108 (1994). (Pubitemid 24117025)
17. Pin, J.P., Gomeza, J., Joly, C & Bockaert, J. The metabotropic glutamate receptors: their second intracellular loop plays a critical role in the G-protein coupling specifcity. Biochem. Soc. Trans. 23, 91-96 (1995).
18. Anton, E.S. et al. Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci. 7, 1319-1328 (2004). (Pubitemid 41057754)
19. Rieff, H.I. et al. Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells. J. Neurosci. 19, 10757-10766 (1999). (Pubitemid 30235722)
20. Ozaki, M., Sasner, M., Yano, R., Lu, H.S. & Buonanno, A. Neuregulin-ß induces expression of an NMDA-receptor subunit. Nature 390, 691-694 (1997). (Pubitemid 28016357)
21. Dalva, M.B. et al. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell 103, 945-956 (2000).
22. Takano, T. et al. Glutamate release promotes growth of malignant gliomas. Nat Med. 7, 1010-1015 (2001). (Pubitemid 32937380)
23. Pollock, P.M. et al. Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nat Genet. 34, 108-112 (2003). (Pubitemid 36548800)
24. Shin, S.S. et al. Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation. Pigment Cell Melanoma Res. 21, 368-378 (2008).
25. Rzeski, W., Turski, L. & Ikonomidou, C Glutamate antagonists limit tumor growth. Proc. Natl. Acad. Sci. USA 98, 6372-6377 (2001). (Pubitemid 32488244)
26. Palavalli, L.H. et al. Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nat Genet. 41, 518-520 (2009).
27. Morente, M.M. et al. TuBaFrost 2: standardising tissue collection and quality control procedures for a European virtual frozen tissue bank network. Eur. J. Cancer 42, 2684-2691 (2006). (Pubitemid 44584676)
28. Davies, M.A. et al. Integrated molecular and clinical analysis of AKT activation in metastatic melanoma. Clin. Cancer Res. 15, 7538-7546 (2009).
29. Teer, J.K. et al. Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing. Genome Res. 20, 1420-1431 (2010).
30. Biesecker, L.G. et al. The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res. 19, 1665-1674 (2009).