Regulation of mitophagy by the Gp78 E3 ubiquitin ligase

Molecular Biology of the Cell

Volumn 24, Issue 8, 2013, Pages 1153-1162

  Fu, Min ^a   St Pierre, Pascal ^a   Shankar, Jay ^a   Wang, Peter T C ^a   Joshi, Bharat ^a   Nabi, Ivan R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALNEXIN; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; ENHANCED GREEN FLUORESCENT PROTEIN; GLYCOPROTEIN 78; MITOCHONDRIAL PROTEIN; POLYUBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENZYME ACTIVITY; FIBROSARCOMA; GENETIC TRANSFECTION; MITOCHONDRION; MITOPHAGY; MUTATION; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RING FINGER MOTIF; UBIQUITINATION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOPLASMIC RETICULUM; GENE KNOCKDOWN TECHNIQUES; GREEN FLUORESCENT PROTEINS; GTP PHOSPHOHYDROLASES; HEK293 CELLS; HELA CELLS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; RECEPTORS, AUTOCRINE MOTILITY FACTOR; RNA, SMALL INTERFERING; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84876524198     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-08-0607     Document Type: Article

References (47)

1. Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann A, Griffths G, Ktistakis NT (2008). Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 182, 685-701.
2. Benlimame N, Le PU, Nabi IR (1998). Localization of autocrine motility factor receptor to caveolae and clathrin-independent internaliza-tion of its ligand to smooth endoplasmic reticulum. Mol Biol Cell 9, 1773-1786. (Pubitemid 28337522)
3. Benlimame N, Simard D, Nabi IR (1995). Autocrine motility factor receptor is a marker for a distinct tubular membrane organelle. J Cell Biol 129, 459-471.
4. Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L (2004). OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci USA 101, 15927-15932. (Pubitemid 39507904)
5. Clark IE, Dodson MW, Jiang C, Cao JH, Huh JR, Seol JH, Yoo SJ, Hay BA, Guo M (2006). Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441, 1162-1166. (Pubitemid 43990738)
6. Dagda RK, Cherra SJ 3rd, Kulich SM, Tandon A, Park D, Chu CT (2009). Loss of PINK1 function promotes mitophagy through effects on oxi-dative stress and mitochondrial fssion. J Biol Chem 284, 13843-13855.
7. Deng H, Dodson MW, Huang H, Guo M (2008). The Parkinson's disease genes pink1 and parkin promote mitochondrial fssion and/or inhibit fusion in Drosophila. Proc Natl Acad Sci USA 105, 14503-14508.
8. Dunn WAJ (1990). Studies on the mechanism of autophagy: formation of the autophagic vacuole. J Cell Biol 110, 1923-1935.
9. Fairbank M, St-Pierre P, Nabi IR (2009). The complex biology of autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and its receptor, the gp78/AMFR E3 ubiquitin ligase. Mol Biosyst 5, 793-801.
10. Fang S, Ferrone M, Yang C, Jensen J P, Tiwari S, Weissman AM (2001). The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc Natl Acad Sci USA 98, 14422-14427. (Pubitemid 33121407)
11. Fang S, Lorick KL, Jensen JP, Weissman AM (2003). RING fnger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer. Semin Cancer Biol 13, 5-14. (Pubitemid 36269176)
12. Fu M, Li L, Albrecht T, Johnson JD, Kojic LD, Nabi IR (2011). Autocrine motility factor/phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release. Cell Death Differ 18, 1057-1070.
13. Gegg ME, Cooper JM, Chau K-Y, Rojo M, Schapira AHV, Taanman J-W (2010). Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/par-kin-dependent manner upon induction of mitophagy. Hum Mol Genet 19, 4861-4870.
14. Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, Springer W (2010). PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 12, 119-131.
15. Goetz JG, Genty H, St. Pierre P, Dang T, Joshi B, Sauvé R, Vogl W, Nabi IR (2007). Reversible interactions between smooth domains of the endoplasmic reticulum and mitochondria are regulated by physiological cytosolic calcium levels. J Cell Sci 120, 3553-3564. (Pubitemid 350120948)
16. Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimori T, Yamamoto A (2009). A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol 11, 1433-1437.
17. Joshi B, Li L, Nabi IR (2010). A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase. J Biol Chem 285, 8830-8839.
18. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T (2000). LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19, 5720-5728.
