2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation

Toxicological Sciences

Volumn 132, Issue 1, 2013, Pages 235-249

  Kennedy, Lawrence H ^a   Sutter, Carrie Hayes ^a   Carrion, Sandra Leon ^a   Tran, Quynh T ^a   Bodreddigari, Sridevi ^a   Kensicki, Elizabeth ^b   Mohney, Robert P ^b   Sutter, Thomas R ^a  

^a University of Memphis   (United States)

^b METABOLON INC   (United States)

Author keywords

2,3,7,8 tetrachlorodibenzo p dioxin; Ceramide biosynthesis; Differentiation; Epidermal barrier; Glycolysis; Mitochondrial dysfunction; Reactive oxygen species

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CERAMIDE; FATTY ACID; GLUCOSE TRANSPORTER 1; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; CELL DIFFERENTIATION; CHEMICAL ANALYSIS; CHROMOSOME 1Q; CITRIC ACID CYCLE; GENE EXPRESSION; GENOMICS; HUMAN; HUMAN CELL; KERATINOCYTE; LIPID ANALYSIS; METABOLOMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; NUCLEOTIDE SEQUENCE;

CELL DIFFERENTIATION; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENE EXPRESSION; GLYCOLYSIS; HUMANS; KERATINOCYTES; MITOCHONDRIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; TETRACHLORODIBENZODIOXIN;

EID: 84876497454     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs325     Document Type: Article

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