19. Kanki T, Klionsky DJ (2009). Mitochondrial abnormalities drive cell death in Wolfram syndrome 2. Cell Res 19, 922-923.
20. Knott AB, Perkins G, Schwarzenbacher R, Bossy-Wetzel E (2008). Mitochon-drial fragmentation in neurodegeneration. Nat Rev 9, 505-518.
21. Lemasters JJ (2005). Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, aging. Rejuvenation Res 8, 3-5.
22. Liang J-S, Kim T, Fang S, Yamaguchi J, Weissman AM, Fisher EA, Ginsberg HN (2003). Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. J Biol Chem 278, 23984-23988. (Pubitemid 36830228)
23. Matsuda N et al. (2010). PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 189, 211-221.
24. Morito D, Hirao K, Oda Y, Hosokawa N, Tokunaga F, Cyr DM, Tanaka K, Iwai K, Nagata K (2008). Gp78 Cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRdeltaF508. Mol Biol Cell 19, 1328-1336. (Pubitemid 351805088)
25. Nabi IR, Watanabe H, Raz A (1990). Identifcation of B16-F1 melanoma autocrine motility-like factor receptor. Cancer Res 50, 409-414. (Pubitemid 20041250)
26. Narendra D, Tanaka A, Suen DF, Youle RJ (2008). Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183, 795-803.
27. Narendra D P, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ (2010). PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 8, e1000298.
28. Nowikovsky K, Reipert S, Devenish RJ, Schweyen RJ (2007). Mdm38 protein depletion causes loss of mitochondrial K+/H+ exchange activity, osmotic swelling and mitophagy. Cell Death Differ 14, 1647-1656. (Pubitemid 47278850)
29. Park J et al. (2006). Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441, 1157-1161. (Pubitemid 43990737)
30. Park Y-Y, Lee S, Karbowski M, Neutzner A, Youle RJ, Cho H (2010). Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. J Cell Sci 123, 619-626.
31. Rambold AS, Kostelecky B, Elia N, Lippincott-Schwartz J (2011). Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci USA 108, 10190-10195.
32. Ryu SW, Choi K, Park JH, Park YM, Kim S, Choi C (2012). Mitofusin 1 inhibits an apoptosis-associated amino-terminal conformational change in Bax, but not its mitochondrial translocation, in a GTPase-dependent manner. Cancer Lett 323, 62-68.
33. Song BL, Sever N, DeBose-Boyd RA (2005). Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. Mol Cell 19, 829-840. (Pubitemid 41316676)
34. St-Pierre P, Dang T, Joshi B, Nabi IR (2012). Peripheral endoplasmic reticu-lum localization of the Gp78 ubiquitin ligase activity. J Cell Sci 125, 1727-1737.
35. Tanaka A, Cleland MM, Xu S, Narendra D P, Suen DF, Karbowski M, Youle RJ (2010). Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol 191, 1367-1380.
36. Tooze SA, Yoshimori T (2010). The origin of the autophagosomal membrane. Nat Cell Biol 12, 831-835.
37. Tsai YC et al. (2007). The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation. Nat Med 13, 1504-1509. (Pubitemid 350224250)
38. Twig G, Hyde B, Shirihai OS (2008). Mitochondrial fusion, fssion and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta 1777, 1092-1097.
39. Unoki M, Nakamura Y (2001). Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene 20, 4457-4465. (Pubitemid 32772428)
40. Vives-Bauza C et al. (2010). PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci USA 107, 378-383.
41. Wang H-J, Benlimame N, Nabi IR (1997). The AMF-R tubule is a smooth ilimaquinone-sensitive subdomain of the endoplasmic reticulum. J Cell Sci 110, 3043-3053. (Pubitemid 28026435)
42. Wang H-J, Guay G, Pogan L, Sauve R, Nabi IR (2000). Calcium regulates the association between mitochondria and a smooth subdomain of the endoplasmic reticulum. J Cell Biol 150, 1489-1498.
43. Weidberg H, Shvets E, Elazar Z (2011). Biogenesis and cargo selectivity of autophagosomes. Annu Rev Biochem 80, 125-156.
44. Yang Y, Ouyang Y, Yang L, Beal MF, McQuibban A, Vogel H, Lu B (2008). Pink1 regulates mitochondrial dynamics through interaction with the fs-sion/fusion machinery. Proc Natl Acad Sci USA 105, 7070-7075. (Pubitemid 351754531)
45. Ylä-Anttila P, Vihinen H, Jokitalo E, Eskelinen E-L (2009). 3D tomography reveals connections between the phagophore and endoplasmic reticulum. Autophagy 5, 1180-1185.
46. Zhong X, Shen Y, Ballar P, Apostolou A, Agami R, Fang S (2004). AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. J Biol Chem 279, 45676-45684. (Pubitemid 39491556)
47. Ziviani E, Tao RN, Whitworth AJ (2010). Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci USA 107, 5018-5023.